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The map label for this gene is mvaK2

Identifier: 94994172

GI number: 94994172

Start: 749297

End: 750352

Strand: Direct

Name: mvaK2

Synonym: MGAS10750_Spy0776

Alternate gene names: NA

Gene position: 749297-750352 (Clockwise)

Preceding gene: 94994171

Following gene: 94994173

Centisome position: 38.68

GC content: 42.9

Gene sequence:

>1056_bases
TTGGCAAGAACTACCGTATTATCGTTTCAAAAACAAAGGATTTACCAGATGTCTAATTATTGTGTGCAAACAGGTGGGAA
ACTATACCTCACAGGCGAATATGCTATCTTAACACCAGGACAAAAAGCCTTAATTCACTTTATTCCACTGATGATGACAG
CAGAAATTAGCCCAGCAGCCCATATTCAATTAGCTTCAGATATGTTTGCCCATAAAGCGGGCATGACACCCGATGCCTCT
TATGCACTGATTCAAGCAACGGTTAAAACCTTTGCTGACTATCTAGGACAGTCGATTGACCAACTGGAGCCATTTTCCCT
AATCATAACAGGAAAAATGGAGCGCGATGGCAAAAAATTTGGCATTGGTTCAAGTGGTAGCGTCACCCTCTTAACCTTAA
AGGCCTTATCGGCCTATTATCAGATCACTTTAACCCCAGAGTTACTCTTTAAACTAGCGGCTTATACCTTGCTTAAGCAA
GGAGATAATGGGTCTATGGGGGATATTGCCTGTATCGCTTACCAGACTTTAGTCGCCTATACCTCCTTTGACCGAGAACA
GGTCAGTAACTGGCTGCAGACCATGCCCTTAAAAAAACTTCTCGTCAAAGATTGGGGTTACCATATCCAAGTCATTCAAC
CAGCCCTGCCTTGTGACTTTTTGGTTGGCTGGACTAAAATACCTGCTATTTCAAGGCAGATGATTCAACAAGTGACAGCG
AGCATTACCCCAGCTTTCTTAAGAACAAGTTACCAGCTAACGCAATCAGCTATGGTAGCTTTGCAAGAAGGTCATAAGGA
AGAACTCAAGAAAAGTTTAGCAGGAGCAAGTCATCTCCTAAAAGAGCTTCATCCAGCTATCTACCATCCTAAGCTAGTAA
CCTTGGTAGCTGCTTGTCAGAAGCAAGATGCTGTTGCTAAATCTTCAGGTTCTGGTGGTGGAGATTGTGGCATCGCGCTT
GCCTTTAATCAGGATGCTAGAGATACCCTTATTTCCAAATGGCAAGAAGCTGATATCGCATTACTTTATCAAGAAAGGTG
GGGAGAGAATGACTAA

Upstream 100 bases:

>100_bases
CTGCGTCAAGAAGGTTTTGCTTGTTATTTTACCATGGACGCAGGTCCAAATGTGAAGGTCCTATGTTTAGAAAAAGACTT
GGCTCAACTGGCAGAACGAC

Downstream 100 bases:

>100_bases
CCGTAAAGATGATCACATCAAATATGCTCTCAAGTACCAATCGCCTTATAATGCTTTTGATGACATAGAACTCATACACC
ATTCCTTACCTAGCTATGAT

Product: phosphomevalonate kinase

Products: ADP; (R)-5-diphosphomevalonate

Alternate protein names: Mevalonate Kinase; Isopentenyl-Diphosphate Delta-Isomerase; GHMP Kinase

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MARTTVLSFQKQRIYQMSNYCVQTGGKLYLTGEYAILTPGQKALIHFIPLMMTAEISPAAHIQLASDMFAHKAGMTPDAS
YALIQATVKTFADYLGQSIDQLEPFSLIITGKMERDGKKFGIGSSGSVTLLTLKALSAYYQITLTPELLFKLAAYTLLKQ
GDNGSMGDIACIAYQTLVAYTSFDREQVSNWLQTMPLKKLLVKDWGYHIQVIQPALPCDFLVGWTKIPAISRQMIQQVTA
SITPAFLRTSYQLTQSAMVALQEGHKEELKKSLAGASHLLKELHPAIYHPKLVTLVAACQKQDAVAKSSGSGGGDCGIAL
AFNQDARDTLISKWQEADIALLYQERWGEND

Sequences:

>Translated_351_residues
MARTTVLSFQKQRIYQMSNYCVQTGGKLYLTGEYAILTPGQKALIHFIPLMMTAEISPAAHIQLASDMFAHKAGMTPDAS
YALIQATVKTFADYLGQSIDQLEPFSLIITGKMERDGKKFGIGSSGSVTLLTLKALSAYYQITLTPELLFKLAAYTLLKQ
GDNGSMGDIACIAYQTLVAYTSFDREQVSNWLQTMPLKKLLVKDWGYHIQVIQPALPCDFLVGWTKIPAISRQMIQQVTA
SITPAFLRTSYQLTQSAMVALQEGHKEELKKSLAGASHLLKELHPAIYHPKLVTLVAACQKQDAVAKSSGSGGGDCGIAL
AFNQDARDTLISKWQEADIALLYQERWGEND
>Mature_350_residues
ARTTVLSFQKQRIYQMSNYCVQTGGKLYLTGEYAILTPGQKALIHFIPLMMTAEISPAAHIQLASDMFAHKAGMTPDASY
ALIQATVKTFADYLGQSIDQLEPFSLIITGKMERDGKKFGIGSSGSVTLLTLKALSAYYQITLTPELLFKLAAYTLLKQG
DNGSMGDIACIAYQTLVAYTSFDREQVSNWLQTMPLKKLLVKDWGYHIQVIQPALPCDFLVGWTKIPAISRQMIQQVTAS
ITPAFLRTSYQLTQSAMVALQEGHKEELKKSLAGASHLLKELHPAIYHPKLVTLVAACQKQDAVAKSSGSGGGDCGIALA
FNQDARDTLISKWQEADIALLYQERWGEND

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.7.4.2

Molecular weight: Translated: 38626; Mature: 38495

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARTTVLSFQKQRIYQMSNYCVQTGGKLYLTGEYAILTPGQKALIHFIPLMMTAEISPAA
CCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEECCCHHHHHHHHHHHHHCCCCCCH
HIQLASDMFAHKAGMTPDASYALIQATVKTFADYLGQSIDQLEPFSLIITGKMERDGKKF
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEEECCCCCCCEE
GIGSSGSVTLLTLKALSAYYQITLTPELLFKLAAYTLLKQGDNGSMGDIACIAYQTLVAY
CCCCCCCEEEEEHHHHHHHEEEEECHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
TSFDREQVSNWLQTMPLKKLLVKDWGYHIQVIQPALPCDFLVGWTKIPAISRQMIQQVTA
HCCCHHHHHHHHHHCCHHHHHHHHCCCEEEEECCCCCHHHHHCCHHCHHHHHHHHHHHHH
SITPAFLRTSYQLTQSAMVALQEGHKEELKKSLAGASHLLKELHPAIYHPKLVTLVAACQ
HCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
KQDAVAKSSGSGGGDCGIALAFNQDARDTLISKWQEADIALLYQERWGEND
HHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCEEEEEHHHCCCCC
>Mature Secondary Structure 
ARTTVLSFQKQRIYQMSNYCVQTGGKLYLTGEYAILTPGQKALIHFIPLMMTAEISPAA
CCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEECCCHHHHHHHHHHHHHCCCCCCH
HIQLASDMFAHKAGMTPDASYALIQATVKTFADYLGQSIDQLEPFSLIITGKMERDGKKF
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEEECCCCCCCEE
GIGSSGSVTLLTLKALSAYYQITLTPELLFKLAAYTLLKQGDNGSMGDIACIAYQTLVAY
CCCCCCCEEEEEHHHHHHHEEEEECHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
TSFDREQVSNWLQTMPLKKLLVKDWGYHIQVIQPALPCDFLVGWTKIPAISRQMIQQVTA
HCCCHHHHHHHHHHCCHHHHHHHHCCCEEEEECCCCCHHHHHCCHHCHHHHHHHHHHHHH
SITPAFLRTSYQLTQSAMVALQEGHKEELKKSLAGASHLLKELHPAIYHPKLVTLVAACQ
HCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
KQDAVAKSSGSGGGDCGIALAFNQDARDTLISKWQEADIALLYQERWGEND
HHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCEEEEEHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; (R)-5-phosphomevalonate

Specific reaction: ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA