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The map label for this gene is dnaX [H]

Identifier: 99080007

GI number: 99080007

Start: 182088

End: 183914

Strand: Reverse

Name: dnaX [H]

Synonym: TM1040_0166

Alternate gene names: 99080007

Gene position: 183914-182088 (Counterclockwise)

Preceding gene: 99080009

Following gene: 99080006

Centisome position: 5.75

GC content: 63.98

Gene sequence:

>1827_bases
ATGAGCGAGCACAGCCCCGAGATCTCTGACGCAGTACAGAGCGGACAATATCAGGTTCTGGCACGCAAGTACCGGCCCGA
AACCTTTGCTGATCTCGTCGGGCAAGACGCTATGGTGCGCACGCTCAAGAACGCCTTTGCCGCGGATCGCATTGCGCAGG
CCTTCATCATGACGGGCATCCGCGGCACGGGCAAAACCACCACCGCGCGGATCATTGCCAAGGGCATGAACTGTATTGGC
GAGGATGGCCAAGGTGGCCCCACTACTGAGCCTTGCGGCAAGTGCGAGCACTGCACCGCAATCATGGAAGGCCGCCACGT
CGACGTGATGGAGATGGACGCCGCATCGCGCACCGGCGTGGGCGACATTCGCGAGATCATCGACAGCGTGGCCTATCGTG
CGGCCTCGGCGCGCTACAAGATCTATATCATCGACGAGGTTCACATGCTGTCGACCTCGGCCTTCAATGCGTTGCTGAAA
ACGCTGGAAGAGCCGCCCGCGCATGTGAAGTTCATTTTTGCCACCACCGAGATCCGCAAGGTGCCTGTGACGGTGCTCTC
CCGCTGTCAACGCTTTGATCTGCGCAGGATCGAACCGGAGGTGATGATCGACCTCTTGCGCCGGATTGCGACCAGCGAGC
AGGCCGAGATTGCCGACGATGCGCTGGCGCTCATTACCCGCGCGGCAGAAGGATCGGCCCGGGATGCGACATCCCTTTTG
GACCAGGCAATCAGCCATGGTGCCGGAGAAACCACGGCCGATCAGGTCCGTGCAATGCTTGGCCTTGCCGATCGGGGCCG
GGTGCTGGATCTGATGGATATGATCCTGCGCGGCGACGCCGCTGCAGCACTGACAGAATTGTCCGCACAATACGCCGAAG
GCGCCGATCCGATGGCTGTGCTGCGCGATCTGGCCGAGATCACCCACTGGGTTTCGGTGGTGAAGATCACGCCGGATGCC
GCCGAGGACCCTACCATCAGCCCTGATGAGCGAGCCCGTGGACAGGATATGGCGGCGCGCCTGCCGATGCGAGTGCTGAC
GCGGATGTGGCAGATGCTACTCAAGGCGCTCGAAGAAGTCGCCGCCGCCCCCAATGCGATGATGGCGGCCGAAATGGCGG
TAATCCGCCTGACCCATGTGGCCGATCTGCCCTCGCCAGAAGAATTGCTGCGCAAACTGCAGGACACACCGCCGCCGCCA
CATCCAGGTGGGCCGGGCGGCGGACACCCCATGCAGGGCATGGGATCGCCTGCGGCGGGCGGGGGAGGCGGGGCTCCGGC
TTACGCCTCCGCCCCGCCGCAAGGCGCGCCCGGTGGGGACCCGCGCGGAGGCCATACGATGTCGACTTCCGGCGGACAGA
GCGCAGTTCTTGCACAGCGCGCCGACAGCGCTCTCGCGCGCTATCCCAGCTTCGAACATGTGATCGAATTGATCCGCCAT
CACCGCGATGTCAAACTGCTGGTGGAGGTCGAAACAGGCGTGAGGCTCGTGTCTTATCAGCCGGGTCGGATCGAATTCAC
CCCCGCCGCCAATGCCCCGCAGGATCTCGCGGCCCGGATCGGCACTGCGCTCCAGAACTGGACCGGCAGCCGCTGGGTCG
TCTCGATCGCCCCGGATGGCGACGCGCCCACGATCGCAGAGCTGCGCGATGCGGCGCAGAACGCTCTGCGGGCCGAAGCC
TCGGCACATCCGCTTGTTCAGGCGGTCCTTCAGAACTTTCCCAAGGCAAAGATCACCAAGATCCGCACCCAAGAGGAGTT
GGCCGCCGAGGTTCAGGCCGAAGCCCTGCCCGAGGTCGAAGACGAATGGGACCCCTTCGAGGAGTGA

Upstream 100 bases:

>100_bases
AGCGGTGGACGAAGCTGTCGTCGGAGCTTAGTTTGCACGGAACACTTGGCGCTGGGGTCGAATCCGGCCTGCGCCCCTAA
AGACCATTCGAAAGGCCCTC

Downstream 100 bases:

>100_bases
CCCATGCGCCGGCGCGCAGCACCAGAGGCTTTGCCCTTGCCTGCACGCAGCCGCTCACATATCTAACGTGGCAAACCTGA
AATCAGGAGTGATAGGATAT

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MSEHSPEISDAVQSGQYQVLARKYRPETFADLVGQDAMVRTLKNAFAADRIAQAFIMTGIRGTGKTTTARIIAKGMNCIG
EDGQGGPTTEPCGKCEHCTAIMEGRHVDVMEMDAASRTGVGDIREIIDSVAYRAASARYKIYIIDEVHMLSTSAFNALLK
TLEEPPAHVKFIFATTEIRKVPVTVLSRCQRFDLRRIEPEVMIDLLRRIATSEQAEIADDALALITRAAEGSARDATSLL
DQAISHGAGETTADQVRAMLGLADRGRVLDLMDMILRGDAAAALTELSAQYAEGADPMAVLRDLAEITHWVSVVKITPDA
AEDPTISPDERARGQDMAARLPMRVLTRMWQMLLKALEEVAAAPNAMMAAEMAVIRLTHVADLPSPEELLRKLQDTPPPP
HPGGPGGGHPMQGMGSPAAGGGGGAPAYASAPPQGAPGGDPRGGHTMSTSGGQSAVLAQRADSALARYPSFEHVIELIRH
HRDVKLLVEVETGVRLVSYQPGRIEFTPAANAPQDLAARIGTALQNWTGSRWVVSIAPDGDAPTIAELRDAAQNALRAEA
SAHPLVQAVLQNFPKAKITKIRTQEELAAEVQAEALPEVEDEWDPFEE

Sequences:

>Translated_608_residues
MSEHSPEISDAVQSGQYQVLARKYRPETFADLVGQDAMVRTLKNAFAADRIAQAFIMTGIRGTGKTTTARIIAKGMNCIG
EDGQGGPTTEPCGKCEHCTAIMEGRHVDVMEMDAASRTGVGDIREIIDSVAYRAASARYKIYIIDEVHMLSTSAFNALLK
TLEEPPAHVKFIFATTEIRKVPVTVLSRCQRFDLRRIEPEVMIDLLRRIATSEQAEIADDALALITRAAEGSARDATSLL
DQAISHGAGETTADQVRAMLGLADRGRVLDLMDMILRGDAAAALTELSAQYAEGADPMAVLRDLAEITHWVSVVKITPDA
AEDPTISPDERARGQDMAARLPMRVLTRMWQMLLKALEEVAAAPNAMMAAEMAVIRLTHVADLPSPEELLRKLQDTPPPP
HPGGPGGGHPMQGMGSPAAGGGGGAPAYASAPPQGAPGGDPRGGHTMSTSGGQSAVLAQRADSALARYPSFEHVIELIRH
HRDVKLLVEVETGVRLVSYQPGRIEFTPAANAPQDLAARIGTALQNWTGSRWVVSIAPDGDAPTIAELRDAAQNALRAEA
SAHPLVQAVLQNFPKAKITKIRTQEELAAEVQAEALPEVEDEWDPFEE
>Mature_607_residues
SEHSPEISDAVQSGQYQVLARKYRPETFADLVGQDAMVRTLKNAFAADRIAQAFIMTGIRGTGKTTTARIIAKGMNCIGE
DGQGGPTTEPCGKCEHCTAIMEGRHVDVMEMDAASRTGVGDIREIIDSVAYRAASARYKIYIIDEVHMLSTSAFNALLKT
LEEPPAHVKFIFATTEIRKVPVTVLSRCQRFDLRRIEPEVMIDLLRRIATSEQAEIADDALALITRAAEGSARDATSLLD
QAISHGAGETTADQVRAMLGLADRGRVLDLMDMILRGDAAAALTELSAQYAEGADPMAVLRDLAEITHWVSVVKITPDAA
EDPTISPDERARGQDMAARLPMRVLTRMWQMLLKALEEVAAAPNAMMAAEMAVIRLTHVADLPSPEELLRKLQDTPPPPH
PGGPGGGHPMQGMGSPAAGGGGGAPAYASAPPQGAPGGDPRGGHTMSTSGGQSAVLAQRADSALARYPSFEHVIELIRHH
RDVKLLVEVETGVRLVSYQPGRIEFTPAANAPQDLAARIGTALQNWTGSRWVVSIAPDGDAPTIAELRDAAQNALRAEAS
AHPLVQAVLQNFPKAKITKIRTQEELAAEVQAEALPEVEDEWDPFEE

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=272, Percent_Identity=25.3676470588235, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI194306571, Length=275, Percent_Identity=25.0909090909091, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI194306567, Length=275, Percent_Identity=25.0909090909091, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI4506491, Length=243, Percent_Identity=23.4567901234568, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI31881687, Length=243, Percent_Identity=23.4567901234568, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI194306569, Length=184, Percent_Identity=26.0869565217391, Blast_Score=67, Evalue=7e-11,
Organism=Escherichia coli, GI1786676, Length=382, Percent_Identity=42.9319371727749, Blast_Score=295, Evalue=5e-81,
Organism=Caenorhabditis elegans, GI17541988, Length=226, Percent_Identity=24.3362831858407, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322528, Length=314, Percent_Identity=23.8853503184713, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324478, Length=237, Percent_Identity=26.1603375527426, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI18859927, Length=230, Percent_Identity=24.7826086956522, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17647857, Length=237, Percent_Identity=26.1603375527426, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 65256; Mature: 65125

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHSPEISDAVQSGQYQVLARKYRPETFADLVGQDAMVRTLKNAFAADRIAQAFIMTGI
CCCCCCCHHHHHHCCCHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
RGTGKTTTARIIAKGMNCIGEDGQGGPTTEPCGKCEHCTAIMEGRHVDVMEMDAASRTGV
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEECCCCCCCCH
GDIREIIDSVAYRAASARYKIYIIDEVHMLSTSAFNALLKTLEEPPAHVKFIFATTEIRK
HHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHH
VPVTVLSRCQRFDLRRIEPEVMIDLLRRIATSEQAEIADDALALITRAAEGSARDATSLL
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
DQAISHGAGETTADQVRAMLGLADRGRVLDLMDMILRGDAAAALTELSAQYAEGADPMAV
HHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHH
LRDLAEITHWVSVVKITPDAAEDPTISPDERARGQDMAARLPMRVLTRMWQMLLKALEEV
HHHHHHHHHHHHHEEECCCCCCCCCCCCCHHHCCCHHHHHCHHHHHHHHHHHHHHHHHHH
AAAPNAMMAAEMAVIRLTHVADLPSPEELLRKLQDTPPPPHPGGPGGGHPMQGMGSPAAG
HCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
GGGGAPAYASAPPQGAPGGDPRGGHTMSTSGGQSAVLAQRADSALARYPSFEHVIELIRH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHC
HRDVKLLVEVETGVRLVSYQPGRIEFTPAANAPQDLAARIGTALQNWTGSRWVVSIAPDG
CCCEEEEEEECCCEEEEEECCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCC
DAPTIAELRDAAQNALRAEASAHPLVQAVLQNFPKAKITKIRTQEELAAEVQAEALPEVE
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC
DEWDPFEE
CCCCCCCC
>Mature Secondary Structure 
SEHSPEISDAVQSGQYQVLARKYRPETFADLVGQDAMVRTLKNAFAADRIAQAFIMTGI
CCCCCCHHHHHHCCCHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
RGTGKTTTARIIAKGMNCIGEDGQGGPTTEPCGKCEHCTAIMEGRHVDVMEMDAASRTGV
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEECCCCCCCCH
GDIREIIDSVAYRAASARYKIYIIDEVHMLSTSAFNALLKTLEEPPAHVKFIFATTEIRK
HHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHH
VPVTVLSRCQRFDLRRIEPEVMIDLLRRIATSEQAEIADDALALITRAAEGSARDATSLL
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
DQAISHGAGETTADQVRAMLGLADRGRVLDLMDMILRGDAAAALTELSAQYAEGADPMAV
HHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHH
LRDLAEITHWVSVVKITPDAAEDPTISPDERARGQDMAARLPMRVLTRMWQMLLKALEEV
HHHHHHHHHHHHHEEECCCCCCCCCCCCCHHHCCCHHHHHCHHHHHHHHHHHHHHHHHHH
AAAPNAMMAAEMAVIRLTHVADLPSPEELLRKLQDTPPPPHPGGPGGGHPMQGMGSPAAG
HCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
GGGGAPAYASAPPQGAPGGDPRGGHTMSTSGGQSAVLAQRADSALARYPSFEHVIELIRH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHC
HRDVKLLVEVETGVRLVSYQPGRIEFTPAANAPQDLAARIGTALQNWTGSRWVVSIAPDG
CCCEEEEEEECCCEEEEEECCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCC
DAPTIAELRDAAQNALRAEASAHPLVQAVLQNFPKAKITKIRTQEELAAEVQAEALPEVE
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC
DEWDPFEE
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]