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The map label for this gene is arsC [H]

Identifier: 99080367

GI number: 99080367

Start: 552342

End: 553172

Strand: Reverse

Name: arsC [H]

Synonym: TM1040_0526

Alternate gene names: 99080367

Gene position: 553172-552342 (Counterclockwise)

Preceding gene: 99080369

Following gene: 99080366

Centisome position: 17.28

GC content: 60.53

Gene sequence:

>831_bases
ATGGAAAAAGAGATTCCCCTTCGCCTGTCCGTTCTGGGCCACCCGCAGCGCCTCATGGTGTTTCGGCTTTTGATGCGCCG
CTATCCCGACCGTGTTCCTGCGGGAGAGATCGCGACAGCGCTGGATGTGAAGCCCAGTACATTGTCGTCATATTTATCTG
CTTTGATGCAGGCCGGATTGGTGACGCAAACCCGCGAGGGCACATGGCTCAACTATCAGGTCGATATGACAGGCATGCGC
GAAACGCTTGATGCCCTGTTTCTCGACTGCTGCCGTGGCCGTCCGGACCTCTGCGTTCCCGCGTCTGCAGACATGACATC
AGAGGTCCCCGCCATGCCCGACTCTAAATACAATGTCCTCTTCATCTGTACCGGCAACTCTGCCCGGTCGATCTTTGCCG
AAACGATCCTGCACAGCGAGGGCGCCGAGCGGTTCAATGTCTACTCGGCGGGCACCCGCCCCTATTCCGAGCTGAACCCG
GTCGCGCTCGACGTGTTGCGCAGCAAGGGCCATGACGTGAGCCGGCTGCGCGCAAAGAACGTCTCCGAGTTTATCGGGGA
TACCGCGCCAAAGTTCGACTTCGTCTTTACCGTCTGTGATCGCGCCGCCAATGAGGAATGCCCGGCGTGGGAAGGTCAGC
CGATCTCTGGCCACTGGGGCATGCCTGACCCGGTCAAGGCCGAAGGCAGCGAAGCGGAACAGAGTCTCGCCTTTCAGCAG
GCCTATGGCACGCTCAAGAACCGGATCCGCGCCTTTGCCGCCCTGCCCTTTACGGAGCTGGACCGGATTTCGCTGCAACG
GGCGGTTGACGACATCGCCCGCACACACTGA

Upstream 100 bases:

>100_bases
AGAACCGGAACACCGGCCTTTTGGCAAAGGCTTCCGGCCACCTAGTGCGACCTGGCTGAATTTTCTTGCACCGCATCAAT
ATTTCGATAAAACCCGAAAT

Downstream 100 bases:

>100_bases
AGCCCCAAGGGGCGCGACCCAATCGATATAAAGGACAGCAGATGACCGTCTACGCAGTAAATGGCCTCGGCCGGATGGGC
AAACTGGCCCTCAACCCCCT

Product: ArsR family transcriptional regulator

Products: NA

Alternate protein names: Arsenate reductase; Arsenical pump modifier; Low molecular weight protein-tyrosine-phosphatase [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MEKEIPLRLSVLGHPQRLMVFRLLMRRYPDRVPAGEIATALDVKPSTLSSYLSALMQAGLVTQTREGTWLNYQVDMTGMR
ETLDALFLDCCRGRPDLCVPASADMTSEVPAMPDSKYNVLFICTGNSARSIFAETILHSEGAERFNVYSAGTRPYSELNP
VALDVLRSKGHDVSRLRAKNVSEFIGDTAPKFDFVFTVCDRAANEECPAWEGQPISGHWGMPDPVKAEGSEAEQSLAFQQ
AYGTLKNRIRAFAALPFTELDRISLQRAVDDIARTH

Sequences:

>Translated_276_residues
MEKEIPLRLSVLGHPQRLMVFRLLMRRYPDRVPAGEIATALDVKPSTLSSYLSALMQAGLVTQTREGTWLNYQVDMTGMR
ETLDALFLDCCRGRPDLCVPASADMTSEVPAMPDSKYNVLFICTGNSARSIFAETILHSEGAERFNVYSAGTRPYSELNP
VALDVLRSKGHDVSRLRAKNVSEFIGDTAPKFDFVFTVCDRAANEECPAWEGQPISGHWGMPDPVKAEGSEAEQSLAFQQ
AYGTLKNRIRAFAALPFTELDRISLQRAVDDIARTH
>Mature_276_residues
MEKEIPLRLSVLGHPQRLMVFRLLMRRYPDRVPAGEIATALDVKPSTLSSYLSALMQAGLVTQTREGTWLNYQVDMTGMR
ETLDALFLDCCRGRPDLCVPASADMTSEVPAMPDSKYNVLFICTGNSARSIFAETILHSEGAERFNVYSAGTRPYSELNP
VALDVLRSKGHDVSRLRAKNVSEFIGDTAPKFDFVFTVCDRAANEECPAWEGQPISGHWGMPDPVKAEGSEAEQSLAFQQ
AYGTLKNRIRAFAALPFTELDRISLQRAVDDIARTH

Specific function: Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances [H]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014064
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 30663; Mature: 30663

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS50987 HTH_ARSR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKEIPLRLSVLGHPQRLMVFRLLMRRYPDRVPAGEIATALDVKPSTLSSYLSALMQAGL
CCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCC
VTQTREGTWLNYQVDMTGMRETLDALFLDCCRGRPDLCVPASADMTSEVPAMPDSKYNVL
CEECCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCEE
FICTGNSARSIFAETILHSEGAERFNVYSAGTRPYSELNPVALDVLRSKGHDVSRLRAKN
EEEECCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHCCHHHHHHHHHCCCCHHHHHHHH
VSEFIGDTAPKFDFVFTVCDRAANEECPAWEGQPISGHWGMPDPVKAEGSEAEQSLAFQQ
HHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
AYGTLKNRIRAFAALPFTELDRISLQRAVDDIARTH
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKEIPLRLSVLGHPQRLMVFRLLMRRYPDRVPAGEIATALDVKPSTLSSYLSALMQAGL
CCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCC
VTQTREGTWLNYQVDMTGMRETLDALFLDCCRGRPDLCVPASADMTSEVPAMPDSKYNVL
CEECCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCEE
FICTGNSARSIFAETILHSEGAERFNVYSAGTRPYSELNPVALDVLRSKGHDVSRLRAKN
EEEECCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHCCHHHHHHHHHCCCCHHHHHHHH
VSEFIGDTAPKFDFVFTVCDRAANEECPAWEGQPISGHWGMPDPVKAEGSEAEQSLAFQQ
HHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
AYGTLKNRIRAFAALPFTELDRISLQRAVDDIARTH
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]