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The map label for this gene is fadA [H]

Identifier: 99080202

GI number: 99080202

Start: 370462

End: 371640

Strand: Direct

Name: fadA [H]

Synonym: TM1040_0361

Alternate gene names: 99080202

Gene position: 370462-371640 (Clockwise)

Preceding gene: 99080201

Following gene: 99080203

Centisome position: 11.57

GC content: 62.0

Gene sequence:

>1179_bases
ATGAAACAAGCAGTTATTGTCTCAACGGCCCGGACCGGCCTCGCCAAATCCTATCGCGGGGCGTTCAACGACACCCATGG
CGCGCAGATGGCAGGGCATGCCATCGAACATGCCGTTGCCCGCTCCAAAGTGGATCCGGCGCTGATTGAGGACGCATTTA
TCGGCTGTGGCTACCCCGAGGGCTGGACCGGCGGCAATATCGCCCGCCAAGCCGTTGTCCGCGCAGGACTGCCCGTGACG
GTGGCGGCAGCGACGGTGAACCGGTTCTGCTCCTCGGGTCTTCAGGCGCTGGCGATGGCGAGCCATGCAGTCACCATGGA
GGGCGCCTCTGCCGCAATTGCGGGCGGGGTCGAAAGCATCAGCCAGATGCCCCCCTCGCGTCCGGCGCAGCGCCGCGACG
CCTGGATCGAGGCCAACAAACCCGATGTCTACATGACCATGATTGAGACGGCGGACGTGGTGGCCAAGCGCTACGGCGTA
AGCCGAGAGGCACAAGACGAACTCGCGCTTCAAAGCCAGATGCGGACTGCTGCTGCGCAGGCTGCGGGCAAATTCGACGA
TGAGATTGTTCCGATTACCGTCACCCAGAAACTCACCGACAAGGAAACCAAGGAAGTCTCTTACAAAGAGGTGGCCTTTG
CGATGGATGACTGCAATCGCCCGGGCACGACGCTCGAAGGGCTGGCGGGACTGAAGCCGGTACGAGGTGAAGAACACTTT
GTAACCGCGGGGAATGCCTCGCAATTGTCTGATGGTGCTGCCGCGCTGGTGGTAATGGATGCTGATCTTGCTGCAAAGCA
AGGGCTGGAGCCCCTGGGTGCGCTCAAGGGGTTTGTGACCGCCGGCTGCGAGCCCGATGAGATGGGGATTGGCCCTGTCT
TTGCGGTGCCGCGCCTGCTGGAGCGTCATGGTCTGAAGGTCTCCGACATCGATCTGTGGGAGCTCAACGAAGCCTTTGCC
TCACAGGCGCTCTACTGCCGGGATCGGCTCGAGATTGATCCGGAGATCTGCAACGTGAACGGCGGGTCGATTTCCATTGG
CCACCCCTTTGGCATGACAGGCGCACGGATGAGCGGGCACCTCTTGTTGGAAGGCAAACGGCGCGGCGCAAAGCTCGGCG
TTGTCACCATGTGCATTGGCGGCGGTCAGGGCGCTGCGGGGCTGTTCGAGATCTTCTGA

Upstream 100 bases:

>100_bases
CTTCCTCTGGCAGCCTGCACCGCTTTTGAAACGATTGGTGGCAGAGGGAAAGACCTTTGCCGATCTCAATAACGCCTGAT
CGCCCAGAGAGGAAAAGACT

Downstream 100 bases:

>100_bases
CGCGGGAACGCCCCGCGGAACATCAGCCACGACGTCCAAGTCCGGGCGTCGTGGTCCCAAAGTGCAAATGCCCCAGAAAA
CAACTGTGAGACTATGGCAA

Product: Acetyl-CoA C-acyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKQAVIVSTARTGLAKSYRGAFNDTHGAQMAGHAIEHAVARSKVDPALIEDAFIGCGYPEGWTGGNIARQAVVRAGLPVT
VAAATVNRFCSSGLQALAMASHAVTMEGASAAIAGGVESISQMPPSRPAQRRDAWIEANKPDVYMTMIETADVVAKRYGV
SREAQDELALQSQMRTAAAQAAGKFDDEIVPITVTQKLTDKETKEVSYKEVAFAMDDCNRPGTTLEGLAGLKPVRGEEHF
VTAGNASQLSDGAAALVVMDADLAAKQGLEPLGALKGFVTAGCEPDEMGIGPVFAVPRLLERHGLKVSDIDLWELNEAFA
SQALYCRDRLEIDPEICNVNGGSISIGHPFGMTGARMSGHLLLEGKRRGAKLGVVTMCIGGGQGAAGLFEIF

Sequences:

>Translated_392_residues
MKQAVIVSTARTGLAKSYRGAFNDTHGAQMAGHAIEHAVARSKVDPALIEDAFIGCGYPEGWTGGNIARQAVVRAGLPVT
VAAATVNRFCSSGLQALAMASHAVTMEGASAAIAGGVESISQMPPSRPAQRRDAWIEANKPDVYMTMIETADVVAKRYGV
SREAQDELALQSQMRTAAAQAAGKFDDEIVPITVTQKLTDKETKEVSYKEVAFAMDDCNRPGTTLEGLAGLKPVRGEEHF
VTAGNASQLSDGAAALVVMDADLAAKQGLEPLGALKGFVTAGCEPDEMGIGPVFAVPRLLERHGLKVSDIDLWELNEAFA
SQALYCRDRLEIDPEICNVNGGSISIGHPFGMTGARMSGHLLLEGKRRGAKLGVVTMCIGGGQGAAGLFEIF
>Mature_392_residues
MKQAVIVSTARTGLAKSYRGAFNDTHGAQMAGHAIEHAVARSKVDPALIEDAFIGCGYPEGWTGGNIARQAVVRAGLPVT
VAAATVNRFCSSGLQALAMASHAVTMEGASAAIAGGVESISQMPPSRPAQRRDAWIEANKPDVYMTMIETADVVAKRYGV
SREAQDELALQSQMRTAAAQAAGKFDDEIVPITVTQKLTDKETKEVSYKEVAFAMDDCNRPGTTLEGLAGLKPVRGEEHF
VTAGNASQLSDGAAALVVMDADLAAKQGLEPLGALKGFVTAGCEPDEMGIGPVFAVPRLLERHGLKVSDIDLWELNEAFA
SQALYCRDRLEIDPEICNVNGGSISIGHPFGMTGARMSGHLLLEGKRRGAKLGVVTMCIGGGQGAAGLFEIF

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=388, Percent_Identity=42.2680412371134, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI167614485, Length=402, Percent_Identity=36.0696517412935, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI4557237, Length=405, Percent_Identity=36.5432098765432, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI148539872, Length=403, Percent_Identity=35.4838709677419, Blast_Score=211, Evalue=9e-55,
Organism=Homo sapiens, GI194353979, Length=387, Percent_Identity=34.1085271317829, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI4504327, Length=439, Percent_Identity=29.8405466970387, Blast_Score=152, Evalue=5e-37,
Organism=Escherichia coli, GI1788554, Length=404, Percent_Identity=39.3564356435644, Blast_Score=251, Evalue=6e-68,
Organism=Escherichia coli, GI1787663, Length=409, Percent_Identity=40.0977995110024, Blast_Score=251, Evalue=6e-68,
Organism=Escherichia coli, GI48994986, Length=396, Percent_Identity=38.8888888888889, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI87082165, Length=402, Percent_Identity=37.5621890547264, Blast_Score=228, Evalue=6e-61,
Organism=Escherichia coli, GI1788683, Length=420, Percent_Identity=32.3809523809524, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI133906874, Length=401, Percent_Identity=36.6583541147132, Blast_Score=235, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI25147385, Length=399, Percent_Identity=34.0852130325814, Blast_Score=214, Evalue=9e-56,
Organism=Caenorhabditis elegans, GI17535921, Length=402, Percent_Identity=36.5671641791045, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17551802, Length=439, Percent_Identity=30.0683371298405, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17535917, Length=397, Percent_Identity=28.463476070529, Blast_Score=146, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322031, Length=400, Percent_Identity=35.75, Blast_Score=213, Evalue=6e-56,
Organism=Saccharomyces cerevisiae, GI6325229, Length=405, Percent_Identity=31.1111111111111, Blast_Score=184, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24655093, Length=397, Percent_Identity=37.0277078085642, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI17648125, Length=338, Percent_Identity=39.6449704142012, Blast_Score=225, Evalue=4e-59,
Organism=Drosophila melanogaster, GI24640423, Length=404, Percent_Identity=35.1485148514851, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI17137578, Length=413, Percent_Identity=31.9612590799031, Blast_Score=174, Evalue=9e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41215; Mature: 41215

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQAVIVSTARTGLAKSYRGAFNDTHGAQMAGHAIEHAVARSKVDPALIEDAFIGCGYPE
CCCEEEEECHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCC
GWTGGNIARQAVVRAGLPVTVAAATVNRFCSSGLQALAMASHAVTMEGASAAIAGGVESI
CCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHCCHHHH
SQMPPSRPAQRRDAWIEANKPDVYMTMIETADVVAKRYGVSREAQDELALQSQMRTAAAQ
HHCCCCCCCHHCCCEEECCCCCEEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AAGKFDDEIVPITVTQKLTDKETKEVSYKEVAFAMDDCNRPGTTLEGLAGLKPVRGEEHF
HCCCCCCCEEEEEEECCCCCCHHHHCHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCE
VTAGNASQLSDGAAALVVMDADLAAKQGLEPLGALKGFVTAGCEPDEMGIGPVFAVPRLL
EECCCHHHCCCCCEEEEEEECCHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
ERHGLKVSDIDLWELNEAFASQALYCRDRLEIDPEICNVNGGSISIGHPFGMTGARMSGH
HHCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEECCCCCCCCCCCCCE
LLLEGKRRGAKLGVVTMCIGGGQGAAGLFEIF
EEEECCCCCCEEEEEEEEEECCCCCCCHHCCC
>Mature Secondary Structure
MKQAVIVSTARTGLAKSYRGAFNDTHGAQMAGHAIEHAVARSKVDPALIEDAFIGCGYPE
CCCEEEEECHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCC
GWTGGNIARQAVVRAGLPVTVAAATVNRFCSSGLQALAMASHAVTMEGASAAIAGGVESI
CCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHCCHHHH
SQMPPSRPAQRRDAWIEANKPDVYMTMIETADVVAKRYGVSREAQDELALQSQMRTAAAQ
HHCCCCCCCHHCCCEEECCCCCEEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AAGKFDDEIVPITVTQKLTDKETKEVSYKEVAFAMDDCNRPGTTLEGLAGLKPVRGEEHF
HCCCCCCCEEEEEEECCCCCCHHHHCHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCE
VTAGNASQLSDGAAALVVMDADLAAKQGLEPLGALKGFVTAGCEPDEMGIGPVFAVPRLL
EECCCHHHCCCCCEEEEEEECCHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
ERHGLKVSDIDLWELNEAFASQALYCRDRLEIDPEICNVNGGSISIGHPFGMTGARMSGH
HHCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEECCCCCCCCCCCCCE
LLLEGKRRGAKLGVVTMCIGGGQGAAGLFEIF
EEEECCCCCCEEEEEEEEEECCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]