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The map label for this gene is tktA [H]

Identifier: 99080954

GI number: 99080954

Start: 1194349

End: 1196370

Strand: Reverse

Name: tktA [H]

Synonym: TM1040_1113

Alternate gene names: 99080954

Gene position: 1196370-1194349 (Counterclockwise)

Preceding gene: 99080957

Following gene: 99080952

Centisome position: 37.38

GC content: 62.56

Gene sequence:

>2022_bases
GTGGATCTGACAGCCCTGCGCTCTGAAAACCCCGATCATTGGAACAAAGCCGCCGCCATCCGCGCCCTGACGCTGGATGC
GGTTGCGGGTGCAAACTCCGGCCACTCCGGCATGCCGATTGGCATGGCCGATGTCGCAACCGTGCTGTTTGAAAAGCACA
TGAAGTTCGACGTCTCCGCCCCCAAATGGGCGGACCGCGATCGCTTCATCCTGTCGGCCGGCCACGGCTCCATGCTGATC
TATTCGCTGCTCTACCTCATGGGCGACGCACAGGTCACGCTCGAGCAGATCAAGAACTTCCGTCAGTCCGGCGCGCTCAC
GGCGGGCCACCCGGAGAACTTTCTTCTGGACGCGGTCGAAGTCACCACCGGCCCGCTTGGCCAGGGGATCTCGAACGCTG
TCGGCTTTGCCATGGCCGAGGAAAGCCTGCGCGCCCAGTATGGCAAGAAGGTTGTCGATCACTACACCTATGTCATCGCG
GGCGACGGCTGCCTCATGGAAGGCGTGAGCCAGGAGGCAATCGGCCTTGCCGGGCGTCACCAGCTGGGCAAGCTCGTGGT
GTTCTGGGACAACAACAACATCACCATCGACGGCACCGTTGATCTCTCTGATCGCACCAATCAGGTGCAGCGCTTCAAAG
CGTCCGGTTGGCATGTGCAGGAAATCGACGGCCATAACCCGGCCGAGATCGACGCCGCCATCGAGGCCGCGAAGAAGACC
AAGAAACCGTCGATGATCGCCTGCAAAACCCATATCGCTCTGGGTCACGCTGCGCAGGATACCTCCAAAGGCCACGGCGC
TCTGACCGACGCCGATCAGCTCAAAGCCGCCAAGGAAGCCTATGGCTGGACCGGTGGCGCCTATGAGGTGCCCGCCGAGA
TCAAATCCCAGTGGGAAGCGATCGGCCAGCGCGGTGCTACGGCGCGCGCTGAATGGGAAGCGCGTTTTGCCGAGATTTCC
AAGCAGAAACAGGACCGGTTCAACCGGGCCTTTGCCCTTGAGGCGCCGAAGAAGCTCTCCGCGACCGTGAAGGCGCTGAA
AAAGCAGATCTCGGAAACCAAACCCAAGGTGGCAACCCGCAAGGCGTCGGAAATGGCGCTTGAGGTCATCAACCCGATCA
TGCCCGAAACCATTGGCGGCTCGGCGGATCTCACCGGCTCCAACAACACCAAGACCGGCGATCTTGGGGTGTTTGACACC
GACAACCGCAAGGGCCGCTATGTCTATTGGGGCATCCGCGAGCATGGTATGGCGGCAGCGATGAACGGCATGGCGCTGCA
TGGCGGTATTCGCCCCTATGGCGGGACGTTCTTCTGCTTTACCGATTATGCGCGTCCGGCCATGCGTCTGGCGGCCCTGT
CGAAGATCCCGACGGTCTTTGTGATGACCCACGATTCCATCGGTGTGGGCGAAGATGGCCCGACCCACCAGCCGGTCGAG
CATCTCGCGATCTGTCGCGCGACCCCGAACACCTATACCTTCCGCCCTGCCGACGCGGTGGAAACCGCAGAAGCCTGGGA
AATCGCGCTGACGGCCAAGGAAACCCCGTCGGTGATCGCGCTCACGCGTCAGGGCCTGCCCACCGTGCGCACCGAGCACA
AGCTGGCCAACCTCACCGAGAAAGGCGCCTATGTGCTGGCCGAGGCCGAGAGCAAGCGTCAGGTGATCCTGATGGCTTCC
GGCTCCGAAGTGTCGGTTGCGATGGCTGCAAAAGACATCCTCGAGGGTCAAGGCATCGGCACCCGCGTGGTCTCTGTGCC
CTGCATGGAGCTGTTCCACGCGCAGGACGAAGCCTACCGCCGCAAGGTTCTGCCCGCAGGTCCCGTGCGCGTGGCCATCG
AGGCCGCCGTGCGCGATGGCGGCTGGGATCGCCTCTTGCTGGGGGAACGCGGCCAGGAGAAGAAGGCAGGCTTTGTCGGC
ATGCAGGGCTTTGGTGCTTCTGCCCCGGCGGGTGAGCTCTTTGAGAAATTCGGCATTACCGCCGAAGGCACCGTCGCCAA
GGTCAAAGAGCTGTTGGGCTAA

Upstream 100 bases:

>100_bases
GAGTGGCGAAACCCCGCAAAACAGGGCCTCAGCGCTTGATCTTTGCTTTGAGACTGCTATCCAGCGGCAAACCCCTGCGA
ACCCAAAGAGGAACAGTTCA

Downstream 100 bases:

>100_bases
GCCGGGTGCTGGGGGCGCTGCCCCCGACCCTTTCGGGTCTCCCCCGGGATATTTTGAGTTAGAAGATGAAAGGGCGCCCC
GGGTTTGGGGCGCCCTTTTT

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 673; Mature: 673

Protein sequence:

>673_residues
MDLTALRSENPDHWNKAAAIRALTLDAVAGANSGHSGMPIGMADVATVLFEKHMKFDVSAPKWADRDRFILSAGHGSMLI
YSLLYLMGDAQVTLEQIKNFRQSGALTAGHPENFLLDAVEVTTGPLGQGISNAVGFAMAEESLRAQYGKKVVDHYTYVIA
GDGCLMEGVSQEAIGLAGRHQLGKLVVFWDNNNITIDGTVDLSDRTNQVQRFKASGWHVQEIDGHNPAEIDAAIEAAKKT
KKPSMIACKTHIALGHAAQDTSKGHGALTDADQLKAAKEAYGWTGGAYEVPAEIKSQWEAIGQRGATARAEWEARFAEIS
KQKQDRFNRAFALEAPKKLSATVKALKKQISETKPKVATRKASEMALEVINPIMPETIGGSADLTGSNNTKTGDLGVFDT
DNRKGRYVYWGIREHGMAAAMNGMALHGGIRPYGGTFFCFTDYARPAMRLAALSKIPTVFVMTHDSIGVGEDGPTHQPVE
HLAICRATPNTYTFRPADAVETAEAWEIALTAKETPSVIALTRQGLPTVRTEHKLANLTEKGAYVLAEAESKRQVILMAS
GSEVSVAMAAKDILEGQGIGTRVVSVPCMELFHAQDEAYRRKVLPAGPVRVAIEAAVRDGGWDRLLLGERGQEKKAGFVG
MQGFGASAPAGELFEKFGITAEGTVAKVKELLG

Sequences:

>Translated_673_residues
MDLTALRSENPDHWNKAAAIRALTLDAVAGANSGHSGMPIGMADVATVLFEKHMKFDVSAPKWADRDRFILSAGHGSMLI
YSLLYLMGDAQVTLEQIKNFRQSGALTAGHPENFLLDAVEVTTGPLGQGISNAVGFAMAEESLRAQYGKKVVDHYTYVIA
GDGCLMEGVSQEAIGLAGRHQLGKLVVFWDNNNITIDGTVDLSDRTNQVQRFKASGWHVQEIDGHNPAEIDAAIEAAKKT
KKPSMIACKTHIALGHAAQDTSKGHGALTDADQLKAAKEAYGWTGGAYEVPAEIKSQWEAIGQRGATARAEWEARFAEIS
KQKQDRFNRAFALEAPKKLSATVKALKKQISETKPKVATRKASEMALEVINPIMPETIGGSADLTGSNNTKTGDLGVFDT
DNRKGRYVYWGIREHGMAAAMNGMALHGGIRPYGGTFFCFTDYARPAMRLAALSKIPTVFVMTHDSIGVGEDGPTHQPVE
HLAICRATPNTYTFRPADAVETAEAWEIALTAKETPSVIALTRQGLPTVRTEHKLANLTEKGAYVLAEAESKRQVILMAS
GSEVSVAMAAKDILEGQGIGTRVVSVPCMELFHAQDEAYRRKVLPAGPVRVAIEAAVRDGGWDRLLLGERGQEKKAGFVG
MQGFGASAPAGELFEKFGITAEGTVAKVKELLG
>Mature_673_residues
MDLTALRSENPDHWNKAAAIRALTLDAVAGANSGHSGMPIGMADVATVLFEKHMKFDVSAPKWADRDRFILSAGHGSMLI
YSLLYLMGDAQVTLEQIKNFRQSGALTAGHPENFLLDAVEVTTGPLGQGISNAVGFAMAEESLRAQYGKKVVDHYTYVIA
GDGCLMEGVSQEAIGLAGRHQLGKLVVFWDNNNITIDGTVDLSDRTNQVQRFKASGWHVQEIDGHNPAEIDAAIEAAKKT
KKPSMIACKTHIALGHAAQDTSKGHGALTDADQLKAAKEAYGWTGGAYEVPAEIKSQWEAIGQRGATARAEWEARFAEIS
KQKQDRFNRAFALEAPKKLSATVKALKKQISETKPKVATRKASEMALEVINPIMPETIGGSADLTGSNNTKTGDLGVFDT
DNRKGRYVYWGIREHGMAAAMNGMALHGGIRPYGGTFFCFTDYARPAMRLAALSKIPTVFVMTHDSIGVGEDGPTHQPVE
HLAICRATPNTYTFRPADAVETAEAWEIALTAKETPSVIALTRQGLPTVRTEHKLANLTEKGAYVLAEAESKRQVILMAS
GSEVSVAMAAKDILEGQGIGTRVVSVPCMELFHAQDEAYRRKVLPAGPVRVAIEAAVRDGGWDRLLLGERGQEKKAGFVG
MQGFGASAPAGELFEKFGITAEGTVAKVKELLG

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=583, Percent_Identity=25.9005145797599, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI4507521, Length=583, Percent_Identity=25.9005145797599, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI133778974, Length=662, Percent_Identity=25.0755287009063, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI225637459, Length=681, Percent_Identity=23.3480176211454, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI225637461, Length=652, Percent_Identity=23.4662576687117, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI225637463, Length=649, Percent_Identity=23.5747303543914, Blast_Score=95, Evalue=2e-19,
Organism=Escherichia coli, GI48994911, Length=667, Percent_Identity=46.7766116941529, Blast_Score=570, Evalue=1e-163,
Organism=Escherichia coli, GI1788808, Length=669, Percent_Identity=45.2914798206278, Blast_Score=546, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI17539652, Length=683, Percent_Identity=27.2327964860908, Blast_Score=159, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6325331, Length=669, Percent_Identity=42.3019431988042, Blast_Score=461, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6319593, Length=676, Percent_Identity=40.3846153846154, Blast_Score=452, Evalue=1e-128,
Organism=Drosophila melanogaster, GI45551847, Length=677, Percent_Identity=25.4062038404727, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI45550715, Length=677, Percent_Identity=25.4062038404727, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24645119, Length=633, Percent_Identity=25.434439178515, Blast_Score=146, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24666278, Length=239, Percent_Identity=31.7991631799163, Blast_Score=107, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72384; Mature: 72384

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLTALRSENPDHWNKAAAIRALTLDAVAGANSGHSGMPIGMADVATVLFEKHMKFDVSA
CCCCCCCCCCCCHHHHHHHHHEEEEHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCEECCC
PKWADRDRFILSAGHGSMLIYSLLYLMGDAQVTLEQIKNFRQSGALTAGHPENFLLDAVE
CCCCCCCCEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEECCCCCCCEEEEHH
VTTGPLGQGISNAVGFAMAEESLRAQYGKKVVDHYTYVIAGDGCLMEGVSQEAIGLAGRH
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHCCCCHHHHCCCCCC
QLGKLVVFWDNNNITIDGTVDLSDRTNQVQRFKASGWHVQEIDGHNPAEIDAAIEAAKKT
CCCCEEEEECCCEEEEEEEEECCCCHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHC
KKPSMIACKTHIALGHAAQDTSKGHGALTDADQLKAAKEAYGWTGGAYEVPAEIKSQWEA
CCCCEEEEEEHEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEECCHHHHHHHHH
IGQRGATARAEWEARFAEISKQKQDRFNRAFALEAPKKLSATVKALKKQISETKPKVATR
HHHCCCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHCCCHHHHH
KASEMALEVINPIMPETIGGSADLTGSNNTKTGDLGVFDTDNRKGRYVYWGIREHGMAAA
HHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCEEECCCCCCCEEEEEHHHCCHHHH
MNGMALHGGIRPYGGTFFCFTDYARPAMRLAALSKIPTVFVMTHDSIGVGEDGPTHQPVE
HCCEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCHH
HLAICRATPNTYTFRPADAVETAEAWEIALTAKETPSVIALTRQGLPTVRTEHKLANLTE
HHEEEECCCCCEEECCCCHHHCCCCEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHC
KGAYVLAEAESKRQVILMASGSEVSVAMAAKDILEGQGIGTRVVSVPCMELFHAQDEAYR
CCCEEEEECCCCCEEEEEECCCCEEEHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHH
RKVLPAGPVRVAIEAAVRDGGWDRLLLGERGQEKKAGFVGMQGFGASAPAGELFEKFGIT
HHCCCCCCCEEEEEEECCCCCCCEEEECCCCCCCCCCEEEECCCCCCCCHHHHHHHHCCC
AEGTVAKVKELLG
CCCHHHHHHHHHC
>Mature Secondary Structure
MDLTALRSENPDHWNKAAAIRALTLDAVAGANSGHSGMPIGMADVATVLFEKHMKFDVSA
CCCCCCCCCCCCHHHHHHHHHEEEEHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCEECCC
PKWADRDRFILSAGHGSMLIYSLLYLMGDAQVTLEQIKNFRQSGALTAGHPENFLLDAVE
CCCCCCCCEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEECCCCCCCEEEEHH
VTTGPLGQGISNAVGFAMAEESLRAQYGKKVVDHYTYVIAGDGCLMEGVSQEAIGLAGRH
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHCCCCHHHHCCCCCC
QLGKLVVFWDNNNITIDGTVDLSDRTNQVQRFKASGWHVQEIDGHNPAEIDAAIEAAKKT
CCCCEEEEECCCEEEEEEEEECCCCHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHC
KKPSMIACKTHIALGHAAQDTSKGHGALTDADQLKAAKEAYGWTGGAYEVPAEIKSQWEA
CCCCEEEEEEHEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEECCHHHHHHHHH
IGQRGATARAEWEARFAEISKQKQDRFNRAFALEAPKKLSATVKALKKQISETKPKVATR
HHHCCCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHCCCHHHHH
KASEMALEVINPIMPETIGGSADLTGSNNTKTGDLGVFDTDNRKGRYVYWGIREHGMAAA
HHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCEEECCCCCCCEEEEEHHHCCHHHH
MNGMALHGGIRPYGGTFFCFTDYARPAMRLAALSKIPTVFVMTHDSIGVGEDGPTHQPVE
HCCEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCHH
HLAICRATPNTYTFRPADAVETAEAWEIALTAKETPSVIALTRQGLPTVRTEHKLANLTE
HHEEEECCCCCEEECCCCHHHCCCCEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHC
KGAYVLAEAESKRQVILMASGSEVSVAMAAKDILEGQGIGTRVVSVPCMELFHAQDEAYR
CCCEEEEECCCCCEEEEEECCCCEEEHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHH
RKVLPAGPVRVAIEAAVRDGGWDRLLLGERGQEKKAGFVGMQGFGASAPAGELFEKFGIT
HHCCCCCCCEEEEEEECCCCCCCEEEECCCCCCCCCCEEEECCCCCCCCHHHHHHHHCCC
AEGTVAKVKELLG
CCCHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8635754; 9256491 [H]