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The map label for this gene is clcB [H]

Identifier: 94994628

GI number: 94994628

Start: 1176935

End: 1178227

Strand: Direct

Name: clcB [H]

Synonym: MGAS10750_Spy1232

Alternate gene names: 94994628

Gene position: 1176935-1178227 (Clockwise)

Preceding gene: 94994624

Following gene: 94994629

Centisome position: 60.76

GC content: 41.76

Gene sequence:

>1293_bases
TTGTCTTCAGTCTGCGAGACTGATAATCTATCAGTCTCTTTTCTTAACTTTTGTTATAATAGTCTTATGAAACGACACTT
TTTACTCTTGACCTTTTACCTCTTTTTAACAGGTTTAACAGCTGGCCTTGTTGCTTTTATCTTAACAAAAGCCATTCACC
TGATTCAGTCCCTCAGTTTTGGATTCAGTCAAGGTTCTTTTAGCACCATGATTGCTAGTGTTCCACCACAAAGACGAGCT
CTTTCACTCCTCTTTGCTGGACTTCTTGCAGGTCTTGGGTGGCACCTATTGGCTAAAAAAGGAAAGGACATTCAATCTAT
TCAGCAAATCATTCAAGATGACATCTCATTTAGTCCCTGGACACAGTTTTGGCATGGTTGGCTCCAATTAACGACCGTAT
CTATGGGAGCTCCTGTCGGCCGAGAAGGAGCTTCGCGGGAAGTCGCTATTGCCTTGACGTCTCTTTGGAGCCAAAGATGT
AACTTGTCAAAAGCCGATCAAAAACTTTTATTAGCTTGCGCTTCTGGCGCTGCCCTTGGTGCTGTCTACAATGCTCCCTT
AGCCACTATTTTATTTATCTTGGAAGCTATTCTTAACCGTTGGTCCCTTAAAAATATATACGCTGCCTGCCTAACGAGCT
ATGTGGCTGTGGAAACAGTTGCTTTATTACAAGGCCGACATGAGATTCAATACCTAATGCCTCAGCAACATTGGACGCTA
GGAACCCTTATTTGGTCCGTCCTGGCTGGTCTTATCCTTTCCCTCTTTGCTCACGCTTACAAACATCTTCTGGAACACCT
TCCTAAGGCTGATGCCAAAAGTCAGTGGTTTATTCCGAAAGTTCTCATCGCTTTTAGCCTTATCGCAGGACTCAGCAGTT
TCTTCCCAGAGATTTTAGGAAATGGCAAAGCTGGATTACTCTTTTTTCTCCATGAAGAACCACATCTGAGCTATATTAGC
TGGCTACTTGTTGCCAAAGCTGTCGCTATCTCTTTAGTTTTTGCTTCTGGAGCAAAAGGGGGTAAAATTGCTCCTTCTAT
GATGCTTGGAGGTGCTAGTGGCTTACTACTAGCTATCCTTAGTCAGTACCTTATTCCTTTGTCTCTATCAAATACGTTAG
CCATTATGGTTGGTGCAACAATCTTTTTAGGTGTGATCAATAAGATACCCTTGGCGGCACCAGTTTTTCTAGTTGAAATT
ACAGGCCAATCGTTACTAATGATTATCCCTTTAGCATTAGCTAACCTCATTTTTTATTTTAGCTATCAGTTTTATCGTTT
CATCCTTAAATGA

Upstream 100 bases:

>100_bases
GTTTTTCTTTGTGTAACATAGGAGAACCTCACAAGTCCTTTTTCTTATATTATACTCCTAAATATCATAAAAAGCCCCTA
GAAAAGCGATTGTAAGGACT

Downstream 100 bases:

>100_bases
TTAGTTAATTACTTTTTTAATAAAAAGGTTCGGATGAATTGGACTTGGTATAATAAAGTAGACACAAAATTAAGTGGAAA
CGAGGAAAAGTCATTATGCC

Product: chloride channel protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MSSVCETDNLSVSFLNFCYNSLMKRHFLLLTFYLFLTGLTAGLVAFILTKAIHLIQSLSFGFSQGSFSTMIASVPPQRRA
LSLLFAGLLAGLGWHLLAKKGKDIQSIQQIIQDDISFSPWTQFWHGWLQLTTVSMGAPVGREGASREVAIALTSLWSQRC
NLSKADQKLLLACASGAALGAVYNAPLATILFILEAILNRWSLKNIYAACLTSYVAVETVALLQGRHEIQYLMPQQHWTL
GTLIWSVLAGLILSLFAHAYKHLLEHLPKADAKSQWFIPKVLIAFSLIAGLSSFFPEILGNGKAGLLFFLHEEPHLSYIS
WLLVAKAVAISLVFASGAKGGKIAPSMMLGGASGLLLAILSQYLIPLSLSNTLAIMVGATIFLGVINKIPLAAPVFLVEI
TGQSLLMIIPLALANLIFYFSYQFYRFILK

Sequences:

>Translated_430_residues
MSSVCETDNLSVSFLNFCYNSLMKRHFLLLTFYLFLTGLTAGLVAFILTKAIHLIQSLSFGFSQGSFSTMIASVPPQRRA
LSLLFAGLLAGLGWHLLAKKGKDIQSIQQIIQDDISFSPWTQFWHGWLQLTTVSMGAPVGREGASREVAIALTSLWSQRC
NLSKADQKLLLACASGAALGAVYNAPLATILFILEAILNRWSLKNIYAACLTSYVAVETVALLQGRHEIQYLMPQQHWTL
GTLIWSVLAGLILSLFAHAYKHLLEHLPKADAKSQWFIPKVLIAFSLIAGLSSFFPEILGNGKAGLLFFLHEEPHLSYIS
WLLVAKAVAISLVFASGAKGGKIAPSMMLGGASGLLLAILSQYLIPLSLSNTLAIMVGATIFLGVINKIPLAAPVFLVEI
TGQSLLMIIPLALANLIFYFSYQFYRFILK
>Mature_429_residues
SSVCETDNLSVSFLNFCYNSLMKRHFLLLTFYLFLTGLTAGLVAFILTKAIHLIQSLSFGFSQGSFSTMIASVPPQRRAL
SLLFAGLLAGLGWHLLAKKGKDIQSIQQIIQDDISFSPWTQFWHGWLQLTTVSMGAPVGREGASREVAIALTSLWSQRCN
LSKADQKLLLACASGAALGAVYNAPLATILFILEAILNRWSLKNIYAACLTSYVAVETVALLQGRHEIQYLMPQQHWTLG
TLIWSVLAGLILSLFAHAYKHLLEHLPKADAKSQWFIPKVLIAFSLIAGLSSFFPEILGNGKAGLLFFLHEEPHLSYISW
LLVAKAVAISLVFASGAKGGKIAPSMMLGGASGLLLAILSQYLIPLSLSNTLAIMVGATIFLGVINKIPLAAPVFLVEIT
GQSLLMIIPLALANLIFYFSYQFYRFILK

Specific function: Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response [H]

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 46999; Mature: 46868

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHC
>Mature Secondary Structure 
SSVCETDNLSVSFLNFCYNSLMKRHFLLLTFYLFLTGLTAGLVAFILTKAIHLIQSLSF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GFSQGSFSTMIASVPPQRRALSLLFAGLLAGLGWHLLAKKGKDIQSIQQIIQDDISFSPW
CCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHH
TQFWHGWLQLTTVSMGAPVGREGASREVAIALTSLWSQRCNLSKADQKLLLACASGAALG
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHH
AVYNAPLATILFILEAILNRWSLKNIYAACLTSYVAVETVALLQGRHEIQYLMPQQHWTL
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHH
GTLIWSVLAGLILSLFAHAYKHLLEHLPKADAKSQWFIPKVLIAFSLIAGLSSFFPEILG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
NGKAGLLFFLHEEPHLSYISWLLVAKAVAISLVFASGAKGGKIAPSMMLGGASGLLLAIL
CCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHH
SQYLIPLSLSNTLAIMVGATIFLGVINKIPLAAPVFLVEITGQSLLMIIPLALANLIFYF
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHH
SYQFYRFILK
HHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA