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The map label for this gene is mrdB [H]

Identifier: 99080310

GI number: 99080310

Start: 487570

End: 488709

Strand: Reverse

Name: mrdB [H]

Synonym: TM1040_0469

Alternate gene names: 99080310

Gene position: 488709-487570 (Counterclockwise)

Preceding gene: 99080311

Following gene: 99080308

Centisome position: 15.27

GC content: 60.18

Gene sequence:

>1140_bases
ATGAGCTATCTTGAGTATCACGCCAAATCGACCCCGACCGGCCTGCGCAAGATCCTGTTTCTGAACTGGCCCCTGGTGCT
GCTGCTCTGCGCGGCTGCAGGCGTTGGCTTCTTGATGCTCTATTCGGTGGCGGGCGGGTCATTCTCGCCCTGGGTCGAAC
CGCAGGCCAAGCGTTTTCTGGTCGGGCTCGGCGTGATGCTGGTGGTGGCGATGGTGCCGATCTGGTTCTGGCGCAATATC
TCAGTGCTGGCCTATCTGATGGCGCTTGTGCTGCTGGTAGCGGTCGAGCTGTTTGGCTCCGTCGGCATGGGGGCGCAGCG
CTGGGTCGATATCGGACCGCTCCGATTGCAACCTTCCGAGCTTATGAAGATCACCCTCGTGATGGTGCTTGCGGCCTATT
ACGACTGGCTGCCCGCCAATCGCACCTCGCGGCCGCTGTTCGTGCTCGTGCCGGTGTTCTTAATCCTTGCACCGACCTTT
TTGGTGCTGAAACAGCCTGACCTTGGGACCTCTATCCTTCTGTTGACAGCGGGCGGCGGGGTGATGTTCCTGGCCGGGGT
ACATTGGGCCTATTTTGCTGCAGTGATTGCCGCCGCCGGTGGGCTGGTCGCCGCTGTTTTCCAGAGCCGGGGCACCGACT
GGCAACTGCTGAAGGATTATCAGTACCGCCGCATCGACACGTTTCTCGATCCTTCCCAAGATCCACTCGGGGCTGGCTAT
CACATCACGCAGTCAAAGATCGCGCTTGGGTCCGGGGGCTGGTCCGGGCGCGGTTTTATGCAGGGTACGCAGTCGCGCCT
GAACTTTCTGCCGGAAAAGCACACCGATTTCATCTTCACCACACTTGCCGAAGAGTTCGGCTTTGTGGGCGGCGTAATGC
TTCTGTCGATCTATGTGATGATCATCGTCTTCTGCGTTGCCACCGCGATCTCGGCCCGGGACCGGTTCTCCTCGCTGGTG
ACACTCGGCATCGCACTCAACTTCTTTTTGTTCTTTGCGGTCAACATGTCGATGGTGATGGGGCTCGCACCTGTGGTCGG
CGTGCCCTTGCCACTGGTCTCCTATGGCGGCTCGGCCATGCTGGTGCTCCTCGCTGCATTCGGGATTGTCCAGAGCGCCA
ACGTCCATCGCCCGCGCTAA

Upstream 100 bases:

>100_bases
AGGCCTACCCGAGAGGCGATCGCAGCAAGATCCAAGCGCAACAGGAACGTCTCCAGCGCGAAATGCATCAGCGTGAGGAA
AGCGGCGGGAGCGACCGGGC

Downstream 100 bases:

>100_bases
GGGCCGCCTTCCTGCCCGATCCCCTCGCGCACCAATGTCAGAAACGGGCTGTCCTGATCGCGCAGACGGTGCAGCAGGCC
AATGCTACGATAAACACCAG

Product: rod shape-determining protein RodA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MSYLEYHAKSTPTGLRKILFLNWPLVLLLCAAAGVGFLMLYSVAGGSFSPWVEPQAKRFLVGLGVMLVVAMVPIWFWRNI
SVLAYLMALVLLVAVELFGSVGMGAQRWVDIGPLRLQPSELMKITLVMVLAAYYDWLPANRTSRPLFVLVPVFLILAPTF
LVLKQPDLGTSILLLTAGGGVMFLAGVHWAYFAAVIAAAGGLVAAVFQSRGTDWQLLKDYQYRRIDTFLDPSQDPLGAGY
HITQSKIALGSGGWSGRGFMQGTQSRLNFLPEKHTDFIFTTLAEEFGFVGGVMLLSIYVMIIVFCVATAISARDRFSSLV
TLGIALNFFLFFAVNMSMVMGLAPVVGVPLPLVSYGGSAMLVLLAAFGIVQSANVHRPR

Sequences:

>Translated_379_residues
MSYLEYHAKSTPTGLRKILFLNWPLVLLLCAAAGVGFLMLYSVAGGSFSPWVEPQAKRFLVGLGVMLVVAMVPIWFWRNI
SVLAYLMALVLLVAVELFGSVGMGAQRWVDIGPLRLQPSELMKITLVMVLAAYYDWLPANRTSRPLFVLVPVFLILAPTF
LVLKQPDLGTSILLLTAGGGVMFLAGVHWAYFAAVIAAAGGLVAAVFQSRGTDWQLLKDYQYRRIDTFLDPSQDPLGAGY
HITQSKIALGSGGWSGRGFMQGTQSRLNFLPEKHTDFIFTTLAEEFGFVGGVMLLSIYVMIIVFCVATAISARDRFSSLV
TLGIALNFFLFFAVNMSMVMGLAPVVGVPLPLVSYGGSAMLVLLAAFGIVQSANVHRPR
>Mature_378_residues
SYLEYHAKSTPTGLRKILFLNWPLVLLLCAAAGVGFLMLYSVAGGSFSPWVEPQAKRFLVGLGVMLVVAMVPIWFWRNIS
VLAYLMALVLLVAVELFGSVGMGAQRWVDIGPLRLQPSELMKITLVMVLAAYYDWLPANRTSRPLFVLVPVFLILAPTFL
VLKQPDLGTSILLLTAGGGVMFLAGVHWAYFAAVIAAAGGLVAAVFQSRGTDWQLLKDYQYRRIDTFLDPSQDPLGAGYH
ITQSKIALGSGGWSGRGFMQGTQSRLNFLPEKHTDFIFTTLAEEFGFVGGVMLLSIYVMIIVFCVATAISARDRFSSLVT
LGIALNFFLFFAVNMSMVMGLAPVVGVPLPLVSYGGSAMLVLLAAFGIVQSANVHRPR

Specific function: This is one of the proteins responsible for the rod shape of the cell. It is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786853, Length=343, Percent_Identity=43.1486880466472, Blast_Score=244, Evalue=7e-66,
Organism=Escherichia coli, GI1786277, Length=323, Percent_Identity=36.2229102167183, Blast_Score=162, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 41245; Mature: 41114

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS00428 FTSW_RODA_SPOVE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYLEYHAKSTPTGLRKILFLNWPLVLLLCAAAGVGFLMLYSVAGGSFSPWVEPQAKRFL
CCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
VGLGVMLVVAMVPIWFWRNISVLAYLMALVLLVAVELFGSVGMGAQRWVDIGPLRLQPSE
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCEECCCCEECHHH
LMKITLVMVLAAYYDWLPANRTSRPLFVLVPVFLILAPTFLVLKQPDLGTSILLLTAGGG
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCCEEEEEECCCC
VMFLAGVHWAYFAAVIAAAGGLVAAVFQSRGTDWQLLKDYQYRRIDTFLDPSQDPLGAGY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCE
HITQSKIALGSGGWSGRGFMQGTQSRLNFLPEKHTDFIFTTLAEEFGFVGGVMLLSIYVM
EEECCEEEECCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IIVFCVATAISARDRFSSLVTLGIALNFFLFFAVNMSMVMGLAPVVGVPLPLVSYGGSAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHH
LVLLAAFGIVQSANVHRPR
HHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SYLEYHAKSTPTGLRKILFLNWPLVLLLCAAAGVGFLMLYSVAGGSFSPWVEPQAKRFL
CCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
VGLGVMLVVAMVPIWFWRNISVLAYLMALVLLVAVELFGSVGMGAQRWVDIGPLRLQPSE
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCEECCCCEECHHH
LMKITLVMVLAAYYDWLPANRTSRPLFVLVPVFLILAPTFLVLKQPDLGTSILLLTAGGG
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCCEEEEEECCCC
VMFLAGVHWAYFAAVIAAAGGLVAAVFQSRGTDWQLLKDYQYRRIDTFLDPSQDPLGAGY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCE
HITQSKIALGSGGWSGRGFMQGTQSRLNFLPEKHTDFIFTTLAEEFGFVGGVMLLSIYVM
EEECCEEEECCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IIVFCVATAISARDRFSSLVTLGIALNFFLFFAVNMSMVMGLAPVVGVPLPLVSYGGSAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHH
LVLLAAFGIVQSANVHRPR
HHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]