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The map label for this gene is gor [H]

Identifier: 94994111

GI number: 94994111

Start: 690372

End: 691724

Strand: Direct

Name: gor [H]

Synonym: MGAS10750_Spy0715

Alternate gene names: 94994111

Gene position: 690372-691724 (Clockwise)

Preceding gene: 94994109

Following gene: 94994114

Centisome position: 35.64

GC content: 43.31

Gene sequence:

>1353_bases
ATGGTTATTCCTTATGATTATATTGTTATTGGTGGAGGGAGTGCAGGTATTGCTTCTGCGAACAGGGCAGCCATGCATGG
GGCCAAAGTATTGTTAGCTGAAGGTAAAGAGATTGGGGGAACCTGTGTTAACCTAGGCTGCGTTCCTAAAAAAGTCATGT
GGTATGGCGCTCAAGTAGCAGATATTTTAGGGACTTACGCTAAGGATTATGGATTTGACTTTAAAGACAAAGCATTTGAT
TTTAAACAATTGAAAGCAAATCGTCAAGCTTATATTGATCGGATTCATGCTTCTTATGAGCGAGGCTTTGAGCAGAATGG
TGTTGACCGTATTTATGATTATGCTGTTTTCAAAGATGCTCATACGGTAGAAATTGCAGGGCAGCTTTATACCGCACCGC
ATATTTTGATTGCCACAGGAGGACATCCTGTTTTTCCAGATATTGAGGGGGCACAATACGGTATCAGCTCGGACGGCTTT
TTTGCCTTAGATGAGGTACCAAAACGTACGGCTGTGGTTGGGGCAGGCTATATTGCTGTGGAACTTGCTGGTGTTTTGCA
TGCTTTGGGATCGAAGACGGATTTGTTTATCCGTCACGATCGACCTTTAAGAAGTTTTGACAAAGCCATTGTGGATGTTT
TAGTTGAGGAAATGGCAGTTGGTGGTCCTTGCTTACACCCTCATTCAGAAGTGGCAAAGGTTGTCAAAAATACTGATGAG
TCCTTGACCCTTTACCTCAAAGATGGCCAAGAAGTTGAGGTTGACCAGCTCATTTGGGCTATCGGTCGCAAGCCTAATCT
AGAAGGTTTTGGTCTTGACAAAACTGGAGTGACGTTAAATGATAAAGGTTATATTGAGACAGATGCCTATGAAAACACGT
CTGTCAAAGGGATTTATGCAGTAGGTGATGTCAATGGTAAACTGGCTTTAACTCCAGTTGCTGTGGCAGCTGGACGTCGC
CTATCAGAGCGTCTTTTCAATGGCAAAACAGACGAGAAATTGGACTACCAAAACGTTGCTACTGTGATTTTTAGTCACCC
TGTTATTGGCTCTGTTGGCTTGTCAGAAGAAGCAGCAGTCAAACAGTATGGGCAAGAAGCAGTTAAAACATATCAATCAC
GTTTTACGTCTATGTTTACTGCTATCACTAACCATCGCCAACCTTGTCTGATGAAGTTGGTAACAGTCGGAGATACCGAA
AAAATAGTTGGTCTTCACGGAATCGGATACGGGGTTGACGAAATGATTCAGGGCTTTGCAGTAGCCATCAAAATGGGAGC
AACCAAGGCGGATTTTGATAACACCGTTGCTATTCACCCAACTGGCTCAGAAGAATTTGTCACCATGCGCTAA

Upstream 100 bases:

>100_bases
TTGACCAAAATAGCAGGCCAGTAGTGGCTTTAATGAAGGCAAGTTGTCTGCTAACTGGCTATGCTAAAACATCAGTATTA
GAAAGTAAAAGGTTATAAAA

Downstream 100 bases:

>100_bases
AAAATGTAGCCTAAGGCAATAAAAAATGATGTTAACAGTTTTTGAGGAAAGTCTTCTAAACTGCTAGCATCGTTTTTTGT
TAGGTGATTAGGGGAATATG

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MVIPYDYIVIGGGSAGIASANRAAMHGAKVLLAEGKEIGGTCVNLGCVPKKVMWYGAQVADILGTYAKDYGFDFKDKAFD
FKQLKANRQAYIDRIHASYERGFEQNGVDRIYDYAVFKDAHTVEIAGQLYTAPHILIATGGHPVFPDIEGAQYGISSDGF
FALDEVPKRTAVVGAGYIAVELAGVLHALGSKTDLFIRHDRPLRSFDKAIVDVLVEEMAVGGPCLHPHSEVAKVVKNTDE
SLTLYLKDGQEVEVDQLIWAIGRKPNLEGFGLDKTGVTLNDKGYIETDAYENTSVKGIYAVGDVNGKLALTPVAVAAGRR
LSERLFNGKTDEKLDYQNVATVIFSHPVIGSVGLSEEAAVKQYGQEAVKTYQSRFTSMFTAITNHRQPCLMKLVTVGDTE
KIVGLHGIGYGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR

Sequences:

>Translated_450_residues
MVIPYDYIVIGGGSAGIASANRAAMHGAKVLLAEGKEIGGTCVNLGCVPKKVMWYGAQVADILGTYAKDYGFDFKDKAFD
FKQLKANRQAYIDRIHASYERGFEQNGVDRIYDYAVFKDAHTVEIAGQLYTAPHILIATGGHPVFPDIEGAQYGISSDGF
FALDEVPKRTAVVGAGYIAVELAGVLHALGSKTDLFIRHDRPLRSFDKAIVDVLVEEMAVGGPCLHPHSEVAKVVKNTDE
SLTLYLKDGQEVEVDQLIWAIGRKPNLEGFGLDKTGVTLNDKGYIETDAYENTSVKGIYAVGDVNGKLALTPVAVAAGRR
LSERLFNGKTDEKLDYQNVATVIFSHPVIGSVGLSEEAAVKQYGQEAVKTYQSRFTSMFTAITNHRQPCLMKLVTVGDTE
KIVGLHGIGYGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR
>Mature_450_residues
MVIPYDYIVIGGGSAGIASANRAAMHGAKVLLAEGKEIGGTCVNLGCVPKKVMWYGAQVADILGTYAKDYGFDFKDKAFD
FKQLKANRQAYIDRIHASYERGFEQNGVDRIYDYAVFKDAHTVEIAGQLYTAPHILIATGGHPVFPDIEGAQYGISSDGF
FALDEVPKRTAVVGAGYIAVELAGVLHALGSKTDLFIRHDRPLRSFDKAIVDVLVEEMAVGGPCLHPHSEVAKVVKNTDE
SLTLYLKDGQEVEVDQLIWAIGRKPNLEGFGLDKTGVTLNDKGYIETDAYENTSVKGIYAVGDVNGKLALTPVAVAAGRR
LSERLFNGKTDEKLDYQNVATVIFSHPVIGSVGLSEEAAVKQYGQEAVKTYQSRFTSMFTAITNHRQPCLMKLVTVGDTE
KIVGLHGIGYGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=463, Percent_Identity=52.4838012958963, Blast_Score=461, Evalue=1e-130,
Organism=Homo sapiens, GI22035672, Length=472, Percent_Identity=38.9830508474576, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI148277065, Length=466, Percent_Identity=33.4763948497854, Blast_Score=221, Evalue=7e-58,
Organism=Homo sapiens, GI33519430, Length=466, Percent_Identity=33.4763948497854, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI33519428, Length=466, Percent_Identity=33.4763948497854, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI33519426, Length=466, Percent_Identity=33.4763948497854, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI148277071, Length=466, Percent_Identity=33.4763948497854, Blast_Score=221, Evalue=9e-58,
Organism=Homo sapiens, GI291045266, Length=470, Percent_Identity=31.7021276595745, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI291045268, Length=470, Percent_Identity=28.2978723404255, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI91199540, Length=466, Percent_Identity=29.1845493562232, Blast_Score=152, Evalue=6e-37,
Organism=Escherichia coli, GI1789915, Length=450, Percent_Identity=63.3333333333333, Blast_Score=557, Evalue=1e-160,
Organism=Escherichia coli, GI1786307, Length=449, Percent_Identity=26.5033407572383, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI87082354, Length=463, Percent_Identity=26.133909287257, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI87081717, Length=452, Percent_Identity=24.7787610619469, Blast_Score=104, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71983419, Length=451, Percent_Identity=52.9933481152993, Blast_Score=425, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI71983429, Length=451, Percent_Identity=52.9933481152993, Blast_Score=425, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=35.8050847457627, Blast_Score=282, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI71982272, Length=483, Percent_Identity=31.8840579710145, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI32565766, Length=458, Percent_Identity=29.0393013100437, Blast_Score=153, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6325166, Length=462, Percent_Identity=48.9177489177489, Blast_Score=430, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6321091, Length=463, Percent_Identity=27.4298056155508, Blast_Score=146, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6325240, Length=464, Percent_Identity=25, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24640551, Length=474, Percent_Identity=39.2405063291139, Blast_Score=264, Evalue=9e-71,
Organism=Drosophila melanogaster, GI24640549, Length=474, Percent_Identity=39.2405063291139, Blast_Score=264, Evalue=9e-71,
Organism=Drosophila melanogaster, GI24640553, Length=474, Percent_Identity=39.2405063291139, Blast_Score=264, Evalue=9e-71,
Organism=Drosophila melanogaster, GI17737741, Length=475, Percent_Identity=36.6315789473684, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI21358499, Length=463, Percent_Identity=28.2937365010799, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48758; Mature: 48758

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIPYDYIVIGGGSAGIASANRAAMHGAKVLLAEGKEIGGTCVNLGCVPKKVMWYGAQVA
CCCCEEEEEEECCCCCCCCCCHHHHCCCEEEEECCCCCCCEEEECCCCCHHHHHHCHHHH
DILGTYAKDYGFDFKDKAFDFKQLKANRQAYIDRIHASYERGFEQNGVDRIYDYAVFKDA
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
HTVEIAGQLYTAPHILIATGGHPVFPDIEGAQYGISSDGFFALDEVPKRTAVVGAGYIAV
CEEEEECEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCEEEEECCHHHH
ELAGVLHALGSKTDLFIRHDRPLRSFDKAIVDVLVEEMAVGGPCLHPHSEVAKVVKNTDE
HHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCC
SLTLYLKDGQEVEVDQLIWAIGRKPNLEGFGLDKTGVTLNDKGYIETDAYENTSVKGIYA
EEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCCCEEEEE
VGDVNGKLALTPVAVAAGRRLSERLFNGKTDEKLDYQNVATVIFSHPVIGSVGLSEEAAV
EECCCCEEEECHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHH
KQYGQEAVKTYQSRFTSMFTAITNHRQPCLMKLVTVGDTEKIVGLHGIGYGVDEMIQGFA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHEEEEECCCCCHHHHHHHHE
VAIKMGATKADFDNTVAIHPTGSEEFVTMR
EEEEECCCCCCCCCEEEEECCCCCCEEEEC
>Mature Secondary Structure
MVIPYDYIVIGGGSAGIASANRAAMHGAKVLLAEGKEIGGTCVNLGCVPKKVMWYGAQVA
CCCCEEEEEEECCCCCCCCCCHHHHCCCEEEEECCCCCCCEEEECCCCCHHHHHHCHHHH
DILGTYAKDYGFDFKDKAFDFKQLKANRQAYIDRIHASYERGFEQNGVDRIYDYAVFKDA
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
HTVEIAGQLYTAPHILIATGGHPVFPDIEGAQYGISSDGFFALDEVPKRTAVVGAGYIAV
CEEEEECEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCEEEEECCHHHH
ELAGVLHALGSKTDLFIRHDRPLRSFDKAIVDVLVEEMAVGGPCLHPHSEVAKVVKNTDE
HHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCC
SLTLYLKDGQEVEVDQLIWAIGRKPNLEGFGLDKTGVTLNDKGYIETDAYENTSVKGIYA
EEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCCCEEEEE
VGDVNGKLALTPVAVAAGRRLSERLFNGKTDEKLDYQNVATVIFSHPVIGSVGLSEEAAV
EECCCCEEEECHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHH
KQYGQEAVKTYQSRFTSMFTAITNHRQPCLMKLVTVGDTEKIVGLHGIGYGVDEMIQGFA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHEEEEECCCCCHHHHHHHHE
VAIKMGATKADFDNTVAIHPTGSEEFVTMR
EEEEECCCCCCCCCEEEEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8525054 [H]