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The map label for this gene is yciC [H]

Identifier: 99079921

GI number: 99079921

Start: 83627

End: 84841

Strand: Reverse

Name: yciC [H]

Synonym: TM1040_0080

Alternate gene names: 99079921

Gene position: 84841-83627 (Counterclockwise)

Preceding gene: 99079922

Following gene: 99079920

Centisome position: 2.65

GC content: 61.89

Gene sequence:

>1215_bases
ATGTCCGATCCCCGCCTTCCCGTCACCGTCCTCTCCGGCTTTCTCGGCGCGGGGAAGACCACGCTTTTGAACCGCATCCT
GAACAACCGCGAAGGCCGGCGCGTTGCGGTGATTGTGAACGATATGAGCGAGGTCAACATCGACGCGGATCTGGTGCGCG
AGGGCGGCGCTGACCTCAGCCAGACCGAAGAAACGCTGGTGGAAATGTCCAACGGCTGCATCTGCTGCACCCTGCGCGAT
GACCTTCTGGCCGAGGTGCGCCGTCTCGCCGCTGAGAACCGCTTTGACTACTTGCTGATTGAGTCCACCGGGATCTCGGA
GCCGCTGCCGGTCGCCGCAACCTTTGATTTTCGCGATGCGGAGGGCGAGAGCCTCTCGGATGTGGCGCGTCTGGACACGA
TGGTCACGGTGGTCGACGCCGTGAACCTGCTGAACGATTTTGCCAGTCACGACCTGCTGGCGGACCGGGGCGAGACGCTG
GGCGAAGAAGACGAGCGCACCCTGGTGCATCTGCTGACCGACCAAATCGAATTTGCCGATGTGGTTGTGCTTAACAAGGT
GAGCCTCGCCAGCGCCGAGCAAGTGGACGCGGCACGCAAGATCATTCGCAGCCTCAACGCAGATGCCGAGATCATCGAGA
CCGATTTCAGCGAGGTGTCTGCCGACAAGATCCTCGACACCAAGCTCTTTGATTTTGAAAAGGCGCATGAACACCCGATG
TGGGCGAAGGAGCTTTATGGCTTTGCCGATCATGTGCCGGAGACCGAAGAATACGGCATCGCGTCCTTTGTCTATCGCGC
ACGGGCGCCGTTTGATCCCAGCAAATTGCACGTGGTGCTGAACGGCAATCTGCCCGGGGTAATCCGCGCCAAGGGGCATT
TCTGGGTTGCGACCCGCCCCGAGTGGGTGGCGGAATTCTCGCTTGCGGGGGCGCTATCAAGCGTGGCGCCCTTGGGGACA
TGGTGGGCATCCGTTCCTGCCGAACGCTGGCCCACCCACCAGCAGGCGCGCGACTATATACAGACGCATTGGCAGGAGCC
CTTTGGCGATCGCCGTCAGGAATTGGTTTTCATCGGCGCGGGCATCGACTGGCCCGCCCTGAAGGCCACGCTGGATGCCT
GCCTGATCCCCGAAGCAACGGCCGAGACTCTGCAGGACTATGCGGATCTGGACGATCCCTTCCCGCTGTGGCGGCGGGCC
GATCAGGCAGCATGA

Upstream 100 bases:

>100_bases
CGCGCGGCGTCTAATTTTGACCAGCGGTGGGCAGCAAGGGTCTTGCCTCTTTTTGCGCATCATGATTGTTATCTTATAAC
ATTTCACACAGGAGTCGCAG

Downstream 100 bases:

>100_bases
TCATGAGACGGCAACAGAGAAACGCCAACCGGGGCGCGGTCGCTTTGCCGACCCGCACCCGACGCGAGGATCCGATGGCC
GCTTATGATCGCCTGCCCGC

Product: cobalamin synthesis protein, P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MSDPRLPVTVLSGFLGAGKTTLLNRILNNREGRRVAVIVNDMSEVNIDADLVREGGADLSQTEETLVEMSNGCICCTLRD
DLLAEVRRLAAENRFDYLLIESTGISEPLPVAATFDFRDAEGESLSDVARLDTMVTVVDAVNLLNDFASHDLLADRGETL
GEEDERTLVHLLTDQIEFADVVVLNKVSLASAEQVDAARKIIRSLNADAEIIETDFSEVSADKILDTKLFDFEKAHEHPM
WAKELYGFADHVPETEEYGIASFVYRARAPFDPSKLHVVLNGNLPGVIRAKGHFWVATRPEWVAEFSLAGALSSVAPLGT
WWASVPAERWPTHQQARDYIQTHWQEPFGDRRQELVFIGAGIDWPALKATLDACLIPEATAETLQDYADLDDPFPLWRRA
DQAA

Sequences:

>Translated_404_residues
MSDPRLPVTVLSGFLGAGKTTLLNRILNNREGRRVAVIVNDMSEVNIDADLVREGGADLSQTEETLVEMSNGCICCTLRD
DLLAEVRRLAAENRFDYLLIESTGISEPLPVAATFDFRDAEGESLSDVARLDTMVTVVDAVNLLNDFASHDLLADRGETL
GEEDERTLVHLLTDQIEFADVVVLNKVSLASAEQVDAARKIIRSLNADAEIIETDFSEVSADKILDTKLFDFEKAHEHPM
WAKELYGFADHVPETEEYGIASFVYRARAPFDPSKLHVVLNGNLPGVIRAKGHFWVATRPEWVAEFSLAGALSSVAPLGT
WWASVPAERWPTHQQARDYIQTHWQEPFGDRRQELVFIGAGIDWPALKATLDACLIPEATAETLQDYADLDDPFPLWRRA
DQAA
>Mature_403_residues
SDPRLPVTVLSGFLGAGKTTLLNRILNNREGRRVAVIVNDMSEVNIDADLVREGGADLSQTEETLVEMSNGCICCTLRDD
LLAEVRRLAAENRFDYLLIESTGISEPLPVAATFDFRDAEGESLSDVARLDTMVTVVDAVNLLNDFASHDLLADRGETLG
EEDERTLVHLLTDQIEFADVVVLNKVSLASAEQVDAARKIIRSLNADAEIIETDFSEVSADKILDTKLFDFEKAHEHPMW
AKELYGFADHVPETEEYGIASFVYRARAPFDPSKLHVVLNGNLPGVIRAKGHFWVATRPEWVAEFSLAGALSSVAPLGTW
WASVPAERWPTHQQARDYIQTHWQEPFGDRRQELVFIGAGIDWPALKATLDACLIPEATAETLQDYADLDDPFPLWRRAD
QAA

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=262, Percent_Identity=34.7328244274809, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI126722884, Length=262, Percent_Identity=34.7328244274809, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI148727351, Length=262, Percent_Identity=34.3511450381679, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI146231952, Length=262, Percent_Identity=33.969465648855, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI223941779, Length=218, Percent_Identity=36.2385321100917, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI223941776, Length=251, Percent_Identity=34.2629482071713, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI119120938, Length=138, Percent_Identity=39.1304347826087, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI87082430, Length=304, Percent_Identity=26.3157894736842, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788499, Length=229, Percent_Identity=26.2008733624454, Blast_Score=65, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6324356, Length=235, Percent_Identity=28.936170212766, Blast_Score=106, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 44861; Mature: 44730

Theoretical pI: Translated: 4.26; Mature: 4.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPRLPVTVLSGFLGAGKTTLLNRILNNREGRRVAVIVNDMSEVNIDADLVREGGADLS
CCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEEECHHHCCCCHHHHHCCCCCHH
QTEETLVEMSNGCICCTLRDDLLAEVRRLAAENRFDYLLIESTGISEPLPVAATFDFRDA
HHHHHHHHHCCCEEEEEECHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCCC
EGESLSDVARLDTMVTVVDAVNLLNDFASHDLLADRGETLGEEDERTLVHLLTDQIEFAD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
VVVLNKVSLASAEQVDAARKIIRSLNADAEIIETDFSEVSADKILDTKLFDFEKAHEHPM
EEEEECHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
WAKELYGFADHVPETEEYGIASFVYRARAPFDPSKLHVVLNGNLPGVIRAKGHFWVATRP
HHHHHHHHHHCCCCCHHCCHHHHHHHHCCCCCCCEEEEEEECCCCEEEEECCEEEEECCC
EWVAEFSLAGALSSVAPLGTWWASVPAERWPTHQQARDYIQTHWQEPFGDRRQELVFIGA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEC
GIDWPALKATLDACLIPEATAETLQDYADLDDPFPLWRRADQAA
CCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHCCCC
>Mature Secondary Structure 
SDPRLPVTVLSGFLGAGKTTLLNRILNNREGRRVAVIVNDMSEVNIDADLVREGGADLS
CCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEEECHHHCCCCHHHHHCCCCCHH
QTEETLVEMSNGCICCTLRDDLLAEVRRLAAENRFDYLLIESTGISEPLPVAATFDFRDA
HHHHHHHHHCCCEEEEEECHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCCC
EGESLSDVARLDTMVTVVDAVNLLNDFASHDLLADRGETLGEEDERTLVHLLTDQIEFAD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
VVVLNKVSLASAEQVDAARKIIRSLNADAEIIETDFSEVSADKILDTKLFDFEKAHEHPM
EEEEECHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
WAKELYGFADHVPETEEYGIASFVYRARAPFDPSKLHVVLNGNLPGVIRAKGHFWVATRP
HHHHHHHHHHCCCCCHHCCHHHHHHHHCCCCCCCEEEEEEECCCCEEEEECCEEEEECCC
EWVAEFSLAGALSSVAPLGTWWASVPAERWPTHQQARDYIQTHWQEPFGDRRQELVFIGA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEC
GIDWPALKATLDACLIPEATAETLQDYADLDDPFPLWRRADQAA
CCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]