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The map label for this gene is ung [H]

Identifier: 94994196

GI number: 94994196

Start: 773434

End: 774087

Strand: Direct

Name: ung [H]

Synonym: MGAS10750_Spy0800

Alternate gene names: 94994196

Gene position: 773434-774087 (Clockwise)

Preceding gene: 94994195

Following gene: 94994197

Centisome position: 39.93

GC content: 42.05

Gene sequence:

>654_bases
ATGACTCATTCAATTTGGCATGAGAAAATCAAATCATTTTTGCCGGAGCATTACTATGGTCGCATCAATCACTTTTTAGA
TGAAGCCTATGCTTCCGGTCTTGTCTACCCCCAACGAGAAAATGTCTTTAAAGCCTTACAAGTGACTCCTTTGGAAGAAA
CCAAAGTGTTGATTTTAGGACAAGACCCTTATCATGGTCCCAAACAGGCCCAGGGCTTATCATTTTCAGTTCCAGAAGAG
ATTTCTGCTCCGCCATCCCTTATTAATATTTTAAAAGAATTAGCAGATGACATTGGTCCTCGTGACCATCATGATTTAAG
CACTTGGGCTAGTCAAGGGGTTCTGCTTTTGAATGCTTGCTTAACAGTGCCAGCAGGCCAGGCTAATGGGCATGCAGGCT
TAATATGGGAGCCATTTACAGACGCTGTTATTAAAGTGCTGAATGAAAAAGACAGCCCTGTAGTTTTCATTTTGTGGGGT
GCTTATGCAAGGAAGAAGAAAGCCTTCATTACTAATTCAAAGCACCACATCATCGAGAGCCCTCATCCAAGCCCTTTGTC
ATCTTATCGTGGCTTTTTTGGCAGCAAACCCTTTTCAAGAACCAACGCTATTTTAGAAAAAGAGGGCATGACTGGCGTAG
ATTGGCTAAAATAA

Upstream 100 bases:

>100_bases
ATATCATATTTTCAGGGTCTTTCTATTTAAAATGTGGTAAACTATATAGAAAAGGACATCGTATTTAACTTAGAAACTGA
CGTGATTAGAAAGGAATCTT

Downstream 100 bases:

>100_bases
GCCAGCCATTTCAACTAAATAGCTTAAGCTAGACATTTTGATACCTTTAATAAGTGAAATGAGCGCAGTAGATTTTTCCT
ATTAAAGAACGTAAGGTCTT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MTHSIWHEKIKSFLPEHYYGRINHFLDEAYASGLVYPQRENVFKALQVTPLEETKVLILGQDPYHGPKQAQGLSFSVPEE
ISAPPSLINILKELADDIGPRDHHDLSTWASQGVLLLNACLTVPAGQANGHAGLIWEPFTDAVIKVLNEKDSPVVFILWG
AYARKKKAFITNSKHHIIESPHPSPLSSYRGFFGSKPFSRTNAILEKEGMTGVDWLK

Sequences:

>Translated_217_residues
MTHSIWHEKIKSFLPEHYYGRINHFLDEAYASGLVYPQRENVFKALQVTPLEETKVLILGQDPYHGPKQAQGLSFSVPEE
ISAPPSLINILKELADDIGPRDHHDLSTWASQGVLLLNACLTVPAGQANGHAGLIWEPFTDAVIKVLNEKDSPVVFILWG
AYARKKKAFITNSKHHIIESPHPSPLSSYRGFFGSKPFSRTNAILEKEGMTGVDWLK
>Mature_216_residues
THSIWHEKIKSFLPEHYYGRINHFLDEAYASGLVYPQRENVFKALQVTPLEETKVLILGQDPYHGPKQAQGLSFSVPEEI
SAPPSLINILKELADDIGPRDHHDLSTWASQGVLLLNACLTVPAGQANGHAGLIWEPFTDAVIKVLNEKDSPVVFILWGA
YARKKKAFITNSKHHIIESPHPSPLSSYRGFFGSKPFSRTNAILEKEGMTGVDWLK

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=213, Percent_Identity=48.8262910798122, Blast_Score=203, Evalue=8e-53,
Organism=Homo sapiens, GI6224979, Length=213, Percent_Identity=48.8262910798122, Blast_Score=203, Evalue=8e-53,
Organism=Escherichia coli, GI1788934, Length=215, Percent_Identity=47.906976744186, Blast_Score=202, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17556304, Length=220, Percent_Identity=41.8181818181818, Blast_Score=176, Evalue=8e-45,
Organism=Saccharomyces cerevisiae, GI6323620, Length=217, Percent_Identity=40.5529953917051, Blast_Score=141, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 24264; Mature: 24133

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHSIWHEKIKSFLPEHYYGRINHFLDEAYASGLVYPQRENVFKALQVTPLEETKVLILG
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCEEEEEE
QDPYHGPKQAQGLSFSVPEEISAPPSLINILKELADDIGPRDHHDLSTWASQGVLLLNAC
CCCCCCCHHCCCCCCCCCHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHEEHHH
LTVPAGQANGHAGLIWEPFTDAVIKVLNEKDSPVVFILWGAYARKKKAFITNSKHHIIES
HHCCCCCCCCCCCEEECHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHCCCCCCCEECC
PHPSPLSSYRGFFGSKPFSRTNAILEKEGMTGVDWLK
CCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
THSIWHEKIKSFLPEHYYGRINHFLDEAYASGLVYPQRENVFKALQVTPLEETKVLILG
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCEEEEEE
QDPYHGPKQAQGLSFSVPEEISAPPSLINILKELADDIGPRDHHDLSTWASQGVLLLNAC
CCCCCCCHHCCCCCCCCCHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHEEHHH
LTVPAGQANGHAGLIWEPFTDAVIKVLNEKDSPVVFILWGAYARKKKAFITNSKHHIIES
HHCCCCCCCCCCCEEECHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHCCCCCCCEECC
PHPSPLSSYRGFFGSKPFSRTNAILEKEGMTGVDWLK
CCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]