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The map label for this gene is cobT

Identifier: 99080419

GI number: 99080419

Start: 614997

End: 616007

Strand: Direct

Name: cobT

Synonym: TM1040_0578

Alternate gene names: 99080419

Gene position: 614997-616007 (Clockwise)

Preceding gene: 99080417

Following gene: 99080423

Centisome position: 19.21

GC content: 65.97

Gene sequence:

>1011_bases
ATGCTGCCAGACCTGACGACGCTTTCTGATTTCCGTAATGCTCTGGCGCAAGCGCCCGGCGCCGATGCTGACGCGCGCGC
GGCCTGCGAGGACCGGAACGGGCAATTGACCAAACCGCCTGGGGCGCTGGGGCAGCTTGAAGAGATCGCGATCTGGTACG
GCAGTTGGCGTGGAACGGCGCGTCCCGAAGTGCGCGCGCCGCAAGTCATTGTCTTTGCCGGAAACCATGGCGTCACCGCG
CGTGGGGTCTCGGCCTTTCCGGCCGAGGTCACGGTGCAGATGGTTGCCAATTTCAAGGCAGGCGGCGCGGCGATCAACCA
GTTGGCCCAGCTCGCTGATGCGCGCATGGATGTCCATGCGCTGGAGCTGGATCGCCCGACGGCTGATTTCACGCAGGGCC
CCGCGATGAGCGAGGAAGACCTGCTGGCCGCGCTGCGCACTGGCTGGAATGCGGTCGATCCGGCGAGCGATGTGCTCGTG
GTGGGCGAAATGGGGATCGGGAACACGACCTCTGCGGCTGCGATCTGCCATGCGCTTTATGGCGGTGAGCCGGGTGATTG
GACGGGCAGGGGCACCGGCGTTGACGACGAGGGCCTTGCCCTGAAGACGGCTGTTATCGCCGAGGCGGTCGCGCTGCACG
GCAGCCGCGACGGGTTGGAGGTTCTGCGTTGCCTTGGCGGGCGTGAGATCGCAGCAATGGCCGGGGCGATCGCTGCGGCG
CGAGTGCTGCGCATTCCGGTTATTCTGGATGGGTTCATCTGCTGTGCCGCTGCGGCCTCTCTGGCGCGCCTGCACGATCA
GGCGTTGGATCACGCTGTCGCAGGCCATCAAAGCGCCGAGGGCGGTCATCAGGCATTGCTGGCGAGACTGGGCAAGGCAC
CGCTGCTGTCGCTGGGGCTGCGCCTTGGAGAGGGCTCTGGGGCGGCACTTGCAATCCAAGTGCTCAAAGGTGCGCTGGCC
TGTCATAGTGGCATGGCCACCTTTGCCGAAGCCGGAGTATCGGACGGCTGA

Upstream 100 bases:

>100_bases
TCGATGCCTCTGGTGGGGCTTCTCGGCAGGGGGCGAGAGCGGTAAACAGTCCTGACATCGCTTTACCTTTGCGGTGCAGT
AGGACGCAACGAGGCTTTTT

Downstream 100 bases:

>100_bases
CCCCGCACAGGGGATCAGCCTCGCGCTCAGGCGCGGTGTTTGATGTGGTCTTCAGCTAGCGACAGCAGCGCCGTTTCCAG
GTCTTTTTCCAGCTCTCTCG

Product: nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Products: NA

Alternate protein names: NN:DBI PRT; N(1)-alpha-phosphoribosyltransferase

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MLPDLTTLSDFRNALAQAPGADADARAACEDRNGQLTKPPGALGQLEEIAIWYGSWRGTARPEVRAPQVIVFAGNHGVTA
RGVSAFPAEVTVQMVANFKAGGAAINQLAQLADARMDVHALELDRPTADFTQGPAMSEEDLLAALRTGWNAVDPASDVLV
VGEMGIGNTTSAAAICHALYGGEPGDWTGRGTGVDDEGLALKTAVIAEAVALHGSRDGLEVLRCLGGREIAAMAGAIAAA
RVLRIPVILDGFICCAAAASLARLHDQALDHAVAGHQSAEGGHQALLARLGKAPLLSLGLRLGEGSGAALAIQVLKGALA
CHSGMATFAEAGVSDG

Sequences:

>Translated_336_residues
MLPDLTTLSDFRNALAQAPGADADARAACEDRNGQLTKPPGALGQLEEIAIWYGSWRGTARPEVRAPQVIVFAGNHGVTA
RGVSAFPAEVTVQMVANFKAGGAAINQLAQLADARMDVHALELDRPTADFTQGPAMSEEDLLAALRTGWNAVDPASDVLV
VGEMGIGNTTSAAAICHALYGGEPGDWTGRGTGVDDEGLALKTAVIAEAVALHGSRDGLEVLRCLGGREIAAMAGAIAAA
RVLRIPVILDGFICCAAAASLARLHDQALDHAVAGHQSAEGGHQALLARLGKAPLLSLGLRLGEGSGAALAIQVLKGALA
CHSGMATFAEAGVSDG
>Mature_336_residues
MLPDLTTLSDFRNALAQAPGADADARAACEDRNGQLTKPPGALGQLEEIAIWYGSWRGTARPEVRAPQVIVFAGNHGVTA
RGVSAFPAEVTVQMVANFKAGGAAINQLAQLADARMDVHALELDRPTADFTQGPAMSEEDLLAALRTGWNAVDPASDVLV
VGEMGIGNTTSAAAICHALYGGEPGDWTGRGTGVDDEGLALKTAVIAEAVALHGSRDGLEVLRCLGGREIAAMAGAIAAA
RVLRIPVILDGFICCAAAASLARLHDQALDHAVAGHQSAEGGHQALLARLGKAPLLSLGLRLGEGSGAALAIQVLKGALA
CHSGMATFAEAGVSDG

Specific function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)

COG id: COG2038

COG function: function code H; NaMN:DMB phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobT family

Homologues:

Organism=Escherichia coli, GI1788300, Length=350, Percent_Identity=31.4285714285714, Blast_Score=145, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBT_SILST (Q1GJ55)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_612573.1
- ProteinModelPortal:   Q1GJ55
- SMR:   Q1GJ55
- STRING:   Q1GJ55
- GeneID:   4076143
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_0578
- NMPDR:   fig|292414.1.peg.2693
- eggNOG:   COG2038
- HOGENOM:   HBG634399
- OMA:   NEMATFS
- PhylomeDB:   Q1GJ55
- ProtClustDB:   PRK00105
- BioCyc:   SSP292414:TM1040_0578-MONOMER
- HAMAP:   MF_00230
- InterPro:   IPR003200
- InterPro:   IPR023195
- InterPro:   IPR017846
- Gene3D:   G3DSA:1.10.1610.10
- TIGRFAMs:   TIGR03160

Pfam domain/function: PF02277 DBI_PRT; SSF52733 NN:DBI_PRT

EC number: =2.4.2.21

Molecular weight: Translated: 34226; Mature: 34226

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: ACT_SITE 304-304

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPDLTTLSDFRNALAQAPGADADARAACEDRNGQLTKPPGALGQLEEIAIWYGSWRGTA
CCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHEEEEEECCCCCC
RPEVRAPQVIVFAGNHGVTARGVSAFPAEVTVQMVANFKAGGAAINQLAQLADARMDVHA
CCCCCCCEEEEEECCCCCEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEE
LELDRPTADFTQGPAMSEEDLLAALRTGWNAVDPASDVLVVGEMGIGNTTSAAAICHALY
EECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHH
GGEPGDWTGRGTGVDDEGLALKTAVIAEAVALHGSRDGLEVLRCLGGREIAAMAGAIAAA
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHH
RVLRIPVILDGFICCAAAASLARLHDQALDHAVAGHQSAEGGHQALLARLGKAPLLSLGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHC
RLGEGSGAALAIQVLKGALACHSGMATFAEAGVSDG
EECCCCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCC
>Mature Secondary Structure
MLPDLTTLSDFRNALAQAPGADADARAACEDRNGQLTKPPGALGQLEEIAIWYGSWRGTA
CCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHEEEEEECCCCCC
RPEVRAPQVIVFAGNHGVTARGVSAFPAEVTVQMVANFKAGGAAINQLAQLADARMDVHA
CCCCCCCEEEEEECCCCCEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEE
LELDRPTADFTQGPAMSEEDLLAALRTGWNAVDPASDVLVVGEMGIGNTTSAAAICHALY
EECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHH
GGEPGDWTGRGTGVDDEGLALKTAVIAEAVALHGSRDGLEVLRCLGGREIAAMAGAIAAA
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHH
RVLRIPVILDGFICCAAAASLARLHDQALDHAVAGHQSAEGGHQALLARLGKAPLLSLGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHC
RLGEGSGAALAIQVLKGALACHSGMATFAEAGVSDG
EECCCCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA