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The map label for this gene is bla [H]

Identifier: 99080052

GI number: 99080052

Start: 227730

End: 228554

Strand: Direct

Name: bla [H]

Synonym: TM1040_0211

Alternate gene names: 99080052

Gene position: 227730-228554 (Clockwise)

Preceding gene: 99080051

Following gene: 99080054

Centisome position: 7.11

GC content: 62.67

Gene sequence:

>825_bases
ATGCGCGCCCGACTTATGTTGCTGCTTTCAGCTCTGGTGATGTGCTTTGCCGCTCCGGTGTGGGCCGAGACGCGTCTGCT
TGACCGGGCCAGTGTCGTGGCGCCCCATGACGGGCGCGTGTCTGATTTTCTTGCGGTCGATATTGGCGCGGGGACGCGGT
GCGTGCTGTCCGGCAGTGATCTGACCCGCCGTCACGCCCCATGGTCGAGCTTCAAAATCCCAAATTTTGTCATCGCGCTT
GAAACTGGGGTCGCAACCGGCCCGGATCATTGGCGCGCCTGGGACCCCAGCCTGCGACCGGCTGCAGGCTTTTGGCCCAA
GAGCTGGCGTCAGGGGCAGACGCTCGAAACCGCGCTTCAGCGTTCGGTGGTCTGGTATTTCCAGGACATCGCCCGAGACG
TGGGGGGCAGCCGCTACCGTGAGATCCTGAAACGCTGGTCCTATGGCAACGCCGAGGCACCTGATGGCGATGACGGCTTT
TGGCTATATGGCCCGCTTGCTATCTCCGTCGAAGAACAGGTGGCTTTTGTCTCCGCCTTGCTTTCCGGCGGGATCGCTCG
GTCTCAGGACACTCTTGCGGCGCTGTTTGCCGCCACGCGCGACAGCGAAGACAAAGGCCGTATCATCTATGGCAAAACCG
GCTCCGGCCCGTTGGAGCAGGGGCGTGCGGGCGCAGGGTTTGAGGGCTGGTATGTCGGATGGGTGACGCGGCAGGACCGC
GCGCCTGTTGCCTTCGCGCATTATGTGCGCGCCAGGACATATGCTGACCTGAGGGTGTTTCGCCGAGACCAGAGCCTGAT
CCTGCTGGAGGCCTGTGGATTTTAA

Upstream 100 bases:

>100_bases
GGCGAAATAGATCGGGACAGACATGGGGTTTGCCAAGTGAAGGCAAGCCGATTTAGCGCTATCAAGACGTAACGAAGCGT
TACGACTCGAAAGGATGACC

Downstream 100 bases:

>100_bases
ACAGGGTAAAAGGGGTGCCGCCGCGCTGGTGAAACAGTGCGGCGGCAGGTCGGCTCACGCATAGGCGCCGGCGGAATAGG
TCAGCTCATAACTGTGGCTA

Product: Beta-lactamase

Products: NA

Alternate protein names: Beta-lactamase PSE-2 [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MRARLMLLLSALVMCFAAPVWAETRLLDRASVVAPHDGRVSDFLAVDIGAGTRCVLSGSDLTRRHAPWSSFKIPNFVIAL
ETGVATGPDHWRAWDPSLRPAAGFWPKSWRQGQTLETALQRSVVWYFQDIARDVGGSRYREILKRWSYGNAEAPDGDDGF
WLYGPLAISVEEQVAFVSALLSGGIARSQDTLAALFAATRDSEDKGRIIYGKTGSGPLEQGRAGAGFEGWYVGWVTRQDR
APVAFAHYVRARTYADLRVFRRDQSLILLEACGF

Sequences:

>Translated_274_residues
MRARLMLLLSALVMCFAAPVWAETRLLDRASVVAPHDGRVSDFLAVDIGAGTRCVLSGSDLTRRHAPWSSFKIPNFVIAL
ETGVATGPDHWRAWDPSLRPAAGFWPKSWRQGQTLETALQRSVVWYFQDIARDVGGSRYREILKRWSYGNAEAPDGDDGF
WLYGPLAISVEEQVAFVSALLSGGIARSQDTLAALFAATRDSEDKGRIIYGKTGSGPLEQGRAGAGFEGWYVGWVTRQDR
APVAFAHYVRARTYADLRVFRRDQSLILLEACGF
>Mature_274_residues
MRARLMLLLSALVMCFAAPVWAETRLLDRASVVAPHDGRVSDFLAVDIGAGTRCVLSGSDLTRRHAPWSSFKIPNFVIAL
ETGVATGPDHWRAWDPSLRPAAGFWPKSWRQGQTLETALQRSVVWYFQDIARDVGGSRYREILKRWSYGNAEAPDGDDGF
WLYGPLAISVEEQVAFVSALLSGGIARSQDTLAALFAATRDSEDKGRIIYGKTGSGPLEQGRAGAGFEGWYVGWVTRQDR
APVAFAHYVRARTYADLRVFRRDQSLILLEACGF

Specific function: Hydrolyzes both carbenicillin and oxacillin [H]

COG id: COG2602

COG function: function code V; Beta-lactamase class D

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-D beta-lactamase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR002137
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00905 Transpeptidase [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 30329; Mature: 30329

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRARLMLLLSALVMCFAAPVWAETRLLDRASVVAPHDGRVSDFLAVDIGAGTRCVLSGSD
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCEECCCCCCCCEEEEEEECCCCEEEEECCC
LTRRHAPWSSFKIPNFVIALETGVATGPDHWRAWDPSLRPAAGFWPKSWRQGQTLETALQ
HHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
RSVVWYFQDIARDVGGSRYREILKRWSYGNAEAPDGDDGFWLYGPLAISVEEQVAFVSAL
HHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEEHHHHHHHHHHH
LSGGIARSQDTLAALFAATRDSEDKGRIIYGKTGSGPLEQGRAGAGFEGWYVGWVTRQDR
HHCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHCCCCCCCCCCEEEEEEEECCC
APVAFAHYVRARTYADLRVFRRDQSLILLEACGF
CCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
>Mature Secondary Structure
MRARLMLLLSALVMCFAAPVWAETRLLDRASVVAPHDGRVSDFLAVDIGAGTRCVLSGSD
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCEECCCCCCCCEEEEEEECCCCEEEEECCC
LTRRHAPWSSFKIPNFVIALETGVATGPDHWRAWDPSLRPAAGFWPKSWRQGQTLETALQ
HHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
RSVVWYFQDIARDVGGSRYREILKRWSYGNAEAPDGDDGFWLYGPLAISVEEQVAFVSAL
HHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEEHHHHHHHHHHH
LSGGIARSQDTLAALFAATRDSEDKGRIIYGKTGSGPLEQGRAGAGFEGWYVGWVTRQDR
HHCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHCCCCCCCCCCEEEEEEEECCC
APVAFAHYVRARTYADLRVFRRDQSLILLEACGF
CCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3126705; 11188693 [H]