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The map label for this gene is dut [H]

Identifier: 99080302

GI number: 99080302

Start: 479863

End: 480354

Strand: Direct

Name: dut [H]

Synonym: TM1040_0461

Alternate gene names: 99080302

Gene position: 479863-480354 (Clockwise)

Preceding gene: 99080301

Following gene: 99080303

Centisome position: 14.99

GC content: 61.99

Gene sequence:

>492_bases
ATGACTGCATCGCAATTTGCGGTAGACGTGAAAATCATTGACCCGCGTATCCGGGATTGGGGGATGCCCAGCTACCAGAC
CCAAGGCTCTGCCGCGATTGACCTTTTTGCCTGTATCGACGCGCCCAAAGAGATCGCGCCGCAGGCGCCTGCAGTGCTGA
TCCCCTCGGGGCTGGCGTTTTACATGGGCGATCAGTCCTGCGCCGCGCTTGTGATGCCGCGGTCCGGGCTTGGTCACAAA
AAAGGGCTGGTGATGGGTAATAATGTCGGCCTCATCGATGCCGACTATACTGGCGAAGTGTTCATCAGCGCCTGGAACCG
CAACCCGCCGGGGGCCGCGCCGATCGTGATCGAGCCGGGGGAACGCATCGCGCAACTCATGTTTGTGCCAGTTCTGCGGG
CGACCTTGAACGAGGTCGAGACATTCTCAAACAGCACGGAGCGTGGTGCGGGCGGCTTCGGCTCGACCGGCTCGGGGGCG
ACCGGCGCATGA

Upstream 100 bases:

>100_bases
CGAAAACCCAGTGGTGTTTCCTACCCGATTTGCGGCATAAACGTCGCGAATTGGACGGCGCGGAACAGGACACGCGCGCA
GAGACAGAAGGATCGCCCCG

Downstream 100 bases:

>100_bases
TTTTGGTACTGGGGCTTGCGGGGCTGATCTGGTGGGGCGGGCGGCTCTTTGGGGCATCGCAGTCGATGCGCTGGGCGTTG
CTTGGTCTTTTGTTCCTGGC

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 163; Mature: 162

Protein sequence:

>163_residues
MTASQFAVDVKIIDPRIRDWGMPSYQTQGSAAIDLFACIDAPKEIAPQAPAVLIPSGLAFYMGDQSCAALVMPRSGLGHK
KGLVMGNNVGLIDADYTGEVFISAWNRNPPGAAPIVIEPGERIAQLMFVPVLRATLNEVETFSNSTERGAGGFGSTGSGA
TGA

Sequences:

>Translated_163_residues
MTASQFAVDVKIIDPRIRDWGMPSYQTQGSAAIDLFACIDAPKEIAPQAPAVLIPSGLAFYMGDQSCAALVMPRSGLGHK
KGLVMGNNVGLIDADYTGEVFISAWNRNPPGAAPIVIEPGERIAQLMFVPVLRATLNEVETFSNSTERGAGGFGSTGSGA
TGA
>Mature_162_residues
TASQFAVDVKIIDPRIRDWGMPSYQTQGSAAIDLFACIDAPKEIAPQAPAVLIPSGLAFYMGDQSCAALVMPRSGLGHKK
GLVMGNNVGLIDADYTGEVFISAWNRNPPGAAPIVIEPGERIAQLMFVPVLRATLNEVETFSNSTERGAGGFGSTGSGAT
GA

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Escherichia coli, GI1790071, Length=151, Percent_Identity=52.9801324503311, Blast_Score=164, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71988561, Length=144, Percent_Identity=35.4166666666667, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 17014; Mature: 16882

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASQFAVDVKIIDPRIRDWGMPSYQTQGSAAIDLFACIDAPKEIAPQAPAVLIPSGLAF
CCCCCEEEEEEEECCCCHHCCCCCCCCCCCCEEEEEEECCCCHHHCCCCCEEEECCCEEE
YMGDQSCAALVMPRSGLGHKKGLVMGNNVGLIDADYTGEVFISAWNRNPPGAAPIVIEPG
EECCCCCEEEEECCCCCCCCCCEEECCCCEEEECCCCCEEEEEEECCCCCCCCCEEECCH
ERIAQLMFVPVLRATLNEVETFSNSTERGAGGFGSTGSGATGA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TASQFAVDVKIIDPRIRDWGMPSYQTQGSAAIDLFACIDAPKEIAPQAPAVLIPSGLAF
CCCCEEEEEEEECCCCHHCCCCCCCCCCCCEEEEEEECCCCHHHCCCCCEEEECCCEEE
YMGDQSCAALVMPRSGLGHKKGLVMGNNVGLIDADYTGEVFISAWNRNPPGAAPIVIEPG
EECCCCCEEEEECCCCCCCCCCEEECCCCEEEECCCCCEEEEEEECCCCCCCCCEEECCH
ERIAQLMFVPVLRATLNEVETFSNSTERGAGGFGSTGSGATGA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA