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The map label for this gene is gph2 [H]

Identifier: 99080133

GI number: 99080133

Start: 298582

End: 299250

Strand: Direct

Name: gph2 [H]

Synonym: TM1040_0292

Alternate gene names: 99080133

Gene position: 298582-299250 (Clockwise)

Preceding gene: 99080132

Following gene: 99080134

Centisome position: 9.33

GC content: 63.83

Gene sequence:

>669_bases
TTGACCTCTGCGCTAAAGCTCATTCTGTTTGATGTCGATGGCACCCTGGTGGACAGCCAGGGGACCATTGTGGCCTGCAT
GAACGAGGCCTTTGAACGCGAGGGGCTTGTGCCCCCGTCGCATGCGGCGATCCTCTCGATTGTGGGGCTGTCGCTGCCGC
AGGCGCTGGCGCAACTGGCACCGGAGCAATCGGCGCAGGCACAGGGTGCGCTCGTAGAGGGCTATAAGCAGGCGTATATG
GCAGCGCGACAGCGCGAGGGGGCAGCACATTCGCCGCTCTATCCCGGTGCGCGCGAGGTGCTGGACACGCTTCATGCGGT
GCCGGAATACATCCTTGGTGTGGCCACCGGCAAATCTCAGCGCGGGTTGGACGCGCTGATCGAGGGGCATGATCTGGGAA
TGTTCGTCACCCGTCAGGTGGCCGATCACCACCCCTCCAAACCGCATCCCTCGATGATCCTCACGGCGATGTCGGAGACG
GGCATCCCGCCTGCCGACACGGTGATGATTGGCGACACCACATTCGACATGGAGATGGGTCGCGCCGCCGGGGTCAAGAC
CATCGGCGTGGATTGGGGCTATCACCCGGCTGCGCATCTGCGCGCCGATCACATGCTTTCGGACTATCGCGCCCTGCCGG
ATCTGCTGCGCCGGATCTGGTCGGACTGA

Upstream 100 bases:

>100_bases
TGACAGTGACTGCCGCGCTGCCCGACCACATGAAAGAGAGCTGGGACACCTTTGGCTGGACCGAGGATCTGGCCGCCGAC
GACCCGTTTGAGACGCTGTT

Downstream 100 bases:

>100_bases
TCCCGTCAGCGACCACGCTAGAGACAAAGACCGAGACGAAGACCGAGACGAAGAAGGACAGACCTAGATGAGTGAATGGA
AACAGAAGCGATTCTGGAAA

Product: HAD family hydrolase

Products: NA

Alternate protein names: PGP 2; PGPase2 [H]

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MTSALKLILFDVDGTLVDSQGTIVACMNEAFEREGLVPPSHAAILSIVGLSLPQALAQLAPEQSAQAQGALVEGYKQAYM
AARQREGAAHSPLYPGAREVLDTLHAVPEYILGVATGKSQRGLDALIEGHDLGMFVTRQVADHHPSKPHPSMILTAMSET
GIPPADTVMIGDTTFDMEMGRAAGVKTIGVDWGYHPAAHLRADHMLSDYRALPDLLRRIWSD

Sequences:

>Translated_222_residues
MTSALKLILFDVDGTLVDSQGTIVACMNEAFEREGLVPPSHAAILSIVGLSLPQALAQLAPEQSAQAQGALVEGYKQAYM
AARQREGAAHSPLYPGAREVLDTLHAVPEYILGVATGKSQRGLDALIEGHDLGMFVTRQVADHHPSKPHPSMILTAMSET
GIPPADTVMIGDTTFDMEMGRAAGVKTIGVDWGYHPAAHLRADHMLSDYRALPDLLRRIWSD
>Mature_221_residues
TSALKLILFDVDGTLVDSQGTIVACMNEAFEREGLVPPSHAAILSIVGLSLPQALAQLAPEQSAQAQGALVEGYKQAYMA
ARQREGAAHSPLYPGAREVLDTLHAVPEYILGVATGKSQRGLDALIEGHDLGMFVTRQVADHHPSKPHPSMILTAMSETG
IPPADTVMIGDTTFDMEMGRAAGVKTIGVDWGYHPAAHLRADHMLSDYRALPDLLRRIWSD

Specific function: Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stres

COG id: COG0546

COG function: function code R; Predicted phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006402
- InterPro:   IPR006346
- InterPro:   IPR023198 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: =3.1.3.18 [H]

Molecular weight: Translated: 23845; Mature: 23713

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSALKLILFDVDGTLVDSQGTIVACMNEAFEREGLVPPSHAAILSIVGLSLPQALAQLA
CCCCEEEEEEECCCEEECCCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHC
PEQSAQAQGALVEGYKQAYMAARQREGAAHSPLYPGAREVLDTLHAVPEYILGVATGKSQ
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
RGLDALIEGHDLGMFVTRQVADHHPSKPHPSMILTAMSETGIPPADTVMIGDTTFDMEMG
CCHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHEEEEHHHCCCCCCCEEEECCCEECHHHC
RAAGVKTIGVDWGYHPAAHLRADHMLSDYRALPDLLRRIWSD
HHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSALKLILFDVDGTLVDSQGTIVACMNEAFEREGLVPPSHAAILSIVGLSLPQALAQLA
CCCEEEEEEECCCEEECCCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHC
PEQSAQAQGALVEGYKQAYMAARQREGAAHSPLYPGAREVLDTLHAVPEYILGVATGKSQ
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
RGLDALIEGHDLGMFVTRQVADHHPSKPHPSMILTAMSETGIPPADTVMIGDTTFDMEMG
CCHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHEEEEHHHCCCCCCCEEEECCCEECHHHC
RAAGVKTIGVDWGYHPAAHLRADHMLSDYRALPDLLRRIWSD
HHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]