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The map label for this gene is aprE [H]

Identifier: 99080369

GI number: 99080369

Start: 554564

End: 555736

Strand: Reverse

Name: aprE [H]

Synonym: TM1040_0528

Alternate gene names: 99080369

Gene position: 555736-554564 (Counterclockwise)

Preceding gene: 99080370

Following gene: 99080367

Centisome position: 17.36

GC content: 60.27

Gene sequence:

>1173_bases
ATGAGCATCGCAGCAGACATGGACATCCTTGAAGGCACCCATGGCGCCAGCCGCATGATCAAGCTGGTGGCGCTGGTGCT
CGTTATGTTTGTCACCTGGGCCGGTTTCGCCTCGGTGGACGAGATCGTGCGCGCCGACGGACAGGTTGTCTCCTCCTCGC
GGGCGCAAATCGTACAGAACCTCGAAGGCGGCATCCTTGCGGAACTCTATGTGCGTCAGGGCGATACCGTGCAGGCCGGG
CAGATCCTCGCCAAGCTGCAGGATACCAAATTTCGGGCAGCCTCAGACGACCTTCAAGACCAGATTGATGCGCTTGAGAT
CAAGCAATACCGCCTCGAGGCGGAGATCGAGGGAGCCTATGAGTTTGCCGTCCCTGACGCACTGGCAAGCCGTTCACCGG
ACATCCTTGCCTCGGAACGCGCGCTGCTCAAGGCGCGTCAGAGCGACTTTGACAGCCGCCGCAACAGCGCCGAGGACATC
CTGCGGCAGCTGAAGAACGAGCTTTCCAACCTGCAGTCCCTGCACGAACAGAAGATTGTCGCACTGCTTGAGGTGAACGA
GGCCAAGAAAAAGGTGAGCGACGCGCAGGCCAAATTCGACGAGATCGGTACCCAGGCCGAATTGACGCTCGCCGAAGAAT
ATTCCGACACCCTGCGCGAGCTGACTTCGCTGCGTCAGGAACAGCGGCTTGCGCGTGACCAGCTTGACCGGACGGTCATC
ACCTCGCCCATGGCGGGGATCGTCAACAGCCTCGCCGTGACCACAATCGGTGGCGTGGTGCGCCCCGGTGATGAGATCCT
CGAGATCATTCCTTTGGGCGAAGAGCTCTTTGTCGAAGCCCGTGTCAAACCCGAAGACATCGCCAATGTGCAGCGCGGGC
AGGATGTGACCATCAAGCTCACCGCCTATGACTACACGATTTATGGTTCGCTCCGGGGCAAGGTGGACATCGTGTCCGCC
GATACCTTTGAGGATGAGCGCGACCCCCGCGCGGCCCCGTTTTACCGGGTCACCGTGCGCGTAGACCGCTCCAGCCTGAC
CGCGCGCCAGAAACAAATCGAAATCCGCCCAGGCATGCGCGCCACGGCAGAGCTGCAAACCGGATCAAAGACGATCCTCA
GTTACCTGTTGAAACCGCTCTATAAATCACGCGAAGCCTTCCGGGAGCCATAG

Upstream 100 bases:

>100_bases
CGCTCACCAACCGCACCTTGATCCTGCAGGCCGGGCGCATGGTTGTGGACGGGCCACGCGACGAGGTGTTGGCGCATCTG
AACGGGGGGAGCAAAGCCTC

Downstream 100 bases:

>100_bases
GTGGGAAACGACAATGTCCGGTTGCCATTCTGGCACCGGATCCTGTCGATAACTCTGGATGCTTACGCGGCGACGGTTTG
CCGTTTTGGCCACATGTCGC

Product: Type I secretion membrane fusion protein, HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MSIAADMDILEGTHGASRMIKLVALVLVMFVTWAGFASVDEIVRADGQVVSSSRAQIVQNLEGGILAELYVRQGDTVQAG
QILAKLQDTKFRAASDDLQDQIDALEIKQYRLEAEIEGAYEFAVPDALASRSPDILASERALLKARQSDFDSRRNSAEDI
LRQLKNELSNLQSLHEQKIVALLEVNEAKKKVSDAQAKFDEIGTQAELTLAEEYSDTLRELTSLRQEQRLARDQLDRTVI
TSPMAGIVNSLAVTTIGGVVRPGDEILEIIPLGEELFVEARVKPEDIANVQRGQDVTIKLTAYDYTIYGSLRGKVDIVSA
DTFEDERDPRAAPFYRVTVRVDRSSLTARQKQIEIRPGMRATAELQTGSKTILSYLLKPLYKSREAFREP

Sequences:

>Translated_390_residues
MSIAADMDILEGTHGASRMIKLVALVLVMFVTWAGFASVDEIVRADGQVVSSSRAQIVQNLEGGILAELYVRQGDTVQAG
QILAKLQDTKFRAASDDLQDQIDALEIKQYRLEAEIEGAYEFAVPDALASRSPDILASERALLKARQSDFDSRRNSAEDI
LRQLKNELSNLQSLHEQKIVALLEVNEAKKKVSDAQAKFDEIGTQAELTLAEEYSDTLRELTSLRQEQRLARDQLDRTVI
TSPMAGIVNSLAVTTIGGVVRPGDEILEIIPLGEELFVEARVKPEDIANVQRGQDVTIKLTAYDYTIYGSLRGKVDIVSA
DTFEDERDPRAAPFYRVTVRVDRSSLTARQKQIEIRPGMRATAELQTGSKTILSYLLKPLYKSREAFREP
>Mature_389_residues
SIAADMDILEGTHGASRMIKLVALVLVMFVTWAGFASVDEIVRADGQVVSSSRAQIVQNLEGGILAELYVRQGDTVQAGQ
ILAKLQDTKFRAASDDLQDQIDALEIKQYRLEAEIEGAYEFAVPDALASRSPDILASERALLKARQSDFDSRRNSAEDIL
RQLKNELSNLQSLHEQKIVALLEVNEAKKKVSDAQAKFDEIGTQAELTLAEEYSDTLRELTSLRQEQRLARDQLDRTVIT
SPMAGIVNSLAVTTIGGVVRPGDEILEIIPLGEELFVEARVKPEDIANVQRGQDVTIKLTAYDYTIYGSLRGKVDIVSAD
TFEDERDPRAAPFYRVTVRVDRSSLTARQKQIEIRPGMRATAELQTGSKTILSYLLKPLYKSREAFREP

Specific function: Involved in the secretion of alkaline protease [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003997
- InterPro:   IPR006143
- InterPro:   IPR006144
- InterPro:   IPR010129 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43343; Mature: 43212

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00543 HLYD_FAMILY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIAADMDILEGTHGASRMIKLVALVLVMFVTWAGFASVDEIVRADGQVVSSSRAQIVQN
CCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHH
LEGGILAELYVRQGDTVQAGQILAKLQDTKFRAASDDLQDQIDALEIKQYRLEAEIEGAY
CCCCCEEHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCE
EFAVPDALASRSPDILASERALLKARQSDFDSRRNSAEDILRQLKNELSNLQSLHEQKIV
EEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
ALLEVNEAKKKVSDAQAKFDEIGTQAELTLAEEYSDTLRELTSLRQEQRLARDQLDRTVI
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSPMAGIVNSLAVTTIGGVVRPGDEILEIIPLGEELFVEARVKPEDIANVQRGQDVTIKL
HCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHEEEECCCHHHHHHHCCCCCEEEEE
TAYDYTIYGSLRGKVDIVSADTFEDERDPRAAPFYRVTVRVDRSSLTARQKQIEIRPGMR
EEEEEEEEEECCCEEEEEECCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHEEECCCCC
ATAELQTGSKTILSYLLKPLYKSREAFREP
EEHHHCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SIAADMDILEGTHGASRMIKLVALVLVMFVTWAGFASVDEIVRADGQVVSSSRAQIVQN
CCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHH
LEGGILAELYVRQGDTVQAGQILAKLQDTKFRAASDDLQDQIDALEIKQYRLEAEIEGAY
CCCCCEEHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCE
EFAVPDALASRSPDILASERALLKARQSDFDSRRNSAEDILRQLKNELSNLQSLHEQKIV
EEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
ALLEVNEAKKKVSDAQAKFDEIGTQAELTLAEEYSDTLRELTSLRQEQRLARDQLDRTVI
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSPMAGIVNSLAVTTIGGVVRPGDEILEIIPLGEELFVEARVKPEDIANVQRGQDVTIKL
HCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHEEEECCCHHHHHHHCCCCCEEEEE
TAYDYTIYGSLRGKVDIVSADTFEDERDPRAAPFYRVTVRVDRSSLTARQKQIEIRPGMR
EEEEEEEEEECCCEEEEEECCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHEEECCCCC
ATAELQTGSKTILSYLLKPLYKSREAFREP
EEHHHCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1427098; 10984043 [H]