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The map label for this gene is adhI [H]

Identifier: 99080377

GI number: 99080377

Start: 567866

End: 568981

Strand: Reverse

Name: adhI [H]

Synonym: TM1040_0536

Alternate gene names: 99080377

Gene position: 568981-567866 (Counterclockwise)

Preceding gene: 99080381

Following gene: 99080372

Centisome position: 17.78

GC content: 60.3

Gene sequence:

>1116_bases
ATGATCAAAACCCGCGCCGCAGTGGCCCTCGAAGCAGGCAAGCCGCTTGAAATCATGGAGGTGAACCTCGAAGGCCCCAA
GGCGGGCGAGGTTCTCGTCGAGATCAAGGCCACTGGCCTCTGCCACACCGACGAATTCACCCGTTCAGGCGATGATCCCG
AAGGTATCTTTCCCGCCATTCTCGGCCACGAGGGCGCAGGCGTTGTGATTGAGGTCGGCGAAGGCGTCAAAAGTCTGAAG
CCAGGCGATCATGTGATCCCGCTCTATACGCCCGAATGCCGCGAGTGCGATTACTGCCTCAACCCAAAGACCAACCTCTG
CCAGGCGATCCGTTCGACGCAGGGTCAGGGTCTTCTGCCCGATGGCACGACCCGCTTTTCGCTACCGGACGGGACGCCGA
TCCATCACTACATGGGCTGCTCGACTTTCGCCAACCACACGGTTGTGCCCGAGATCGCGCTCGCCAAGATCCGTGAGGAC
GCGCCCTTTGACAAAGTGTGCTACATCGGTTGCGGCGTCACGACGGGCATCGGTGCTGTGATCAACACGGCCAAGGTCGA
AATCGGGTCGACTGCGATCGTGTTTGGCCTTGGCGGGATTGGTCTCAACGTTATTCAGGGCCTTCGCTTGGCCGGTGCGG
ACCAGATCGTCGGTGTGGACCTCAACCCCGGCAAGGTTGCGATGGCGGAAAAATTCGGCATGACCGATTTTGTAAACCCC
TCCGAAGTCGAGGGTGATCTGGTGGCGCACCTTGTTGAGCTCACGGGCGGCGGTGCGGATTACACCTTTGACGCCACCGG
GAATGTCAGCGTCATGCGCACTGCACTCGAAGCGGCCCACAAAGGCTGGGGCGAGAGCATCATCATCGGCGTGGCTCCGG
CGGGCGCAGAGATTTCCACCCGCCCCTTCCAGCTTGTGACCGGCCGTTCCTGGCGCGGCACCGCCTTTGGCGGCGCGTCC
GGTCGCACAGATGTGCCAAAGATCGTGGACTGGTACATGGACGGCAAGATCGAGATCGATCCGATGATCACCCACAAACT
GACGCTTGATCAGATCAACGAAGGGTTTGACCTCATGCACGAGGGCAAATCGATCCGAGCCGTTGTCGAGTTCTAA

Upstream 100 bases:

>100_bases
ACCTGTGACCACATATGCCCAAATCGTTTGCCTGCGTCTGCGCCGCCACACCCGGCAGCAGGCGTAACGGTCTGAAACGT
CTGAGAAGAAGGACAAAGTG

Downstream 100 bases:

>100_bases
GAAGCCCCTGATACAAAAAACAAAAGGCGGCCTCCTTGGGCCGCCTTTTTTGCTCTGAGGTTCGCAGGTTTTACTGTGGT
CCGTCCGCAACCGCGTCGAG

Product: alcohol dehydrogenase GroES-like protein

Products: NA

Alternate protein names: Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MIKTRAAVALEAGKPLEIMEVNLEGPKAGEVLVEIKATGLCHTDEFTRSGDDPEGIFPAILGHEGAGVVIEVGEGVKSLK
PGDHVIPLYTPECRECDYCLNPKTNLCQAIRSTQGQGLLPDGTTRFSLPDGTPIHHYMGCSTFANHTVVPEIALAKIRED
APFDKVCYIGCGVTTGIGAVINTAKVEIGSTAIVFGLGGIGLNVIQGLRLAGADQIVGVDLNPGKVAMAEKFGMTDFVNP
SEVEGDLVAHLVELTGGGADYTFDATGNVSVMRTALEAAHKGWGESIIIGVAPAGAEISTRPFQLVTGRSWRGTAFGGAS
GRTDVPKIVDWYMDGKIEIDPMITHKLTLDQINEGFDLMHEGKSIRAVVEF

Sequences:

>Translated_371_residues
MIKTRAAVALEAGKPLEIMEVNLEGPKAGEVLVEIKATGLCHTDEFTRSGDDPEGIFPAILGHEGAGVVIEVGEGVKSLK
PGDHVIPLYTPECRECDYCLNPKTNLCQAIRSTQGQGLLPDGTTRFSLPDGTPIHHYMGCSTFANHTVVPEIALAKIRED
APFDKVCYIGCGVTTGIGAVINTAKVEIGSTAIVFGLGGIGLNVIQGLRLAGADQIVGVDLNPGKVAMAEKFGMTDFVNP
SEVEGDLVAHLVELTGGGADYTFDATGNVSVMRTALEAAHKGWGESIIIGVAPAGAEISTRPFQLVTGRSWRGTAFGGAS
GRTDVPKIVDWYMDGKIEIDPMITHKLTLDQINEGFDLMHEGKSIRAVVEF
>Mature_371_residues
MIKTRAAVALEAGKPLEIMEVNLEGPKAGEVLVEIKATGLCHTDEFTRSGDDPEGIFPAILGHEGAGVVIEVGEGVKSLK
PGDHVIPLYTPECRECDYCLNPKTNLCQAIRSTQGQGLLPDGTTRFSLPDGTPIHHYMGCSTFANHTVVPEIALAKIRED
APFDKVCYIGCGVTTGIGAVINTAKVEIGSTAIVFGLGGIGLNVIQGLRLAGADQIVGVDLNPGKVAMAEKFGMTDFVNP
SEVEGDLVAHLVELTGGGADYTFDATGNVSVMRTALEAAHKGWGESIIIGVAPAGAEISTRPFQLVTGRSWRGTAFGGAS
GRTDVPKIVDWYMDGKIEIDPMITHKLTLDQINEGFDLMHEGKSIRAVVEF

Specific function: Oxidizes long-chain aliphatic alcohols, long-chain hydroxylated fatty acids and S-hydroxymethylglutathione (hmGSH) in increasing order of preference. Shows little or no activity with short-chain aliphatic alcohols [H]

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=371, Percent_Identity=59.5687331536388, Blast_Score=445, Evalue=1e-125,
Organism=Homo sapiens, GI34577061, Length=371, Percent_Identity=46.3611859838275, Blast_Score=348, Evalue=5e-96,
Organism=Homo sapiens, GI71565152, Length=376, Percent_Identity=46.2765957446808, Blast_Score=344, Evalue=9e-95,
Organism=Homo sapiens, GI262073058, Length=372, Percent_Identity=46.2365591397849, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI71743840, Length=372, Percent_Identity=46.2365591397849, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI4501933, Length=371, Percent_Identity=46.0916442048518, Blast_Score=340, Evalue=1e-93,
Organism=Homo sapiens, GI4501929, Length=371, Percent_Identity=46.0916442048518, Blast_Score=338, Evalue=4e-93,
Organism=Homo sapiens, GI156523966, Length=369, Percent_Identity=43.6314363143631, Blast_Score=328, Evalue=4e-90,
Organism=Homo sapiens, GI4501939, Length=363, Percent_Identity=43.801652892562, Blast_Score=322, Evalue=3e-88,
Organism=Escherichia coli, GI1786552, Length=370, Percent_Identity=60.5405405405405, Blast_Score=452, Evalue=1e-128,
Organism=Escherichia coli, GI87082125, Length=383, Percent_Identity=26.1096605744125, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788073, Length=350, Percent_Identity=26.5714285714286, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1790045, Length=378, Percent_Identity=25.3968253968254, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1787863, Length=358, Percent_Identity=23.7430167597765, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1788075, Length=363, Percent_Identity=26.7217630853994, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87081918, Length=361, Percent_Identity=27.9778393351801, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786825, Length=272, Percent_Identity=28.6764705882353, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI226510992, Length=365, Percent_Identity=25.7534246575342, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786518, Length=367, Percent_Identity=26.4305177111717, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI25146526, Length=375, Percent_Identity=55.4666666666667, Blast_Score=431, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI71997431, Length=377, Percent_Identity=55.1724137931034, Blast_Score=427, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17565904, Length=344, Percent_Identity=54.9418604651163, Blast_Score=397, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17562584, Length=379, Percent_Identity=27.1767810026385, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71988145, Length=375, Percent_Identity=27.4666666666667, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17562582, Length=373, Percent_Identity=26.2734584450402, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17562876, Length=370, Percent_Identity=23.5135135135135, Blast_Score=79, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320033, Length=372, Percent_Identity=52.9569892473118, Blast_Score=423, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6319621, Length=377, Percent_Identity=30.5039787798408, Blast_Score=109, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6323961, Length=367, Percent_Identity=28.3378746594005, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323099, Length=388, Percent_Identity=28.0927835051546, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324486, Length=374, Percent_Identity=27.807486631016, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6319955, Length=362, Percent_Identity=27.6243093922652, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6322619, Length=362, Percent_Identity=27.6243093922652, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6323729, Length=378, Percent_Identity=26.984126984127, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6319257, Length=276, Percent_Identity=26.8115942028986, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6319258, Length=278, Percent_Identity=26.6187050359712, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17737895, Length=373, Percent_Identity=57.9088471849866, Blast_Score=450, Evalue=1e-127,
Organism=Drosophila melanogaster, GI17137530, Length=342, Percent_Identity=25.7309941520468, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1; =1.1.1.284 [H]

Molecular weight: Translated: 39226; Mature: 39226

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKTRAAVALEAGKPLEIMEVNLEGPKAGEVLVEIKATGLCHTDEFTRSGDDPEGIFPAI
CCCCCEEEEEECCCCEEEEEEECCCCCCCCEEEEEEECCCEECCHHHCCCCCCCCCCHHH
LGHEGAGVVIEVGEGVKSLKPGDHVIPLYTPECRECDYCLNPKTNLCQAIRSTQGQGLLP
HCCCCCEEEEECCCCHHHCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
DGTTRFSLPDGTPIHHYMGCSTFANHTVVPEIALAKIREDAPFDKVCYIGCGVTTGIGAV
CCCEEEECCCCCCHHHHCCCHHHCCCCCCCHHHHHHHHCCCCCCCEEEEECCHHHHHHHH
INTAKVEIGSTAIVFGLGGIGLNVIQGLRLAGADQIVGVDLNPGKVAMAEKFGMTDFVNP
EEEEEEEECCEEEEEEECCCHHHHHHHHEECCCCEEEEEECCCCCEEEHHHCCCCCCCCH
SEVEGDLVAHLVELTGGGADYTFDATGNVSVMRTALEAAHKGWGESIIIGVAPAGAEIST
HHCCHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCC
RPFQLVTGRSWRGTAFGGASGRTDVPKIVDWYMDGKIEIDPMITHKLTLDQINEGFDLMH
CCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCEEEECCEEEEEEEHHHHCCCHHHHH
EGKSIRAVVEF
CCCCEEEEEEC
>Mature Secondary Structure
MIKTRAAVALEAGKPLEIMEVNLEGPKAGEVLVEIKATGLCHTDEFTRSGDDPEGIFPAI
CCCCCEEEEEECCCCEEEEEEECCCCCCCCEEEEEEECCCEECCHHHCCCCCCCCCCHHH
LGHEGAGVVIEVGEGVKSLKPGDHVIPLYTPECRECDYCLNPKTNLCQAIRSTQGQGLLP
HCCCCCEEEEECCCCHHHCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
DGTTRFSLPDGTPIHHYMGCSTFANHTVVPEIALAKIREDAPFDKVCYIGCGVTTGIGAV
CCCEEEECCCCCCHHHHCCCHHHCCCCCCCHHHHHHHHCCCCCCCEEEEECCHHHHHHHH
INTAKVEIGSTAIVFGLGGIGLNVIQGLRLAGADQIVGVDLNPGKVAMAEKFGMTDFVNP
EEEEEEEECCEEEEEEECCCHHHHHHHHEECCCCEEEEEECCCCCEEEHHHCCCCCCCCH
SEVEGDLVAHLVELTGGGADYTFDATGNVSVMRTALEAAHKGWGESIIIGVAPAGAEIST
HHCCHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCC
RPFQLVTGRSWRGTAFGGASGRTDVPKIVDWYMDGKIEIDPMITHKLTLDQINEGFDLMH
CCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCEEEECCEEEEEEEHHHHCCCHHHHH
EGKSIRAVVEF
CCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8631716 [H]