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The map label for this gene is trpS [H]

Identifier: 99080284

GI number: 99080284

Start: 459119

End: 460147

Strand: Reverse

Name: trpS [H]

Synonym: TM1040_0443

Alternate gene names: 99080284

Gene position: 460147-459119 (Counterclockwise)

Preceding gene: 99080286

Following gene: 99080278

Centisome position: 14.38

GC content: 59.38

Gene sequence:

>1029_bases
ATGAGCGAAACCAGCTTCACCCCGCGTGTCTTTTCAGGCATCCAGCCTTCGGGCAATCTGCATCTGGGGAATTACCTCGG
TGCATTGAAGCGGTTCGTCGACTGGCAATCGCGGGACGTGGAGTCGATCTACTGCATGGTTGACCTTCATGCGATCACCG
TCTGGCAAGACCCGGCAGACCTGAAGAAGGCCACGCGTGAGCTGTGCGCAGGCTTCATTGCCGCGGGGCTTGATCCGGAA
AAATCCATCCTGATCAATCAGAGCCAGGTGCCGGAGCACGCGCAGCTTGCATGGATCTTCAACTGCGTCGCCCGCATGGG
GTGGATGCAGCGGATGACCCAGTGGAAGGATAAGGCAGGTAAAAACCAGCAAAACGCCTCGCTGGGTCTGTTGGCCTATC
CGTCCCTGATGGCCGCCGATATCCTGATCTACCACGCCACCCATGTGCCGGTGGGCGAGGACCAGAAACAGCACCTCGAG
CTTACCCGCGACATCGCGACCAAGTTCAACCACGACTATGGCGTTGACTTCTTCCCGCTGACCGAGCCGGTGATCGAAGG
CGCGGCCACCCGTGTCATGAGCCTGCGTGATGGCTCCAAGAAGATGTCGAAATCCGACCCTTCTGATGCGAGCCGGATCA
ATCTCACCGATGATGCGGACACCATCGCCAAGAAAATCCGCAAGGCCAAGACCGATCCCGAGGCCCTGCCCTCCGAGGCC
AAAGGGCTTGAAGAGCGCCCCGAGGCACGCAACCTTGTGAACATCTACGCGGCGATGGCCGATCAGACGGTGGATCAGGT
TCTTGCAGATGTGGGTGGCAAACAGTTCTCGGAATTCAAGCCGATGCTGGCCGATCTCGCGGTCGAGCGTATGGCGCCGA
TCACCACCGAGATGGCCCGTCTGATGGAAAACCAGGACGAGATCGACAAGATCCTCGCACGGGGATCAGAGCGTGCGCGC
GCAATCACTGCACCGATCCTGCGTAAGACCTACGACATTGTGGGCATGGTCGCCCCGGTCGAGATTTGA

Upstream 100 bases:

>100_bases
GGCGCTCTGGCGCGCTCTCTACGGGTCTACGCCTGTTGACGATACTCTGCGCCATGGGTAAGCGACGATGGTGCATAATT
CCAGACGGGAGTTTTCGACA

Downstream 100 bases:

>100_bases
TCGCAGCACATCAACTGCGATGACCAGAACTGCCGAGGGCCGCCCGTTTGATTGGGCGGCCCTCTTCTTTGCACGAAGCC
TTTGTTTGCGCGACACTCTC

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MSETSFTPRVFSGIQPSGNLHLGNYLGALKRFVDWQSRDVESIYCMVDLHAITVWQDPADLKKATRELCAGFIAAGLDPE
KSILINQSQVPEHAQLAWIFNCVARMGWMQRMTQWKDKAGKNQQNASLGLLAYPSLMAADILIYHATHVPVGEDQKQHLE
LTRDIATKFNHDYGVDFFPLTEPVIEGAATRVMSLRDGSKKMSKSDPSDASRINLTDDADTIAKKIRKAKTDPEALPSEA
KGLEERPEARNLVNIYAAMADQTVDQVLADVGGKQFSEFKPMLADLAVERMAPITTEMARLMENQDEIDKILARGSERAR
AITAPILRKTYDIVGMVAPVEI

Sequences:

>Translated_342_residues
MSETSFTPRVFSGIQPSGNLHLGNYLGALKRFVDWQSRDVESIYCMVDLHAITVWQDPADLKKATRELCAGFIAAGLDPE
KSILINQSQVPEHAQLAWIFNCVARMGWMQRMTQWKDKAGKNQQNASLGLLAYPSLMAADILIYHATHVPVGEDQKQHLE
LTRDIATKFNHDYGVDFFPLTEPVIEGAATRVMSLRDGSKKMSKSDPSDASRINLTDDADTIAKKIRKAKTDPEALPSEA
KGLEERPEARNLVNIYAAMADQTVDQVLADVGGKQFSEFKPMLADLAVERMAPITTEMARLMENQDEIDKILARGSERAR
AITAPILRKTYDIVGMVAPVEI
>Mature_341_residues
SETSFTPRVFSGIQPSGNLHLGNYLGALKRFVDWQSRDVESIYCMVDLHAITVWQDPADLKKATRELCAGFIAAGLDPEK
SILINQSQVPEHAQLAWIFNCVARMGWMQRMTQWKDKAGKNQQNASLGLLAYPSLMAADILIYHATHVPVGEDQKQHLEL
TRDIATKFNHDYGVDFFPLTEPVIEGAATRVMSLRDGSKKMSKSDPSDASRINLTDDADTIAKKIRKAKTDPEALPSEAK
GLEERPEARNLVNIYAAMADQTVDQVLADVGGKQFSEFKPMLADLAVERMAPITTEMARLMENQDEIDKILARGSERARA
ITAPILRKTYDIVGMVAPVEI

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=330, Percent_Identity=43.3333333333333, Blast_Score=284, Evalue=7e-77,
Organism=Homo sapiens, GI41352700, Length=177, Percent_Identity=53.6723163841808, Blast_Score=206, Evalue=3e-53,
Organism=Escherichia coli, GI1789786, Length=331, Percent_Identity=43.202416918429, Blast_Score=279, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI71982800, Length=340, Percent_Identity=35.2941176470588, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI71982793, Length=340, Percent_Identity=35.2941176470588, Blast_Score=204, Evalue=7e-53,
Organism=Saccharomyces cerevisiae, GI6320474, Length=346, Percent_Identity=39.8843930635838, Blast_Score=231, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24666151, Length=313, Percent_Identity=40.5750798722045, Blast_Score=236, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 38016; Mature: 37885

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETSFTPRVFSGIQPSGNLHLGNYLGALKRFVDWQSRDVESIYCMVDLHAITVWQDPAD
CCCCCCCHHHHHCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEEEEECCHHH
LKKATRELCAGFIAAGLDPEKSILINQSQVPEHAQLAWIFNCVARMGWMQRMTQWKDKAG
HHHHHHHHHHHHHHCCCCCCHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KNQQNASLGLLAYPSLMAADILIYHATHVPVGEDQKQHLELTRDIATKFNHDYGVDFFPL
CCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
TEPVIEGAATRVMSLRDGSKKMSKSDPSDASRINLTDDADTIAKKIRKAKTDPEALPSEA
CHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEECCCCHHHHHHHHHHCCCCHHHCCHHH
KGLEERPEARNLVNIYAAMADQTVDQVLADVGGKQFSEFKPMLADLAVERMAPITTEMAR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMENQDEIDKILARGSERARAITAPILRKTYDIVGMVAPVEI
HHHCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SETSFTPRVFSGIQPSGNLHLGNYLGALKRFVDWQSRDVESIYCMVDLHAITVWQDPAD
CCCCCCHHHHHCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEEEEECCHHH
LKKATRELCAGFIAAGLDPEKSILINQSQVPEHAQLAWIFNCVARMGWMQRMTQWKDKAG
HHHHHHHHHHHHHHCCCCCCHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KNQQNASLGLLAYPSLMAADILIYHATHVPVGEDQKQHLELTRDIATKFNHDYGVDFFPL
CCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
TEPVIEGAATRVMSLRDGSKKMSKSDPSDASRINLTDDADTIAKKIRKAKTDPEALPSEA
CHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEECCCCHHHHHHHHHHCCCCHHHCCHHH
KGLEERPEARNLVNIYAAMADQTVDQVLADVGGKQFSEFKPMLADLAVERMAPITTEMAR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMENQDEIDKILARGSERARAITAPILRKTYDIVGMVAPVEI
HHHCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]