Click here to switch to the map view.

The map label for this gene is fumC [H]

Identifier: 94986425

GI number: 94986425

Start: 2447539

End: 2448978

Strand: Reverse

Name: fumC [H]

Synonym: Dgeo_2328

Alternate gene names: 94986425

Gene position: 2448978-2447539 (Counterclockwise)

Preceding gene: 94986430

Following gene: 94986424

Centisome position: 99.26

GC content: 63.96

Gene sequence:

>1440_bases
GTGACCGCGGCGGCCTATTACACTCAGGGTATGACGCAGACCACACAGGGACAGACCCGCACCGAGTCCGACACGATGGG
TCAGGTCCAGGTGCCCGCCGACCGCTACTGGGGCGCGCAGACCGAACGCTCGATCCACAACTTTCCAATTGGCCGCGACA
CCTTTGTCTGGGGCCGCCCGATCATCCGCGCGCTGGGCATCCTGAAAAAGGGTGCGGCGCAGGCGAACGCGGAACTGGGC
GAGCTGCCGCAGGACCTCGCCGACCTGATTGTGCGGGCCGCCGATGAGGTGATTGCTGGGAAGCTGGACGACCACTTCCC
GCTCGTTGTGTTTCAGACCGGCTCAGGTACCCAGAGCAACATGAACGCGAACGAGGTGATCGCCAACCGCGCAATTGAAC
TCGCGGGTGGCGAGCTGGGCAGCAAGAAGCCGGTTCACCCCAACGACCACGTGAACCGCGGTCAGAGCAGCAACGACACC
TTCCCGACCGCCATGCACATCGCCGTCGTGCTGGAACTCAACGAGCGGCTCTACGGCGCGGTGGGCAAGCTACGCGATAC
GCTGGCGCAGAAGGCCGAGCAGTTCAGGGATCTGGTGAAGGTGGGCCGCACCCACCTGCAAGACGCCACACCCATCACGC
TAGGCCAGGAGATCGGCGGCTGGGTGGCGCAGATCGACTACGCGCTCGCTGAGGTCCGGCACGCCGAGCAGGGTCTTTAT
GATCTCGCGATCGGCGGCACGGCGGTGGGCACCGGCCTGAACGCGCACCCGCAGTTTGGTGACCTCGCCGCGCAGAAGTT
CGCTCAGGAAACCGGCTTTCCCTTCCGCTCCGCGGAGAACAAGTTCGCGGCCCTCTCGGCCCACGACGCGTTGGTGCAGA
CCTCAGCGGCGCTGCGGACCCTCGCGGGCGCGCTGATGAAGATGGCGAATGACGTGCGCTGGCTGGCGAGCGGCCCCCGC
AATGGCATCGGTGAGATCACCATTCCCGAGAATGAACCCGGCTCCAGCATCATGCCCGGTAAGGTGAATCCCACCCAGTC
CGAGGCGATGACGATGGTCACCACCCGGGTTTTCGGCAACGACGCGACAGTCGCCTTTGCGGGCACCCAGGGCAACTTCC
AGCTCAACGTCTTCAAGCCGGTGATGGTTCACGCTGTATTGGAAAGCATCCGCCTGATCAGCGACGCCTGCCTCGCCTTC
AATGACAACTGTGCGGTCGGCATTGAGCCGAACGAGGCCCGCATCAAAGAAAACCTCGACAAGAACCTGATGCAGGTCAC
CGCTCTCAACCGCCACATCGGCTACGACAAGGCCGCGGCCATCGCCAAAAAGGCTCATAAGGAGGGCACCAGCCTGAAGG
AGGCTGCCCTTGCGCTGGGCTACGTCACCGAAGACGAGTTCAACCGGTGGGTGGTGCCGCTCGACATGACCCATAGCTAA

Upstream 100 bases:

>100_bases
GGCCATGCGGCCATTGTGACCGCTCCCGGCGGGCCCGGCATCCGCCAGGGTGCGGAGGTGACGCCCAAGCCGCAGCGGCG
AGGCGGGCGTTCCCCAGAAA

Downstream 100 bases:

>100_bases
GCCGGGCCAGTCTGGGGGGCGCCTCCTCGGGCAGGGGGAGCCCCTTTCCTTCCTCCCATGGAGGGCCACGTTGTAGGTTC
TGCCTGCGCTGAGCCGCCTG

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MTAAAYYTQGMTQTTQGQTRTESDTMGQVQVPADRYWGAQTERSIHNFPIGRDTFVWGRPIIRALGILKKGAAQANAELG
ELPQDLADLIVRAADEVIAGKLDDHFPLVVFQTGSGTQSNMNANEVIANRAIELAGGELGSKKPVHPNDHVNRGQSSNDT
FPTAMHIAVVLELNERLYGAVGKLRDTLAQKAEQFRDLVKVGRTHLQDATPITLGQEIGGWVAQIDYALAEVRHAEQGLY
DLAIGGTAVGTGLNAHPQFGDLAAQKFAQETGFPFRSAENKFAALSAHDALVQTSAALRTLAGALMKMANDVRWLASGPR
NGIGEITIPENEPGSSIMPGKVNPTQSEAMTMVTTRVFGNDATVAFAGTQGNFQLNVFKPVMVHAVLESIRLISDACLAF
NDNCAVGIEPNEARIKENLDKNLMQVTALNRHIGYDKAAAIAKKAHKEGTSLKEAALALGYVTEDEFNRWVVPLDMTHS

Sequences:

>Translated_479_residues
MTAAAYYTQGMTQTTQGQTRTESDTMGQVQVPADRYWGAQTERSIHNFPIGRDTFVWGRPIIRALGILKKGAAQANAELG
ELPQDLADLIVRAADEVIAGKLDDHFPLVVFQTGSGTQSNMNANEVIANRAIELAGGELGSKKPVHPNDHVNRGQSSNDT
FPTAMHIAVVLELNERLYGAVGKLRDTLAQKAEQFRDLVKVGRTHLQDATPITLGQEIGGWVAQIDYALAEVRHAEQGLY
DLAIGGTAVGTGLNAHPQFGDLAAQKFAQETGFPFRSAENKFAALSAHDALVQTSAALRTLAGALMKMANDVRWLASGPR
NGIGEITIPENEPGSSIMPGKVNPTQSEAMTMVTTRVFGNDATVAFAGTQGNFQLNVFKPVMVHAVLESIRLISDACLAF
NDNCAVGIEPNEARIKENLDKNLMQVTALNRHIGYDKAAAIAKKAHKEGTSLKEAALALGYVTEDEFNRWVVPLDMTHS
>Mature_478_residues
TAAAYYTQGMTQTTQGQTRTESDTMGQVQVPADRYWGAQTERSIHNFPIGRDTFVWGRPIIRALGILKKGAAQANAELGE
LPQDLADLIVRAADEVIAGKLDDHFPLVVFQTGSGTQSNMNANEVIANRAIELAGGELGSKKPVHPNDHVNRGQSSNDTF
PTAMHIAVVLELNERLYGAVGKLRDTLAQKAEQFRDLVKVGRTHLQDATPITLGQEIGGWVAQIDYALAEVRHAEQGLYD
LAIGGTAVGTGLNAHPQFGDLAAQKFAQETGFPFRSAENKFAALSAHDALVQTSAALRTLAGALMKMANDVRWLASGPRN
GIGEITIPENEPGSSIMPGKVNPTQSEAMTMVTTRVFGNDATVAFAGTQGNFQLNVFKPVMVHAVLESIRLISDACLAFN
DNCAVGIEPNEARIKENLDKNLMQVTALNRHIGYDKAAAIAKKAHKEGTSLKEAALALGYVTEDEFNRWVVPLDMTHS

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=462, Percent_Identity=58.4415584415584, Blast_Score=555, Evalue=1e-158,
Organism=Escherichia coli, GI1787896, Length=461, Percent_Identity=57.7006507592191, Blast_Score=536, Evalue=1e-153,
Organism=Escherichia coli, GI87082375, Length=460, Percent_Identity=40, Blast_Score=336, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI17553882, Length=465, Percent_Identity=58.0645161290323, Blast_Score=550, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI32565146, Length=322, Percent_Identity=55.9006211180124, Blast_Score=374, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6324993, Length=457, Percent_Identity=58.2056892778993, Blast_Score=548, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24640179, Length=458, Percent_Identity=58.296943231441, Blast_Score=555, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24640177, Length=458, Percent_Identity=58.296943231441, Blast_Score=554, Evalue=1e-158,
Organism=Drosophila melanogaster, GI78710009, Length=459, Percent_Identity=55.9912854030501, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24662684, Length=468, Percent_Identity=54.9145299145299, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24583245, Length=460, Percent_Identity=49.3478260869565, Blast_Score=456, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 51636; Mature: 51505

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAAAYYTQGMTQTTQGQTRTESDTMGQVQVPADRYWGAQTERSIHNFPIGRDTFVWGRP
CCCHHHHHCCCCCCCCCCCCCCCCCCCEEECCHHHHCCCCHHCHHHCCCCCCCCEECCHH
IIRALGILKKGAAQANAELGELPQDLADLIVRAADEVIAGKLDDHFPLVVFQTGSGTQSN
HHHHHHHHHHCCHHCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
MNANEVIANRAIELAGGELGSKKPVHPNDHVNRGQSSNDTFPTAMHIAVVLELNERLYGA
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEEEEEEEHHHHHHHH
VGKLRDTLAQKAEQFRDLVKVGRTHLQDATPITLGQEIGGWVAQIDYALAEVRHAEQGLY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHCCCE
DLAIGGTAVGTGLNAHPQFGDLAAQKFAQETGFPFRSAENKFAALSAHDALVQTSAALRT
EEEECCHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHH
LAGALMKMANDVRWLASGPRNGIGEITIPENEPGSSIMPGKVNPTQSEAMTMVTTRVFGN
HHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHEEECC
DATVAFAGTQGNFQLNVFKPVMVHAVLESIRLISDACLAFNDNCAVGIEPNEARIKENLD
CCEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHEECCCEEEECCCCHHHHHHHHH
KNLMQVTALNRHIGYDKAAAIAKKAHKEGTSLKEAALALGYVTEDEFNRWVVPLDMTHS
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHCEEHHCCCCEEEEEECCCC
>Mature Secondary Structure 
TAAAYYTQGMTQTTQGQTRTESDTMGQVQVPADRYWGAQTERSIHNFPIGRDTFVWGRP
CCHHHHHCCCCCCCCCCCCCCCCCCCEEECCHHHHCCCCHHCHHHCCCCCCCCEECCHH
IIRALGILKKGAAQANAELGELPQDLADLIVRAADEVIAGKLDDHFPLVVFQTGSGTQSN
HHHHHHHHHHCCHHCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
MNANEVIANRAIELAGGELGSKKPVHPNDHVNRGQSSNDTFPTAMHIAVVLELNERLYGA
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEEEEEEEHHHHHHHH
VGKLRDTLAQKAEQFRDLVKVGRTHLQDATPITLGQEIGGWVAQIDYALAEVRHAEQGLY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHCCCE
DLAIGGTAVGTGLNAHPQFGDLAAQKFAQETGFPFRSAENKFAALSAHDALVQTSAALRT
EEEECCHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHH
LAGALMKMANDVRWLASGPRNGIGEITIPENEPGSSIMPGKVNPTQSEAMTMVTTRVFGN
HHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHEEECC
DATVAFAGTQGNFQLNVFKPVMVHAVLESIRLISDACLAFNDNCAVGIEPNEARIKENLD
CCEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHEECCCEEEECCCCHHHHHHHHH
KNLMQVTALNRHIGYDKAAAIAKKAHKEGTSLKEAALALGYVTEDEFNRWVVPLDMTHS
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHCEEHHCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]