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The map label for this gene is nqo3 [H]

Identifier: 99080592

GI number: 99080592

Start: 806806

End: 808788

Strand: Direct

Name: nqo3 [H]

Synonym: TM1040_0751

Alternate gene names: 99080592

Gene position: 806806-808788 (Clockwise)

Preceding gene: 99080591

Following gene: 99080593

Centisome position: 25.21

GC content: 61.88

Gene sequence:

>1983_bases
ATGTCTGACCTCCGCAAGATCAACATTGACGGAACCGAGATCGAAGTCGACGGGGCGATGACCCTGATCCAGGCTTGCGA
GCAGGCCGGGATCGAGATCCCGCGTTTTTGCTATCACGAACGTCTGTCGATTGCCGGCAACTGCCGTATGTGCCTCGTCG
AGGTGGTGGGCGGCCCGCCGAAACCGGCAGCGTCCTGTGCGATGCAGGTCCGCGATCTGCGCCCGGGACCAGAGGGGCAG
GCCCCGCAGGTGAAGACCAATTCACCGATGGTCAAAAAGGCGCGTGAAGGGGTGATGGAGTTTCTCCTGATCAACCACCC
GCTCGACTGCCCGATCTGCGATCAGGGCGGCGAATGCGACCTGCAAGATCAGGCGATGGCTTACGGCGTTGATTTCTCGC
GCTTCCGCGAACCCAAACGCGCGGTGGACGATCTGAACCTCGGCCCGCTTGTGGGCACCGCGATGACCCGCTGCATTTCC
TGCACCCGTTGCGTGCGCTTCACCACCGAGGTCGCAGGCATTTCGCAGATGGGTCAGACCGGGCGCGGCGAGGATGCGGA
GATCACCTCCTACCTCAATGAGACGCTGGATTCGAACCTGCAGGGCAACATCATCGATCTTTGTCCCGTGGGCGCGCTGA
CCTCGAAACCTTATGCGTTTACCGCGCGTCCGTGGGAACTCACCAAGACCGAGACCATCGACGTGATGGACGCGCTCGGA
TCAAACATCCGCGTGGACACTAAGGGCCGCGAAGTGATGCGTATTCTGCCGCGCAACCATGATGGCGTGAACGAAGAGTG
GATCTCTGACAAGACCCGTTTTGTCTGGGATGGTCTGCGCCGTCAGCGGCTTGACCGCCCCTATGTGCGCGTCGATGGCA
AGCTGAAGCCTGCCACTTGGCCCGAGGCGCTGGAGGCTGTCGCCACCGCGATGAAAGGCAAAAAAGTTGCCGGTTTGATT
GGCGATCTGGTTCCGGTCGAGGCAGCTTATGCGCTCAAAGGCCTGATCGAGAGCCTCGAGGGCAAGGTGGACTGCCGCAC
GGATAATGCGCGCCTGCCCATTGGCAACCGCGCAGGCTATGTGGGCACCGCTACGATCGAGGACATCGATACTGCCAGGG
ACATCATCCTGATTGGCACCAACCCTCGCGACGAGGCGCCGGTGCTGAACGCGCGCATCCGCAAGGCGTGGCTCAAGGGG
GCCAATGTCAAACTCGTCGGTCCTGCCGCTGATTTGACCTATGACTATGAACATCTCGGCACTGATCGCGCGGCGCTTGA
TGCGCTCTCTGCGATTGAGGACGCGATTGTCATCGTGGGGCAGGGTGCCCTGCGCGAAGCCGACGGTCTGGCGGTTCTCG
CCAAGGCGCAGTCTCTGGGTAAGCTGCTGGTCCTGCACACCGCCGCCGCTCGTGTGGGCGCGATGGACATTGGGGCCGTC
ACCGAGGGTGGCATGGCAGCAGCCATCGACGGAGCAGAGGTGATTTATAACCTCGGTGCCGACGAGGTGGAAATCGACGC
GGGTGCTTTCGTGATCTATCAAGGTTCGCACGGCGACCGCGGCGCGCATCGCGCTGACGTGATCCTGCCGGGGGCAGCCT
ACACCGAAGAAAACGGTCTCTTTGTGAACACCGAAGGCCGTACACAGCTCTCGATGCGGGCTGGATTTGCACCGGGGGAG
GCGAAAGAAAACTGGGCCATCCTGCGGGCGCTTTCCGCAGAGCTCGATGCCAAACTGCCCTATGACAGCCTCGCGCAACT
GCGAAAGGCGCTGATCAAGGACGTGCCGCATCTGGCCAAGGTGGATCAGGTGGTCGCCAATGAAGGCGAGGCTCTGCCAG
CTGAAAAACTCGGTAAGGCGGATTTCCTTCCTGCGGTGAACGACTTTTACCTGACCAACCCGATTGCACGCGCATCGCAG
CTGATGGCGGAGCTCTCCGCTCAGGCCAAGGCGCGCCGCGAAACGGCGCTGGCGGCAGAGTGA

Upstream 100 bases:

>100_bases
CGGGGTGAAACTGGACCAACCGGAAACATTCTGTGCTTACGGGCTTGCAGAAATTGAGAAAAACAGCGCGATCGGCGTGT
TACTGAGGGCGAAATAGACC

Downstream 100 bases:

>100_bases
TCCGCACGGCGCTCATATCGCTTTTGGGGCTCAACCTCATCGCCTGCACGGATGTCACGGGTGATGAGGTAAGCCGTGCC
GCGCCCGACTATCTGGGCGT

Product: NADH dehydrogenase subunit G

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 3; NDH-1, chain 3 [H]

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MSDLRKINIDGTEIEVDGAMTLIQACEQAGIEIPRFCYHERLSIAGNCRMCLVEVVGGPPKPAASCAMQVRDLRPGPEGQ
APQVKTNSPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQDQAMAYGVDFSRFREPKRAVDDLNLGPLVGTAMTRCIS
CTRCVRFTTEVAGISQMGQTGRGEDAEITSYLNETLDSNLQGNIIDLCPVGALTSKPYAFTARPWELTKTETIDVMDALG
SNIRVDTKGREVMRILPRNHDGVNEEWISDKTRFVWDGLRRQRLDRPYVRVDGKLKPATWPEALEAVATAMKGKKVAGLI
GDLVPVEAAYALKGLIESLEGKVDCRTDNARLPIGNRAGYVGTATIEDIDTARDIILIGTNPRDEAPVLNARIRKAWLKG
ANVKLVGPAADLTYDYEHLGTDRAALDALSAIEDAIVIVGQGALREADGLAVLAKAQSLGKLLVLHTAAARVGAMDIGAV
TEGGMAAAIDGAEVIYNLGADEVEIDAGAFVIYQGSHGDRGAHRADVILPGAAYTEENGLFVNTEGRTQLSMRAGFAPGE
AKENWAILRALSAELDAKLPYDSLAQLRKALIKDVPHLAKVDQVVANEGEALPAEKLGKADFLPAVNDFYLTNPIARASQ
LMAELSAQAKARRETALAAE

Sequences:

>Translated_660_residues
MSDLRKINIDGTEIEVDGAMTLIQACEQAGIEIPRFCYHERLSIAGNCRMCLVEVVGGPPKPAASCAMQVRDLRPGPEGQ
APQVKTNSPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQDQAMAYGVDFSRFREPKRAVDDLNLGPLVGTAMTRCIS
CTRCVRFTTEVAGISQMGQTGRGEDAEITSYLNETLDSNLQGNIIDLCPVGALTSKPYAFTARPWELTKTETIDVMDALG
SNIRVDTKGREVMRILPRNHDGVNEEWISDKTRFVWDGLRRQRLDRPYVRVDGKLKPATWPEALEAVATAMKGKKVAGLI
GDLVPVEAAYALKGLIESLEGKVDCRTDNARLPIGNRAGYVGTATIEDIDTARDIILIGTNPRDEAPVLNARIRKAWLKG
ANVKLVGPAADLTYDYEHLGTDRAALDALSAIEDAIVIVGQGALREADGLAVLAKAQSLGKLLVLHTAAARVGAMDIGAV
TEGGMAAAIDGAEVIYNLGADEVEIDAGAFVIYQGSHGDRGAHRADVILPGAAYTEENGLFVNTEGRTQLSMRAGFAPGE
AKENWAILRALSAELDAKLPYDSLAQLRKALIKDVPHLAKVDQVVANEGEALPAEKLGKADFLPAVNDFYLTNPIARASQ
LMAELSAQAKARRETALAAE
>Mature_659_residues
SDLRKINIDGTEIEVDGAMTLIQACEQAGIEIPRFCYHERLSIAGNCRMCLVEVVGGPPKPAASCAMQVRDLRPGPEGQA
PQVKTNSPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQDQAMAYGVDFSRFREPKRAVDDLNLGPLVGTAMTRCISC
TRCVRFTTEVAGISQMGQTGRGEDAEITSYLNETLDSNLQGNIIDLCPVGALTSKPYAFTARPWELTKTETIDVMDALGS
NIRVDTKGREVMRILPRNHDGVNEEWISDKTRFVWDGLRRQRLDRPYVRVDGKLKPATWPEALEAVATAMKGKKVAGLIG
DLVPVEAAYALKGLIESLEGKVDCRTDNARLPIGNRAGYVGTATIEDIDTARDIILIGTNPRDEAPVLNARIRKAWLKGA
NVKLVGPAADLTYDYEHLGTDRAALDALSAIEDAIVIVGQGALREADGLAVLAKAQSLGKLLVLHTAAARVGAMDIGAVT
EGGMAAAIDGAEVIYNLGADEVEIDAGAFVIYQGSHGDRGAHRADVILPGAAYTEENGLFVNTEGRTQLSMRAGFAPGEA
KENWAILRALSAELDAKLPYDSLAQLRKALIKDVPHLAKVDQVVANEGEALPAEKLGKADFLPAVNDFYLTNPIARASQL
MAELSAQAKARRETALAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1034

COG function: function code C; NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI33519475, Length=707, Percent_Identity=47.9490806223479, Blast_Score=611, Evalue=1e-175,
Organism=Escherichia coli, GI145693161, Length=333, Percent_Identity=31.5315315315315, Blast_Score=190, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17565758, Length=704, Percent_Identity=46.875, Blast_Score=570, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI32566231, Length=585, Percent_Identity=50.0854700854701, Blast_Score=526, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI193209088, Length=259, Percent_Identity=60.2316602316602, Blast_Score=323, Evalue=1e-88,
Organism=Drosophila melanogaster, GI24640559, Length=693, Percent_Identity=46.7532467532467, Blast_Score=575, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24640557, Length=693, Percent_Identity=46.7532467532467, Blast_Score=575, Evalue=1e-164,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR006656
- InterPro:   IPR000283
- InterPro:   IPR010228
- InterPro:   IPR019574
- InterPro:   IPR015405 [H]

Pfam domain/function: PF09326 DUF1982; PF00111 Fer2; PF00384 Molybdopterin; PF10588 NADH-G_4Fe-4S_3 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 71033; Mature: 70902

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00641 COMPLEX1_75K_1 ; PS00642 COMPLEX1_75K_2 ; PS00643 COMPLEX1_75K_3 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLRKINIDGTEIEVDGAMTLIQACEQAGIEIPRFCYHERLSIAGNCRMCLVEVVGGPP
CCCCEEECCCCCEEEECHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCC
KPAASCAMQVRDLRPGPEGQAPQVKTNSPMVKKAREGVMEFLLINHPLDCPICDQGGECD
CHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
LQDQAMAYGVDFSRFREPKRAVDDLNLGPLVGTAMTRCISCTRCVRFTTEVAGISQMGQT
CCCCHHHCCCCHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GRGEDAEITSYLNETLDSNLQGNIIDLCPVGALTSKPYAFTARPWELTKTETIDVMDALG
CCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCEEEECCCCCCCCCHHHHHHHHCC
SNIRVDTKGREVMRILPRNHDGVNEEWISDKTRFVWDGLRRQRLDRPYVRVDGKLKPATW
CCEEEECCCHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHCCCCEEEECCEECCCCC
PEALEAVATAMKGKKVAGLIGDLVPVEAAYALKGLIESLEGKVDCRTDNARLPIGNRAGY
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCE
VGTATIEDIDTARDIILIGTNPRDEAPVLNARIRKAWLKGANVKLVGPAADLTYDYEHLG
EEECCHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCEECHHHHC
TDRAALDALSAIEDAIVIVGQGALREADGLAVLAKAQSLGKLLVLHTAAARVGAMDIGAV
CCHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEHHHHCCEEEEEHHHHHHCCCEECCC
TEGGMAAAIDGAEVIYNLGADEVEIDAGAFVIYQGSHGDRGAHRADVILPGAAYTEENGL
CCCCEEEEECHHHHHEECCCCCEEECCCEEEEEECCCCCCCCCCCCEEECCCCEECCCCE
FVNTEGRTQLSMRAGFAPGEAKENWAILRALSAELDAKLPYDSLAQLRKALIKDVPHLAK
EEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHH
VDQVVANEGEALPAEKLGKADFLPAVNDFYLTNPIARASQLMAELSAQAKARRETALAAE
HHHHHHCCCCCCCHHHCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SDLRKINIDGTEIEVDGAMTLIQACEQAGIEIPRFCYHERLSIAGNCRMCLVEVVGGPP
CCCEEECCCCCEEEECHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCC
KPAASCAMQVRDLRPGPEGQAPQVKTNSPMVKKAREGVMEFLLINHPLDCPICDQGGECD
CHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
LQDQAMAYGVDFSRFREPKRAVDDLNLGPLVGTAMTRCISCTRCVRFTTEVAGISQMGQT
CCCCHHHCCCCHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GRGEDAEITSYLNETLDSNLQGNIIDLCPVGALTSKPYAFTARPWELTKTETIDVMDALG
CCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCEEEECCCCCCCCCHHHHHHHHCC
SNIRVDTKGREVMRILPRNHDGVNEEWISDKTRFVWDGLRRQRLDRPYVRVDGKLKPATW
CCEEEECCCHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHCCCCEEEECCEECCCCC
PEALEAVATAMKGKKVAGLIGDLVPVEAAYALKGLIESLEGKVDCRTDNARLPIGNRAGY
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCE
VGTATIEDIDTARDIILIGTNPRDEAPVLNARIRKAWLKGANVKLVGPAADLTYDYEHLG
EEECCHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCEECHHHHC
TDRAALDALSAIEDAIVIVGQGALREADGLAVLAKAQSLGKLLVLHTAAARVGAMDIGAV
CCHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEHHHHCCEEEEEHHHHHHCCCEECCC
TEGGMAAAIDGAEVIYNLGADEVEIDAGAFVIYQGSHGDRGAHRADVILPGAAYTEENGL
CCCCEEEEECHHHHHEECCCCCEEECCCEEEEEECCCCCCCCCCCCEEECCCCEECCCCE
FVNTEGRTQLSMRAGFAPGEAKENWAILRALSAELDAKLPYDSLAQLRKALIKDVPHLAK
EEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHH
VDQVVANEGEALPAEKLGKADFLPAVNDFYLTNPIARASQLMAELSAQAKARRETALAAE
HHHHHHCCCCCCCHHHCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1605643; 8422400 [H]