Click here to switch to the map view.

The map label for this gene is spi [H]

Identifier: 94995020

GI number: 94995020

Start: 1559794

End: 1560453

Strand: Direct

Name: spi [H]

Synonym: MGAS10750_Spy1624

Alternate gene names: 94995020

Gene position: 1559794-1560453 (Clockwise)

Preceding gene: 94995019

Following gene: 94995021

Centisome position: 80.52

GC content: 37.73

Gene sequence:

>660_bases
GTGCTAAACTTCACTTCGCCAACACTCACAAAGCGCAAGCGCTTCTCACTAAATAAAAGGAATCATATGAAACAGTTTAT
TAAAGAATGGGGCCCATTCACTCTCTTTTTAATTCTCTTTGGTCTATCTCGTCTTTTTTTGTGGCAGGCTGTTAAAGTAG
ACGGCCATTCTATGGACCCAACTCTAGCTCATGGCGAACGCCTTATCGTTTTTAATCAAGCTAGGATTGATCGCTTTGAT
ATTGTAGTTGCTCAGGAAGAAGAAAACGGACAAAAGAAAGAAATCGTAAAAAGAGTTGTTGGATTGCCAGGCGATACCAT
TTCTTATAATGATGACACACTTTATATTAATGGTAAAAAAACAGTTGAGCCGTATTTGGCTGAGTATCTAAAACAATTTA
AAAACGATAAACTCCAAAAAACTTACGCCTATAATACCCTATTCCAACAGTTAGCAGAAACATCTGATGCTTTTACAACT
AATTCTGAGGGACAAACACGCTTTGAGATGAGTGTTCCAAAAGGAGAATACCTTCTTCTTGGTGATGATCGTATTGTTTC
CAGGGATAGTCGCGAAGTTGGTAGTTTCAAAAAAGAAAACCTTATCGGTGAAGTGAAAGCTCGTTTTTGGCCACTCAATA
AAATGACCGTCTTTAATTAG

Upstream 100 bases:

>100_bases
CAAGATTTAGGTTACCAACTCCCAAGCGGTGCTGGTTCAGCTTCAGATAAAGTTGCTAGCCAACTCTTAGCCGCTTATGG
TATGTCTAGCTTAGAATATA

Downstream 100 bases:

>100_bases
AAAAAACCTGCCTTTGGGCAGGTTTTCGACTATCTTGTATAGACAGAAAGGTGCCTTATGGAACACTTTTTTACTGGTAC
TGTTGACCGCATTATCTTTG

Product: Signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MLNFTSPTLTKRKRFSLNKRNHMKQFIKEWGPFTLFLILFGLSRLFLWQAVKVDGHSMDPTLAHGERLIVFNQARIDRFD
IVVAQEEENGQKKEIVKRVVGLPGDTISYNDDTLYINGKKTVEPYLAEYLKQFKNDKLQKTYAYNTLFQQLAETSDAFTT
NSEGQTRFEMSVPKGEYLLLGDDRIVSRDSREVGSFKKENLIGEVKARFWPLNKMTVFN

Sequences:

>Translated_219_residues
MLNFTSPTLTKRKRFSLNKRNHMKQFIKEWGPFTLFLILFGLSRLFLWQAVKVDGHSMDPTLAHGERLIVFNQARIDRFD
IVVAQEEENGQKKEIVKRVVGLPGDTISYNDDTLYINGKKTVEPYLAEYLKQFKNDKLQKTYAYNTLFQQLAETSDAFTT
NSEGQTRFEMSVPKGEYLLLGDDRIVSRDSREVGSFKKENLIGEVKARFWPLNKMTVFN
>Mature_219_residues
MLNFTSPTLTKRKRFSLNKRNHMKQFIKEWGPFTLFLILFGLSRLFLWQAVKVDGHSMDPTLAHGERLIVFNQARIDRFD
IVVAQEEENGQKKEIVKRVVGLPGDTISYNDDTLYINGKKTVEPYLAEYLKQFKNDKLQKTYAYNTLFQQLAETSDAFTT
NSEGQTRFEMSVPKGEYLLLGDDRIVSRDSREVGSFKKENLIGEVKARFWPLNKMTVFN

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 25476; Mature: 25476

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNFTSPTLTKRKRFSLNKRNHMKQFIKEWGPFTLFLILFGLSRLFLWQAVKVDGHSMDP
CCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TLAHGERLIVFNQARIDRFDIVVAQEEENGQKKEIVKRVVGLPGDTISYNDDTLYINGKK
HHHCCCEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHCCCCCEEEECCCEEEECCCC
TVEPYLAEYLKQFKNDKLQKTYAYNTLFQQLAETSDAFTTNSEGQTRFEMSVPKGEYLLL
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCEEEE
GDDRIVSRDSREVGSFKKENLIGEVKARFWPLNKMTVFN
CCCCEECCCCHHHHCHHHHHHHHHHHHHEECCCCEEECC
>Mature Secondary Structure
MLNFTSPTLTKRKRFSLNKRNHMKQFIKEWGPFTLFLILFGLSRLFLWQAVKVDGHSMDP
CCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TLAHGERLIVFNQARIDRFDIVVAQEEENGQKKEIVKRVVGLPGDTISYNDDTLYINGKK
HHHCCCEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHCCCCCEEEECCCEEEECCCC
TVEPYLAEYLKQFKNDKLQKTYAYNTLFQQLAETSDAFTTNSEGQTRFEMSVPKGEYLLL
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCEEEE
GDDRIVSRDSREVGSFKKENLIGEVKARFWPLNKMTVFN
CCCCEECCCCHHHHCHHHHHHHHHHHHHEECCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9272867; 11463916 [H]