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The map label for this gene is lpxC [H]

Identifier: 99080531

GI number: 99080531

Start: 739957

End: 740904

Strand: Direct

Name: lpxC [H]

Synonym: TM1040_0690

Alternate gene names: 99080531

Gene position: 739957-740904 (Clockwise)

Preceding gene: 99080530

Following gene: 99080532

Centisome position: 23.12

GC content: 61.08

Gene sequence:

>948_bases
ATGAGGCACATTGTGCAGAATACGCTCAAAGCAGCAGTCACCTTTGAAGGCACCGGCCTGCATTCTGGCAAACCGGCCAA
GATGGTTGTGCATCCGGCTCCGGCTGGTCACGGCATCACCTTCGTGCGTGTGGACATTGCTCTGGGCAATACCCTCATTC
CGGCACGCTGGGATATGGTGGAGCGCACCGCGCTCTGCACCCGCCTCGTAAACGGGGCCGGGGTATCCGTGTCGACGGTC
GAGCACATCATGGCAGCGCTTGCAGGCTGTGGTGTTCACAATGCACGTGTGGAGATCGACGGGCCCGAAGTTCCGATCAT
GGACGGCTCCTCGGCAGAGTTTGTGCGTGAGATCATGGCCACGGGTATTCAGCGCCTTGGCGTCCCCGTGCGCGCCTGGA
AAGTGCTGAAGCCGGTTATGGTTGAAACCGAAGATGCGCGCGCGACATTGCTGCCCTGCGATCGACTAAAAATCTCCTTT
GATATCGACTTTGCGGAAGAAGGTATTGGCCATCAGAGCCGTGAGCTGGATCTGCGCAACGGTACCTTCGCGCGCGAACT
TTGCGACAGCCGCACCTTCTGCCGCCGCGCAGATGTCGAGACGATGCAGGCCAACGGTCTTGCGCTTGGTGGTGTGCCGG
GCGAAAACGCGGTCGTGTTTGATGGCCCCACCGTGCATGCAGGGTCCGGCCTTCGCCATCCTGATGAGCCTGTGCGTCAC
AAGATGCTGGATGCGCTTGGTGATCTTGCATTGGCGGGCGCGCCGATCTTTGGTCACTATGTTGGTGAACGGGCAGGGCA
CTCGCTCACCAATACGCTTCTTCGTGCGCTTTTTGACACCCCTGGCGCAGTGCGCGAAGTCACCTGCGACCCGATCATGA
CCGCGCGCCTGCCTGGTCAGGGGCTCGTCTGGTCCGAAATCCCCGCGCAGGTGCGCCGCGTCGCCTGA

Upstream 100 bases:

>100_bases
TAATATTCATGTTTCATTCGGTTACAAAGATTGAATTGAGGCTCGCGGCAGGAGCGCTTAGGTGTACCGGCGAGACGGTC
CCTCAGGGCCGAAGCTATCC

Downstream 100 bases:

>100_bases
TCCGCGCGGGCCTCATTTAGCGCGCCGCGAAACGGTCGAGTGCTCTTGGAAACGGTCGATGACATCGGCCGTTTTTTGCA
TTTCCGCTGCATCCTGAGCC

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MRHIVQNTLKAAVTFEGTGLHSGKPAKMVVHPAPAGHGITFVRVDIALGNTLIPARWDMVERTALCTRLVNGAGVSVSTV
EHIMAALAGCGVHNARVEIDGPEVPIMDGSSAEFVREIMATGIQRLGVPVRAWKVLKPVMVETEDARATLLPCDRLKISF
DIDFAEEGIGHQSRELDLRNGTFARELCDSRTFCRRADVETMQANGLALGGVPGENAVVFDGPTVHAGSGLRHPDEPVRH
KMLDALGDLALAGAPIFGHYVGERAGHSLTNTLLRALFDTPGAVREVTCDPIMTARLPGQGLVWSEIPAQVRRVA

Sequences:

>Translated_315_residues
MRHIVQNTLKAAVTFEGTGLHSGKPAKMVVHPAPAGHGITFVRVDIALGNTLIPARWDMVERTALCTRLVNGAGVSVSTV
EHIMAALAGCGVHNARVEIDGPEVPIMDGSSAEFVREIMATGIQRLGVPVRAWKVLKPVMVETEDARATLLPCDRLKISF
DIDFAEEGIGHQSRELDLRNGTFARELCDSRTFCRRADVETMQANGLALGGVPGENAVVFDGPTVHAGSGLRHPDEPVRH
KMLDALGDLALAGAPIFGHYVGERAGHSLTNTLLRALFDTPGAVREVTCDPIMTARLPGQGLVWSEIPAQVRRVA
>Mature_315_residues
MRHIVQNTLKAAVTFEGTGLHSGKPAKMVVHPAPAGHGITFVRVDIALGNTLIPARWDMVERTALCTRLVNGAGVSVSTV
EHIMAALAGCGVHNARVEIDGPEVPIMDGSSAEFVREIMATGIQRLGVPVRAWKVLKPVMVETEDARATLLPCDRLKISF
DIDFAEEGIGHQSRELDLRNGTFARELCDSRTFCRRADVETMQANGLALGGVPGENAVVFDGPTVHAGSGLRHPDEPVRH
KMLDALGDLALAGAPIFGHYVGERAGHSLTNTLLRALFDTPGAVREVTCDPIMTARLPGQGLVWSEIPAQVRRVA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=287, Percent_Identity=40.0696864111498, Blast_Score=194, Evalue=5e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 33761; Mature: 33761

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHIVQNTLKAAVTFEGTGLHSGKPAKMVVHPAPAGHGITFVRVDIALGNTLIPARWDMV
CCHHHHHHHHEEEEECCCCCCCCCCCEEEEECCCCCCCEEEEEEEEEECCEECCCHHHHH
ERTALCTRLVNGAGVSVSTVEHIMAALAGCGVHNARVEIDGPEVPIMDGSSAEFVREIMA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCEECCCHHHHHHHHHH
TGIQRLGVPVRAWKVLKPVMVETEDARATLLPCDRLKISFDIDFAEEGIGHQSRELDLRN
HHHHHHCCCHHHHHHHHHHHEECCCCCEEEECCCCEEEEEECCHHHHCCCCCCCEEECCC
GTFARELCDSRTFCRRADVETMQANGLALGGVPGENAVVFDGPTVHAGSGLRHPDEPVRH
CCHHHHHHCCHHHHHHCCCCHHHCCCEEECCCCCCCEEEECCCEEECCCCCCCCCHHHHH
KMLDALGDLALAGAPIFGHYVGERAGHSLTNTLLRALFDTPGAVREVTCDPIMTARLPGQ
HHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEECCCEEEECCCCC
GLVWSEIPAQVRRVA
CCCHHHHHHHHHHCC
>Mature Secondary Structure
MRHIVQNTLKAAVTFEGTGLHSGKPAKMVVHPAPAGHGITFVRVDIALGNTLIPARWDMV
CCHHHHHHHHEEEEECCCCCCCCCCCEEEEECCCCCCCEEEEEEEEEECCEECCCHHHHH
ERTALCTRLVNGAGVSVSTVEHIMAALAGCGVHNARVEIDGPEVPIMDGSSAEFVREIMA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCEECCCHHHHHHHHHH
TGIQRLGVPVRAWKVLKPVMVETEDARATLLPCDRLKISFDIDFAEEGIGHQSRELDLRN
HHHHHHCCCHHHHHHHHHHHEECCCCCEEEECCCCEEEEEECCHHHHCCCCCCCEEECCC
GTFARELCDSRTFCRRADVETMQANGLALGGVPGENAVVFDGPTVHAGSGLRHPDEPVRH
CCHHHHHHCCHHHHHHCCCCHHHCCCEEECCCCCCCEEEECCCEEECCCCCCCCCHHHHH
KMLDALGDLALAGAPIFGHYVGERAGHSLTNTLLRALFDTPGAVREVTCDPIMTARLPGQ
HHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEECCCEEEECCCCC
GLVWSEIPAQVRRVA
CCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA