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The map label for this gene is pyrP [H]

Identifier: 94994125

GI number: 94994125

Start: 703243

End: 704502

Strand: Direct

Name: pyrP [H]

Synonym: MGAS10750_Spy0729

Alternate gene names: 94994125

Gene position: 703243-704502 (Clockwise)

Preceding gene: 94994124

Following gene: 94994126

Centisome position: 36.3

GC content: 38.97

Gene sequence:

>1260_bases
GTGAAAGATGTCATTTATGATGTGGAAGAAGTGCCAAAGGCAGGTATGTTAGTTGGTTTGTCCTTTCAGCATTTATTTGC
CATGTTTGGGGCGACGGTTCTTGTTCCTATTTTAGTTGGAATTGACCCGTCTGTGGCCCTCCTATCGAGTGGTTTAGGAA
CACTTGCACATTTATCGGTAACCAAATTTAAAATTCCAGCCTACATGGGCTCAAGTTTTGCTTATATAGCAGCTATGCAG
TTACTGATGAAGACAAATGGTATTGGTGCTGTAGCTCAAGGGGCTATGACAGGAGGTCTCGTTTACCTGATTGTAGCTTT
GATTGTTAAAGTTATTGGCAATGATTGGATTGATAAGATTTTACCACCGATTGTAGTTGGTCCGATTGTTATGGTCATTG
GTCTAAGTCTAGCTTCTACAGCTGTTAATGATGTCATGTTAAAAAATGGGAACTATAATCTGACTTATCTTGTTATTGGG
TTAGTCACCTTATTATCAGTTATTTTTTTCAATATTTATGGTAAGGGAATTGTTGCTATTGTACCGCTTTTATTAGGGCT
ATTAGTTGGTTATGTTGTAGCCCTTTTAGTGGGTGTTCTCACCGGTCAAGAAATTGTTGATTTTACCAATGTGGCTCAGG
CCAAATGGTTTAGTATCCCATCAGTGGAAATTCCTTTCTTAACCTACGGGGTTAAATTCTACCCAAGTGCCATTTTAACT
ATGGCACCCATTGCCTTTGTTACAATGACAGAACATTTTGGACACATTATGGTCTTAAATAGTTTGACAAAAAGAGATTA
TTTCAAGGATCCAGGACTTGAAAAGACTTTAACTGGTGATGGTTTTGCGCAAATCATTGCCGGCTTCTTAGGGGCACCTC
CGGTCACTTCTTATGGTGAAAACATCGGTGTAATGGCTCTGAATAAAATATTCTCGGTCTATGTTATTGCAGGTGCCGCA
GTGATTGCCGCTCTCCTCAGTTTTATCGGTAAGGTATCAGCCTTAATTCAATCTATTCCAACACCAGTTATTGGAGGTAT
ATCAGTTGCCTTGTTTGGTGTGATAGCTTCTAGCGGTTTGAAAATCTTGATTGAATCCAAAGTTGATATGGATAATAAGA
AAAACTTATTGATTGCCAGTGTCATTTTGGTCTCTGGGATTGGAGGATTGATGCTTCAAGTAAATGGTCTTCAAATTTCA
GGTGTCGCTTTCTCAACACTTCTTGGCATCATCTTATATCAGGTACTTCCTGAAAAATAG

Upstream 100 bases:

>100_bases
TCCAACAAGCAGTGTAGAAGAAATTGTTGTTGAGGTTGTCGAAGTTGATGGCCGTGATCGTGTTAGCATTATTGACCCAA
CATAAGAAGGAGGTTTTACT

Downstream 100 bases:

>100_bases
GAAGAATTGTTGTTAGACTACTTACATAGTCATCAGTCGTTAGTGATAAAGGGGATAATCATGTCAGTTGTAAATAATCG
CGTTGCACTTACCAATTTAG

Product: uracil permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MKDVIYDVEEVPKAGMLVGLSFQHLFAMFGATVLVPILVGIDPSVALLSSGLGTLAHLSVTKFKIPAYMGSSFAYIAAMQ
LLMKTNGIGAVAQGAMTGGLVYLIVALIVKVIGNDWIDKILPPIVVGPIVMVIGLSLASTAVNDVMLKNGNYNLTYLVIG
LVTLLSVIFFNIYGKGIVAIVPLLLGLLVGYVVALLVGVLTGQEIVDFTNVAQAKWFSIPSVEIPFLTYGVKFYPSAILT
MAPIAFVTMTEHFGHIMVLNSLTKRDYFKDPGLEKTLTGDGFAQIIAGFLGAPPVTSYGENIGVMALNKIFSVYVIAGAA
VIAALLSFIGKVSALIQSIPTPVIGGISVALFGVIASSGLKILIESKVDMDNKKNLLIASVILVSGIGGLMLQVNGLQIS
GVAFSTLLGIILYQVLPEK

Sequences:

>Translated_419_residues
MKDVIYDVEEVPKAGMLVGLSFQHLFAMFGATVLVPILVGIDPSVALLSSGLGTLAHLSVTKFKIPAYMGSSFAYIAAMQ
LLMKTNGIGAVAQGAMTGGLVYLIVALIVKVIGNDWIDKILPPIVVGPIVMVIGLSLASTAVNDVMLKNGNYNLTYLVIG
LVTLLSVIFFNIYGKGIVAIVPLLLGLLVGYVVALLVGVLTGQEIVDFTNVAQAKWFSIPSVEIPFLTYGVKFYPSAILT
MAPIAFVTMTEHFGHIMVLNSLTKRDYFKDPGLEKTLTGDGFAQIIAGFLGAPPVTSYGENIGVMALNKIFSVYVIAGAA
VIAALLSFIGKVSALIQSIPTPVIGGISVALFGVIASSGLKILIESKVDMDNKKNLLIASVILVSGIGGLMLQVNGLQIS
GVAFSTLLGIILYQVLPEK
>Mature_419_residues
MKDVIYDVEEVPKAGMLVGLSFQHLFAMFGATVLVPILVGIDPSVALLSSGLGTLAHLSVTKFKIPAYMGSSFAYIAAMQ
LLMKTNGIGAVAQGAMTGGLVYLIVALIVKVIGNDWIDKILPPIVVGPIVMVIGLSLASTAVNDVMLKNGNYNLTYLVIG
LVTLLSVIFFNIYGKGIVAIVPLLLGLLVGYVVALLVGVLTGQEIVDFTNVAQAKWFSIPSVEIPFLTYGVKFYPSAILT
MAPIAFVTMTEHFGHIMVLNSLTKRDYFKDPGLEKTLTGDGFAQIIAGFLGAPPVTSYGENIGVMALNKIFSVYVIAGAA
VIAALLSFIGKVSALIQSIPTPVIGGISVALFGVIASSGLKILIESKVDMDNKKNLLIASVILVSGIGGLMLQVNGLQIS
GVAFSTLLGIILYQVLPEK

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=437, Percent_Identity=24.4851258581236, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI44680143, Length=444, Percent_Identity=24.7747747747748, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI44680148, Length=442, Percent_Identity=24.4343891402715, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI40316845, Length=442, Percent_Identity=24.4343891402715, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1788843, Length=406, Percent_Identity=42.3645320197044, Blast_Score=315, Evalue=4e-87,
Organism=Escherichia coli, GI87081818, Length=424, Percent_Identity=37.9716981132075, Blast_Score=255, Evalue=3e-69,
Organism=Escherichia coli, GI87082181, Length=399, Percent_Identity=25.31328320802, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI87082178, Length=388, Percent_Identity=26.0309278350515, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790087, Length=460, Percent_Identity=23.4782608695652, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21356175, Length=448, Percent_Identity=24.3303571428571, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 44081; Mature: 44081

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDVIYDVEEVPKAGMLVGLSFQHLFAMFGATVLVPILVGIDPSVALLSSGLGTLAHLSV
CCCCHHCHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHH
TKFKIPAYMGSSFAYIAAMQLLMKTNGIGAVAQGAMTGGLVYLIVALIVKVIGNDWIDKI
HEEECCHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHH
LPPIVVGPIVMVIGLSLASTAVNDVMLKNGNYNLTYLVIGLVTLLSVIFFNIYGKGIVAI
CCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHH
VPLLLGLLVGYVVALLVGVLTGQEIVDFTNVAQAKWFSIPSVEIPFLTYGVKFYPSAILT
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
MAPIAFVTMTEHFGHIMVLNSLTKRDYFKDPGLEKTLTGDGFAQIIAGFLGAPPVTSYGE
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
NIGVMALNKIFSVYVIAGAAVIAALLSFIGKVSALIQSIPTPVIGGISVALFGVIASSGL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
KILIESKVDMDNKKNLLIASVILVSGIGGLMLQVNGLQISGVAFSTLLGIILYQVLPEK
EEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEECCEEECHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKDVIYDVEEVPKAGMLVGLSFQHLFAMFGATVLVPILVGIDPSVALLSSGLGTLAHLSV
CCCCHHCHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHH
TKFKIPAYMGSSFAYIAAMQLLMKTNGIGAVAQGAMTGGLVYLIVALIVKVIGNDWIDKI
HEEECCHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHH
LPPIVVGPIVMVIGLSLASTAVNDVMLKNGNYNLTYLVIGLVTLLSVIFFNIYGKGIVAI
CCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHH
VPLLLGLLVGYVVALLVGVLTGQEIVDFTNVAQAKWFSIPSVEIPFLTYGVKFYPSAILT
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
MAPIAFVTMTEHFGHIMVLNSLTKRDYFKDPGLEKTLTGDGFAQIIAGFLGAPPVTSYGE
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
NIGVMALNKIFSVYVIAGAAVIAALLSFIGKVSALIQSIPTPVIGGISVALFGVIASSGL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
KILIESKVDMDNKKNLLIASVILVSGIGGLMLQVNGLQISGVAFSTLLGIILYQVLPEK
EEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEECCEEECHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8206848 [H]