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The map label for this gene is nylA [H]

Identifier: 94995184

GI number: 94995184

Start: 1742450

End: 1744423

Strand: Direct

Name: nylA [H]

Synonym: MGAS10750_Spy1788

Alternate gene names: 94995184

Gene position: 1742450-1744423 (Clockwise)

Preceding gene: 94995178

Following gene: 94995185

Centisome position: 89.95

GC content: 47.47

Gene sequence:

>1974_bases
ATGAGATATTCTAGACGCTACCCTTCTCAGACAAGACAGATGCTTCTTGCCTTGTTATTAATGACTGCCAGCCTACAAGC
TGGAGCTATGACTACTTATGCGGATGAGGTTAATACCAACCATCAACCACTAACGGCCCAAGTGGAAGCTAGTAAGCCGA
CAGCCATGGAATCTGTCACTTCACCTGCAGACCAGACCCATCCAATCTCAACGCAAGAGGCTTCGTCTCCTTTACACCCT
TTAACAACAGAGGCCACTCCTGCCGCCCAAGAATCTCCGATTACCTTAGAAGACTATAAGGCAGCCAGTGCGAGCCAATT
AGCTGAGTGGGCTCGCCAGCAACGGGTCACAGGCCAACAGCTGCTAGATTTTGCCTTGGAAACCATCAAAGAAACTAACC
CTGAGCTCAATAATGTCATTTCTCTGCGTGAACCATTGGCTCGACAAGAGAGCGAGCAAATGACAGATGAGGGGCAACCC
TTTTACAAGGTTCCTATTCTGGTTAAAGGGTTAGGACACACCGTTGCTGGAAGTAGCAACACCAACGGGCTTGCCTTTTT
GAAAGACAAAACCAGCTCATCTACCAGCGCCTTTGTCAAACAACTCCAAAAGGCTGGTTTTATCGTGGTAGGGCAGTCCT
CTTTCCCTGAAATGGGATGGATTAATGTGACGAATTCCAATCTTTACGGAAATACACATAACCCATGGCAGCTTGACCAA
AATCCTGGCGGGTCCTCTGGTGGCTCTGCAGCTGCTGTGGCTTCAGGACAAGTCAGTCTAGCCAGTGCTTCTGATGGTGG
GGGCTCAACCCGCATTCCAGCTTCTTGGAGTGGCTTGATTGGCCTACACCCAACACGTGGCATTTTAGAGGGAAATCCGA
CTTCTGAACGTAGCAATGTTAGCCATTTTGCTCTAACTAAGAGCATGGAAGACACTGAAAAGCTCTTCCAATTCCTCTTA
AAAGACAAGGCTAAAGCGCAACAAAACCCACAGCGTTTAGACACAAGTATCCCCATTGCTTACAGCACCCAGACACCAGC
TGGAACACCAATTAGTGAGGAAGCTATTGCTGCGATCAAAGAAGCTGTAGCCTTTTTACAGGAGCAAGGTTATCAAACCG
TAGAAGTGCCTTACCCCGTTGATGGTAAGCTCATGATGCAATACTATTACACTATTGCTGCTTCTGCAGCGCCATCTATC
AATTTTATGGCACAACAAACCTTGAAACGCCCCCTTCAAAAAGAGGATGTCGAACTCCTATCATGGGCGCTCTACCAAAC
TGGGAAAGACTTGACCAAAGAGGATGTCAACAAAGCCTGGGAGGGTATCGCAGCCATGACCGAGCAATTAAACCAGTTCT
ACCAAAAATACCCCATCTTCTTAACACCGACAACAGCCTATCCCGCCCCTGCTGCCGATTACCACCACATTCCGAAAGAC
CTAGTAGCACAGCTCAGTGACATGTCAGGCTTGAGCAAAGAAGAAAAATTGGACCTTATTTACCGGCAATGGTTACCTGC
ATGGACGCTAACACCATTTACCCAGCTTGCTAACCTGACGGGAACACCATCCTTGTCCTTACCAACCCATGTGACGAAAA
GCGGTCTACCTCTTGGCATTTTGGTGAATAGCGGAGCTCATAACGATAGTCTCCTGTTACAACTGGGACAGCTCTTTGAA
AAAGCAAATCGTTTCCATATCCTGACGGCTGGCAAAAAAGGATTGCCAGAAACTCCTGCGCATGAGCATAACCTCTCAAC
TCAATCTGAAAACAAACAAGGCGTTGCCATTCCAGTGACTTATCAAACCAAGGGATTTACTACTGGACCAACCAAGGGCC
AGAACGGCTTAGTAACCCTCCCTCAAACTGGTGATGGTCAGTCAAAAGGTGTGTTGTTAACTAGCTACATCAGCCTTTTC
CTTGGAACCCTCTTCTTAGCAGGAAGCTTCTGGAGCAATAAAGTAAAAGACTAG

Upstream 100 bases:

>100_bases
GCTGACTGATGGGCCTTCTGTATTTTAGTAAGCGTTTTACCCCTTACTTTCCTCCCATTATGTTAAACTAATAAGCGATT
ATGATGTTAGGAGAAAAAGA

Downstream 100 bases:

>100_bases
GCTATTGTCGTCGGAGATTTAACCTACCTAAACATTCACTGCTGCTTGCCTTACGATAAGAGTATATTGTAGTCAATCAA
GACTGAACTTTCACTAAGAA

Product: Amidase family protein

Products: NA

Alternate protein names: Nylon oligomers-degrading enzyme EI [H]

Number of amino acids: Translated: 657; Mature: 657

Protein sequence:

>657_residues
MRYSRRYPSQTRQMLLALLLMTASLQAGAMTTYADEVNTNHQPLTAQVEASKPTAMESVTSPADQTHPISTQEASSPLHP
LTTEATPAAQESPITLEDYKAASASQLAEWARQQRVTGQQLLDFALETIKETNPELNNVISLREPLARQESEQMTDEGQP
FYKVPILVKGLGHTVAGSSNTNGLAFLKDKTSSSTSAFVKQLQKAGFIVVGQSSFPEMGWINVTNSNLYGNTHNPWQLDQ
NPGGSSGGSAAAVASGQVSLASASDGGGSTRIPASWSGLIGLHPTRGILEGNPTSERSNVSHFALTKSMEDTEKLFQFLL
KDKAKAQQNPQRLDTSIPIAYSTQTPAGTPISEEAIAAIKEAVAFLQEQGYQTVEVPYPVDGKLMMQYYYTIAASAAPSI
NFMAQQTLKRPLQKEDVELLSWALYQTGKDLTKEDVNKAWEGIAAMTEQLNQFYQKYPIFLTPTTAYPAPAADYHHIPKD
LVAQLSDMSGLSKEEKLDLIYRQWLPAWTLTPFTQLANLTGTPSLSLPTHVTKSGLPLGILVNSGAHNDSLLLQLGQLFE
KANRFHILTAGKKGLPETPAHEHNLSTQSENKQGVAIPVTYQTKGFTTGPTKGQNGLVTLPQTGDGQSKGVLLTSYISLF
LGTLFLAGSFWSNKVKD

Sequences:

>Translated_657_residues
MRYSRRYPSQTRQMLLALLLMTASLQAGAMTTYADEVNTNHQPLTAQVEASKPTAMESVTSPADQTHPISTQEASSPLHP
LTTEATPAAQESPITLEDYKAASASQLAEWARQQRVTGQQLLDFALETIKETNPELNNVISLREPLARQESEQMTDEGQP
FYKVPILVKGLGHTVAGSSNTNGLAFLKDKTSSSTSAFVKQLQKAGFIVVGQSSFPEMGWINVTNSNLYGNTHNPWQLDQ
NPGGSSGGSAAAVASGQVSLASASDGGGSTRIPASWSGLIGLHPTRGILEGNPTSERSNVSHFALTKSMEDTEKLFQFLL
KDKAKAQQNPQRLDTSIPIAYSTQTPAGTPISEEAIAAIKEAVAFLQEQGYQTVEVPYPVDGKLMMQYYYTIAASAAPSI
NFMAQQTLKRPLQKEDVELLSWALYQTGKDLTKEDVNKAWEGIAAMTEQLNQFYQKYPIFLTPTTAYPAPAADYHHIPKD
LVAQLSDMSGLSKEEKLDLIYRQWLPAWTLTPFTQLANLTGTPSLSLPTHVTKSGLPLGILVNSGAHNDSLLLQLGQLFE
KANRFHILTAGKKGLPETPAHEHNLSTQSENKQGVAIPVTYQTKGFTTGPTKGQNGLVTLPQTGDGQSKGVLLTSYISLF
LGTLFLAGSFWSNKVKD
>Mature_657_residues
MRYSRRYPSQTRQMLLALLLMTASLQAGAMTTYADEVNTNHQPLTAQVEASKPTAMESVTSPADQTHPISTQEASSPLHP
LTTEATPAAQESPITLEDYKAASASQLAEWARQQRVTGQQLLDFALETIKETNPELNNVISLREPLARQESEQMTDEGQP
FYKVPILVKGLGHTVAGSSNTNGLAFLKDKTSSSTSAFVKQLQKAGFIVVGQSSFPEMGWINVTNSNLYGNTHNPWQLDQ
NPGGSSGGSAAAVASGQVSLASASDGGGSTRIPASWSGLIGLHPTRGILEGNPTSERSNVSHFALTKSMEDTEKLFQFLL
KDKAKAQQNPQRLDTSIPIAYSTQTPAGTPISEEAIAAIKEAVAFLQEQGYQTVEVPYPVDGKLMMQYYYTIAASAAPSI
NFMAQQTLKRPLQKEDVELLSWALYQTGKDLTKEDVNKAWEGIAAMTEQLNQFYQKYPIFLTPTTAYPAPAADYHHIPKD
LVAQLSDMSGLSKEEKLDLIYRQWLPAWTLTPFTQLANLTGTPSLSLPTHVTKSGLPLGILVNSGAHNDSLLLQLGQLFE
KANRFHILTAGKKGLPETPAHEHNLSTQSENKQGVAIPVTYQTKGFTTGPTKGQNGLVTLPQTGDGQSKGVLLTSYISLF
LGTLFLAGSFWSNKVKD

Specific function: Specifically catalyzes the hydrolysis of 6-aminohexanoic acid cyclic dimer (1,8-diazacyclotetradecane-2,9-dione) to form the linear dimer 6-aminohexanoyl-6-aminohexanoic acid. Is inactive on 6-aminohexanoic acid oligomers (degree of polymerization 2 to 6)

COG id: COG0154

COG function: function code J; Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amidase family [H]

Homologues:

Organism=Homo sapiens, GI195972892, Length=534, Percent_Identity=24.7191011235955, Blast_Score=106, Evalue=8e-23,
Organism=Homo sapiens, GI222831590, Length=521, Percent_Identity=22.8406909788868, Blast_Score=78, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17537465, Length=524, Percent_Identity=23.8549618320611, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17556264, Length=245, Percent_Identity=31.0204081632653, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17543272, Length=461, Percent_Identity=25.5965292841649, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71990152, Length=259, Percent_Identity=30.1158301158301, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17556276, Length=280, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17556278, Length=270, Percent_Identity=28.5185185185185, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24648435, Length=494, Percent_Identity=23.0769230769231, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24648437, Length=494, Percent_Identity=23.0769230769231, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI45550774, Length=494, Percent_Identity=23.0769230769231, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21356731, Length=498, Percent_Identity=24.2971887550201, Blast_Score=107, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24648441, Length=434, Percent_Identity=23.963133640553, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24648439, Length=434, Percent_Identity=23.963133640553, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24644968, Length=521, Percent_Identity=23.4165067178503, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24652985, Length=214, Percent_Identity=29.4392523364486, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19922090, Length=214, Percent_Identity=29.4392523364486, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24652981, Length=214, Percent_Identity=29.4392523364486, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24652983, Length=214, Percent_Identity=29.4392523364486, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI161078093, Length=509, Percent_Identity=22.7897838899804, Blast_Score=76, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000120
- InterPro:   IPR020556 [H]

Pfam domain/function: PF01425 Amidase [H]

EC number: =3.5.2.12 [H]

Molecular weight: Translated: 71259; Mature: 71259

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYSRRYPSQTRQMLLALLLMTASLQAGAMTTYADEVNTNHQPLTAQVEASKPTAMESVT
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEHHHCCCCCCCEEEEEECCCCHHHHHHC
SPADQTHPISTQEASSPLHPLTTEATPAAQESPITLEDYKAASASQLAEWARQQRVTGQQ
CCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCHHH
LLDFALETIKETNPELNNVISLREPLARQESEQMTDEGQPFYKVPILVKGLGHTVAGSSN
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEEEECCCCEECCCCC
TNGLAFLKDKTSSSTSAFVKQLQKAGFIVVGQSSFPEMGWINVTNSNLYGNTHNPWQLDQ
CCCEEEEECCCCCHHHHHHHHHHHCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCC
NPGGSSGGSAAAVASGQVSLASASDGGGSTRIPASWSGLIGLHPTRGILEGNPTSERSNV
CCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCC
SHFALTKSMEDTEKLFQFLLKDKAKAQQNPQRLDTSIPIAYSTQTPAGTPISEEAIAAIK
HHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCEEEECCCCCCCCCCHHHHHHHH
EAVAFLQEQGYQTVEVPYPVDGKLMMQYYYTIAASAAPSINFMAQQTLKRPLQKEDVELL
HHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHH
SWALYQTGKDLTKEDVNKAWEGIAAMTEQLNQFYQKYPIFLTPTTAYPAPAADYHHIPKD
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCHHCCCHH
LVAQLSDMSGLSKEEKLDLIYRQWLPAWTLTPFTQLANLTGTPSLSLPTHVTKSGLPLGI
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCHHHCCCCCEEE
LVNSGAHNDSLLLQLGQLFEKANRFHILTAGKKGLPETPAHEHNLSTQSENKQGVAIPVT
EEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
YQTKGFTTGPTKGQNGLVTLPQTGDGQSKGVLLTSYISLFLGTLFLAGSFWSNKVKD
EECCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRYSRRYPSQTRQMLLALLLMTASLQAGAMTTYADEVNTNHQPLTAQVEASKPTAMESVT
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEHHHCCCCCCCEEEEEECCCCHHHHHHC
SPADQTHPISTQEASSPLHPLTTEATPAAQESPITLEDYKAASASQLAEWARQQRVTGQQ
CCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCHHH
LLDFALETIKETNPELNNVISLREPLARQESEQMTDEGQPFYKVPILVKGLGHTVAGSSN
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEEEECCCCEECCCCC
TNGLAFLKDKTSSSTSAFVKQLQKAGFIVVGQSSFPEMGWINVTNSNLYGNTHNPWQLDQ
CCCEEEEECCCCCHHHHHHHHHHHCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCC
NPGGSSGGSAAAVASGQVSLASASDGGGSTRIPASWSGLIGLHPTRGILEGNPTSERSNV
CCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCC
SHFALTKSMEDTEKLFQFLLKDKAKAQQNPQRLDTSIPIAYSTQTPAGTPISEEAIAAIK
HHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCEEEECCCCCCCCCCHHHHHHHH
EAVAFLQEQGYQTVEVPYPVDGKLMMQYYYTIAASAAPSINFMAQQTLKRPLQKEDVELL
HHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHH
SWALYQTGKDLTKEDVNKAWEGIAAMTEQLNQFYQKYPIFLTPTTAYPAPAADYHHIPKD
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCHHCCCHH
LVAQLSDMSGLSKEEKLDLIYRQWLPAWTLTPFTQLANLTGTPSLSLPTHVTKSGLPLGI
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCHHHCCCCCEEE
LVNSGAHNDSLLLQLGQLFEKANRFHILTAGKKGLPETPAHEHNLSTQSENKQGVAIPVT
EEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
YQTKGFTTGPTKGQNGLVTLPQTGDGQSKGVLLTSYISLFLGTLFLAGSFWSNKVKD
EECCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2722746 [H]