| Definition | Streptococcus pyogenes MGAS10750 chromosome, complete genome. |
|---|---|
| Accession | NC_008024 |
| Length | 1,937,111 |
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The map label for this gene is pabB [H]
Identifier: 94995185
GI number: 94995185
Start: 1744602
End: 1746365
Strand: Direct
Name: pabB [H]
Synonym: MGAS10750_Spy1789
Alternate gene names: 94995185
Gene position: 1744602-1746365 (Clockwise)
Preceding gene: 94995184
Following gene: 94995186
Centisome position: 90.06
GC content: 44.67
Gene sequence:
>1764_bases TTGGGTATGCATAGAAAAACCATTATTGATTTCAAGGAGCTTGGGCACCGCTTCTTGTTTGAAAAAACCTTACTAGAGTT GGTAGCCAAGTCCTTAGATCAGGTCGGCCCAGTCATTCAACAGGTTCAGCACTACCAAGAACTGGGGTACTACGTGGTGG GCTACCTCAGTTACGAAGCAGCTGCTTTTTTTGACAACGCCTTACAAACCCATAATGACCGATTAGGCAACGAGTATCTT GCCTATTTTACGGTGCACAAAACCTGTCAGAAAGAAGACCTACCTCTTGATTATGACAGCATTACTATCCCTAACCAATG GGTCAGCGCCACTCAAAAAGAAGCCTATCAAAAAGCCATTGAAACCATTCACCATGAGATGCGACAGGGCAATACTTATC AGGTTAACTACACCCTTCAATTAACTCAGGAACTCAATGCAGCTGACAGCTTAGCCATTTACAATAAACTCGTCGTTGAA CAGGCTGCTGGCTACAATGCCTATATCGCCCATGATGACTTTGCTGTTATTTCAGCTAGTCCTGAATTGTTCTTTAAACA GGAAGGCAATCAACTCATCACCAGACCTATGAAGGGTACCACTAAGCGCGGGGTTAACACCTGGCTGGATCAACAAGAAC ATGATTGGCTCCAAACTGACAGGAAAAATCGCTCTGAAAACATGATGATTGTTGACTTGCTCCGCAATGACATGGGAAAA ATTTGCCAAACAGGCAGTGTTTGTGTCGATAGGCTCTGTGAGGTGGAACAATACTCTACCGTCTGGCAAATGACCTCAAC CATTGTTGGTGACCTCAAAGCGGACTGTGACCTGATAGACATTCTCACAGCTCTCTTTCCTTGTGGCTCTATCACAGGGG CTCCTAAAGTCTCCACCATGGCGATTATCACATCTCTGGAGCCAAACCCAAGGGGGATTTATTGTGGAAGTATTGGCATT TGTTTACCTGACGGTCGCCGTTTCTTCAATGTTCCCATTAGAACCATCCAGCTCAGTCATAATCAAGCTACTTATGGTGT CGGAGGCGGTATCACTTGGCAAAGCAAGTGGGAAGACGAATACGAAGAAGTCCATCAAAAAACAACTTTTCTCTATCGGC ACAAACAAATCTTTGACCTCAAAACAACCGCCAAGGTGGAACACCAAAAAATAGCCTTCCTTGAGCAACACCTCAATCGC CTTAAAGAAGCAGCCACTTATTTTGCTTACCCTTACGATGAGAAAGCTTTGCAGAAACAACTGTCAACCTATTTGGAAAA TAAGAATAATGCTGCCTACCGTTTGATGATTCGTTTATCCAAAGATGGAAAGATTAGCCTCTCTGATCAACCCTTGGAAC CTTTGTCAGCCGATTTTCTGACAGCTCAACTCTCTTTACAGAAAAAGGACGTGACAGCTTCGCCTTTTACCTACTTTAAG ACCAGCTACCGGCCTCATATTGAGCAAAAATCTTATGAACAGCTATTCTATAACCAAGCGGGGCAATTATTAGAAACGTC CATCGGCAATCTTTTTATCCAGCTGGGTCGGACCCTCTACACACCACCAGTGGCGGTGGGTGTTTTACCAGGACTTTTTC GCCAAGAGCTGCTAGCTACTGGTCAAGCTCAGGAAAAAGAGGTGACACTAGCTGATTTAAAAGAGGCTAGCGCTATTTTT GGAGGAAATGCTGTCCGTGGCCTCTATCCTCTCAACCTTGAGCTTACTCACCTTGATGCCCTCTTAGCTAAGAGTCAAGC CTAA
Upstream 100 bases:
>100_bases AAGACTGAACTTTCACTAAGAAAGTTCAGTCTTTTTACGTGGTCAAAAGACAGTTGTTGCCTGTTCTCATTAGGCTTGGC AAACGCTTTTATGATATAAT
Downstream 100 bases:
>100_bases ACTGCCACTCATCTTTTGTTATTAAGGAACCTATGATACTCTTAATTGATAATTACGATTCATTTACCTACAACCTCTCC CAATATCTAAGTGAATTTGA
Product: Para-aminobenzoate synthetase component I / 4-amino-4-deoxychorismate lyase
Products: NA
Alternate protein names: ADC synthase; Para-aminobenzoate synthase component I [H]
Number of amino acids: Translated: 587; Mature: 586
Protein sequence:
>587_residues MGMHRKTIIDFKELGHRFLFEKTLLELVAKSLDQVGPVIQQVQHYQELGYYVVGYLSYEAAAFFDNALQTHNDRLGNEYL AYFTVHKTCQKEDLPLDYDSITIPNQWVSATQKEAYQKAIETIHHEMRQGNTYQVNYTLQLTQELNAADSLAIYNKLVVE QAAGYNAYIAHDDFAVISASPELFFKQEGNQLITRPMKGTTKRGVNTWLDQQEHDWLQTDRKNRSENMMIVDLLRNDMGK ICQTGSVCVDRLCEVEQYSTVWQMTSTIVGDLKADCDLIDILTALFPCGSITGAPKVSTMAIITSLEPNPRGIYCGSIGI CLPDGRRFFNVPIRTIQLSHNQATYGVGGGITWQSKWEDEYEEVHQKTTFLYRHKQIFDLKTTAKVEHQKIAFLEQHLNR LKEAATYFAYPYDEKALQKQLSTYLENKNNAAYRLMIRLSKDGKISLSDQPLEPLSADFLTAQLSLQKKDVTASPFTYFK TSYRPHIEQKSYEQLFYNQAGQLLETSIGNLFIQLGRTLYTPPVAVGVLPGLFRQELLATGQAQEKEVTLADLKEASAIF GGNAVRGLYPLNLELTHLDALLAKSQA
Sequences:
>Translated_587_residues MGMHRKTIIDFKELGHRFLFEKTLLELVAKSLDQVGPVIQQVQHYQELGYYVVGYLSYEAAAFFDNALQTHNDRLGNEYL AYFTVHKTCQKEDLPLDYDSITIPNQWVSATQKEAYQKAIETIHHEMRQGNTYQVNYTLQLTQELNAADSLAIYNKLVVE QAAGYNAYIAHDDFAVISASPELFFKQEGNQLITRPMKGTTKRGVNTWLDQQEHDWLQTDRKNRSENMMIVDLLRNDMGK ICQTGSVCVDRLCEVEQYSTVWQMTSTIVGDLKADCDLIDILTALFPCGSITGAPKVSTMAIITSLEPNPRGIYCGSIGI CLPDGRRFFNVPIRTIQLSHNQATYGVGGGITWQSKWEDEYEEVHQKTTFLYRHKQIFDLKTTAKVEHQKIAFLEQHLNR LKEAATYFAYPYDEKALQKQLSTYLENKNNAAYRLMIRLSKDGKISLSDQPLEPLSADFLTAQLSLQKKDVTASPFTYFK TSYRPHIEQKSYEQLFYNQAGQLLETSIGNLFIQLGRTLYTPPVAVGVLPGLFRQELLATGQAQEKEVTLADLKEASAIF GGNAVRGLYPLNLELTHLDALLAKSQA >Mature_586_residues GMHRKTIIDFKELGHRFLFEKTLLELVAKSLDQVGPVIQQVQHYQELGYYVVGYLSYEAAAFFDNALQTHNDRLGNEYLA YFTVHKTCQKEDLPLDYDSITIPNQWVSATQKEAYQKAIETIHHEMRQGNTYQVNYTLQLTQELNAADSLAIYNKLVVEQ AAGYNAYIAHDDFAVISASPELFFKQEGNQLITRPMKGTTKRGVNTWLDQQEHDWLQTDRKNRSENMMIVDLLRNDMGKI CQTGSVCVDRLCEVEQYSTVWQMTSTIVGDLKADCDLIDILTALFPCGSITGAPKVSTMAIITSLEPNPRGIYCGSIGIC LPDGRRFFNVPIRTIQLSHNQATYGVGGGITWQSKWEDEYEEVHQKTTFLYRHKQIFDLKTTAKVEHQKIAFLEQHLNRL KEAATYFAYPYDEKALQKQLSTYLENKNNAAYRLMIRLSKDGKISLSDQPLEPLSADFLTAQLSLQKKDVTASPFTYFKT SYRPHIEQKSYEQLFYNQAGQLLETSIGNLFIQLGRTLYTPPVAVGVLPGLFRQELLATGQAQEKEVTLADLKEASAIFG GNAVRGLYPLNLELTHLDALLAKSQA
Specific function: Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine [H]
COG id: COG0147
COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the anthranilate synthase component I family [H]
Homologues:
Organism=Escherichia coli, GI1788114, Length=311, Percent_Identity=34.4051446945338, Blast_Score=165, Evalue=9e-42, Organism=Escherichia coli, GI1787518, Length=282, Percent_Identity=29.4326241134752, Blast_Score=128, Evalue=9e-31, Organism=Escherichia coli, GI1786809, Length=222, Percent_Identity=23.8738738738739, Blast_Score=85, Evalue=1e-17, Organism=Escherichia coli, GI87082077, Length=209, Percent_Identity=29.1866028708134, Blast_Score=71, Evalue=2e-13, Organism=Saccharomyces cerevisiae, GI6320935, Length=261, Percent_Identity=34.4827586206897, Blast_Score=156, Evalue=1e-38, Organism=Saccharomyces cerevisiae, GI6324361, Length=301, Percent_Identity=28.2392026578073, Blast_Score=96, Evalue=1e-20,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005801 - InterPro: IPR019999 - InterPro: IPR006805 - InterPro: IPR015890 [H]
Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]
EC number: =2.6.1.85 [H]
Molecular weight: Translated: 66634; Mature: 66502
Theoretical pI: Translated: 6.31; Mature: 6.31
Prosite motif: PS00770 AA_TRANSFER_CLASS_4
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 1.7 %Met (Translated Protein) 3.1 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 1.5 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MGMHRKTIIDFKELGHRFLFEKTLLELVAKSLDQVGPVIQQVQHYQELGYYVVGYLSYEA CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHH AAFFDNALQTHNDRLGNEYLAYFTVHKTCQKEDLPLDYDSITIPNQWVSATQKEAYQKAI HHHHHHHHHHHCHHCCCCEEEEEEEHHHCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHH ETIHHEMRQGNTYQVNYTLQLTQELNAADSLAIYNKLVVEQAAGYNAYIAHDDFAVISAS HHHHHHHHCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCEEEEECC PELFFKQEGNQLITRPMKGTTKRGVNTWLDQQEHDWLQTDRKNRSENMMIVDLLRNDMGK CCEEEECCCCCEEECCCCCCCHHCHHHHHCCHHHHHHHHHCCCCCCCEEEHHHHHHHHHH ICQTGSVCVDRLCEVEQYSTVWQMTSTIVGDLKADCDLIDILTALFPCGSITGAPKVSTM HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCEEE AIITSLEPNPRGIYCGSIGICLPDGRRFFNVPIRTIQLSHNQATYGVGGGITWQSKWEDE EEEEECCCCCCEEEECCEEEECCCCCEEEECCEEEEEEECCCEEECCCCCCCCCCCCCHH YEEVHQKTTFLYRHKQIFDLKTTAKVEHQKIAFLEQHLNRLKEAATYFAYPYDEKALQKQ HHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH LSTYLENKNNAAYRLMIRLSKDGKISLSDQPLEPLSADFLTAQLSLQKKDVTASPFTYFK HHHHHCCCCCCEEEEEEEECCCCEEEECCCCCCCCCHHHHHHHHEEECCCCCCCCHHHHH TSYRPHIEQKSYEQLFYNQAGQLLETSIGNLFIQLGRTLYTPPVAVGVLPGLFRQELLAT CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCHHHHHHHHHHHHHHHHC GQAQEKEVTLADLKEASAIFGGNAVRGLYPLNLELTHLDALLAKSQA CCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCEEHHHHHHHHHHCCC >Mature Secondary Structure GMHRKTIIDFKELGHRFLFEKTLLELVAKSLDQVGPVIQQVQHYQELGYYVVGYLSYEA CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHH AAFFDNALQTHNDRLGNEYLAYFTVHKTCQKEDLPLDYDSITIPNQWVSATQKEAYQKAI HHHHHHHHHHHCHHCCCCEEEEEEEHHHCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHH ETIHHEMRQGNTYQVNYTLQLTQELNAADSLAIYNKLVVEQAAGYNAYIAHDDFAVISAS HHHHHHHHCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCEEEEECC PELFFKQEGNQLITRPMKGTTKRGVNTWLDQQEHDWLQTDRKNRSENMMIVDLLRNDMGK CCEEEECCCCCEEECCCCCCCHHCHHHHHCCHHHHHHHHHCCCCCCCEEEHHHHHHHHHH ICQTGSVCVDRLCEVEQYSTVWQMTSTIVGDLKADCDLIDILTALFPCGSITGAPKVSTM HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCEEE AIITSLEPNPRGIYCGSIGICLPDGRRFFNVPIRTIQLSHNQATYGVGGGITWQSKWEDE EEEEECCCCCCEEEECCEEEECCCCCEEEECCEEEEEEECCCEEECCCCCCCCCCCCCHH YEEVHQKTTFLYRHKQIFDLKTTAKVEHQKIAFLEQHLNRLKEAATYFAYPYDEKALQKQ HHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH LSTYLENKNNAAYRLMIRLSKDGKISLSDQPLEPLSADFLTAQLSLQKKDVTASPFTYFK HHHHHCCCCCCEEEEEEEECCCCEEEECCCCCCCCCHHHHHHHHEEECCCCCCCCHHHHH TSYRPHIEQKSYEQLFYNQAGQLLETSIGNLFIQLGRTLYTPPVAVGVLPGLFRQELLAT CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCHHHHHHHHHHHHHHHHC GQAQEKEVTLADLKEASAIFGGNAVRGLYPLNLELTHLDALLAKSQA CCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCEEHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 2123867; 7584024; 9384377 [H]