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The map label for this gene is dinB1 [H]

Identifier: 99079968

GI number: 99079968

Start: 134637

End: 135908

Strand: Reverse

Name: dinB1 [H]

Synonym: TM1040_0127

Alternate gene names: 99079968

Gene position: 135908-134637 (Counterclockwise)

Preceding gene: 99079970

Following gene: 99079966

Centisome position: 4.25

GC content: 60.06

Gene sequence:

>1272_bases
ATGCCTGCCCTATGCCGCGAATGCCTGCATTGTTTTGACCCCGGCACGTCACCTCGCGGCCCCAAACGCTGCCCGGTCTG
CCGCAGCCCGCGCGTTAAGCAGCATGAGGAACTCTTGTCGCTCTCCATCGCGCATATGGACTGTGATGCGTTTTATGCAA
GTGTTGAAAAACGCGATAATCCTGAGCTCGCAGACAAGCCGGTCATAATTGGCGGGGGGCATCGCGGTGTGGTCTCCACG
GCCTGCTATGTGGCGCGCATTCGCGGCGTTCGCTCCGCAATGCCGATGTTTCAGGCGCTCAAACTCTGCCCCGATGCAGT
CGTGATCAAACCCCGCATGGAGGTCTACGCCGAAACCAGCCGCGCCATTCGCGCTATGATGGACGAACTGACACCTGAAG
TAGAGCCGCTTTCTCTGGATGAGGCCTTCATGGATCTCTCGGGCACAGAGCGGCTGCATGGCGCAGCGCCTGCCGTCATG
CTCGCGCGGCTTGTGAAGCGCATGAAGGACGAATTGGGGGTCACGGGCTCCATTGGCCTCAGCCATAATAAGTTCCTCGC
CAAAGTGGCGTCCGACCTCGACAAGCCGCGCGGGTTTTCCGTAATCGGCAAAGCTGAAACCGCGGAGTTTCTTCGCGACA
AACCTGTGCGCCTCATCTGGGGCATTGGCCCCGCTGCACAGGCTTCGCTCGAAAAGGCGGGTATCCGAGCCTTCTCTGAC
CTTCTGCGTTGGGAACGGCGCGATCTCCATGACAGATTTGGCAGCATGGGAGATCGGCTCTGGCATCTTGCGCGCGGCGA
GGACCGCCGCAAGGTCTCTGCGCGCGCGCCGGTCAAATCCATCTCCAAAGAAACCACTTTCTTTGAGGACACGATGCATT
CTGAGGTACTGGATGGCCACCTCTGGCGCCTCGCGGAACAGGTTTCAGATCGCGCCAAGGCCAAAGGTCTCGCGGGACGG
GTGGTAACACTGAAACTCAAGCGCGCGAACCATTCGACCCTCACTCGGCGACAGTCCCTGCACAGCCCGACGCAATATGC
AGATCAAATCTATCGCACGGCGCGGCGCCTGTTGGACCAGACGATCCAGCAAGGCCCATTTCGATTGCTTGGTTGCGGCA
TCAGCGAGTTGGCGCCCGAAGCGCAAGCGGATGCCACAGGGGACCTGCTGGACCCGGACGCAACCAAACGCGCCAATGCA
GAACGCGCGACGGATGAGATTCGCAAACGCTTTGGCAAAGAGGCGATCCGAAAAGGTCGGTCACTTCGTTAG

Upstream 100 bases:

>100_bases
TACAGTTCAACCCCGCATGGATGCGCCTGCTTGCGCTGCGTGCACGCTACTGTGAACGCCATCGGTAAGCACCCCTATTC
TGCCTTAGTTCGAGCCCCTC

Downstream 100 bases:

>100_bases
AATCTGGAACGCCCCCGGGGGCTTGCTCGGTTCGGGCTATTCTGCTGCCATCGGGGTGAGATCCTCACCCAGTTGCGCAA
TCCGCTGCAACGCCAGGGTC

Product: DNA polymerase IV

Products: NA

Alternate protein names: Pol IV 1 [H]

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MPALCRECLHCFDPGTSPRGPKRCPVCRSPRVKQHEELLSLSIAHMDCDAFYASVEKRDNPELADKPVIIGGGHRGVVST
ACYVARIRGVRSAMPMFQALKLCPDAVVIKPRMEVYAETSRAIRAMMDELTPEVEPLSLDEAFMDLSGTERLHGAAPAVM
LARLVKRMKDELGVTGSIGLSHNKFLAKVASDLDKPRGFSVIGKAETAEFLRDKPVRLIWGIGPAAQASLEKAGIRAFSD
LLRWERRDLHDRFGSMGDRLWHLARGEDRRKVSARAPVKSISKETTFFEDTMHSEVLDGHLWRLAEQVSDRAKAKGLAGR
VVTLKLKRANHSTLTRRQSLHSPTQYADQIYRTARRLLDQTIQQGPFRLLGCGISELAPEAQADATGDLLDPDATKRANA
ERATDEIRKRFGKEAIRKGRSLR

Sequences:

>Translated_423_residues
MPALCRECLHCFDPGTSPRGPKRCPVCRSPRVKQHEELLSLSIAHMDCDAFYASVEKRDNPELADKPVIIGGGHRGVVST
ACYVARIRGVRSAMPMFQALKLCPDAVVIKPRMEVYAETSRAIRAMMDELTPEVEPLSLDEAFMDLSGTERLHGAAPAVM
LARLVKRMKDELGVTGSIGLSHNKFLAKVASDLDKPRGFSVIGKAETAEFLRDKPVRLIWGIGPAAQASLEKAGIRAFSD
LLRWERRDLHDRFGSMGDRLWHLARGEDRRKVSARAPVKSISKETTFFEDTMHSEVLDGHLWRLAEQVSDRAKAKGLAGR
VVTLKLKRANHSTLTRRQSLHSPTQYADQIYRTARRLLDQTIQQGPFRLLGCGISELAPEAQADATGDLLDPDATKRANA
ERATDEIRKRFGKEAIRKGRSLR
>Mature_422_residues
PALCRECLHCFDPGTSPRGPKRCPVCRSPRVKQHEELLSLSIAHMDCDAFYASVEKRDNPELADKPVIIGGGHRGVVSTA
CYVARIRGVRSAMPMFQALKLCPDAVVIKPRMEVYAETSRAIRAMMDELTPEVEPLSLDEAFMDLSGTERLHGAAPAVML
ARLVKRMKDELGVTGSIGLSHNKFLAKVASDLDKPRGFSVIGKAETAEFLRDKPVRLIWGIGPAAQASLEKAGIRAFSDL
LRWERRDLHDRFGSMGDRLWHLARGEDRRKVSARAPVKSISKETTFFEDTMHSEVLDGHLWRLAEQVSDRAKAKGLAGRV
VTLKLKRANHSTLTRRQSLHSPTQYADQIYRTARRLLDQTIQQGPFRLLGCGISELAPEAQADATGDLLDPDATKRANAE
RATDEIRKRFGKEAIRKGRSLR

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Homo sapiens, GI154350220, Length=281, Percent_Identity=30.2491103202847, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI7705344, Length=109, Percent_Identity=43.1192660550459, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI84043967, Length=269, Percent_Identity=26.0223048327138, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI7706681, Length=269, Percent_Identity=26.0223048327138, Blast_Score=102, Evalue=8e-22,
Organism=Escherichia coli, GI1786425, Length=347, Percent_Identity=38.0403458213257, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1787432, Length=368, Percent_Identity=26.6304347826087, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI193205700, Length=403, Percent_Identity=29.0322580645161, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI193205702, Length=348, Percent_Identity=27.0114942528736, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17537959, Length=189, Percent_Identity=26.4550264550265, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355641, Length=333, Percent_Identity=27.6276276276276, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24644984, Length=333, Percent_Identity=27.6276276276276, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI19923006, Length=343, Percent_Identity=23.6151603498542, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 47106; Mature: 46975

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPALCRECLHCFDPGTSPRGPKRCPVCRSPRVKQHEELLSLSIAHMDCDAFYASVEKRDN
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PELADKPVIIGGGHRGVVSTACYVARIRGVRSAMPMFQALKLCPDAVVIKPRMEVYAETS
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHH
RAIRAMMDELTPEVEPLSLDEAFMDLSGTERLHGAAPAVMLARLVKRMKDELGVTGSIGL
HHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
SHNKFLAKVASDLDKPRGFSVIGKAETAEFLRDKPVRLIWGIGPAAQASLEKAGIRAFSD
CHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHH
LLRWERRDLHDRFGSMGDRLWHLARGEDRRKVSARAPVKSISKETTFFEDTMHSEVLDGH
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LWRLAEQVSDRAKAKGLAGRVVTLKLKRANHSTLTRRQSLHSPTQYADQIYRTARRLLDQ
HHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
TIQQGPFRLLGCGISELAPEAQADATGDLLDPDATKRANAERATDEIRKRFGKEAIRKGR
HHHHCCCEEECCCHHHHCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCC
SLR
CCC
>Mature Secondary Structure 
PALCRECLHCFDPGTSPRGPKRCPVCRSPRVKQHEELLSLSIAHMDCDAFYASVEKRDN
CHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PELADKPVIIGGGHRGVVSTACYVARIRGVRSAMPMFQALKLCPDAVVIKPRMEVYAETS
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHH
RAIRAMMDELTPEVEPLSLDEAFMDLSGTERLHGAAPAVMLARLVKRMKDELGVTGSIGL
HHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
SHNKFLAKVASDLDKPRGFSVIGKAETAEFLRDKPVRLIWGIGPAAQASLEKAGIRAFSD
CHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHH
LLRWERRDLHDRFGSMGDRLWHLARGEDRRKVSARAPVKSISKETTFFEDTMHSEVLDGH
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LWRLAEQVSDRAKAKGLAGRVVTLKLKRANHSTLTRRQSLHSPTQYADQIYRTARRLLDQ
HHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
TIQQGPFRLLGCGISELAPEAQADATGDLLDPDATKRANAERATDEIRKRFGKEAIRKGR
HHHHCCCEEECCCHHHHCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCC
SLR
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]