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The map label for this gene is vllY [H]

Identifier: 99080423

GI number: 99080423

Start: 619950

End: 621050

Strand: Direct

Name: vllY [H]

Synonym: TM1040_0582

Alternate gene names: 99080423

Gene position: 619950-621050 (Clockwise)

Preceding gene: 99080419

Following gene: 99080425

Centisome position: 19.37

GC content: 55.77

Gene sequence:

>1101_bases
ATGGGACCTTTCCCTCATGATGCCCCCAAATCGGTGATCAGCGCTGAGAACCCGGCCGGAACCGATGGATTTGAATTTGT
AGAGTTTGCCAGCCCGAACCCCGAAGAACTGCGCGAGCTCTTTGCCAAGATGGGGTACGAGTTGGTCGGACGTCACAAGA
CCAAGCCGGGTATCGAGCTTTGGCAGCAGGGGGACATCACCTACATCCTCAATGCCGAGAAAGGCTCTTTTGCGGAAAAG
TTCGTTGAACTTCACGGCCCCTGTGCCCCCTCGATGGGCTGGCGTGTGGTCGATGCGCAAAAGGCGTTTGAGCACGCGGT
GGCCAAGGGGGCGGAGCCCTATGAAGGCGATGACAAAACAATGGATGTGCCTGCAATCAAAGGGATTGGCGGCTCGCTCA
TCTACTTCATCGACCAGTATTACGACACCTCGCCCTATAACGAGGAATTCGAGTGGCTGAAGCAGTCCAAACCGCGCGGC
GTCGGTTTTTATTACCTCGATCACCTCACGCACAATGTCTTCAAAGGCAACATGGACAAGTGGTTCCACTTTTATGGCGA
CCTGTTCAACTTCAAGGAAATCCGGTTCTTTGACATTCAGGGCAAGTATACCGGCCTCTTCAGCCGTGCCTTGACCTCGC
CTTGCGGCCGCATTCGCATTCCGATCAACGAGGACCGTGGCGAGACCGGGCAGATCGTTGCCTATCTCAAGAAGTACAAT
GGCGAAGGCATCCAGCACATCGCTGTGGGCGCGCGTGACATCTATGATGCCACTGACGAGATCTCCGAACGTGGCATCCA
GTTCATGCCGGCCCCGCCTGCAACCTATTACGACATGAGCCACGACCGTGTCCAAGGCCACGAAGAGCCGCTGGATCGTA
TGAAAAAGCACGGCATCCTCATCGACGGCGAAGGCGTGGTGGACGGGGGCGAGACACGCATCCTGCTGCAGATCTTCTCA
AAAACGGTGATCGGGCCGATCTTCTTTGAGTTCATCCAGCGCAAAGGCGATGACGGCTTTGGCGAGGGCAACTTCAAGGC
GCTCTTTGAATCGATCGAACAGGAGCAAATCAACAACGGTGAAATCTCCGCTGCCGAGTGA

Upstream 100 bases:

>100_bases
ATATGTATGATTGGAAAGAATGGACGGTGATGTTGCGCAGAATAAGCACATTATGTGCGGTACACTCGGTCAAACGCAGC
AAGCAACGCAGGAGATACGC

Downstream 100 bases:

>100_bases
TGAGATCTGAGGCGGTGTCGCATGGCGGCGCCGCCCCTTGAATACAAAAGAGAAAGCCGGGCAATTTGCCCGGCTTTTGC
GTTCACTTCAGGAACGTTGC

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: homogentisate; CO2

Alternate protein names: NA

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MGPFPHDAPKSVISAENPAGTDGFEFVEFASPNPEELRELFAKMGYELVGRHKTKPGIELWQQGDITYILNAEKGSFAEK
FVELHGPCAPSMGWRVVDAQKAFEHAVAKGAEPYEGDDKTMDVPAIKGIGGSLIYFIDQYYDTSPYNEEFEWLKQSKPRG
VGFYYLDHLTHNVFKGNMDKWFHFYGDLFNFKEIRFFDIQGKYTGLFSRALTSPCGRIRIPINEDRGETGQIVAYLKKYN
GEGIQHIAVGARDIYDATDEISERGIQFMPAPPATYYDMSHDRVQGHEEPLDRMKKHGILIDGEGVVDGGETRILLQIFS
KTVIGPIFFEFIQRKGDDGFGEGNFKALFESIEQEQINNGEISAAE

Sequences:

>Translated_366_residues
MGPFPHDAPKSVISAENPAGTDGFEFVEFASPNPEELRELFAKMGYELVGRHKTKPGIELWQQGDITYILNAEKGSFAEK
FVELHGPCAPSMGWRVVDAQKAFEHAVAKGAEPYEGDDKTMDVPAIKGIGGSLIYFIDQYYDTSPYNEEFEWLKQSKPRG
VGFYYLDHLTHNVFKGNMDKWFHFYGDLFNFKEIRFFDIQGKYTGLFSRALTSPCGRIRIPINEDRGETGQIVAYLKKYN
GEGIQHIAVGARDIYDATDEISERGIQFMPAPPATYYDMSHDRVQGHEEPLDRMKKHGILIDGEGVVDGGETRILLQIFS
KTVIGPIFFEFIQRKGDDGFGEGNFKALFESIEQEQINNGEISAAE
>Mature_365_residues
GPFPHDAPKSVISAENPAGTDGFEFVEFASPNPEELRELFAKMGYELVGRHKTKPGIELWQQGDITYILNAEKGSFAEKF
VELHGPCAPSMGWRVVDAQKAFEHAVAKGAEPYEGDDKTMDVPAIKGIGGSLIYFIDQYYDTSPYNEEFEWLKQSKPRGV
GFYYLDHLTHNVFKGNMDKWFHFYGDLFNFKEIRFFDIQGKYTGLFSRALTSPCGRIRIPINEDRGETGQIVAYLKKYNG
EGIQHIAVGARDIYDATDEISERGIQFMPAPPATYYDMSHDRVQGHEEPLDRMKKHGILIDGEGVVDGGETRILLQIFSK
TVIGPIFFEFIQRKGDDGFGEGNFKALFESIEQEQINNGEISAAE

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=383, Percent_Identity=25.8485639686684, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI285002264, Length=339, Percent_Identity=26.5486725663717, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI14249394, Length=224, Percent_Identity=29.0178571428571, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17555220, Length=221, Percent_Identity=37.10407239819, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17550752, Length=211, Percent_Identity=29.8578199052133, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21356105, Length=305, Percent_Identity=29.8360655737705, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24667510, Length=305, Percent_Identity=29.8360655737705, Blast_Score=108, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 1.13.11.27

Molecular weight: Translated: 41287; Mature: 41156

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPFPHDAPKSVISAENPAGTDGFEFVEFASPNPEELRELFAKMGYELVGRHKTKPGIEL
CCCCCCCCCHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCHHHHCCCCCCCCHHH
WQQGDITYILNAEKGSFAEKFVELHGPCAPSMGWRVVDAQKAFEHAVAKGAEPYEGDDKT
HHCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCCCCCCE
MDVPAIKGIGGSLIYFIDQYYDTSPYNEEFEWLKQSKPRGVGFYYLDHLTHNVFKGNMDK
ECCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHH
WFHFYGDLFNFKEIRFFDIQGKYTGLFSRALTSPCGRIRIPINEDRGETGQIVAYLKKYN
HHHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHC
GEGIQHIAVGARDIYDATDEISERGIQFMPAPPATYYDMSHDRVQGHEEPLDRMKKHGIL
CCCEEEEECCCHHHHHHHHHHHHCCCEEECCCCCCEECCCCHHHCCCHHHHHHHHHCCEE
IDGEGVVDGGETRILLQIFSKTVIGPIFFEFIQRKGDDGFGEGNFKALFESIEQEQINNG
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCC
EISAAE
CCCCCC
>Mature Secondary Structure 
GPFPHDAPKSVISAENPAGTDGFEFVEFASPNPEELRELFAKMGYELVGRHKTKPGIEL
CCCCCCCCHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCHHHHCCCCCCCCHHH
WQQGDITYILNAEKGSFAEKFVELHGPCAPSMGWRVVDAQKAFEHAVAKGAEPYEGDDKT
HHCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCCCCCCE
MDVPAIKGIGGSLIYFIDQYYDTSPYNEEFEWLKQSKPRGVGFYYLDHLTHNVFKGNMDK
ECCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHH
WFHFYGDLFNFKEIRFFDIQGKYTGLFSRALTSPCGRIRIPINEDRGETGQIVAYLKKYN
HHHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHC
GEGIQHIAVGARDIYDATDEISERGIQFMPAPPATYYDMSHDRVQGHEEPLDRMKKHGIL
CCCEEEEECCCHHHHHHHHHHHHCCCEEECCCCCCEECCCCHHHCCCHHHHHHHHHCCEE
IDGEGVVDGGETRILLQIFSKTVIGPIFFEFIQRKGDDGFGEGNFKALFESIEQEQINNG
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCC
EISAAE
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-hydroxyphenylpyruvate; O2

Specific reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA