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The map label for this gene is nuoH

Identifier: 99080594

GI number: 99080594

Start: 809184

End: 810221

Strand: Direct

Name: nuoH

Synonym: TM1040_0753

Alternate gene names: 99080594

Gene position: 809184-810221 (Clockwise)

Preceding gene: 99080593

Following gene: 99080595

Centisome position: 25.28

GC content: 58.86

Gene sequence:

>1038_bases
ATGGCTGAATTCTTTAACACCCCAGGCGGCATTGCTGTCATCATCCTGGCGCAGACCCTGGCGGTTGTCGCCTTTGTGAT
GATCTCGCTTCTGTTCCTTGTCTACGGCGACCGCAAGATCTGGGCCGCCGTCCAGATGCGGCGCGGCCCCAACGTGGTTG
GGGTTTACGGTCTGTTGCAGACCGTCGCGGATGCGCTCAAATATGTTGTGAAAGAGGTGGTCATCCCGGCCGGCTCTGAC
CGGACAGTCTTCATTCTGGCACCGCTCACCTCCTTTGTGCTGGCGATGATCGCCTGGGCGGTGATCCCGTTCAACGACAC
TTGGGTGCTCTCGGACATCAACGTCGCCATCCTGTATGTATTCGCGGTCTCCTCGCTTGAGGTTTACGGCGTCATCATGG
GCGGCTGGGCTTCGAACTCCAAGTATCCGTTCCTCGGCTCCTTGCGGTCGGCGGCGCAGATGATTTCCTACGAGGTCTCC
ATCGGCCTCATCATCATCGGTGTGATCCTCTCGACCGGGTCCATGAACTTTGGCGATATCGTGCGCGCGCAGGACGGGGA
TGCTGGCCTCTTCAACTGGTACTGGCTGCCGCATTTCCCGATGGTGTTCCTGTTCTTCATCTCCTGCCTTGCGGAAACCA
ACCGCCCGCCGTTTGACCTTCCCGAAGCGGAGTCGGAACTGGTGGCAGGCTACCAGGTGGAATACTCCTCAACGCCGTTC
CTGTTGTTCATGGCCGGTGAATACATTGCCATCTTCCTGATGTGCGCGCTCACCTCGCTTCTGTTTTTCGGCGGCTGGCT
CTCGCCGGTACCGTTCCTGCCGGACAGCCCGCTGTGGATGGTCGCAAAGATGGCGTTCTTCTTCTTCCTCTTTGCCATGG
TCAAAGCCATCACCCCGCGCTACCGCTACGATCAGTTGATGCGTCTGGGCTGGAAAGTCTTCCTGCCGTTCTCGCTGATC
TGGGTGGTGTTCGTGGCCTTTGCCGCACGTTTCGAATGGTTCTGGGGTGCGTTTGCACGCTGGAGCACAGGAGGCTGA

Upstream 100 bases:

>100_bases
CACCATCTCGCCCGCCTTACCGCGCGGTTTGCGCACCCTCGACGCAGAAGTCGTGGTGCAGGACTGCAAGGCAAACGGAA
TACCTACGGTGTGAGGACCC

Downstream 100 bases:

>100_bases
TATGACCCAGATCGACTACACCCGCGCTGCCAAATACTTCCTGCTGCAAGACGTGTGGCAGGGGTTCAAGCTGGGGCTGA
AGTATTTCTTCGCCCCCAAG

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MAEFFNTPGGIAVIILAQTLAVVAFVMISLLFLVYGDRKIWAAVQMRRGPNVVGVYGLLQTVADALKYVVKEVVIPAGSD
RTVFILAPLTSFVLAMIAWAVIPFNDTWVLSDINVAILYVFAVSSLEVYGVIMGGWASNSKYPFLGSLRSAAQMISYEVS
IGLIIIGVILSTGSMNFGDIVRAQDGDAGLFNWYWLPHFPMVFLFFISCLAETNRPPFDLPEAESELVAGYQVEYSSTPF
LLFMAGEYIAIFLMCALTSLLFFGGWLSPVPFLPDSPLWMVAKMAFFFFLFAMVKAITPRYRYDQLMRLGWKVFLPFSLI
WVVFVAFAARFEWFWGAFARWSTGG

Sequences:

>Translated_345_residues
MAEFFNTPGGIAVIILAQTLAVVAFVMISLLFLVYGDRKIWAAVQMRRGPNVVGVYGLLQTVADALKYVVKEVVIPAGSD
RTVFILAPLTSFVLAMIAWAVIPFNDTWVLSDINVAILYVFAVSSLEVYGVIMGGWASNSKYPFLGSLRSAAQMISYEVS
IGLIIIGVILSTGSMNFGDIVRAQDGDAGLFNWYWLPHFPMVFLFFISCLAETNRPPFDLPEAESELVAGYQVEYSSTPF
LLFMAGEYIAIFLMCALTSLLFFGGWLSPVPFLPDSPLWMVAKMAFFFFLFAMVKAITPRYRYDQLMRLGWKVFLPFSLI
WVVFVAFAARFEWFWGAFARWSTGG
>Mature_344_residues
AEFFNTPGGIAVIILAQTLAVVAFVMISLLFLVYGDRKIWAAVQMRRGPNVVGVYGLLQTVADALKYVVKEVVIPAGSDR
TVFILAPLTSFVLAMIAWAVIPFNDTWVLSDINVAILYVFAVSSLEVYGVIMGGWASNSKYPFLGSLRSAAQMISYEVSI
GLIIIGVILSTGSMNFGDIVRAQDGDAGLFNWYWLPHFPMVFLFFISCLAETNRPPFDLPEAESELVAGYQVEYSSTPFL
LFMAGEYIAIFLMCALTSLLFFGGWLSPVPFLPDSPLWMVAKMAFFFFLFAMVKAITPRYRYDQLMRLGWKVFLPFSLIW
VVFVAFAARFEWFWGAFARWSTGG

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=291, Percent_Identity=42.6116838487972, Blast_Score=222, Evalue=3e-58,
Organism=Escherichia coli, GI1788618, Length=317, Percent_Identity=41.9558359621451, Blast_Score=244, Evalue=6e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_SILST (Q1GIN0)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_612748.1
- STRING:   Q1GIN0
- GeneID:   4076162
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_0753
- NMPDR:   fig|292414.1.peg.2856
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   SVYGIIM
- PhylomeDB:   Q1GIN0
- ProtClustDB:   PRK06076
- BioCyc:   SSP292414:TM1040_0753-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 38546; Mature: 38415

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe27da50)-; HASH(0xeb1e61c)-; HASH(0xe33aa94)-; HASH(0xdc1c47c)-; HASH(0xe2f04bc)-; HASH(0xddcc1b0)-; HASH(0xe7ae7fc)-; HASH(0xd931570)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEFFNTPGGIAVIILAQTLAVVAFVMISLLFLVYGDRKIWAAVQMRRGPNVVGVYGLLQ
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEHHHHHHH
TVADALKYVVKEVVIPAGSDRTVFILAPLTSFVLAMIAWAVIPFNDTWVLSDINVAILYV
HHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHH
FAVSSLEVYGVIMGGWASNSKYPFLGSLRSAAQMISYEVSIGLIIIGVILSTGSMNFGDI
HHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
VRAQDGDAGLFNWYWLPHFPMVFLFFISCLAETNRPPFDLPEAESELVAGYQVEYSSTPF
EEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCEEEEECCCCE
LLFMAGEYIAIFLMCALTSLLFFGGWLSPVPFLPDSPLWMVAKMAFFFFLFAMVKAITPR
EEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
YRYDQLMRLGWKVFLPFSLIWVVFVAFAARFEWFWGAFARWSTGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
>Mature Secondary Structure 
AEFFNTPGGIAVIILAQTLAVVAFVMISLLFLVYGDRKIWAAVQMRRGPNVVGVYGLLQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEHHHHHHH
TVADALKYVVKEVVIPAGSDRTVFILAPLTSFVLAMIAWAVIPFNDTWVLSDINVAILYV
HHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHH
FAVSSLEVYGVIMGGWASNSKYPFLGSLRSAAQMISYEVSIGLIIIGVILSTGSMNFGDI
HHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
VRAQDGDAGLFNWYWLPHFPMVFLFFISCLAETNRPPFDLPEAESELVAGYQVEYSSTPF
EEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCEEEEECCCCE
LLFMAGEYIAIFLMCALTSLLFFGGWLSPVPFLPDSPLWMVAKMAFFFFLFAMVKAITPR
EEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
YRYDQLMRLGWKVFLPFSLIWVVFVAFAARFEWFWGAFARWSTGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA