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The map label for this gene is argH

Identifier: 94986164

GI number: 94986164

Start: 2170661

End: 2172058

Strand: Reverse

Name: argH

Synonym: Dgeo_2065

Alternate gene names: 94986164

Gene position: 2172058-2170661 (Counterclockwise)

Preceding gene: 94986165

Following gene: 94986163

Centisome position: 88.04

GC content: 65.59

Gene sequence:

>1398_bases
ATGACCAACACAACACAAGACAAGAAACTCTGGGGCGGGCGTTTTGCCGAGGCGACCGACGGCCTGGTCGAACTGTTCAA
CGCCTCCGTCGCCTTCGACCAGCGCCTGGCTGAGCAGGACATTCGCGGTTCTCTGGCGCATGTGGCGATGTTGGGGCAGA
CAGGCATCCTGACCCCGGACGAGGTGGCACAGATCGAGGAGGGGCTGCAAGGCATCCTGGCGGACATCCGCGCGGGCAGA
TTTGACTGGCGGCTGGACCGCGAGGACGTGCATATGAACGTCGAGGCCGCGCTGCGCGACCGCATCGGACCGGTGGCCGG
CAAACTGCATACTGCTCGCTCGCGCAACGATCAGGTGGCGGTCGATTTCCGCCTGTTTACCAAAGAGGCAGCGCTCGACC
TCGCCGCCAAGGTGCGGGCCTTGCGGGCTGTCTTGGTGGCGGAGGCCGAAAAGCACTTGCAGGACGAGGTCATTCTGCCT
GGCTACACCCACCTGCAGGTCGCGCAGCCCATCTTGCTGAGTCACTGGTTGATGGCCTACGCGGCGATGCTGGAGCGTGA
CGAGGGCCGGTTCCGCGACGCGGCAGAACGCATGGATGAGTCGCCGCTGGGATCATCGGCGCTCGCCGGCACGCCCTGGC
CGATCGACCGCTTTGCGACCGCCGCCGCCCTGGGCTTTGCGCGGCCCACCGCCAACAGTCTCGATGGGGTGGGCAGCCGG
GATTTTGCACTGGAATTTCTGTCGGCCTGTGCGATTCTCGCCGCGCATCTCTCGCGCCTTTCCGAAGAGCTGATCCTGTA
CTCGACCTTCGAGTTCGGCTTCCTGACCTTGCCGGATTCGCATACCACCGGCTCCTCCATCATGCCGCAGAAGAAAAACC
CCGATGTGGCCGAACTCGCCCGTGGCAAGGCGGGCCGCGTCTTTGGCAACTTAATGGGTCTGCTGACGGTGGTGAAAGGT
ACGCCGCTCGCCTACAACAAGGACCTGCAAGAGGACAAGGAGGGCGTTTTCGACTCCTACGACACCCTCTCCATCGTGCT
CCGGCTCTACGCCGACATGCTGCCCAAGACCGTGTGGCACGCGGACGTGACGAAGCTGGCGGCGGCACGTGGCTTTTCTA
CCGCGACCGATCTTGCGGACTTCCTGGCCCGTTCGGGTGTGCCCTTCCGCGAGGCGCACGAGGTGGTGGGCCGACTGGTG
GGCCTGGCCAGCCGCACCGGGCGGCAGCTCTGGGACCTGACCGACGAGGAGTTGCGCGCGGCTCACCCGCTGCTGAGCGC
CGAAGTGGCCCGCGCCCTCACCGTCGAGGAGAGTGTGAAATCTCGCCGGAGTTACGGGGGCACCGCGCCGGAGCGCGTGC
GTGAACAGGTCGCGGCAGCAAAGGCGGCGCTCTCGTGA

Upstream 100 bases:

>100_bases
CCGCTGGTGCTGGTGAAGGAGGCGGCCCGTTTCCCGTGAGCCGCCGCCAGCGAGAATCCGGAGCCTTCAAAGCTGGCAAC
AGGTTGAGCCAAAGGACGAC

Downstream 100 bases:

>100_bases
AGGTGACCGTGCATCTGGACGGCACCCTGTTGAAGAAGCGCGAGGAGGAAGGGGCGTACTGGCTGGCTCATCCGGACAAG
AACCCGCTCGCGATCCGCGC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MTNTTQDKKLWGGRFAEATDGLVELFNASVAFDQRLAEQDIRGSLAHVAMLGQTGILTPDEVAQIEEGLQGILADIRAGR
FDWRLDREDVHMNVEAALRDRIGPVAGKLHTARSRNDQVAVDFRLFTKEAALDLAAKVRALRAVLVAEAEKHLQDEVILP
GYTHLQVAQPILLSHWLMAYAAMLERDEGRFRDAAERMDESPLGSSALAGTPWPIDRFATAAALGFARPTANSLDGVGSR
DFALEFLSACAILAAHLSRLSEELILYSTFEFGFLTLPDSHTTGSSIMPQKKNPDVAELARGKAGRVFGNLMGLLTVVKG
TPLAYNKDLQEDKEGVFDSYDTLSIVLRLYADMLPKTVWHADVTKLAAARGFSTATDLADFLARSGVPFREAHEVVGRLV
GLASRTGRQLWDLTDEELRAAHPLLSAEVARALTVEESVKSRRSYGGTAPERVREQVAAAKAALS

Sequences:

>Translated_465_residues
MTNTTQDKKLWGGRFAEATDGLVELFNASVAFDQRLAEQDIRGSLAHVAMLGQTGILTPDEVAQIEEGLQGILADIRAGR
FDWRLDREDVHMNVEAALRDRIGPVAGKLHTARSRNDQVAVDFRLFTKEAALDLAAKVRALRAVLVAEAEKHLQDEVILP
GYTHLQVAQPILLSHWLMAYAAMLERDEGRFRDAAERMDESPLGSSALAGTPWPIDRFATAAALGFARPTANSLDGVGSR
DFALEFLSACAILAAHLSRLSEELILYSTFEFGFLTLPDSHTTGSSIMPQKKNPDVAELARGKAGRVFGNLMGLLTVVKG
TPLAYNKDLQEDKEGVFDSYDTLSIVLRLYADMLPKTVWHADVTKLAAARGFSTATDLADFLARSGVPFREAHEVVGRLV
GLASRTGRQLWDLTDEELRAAHPLLSAEVARALTVEESVKSRRSYGGTAPERVREQVAAAKAALS
>Mature_464_residues
TNTTQDKKLWGGRFAEATDGLVELFNASVAFDQRLAEQDIRGSLAHVAMLGQTGILTPDEVAQIEEGLQGILADIRAGRF
DWRLDREDVHMNVEAALRDRIGPVAGKLHTARSRNDQVAVDFRLFTKEAALDLAAKVRALRAVLVAEAEKHLQDEVILPG
YTHLQVAQPILLSHWLMAYAAMLERDEGRFRDAAERMDESPLGSSALAGTPWPIDRFATAAALGFARPTANSLDGVGSRD
FALEFLSACAILAAHLSRLSEELILYSTFEFGFLTLPDSHTTGSSIMPQKKNPDVAELARGKAGRVFGNLMGLLTVVKGT
PLAYNKDLQEDKEGVFDSYDTLSIVLRLYADMLPKTVWHADVTKLAAARGFSTATDLADFLARSGVPFREAHEVVGRLVG
LASRTGRQLWDLTDEELRAAHPLLSAEVARALTVEESVKSRRSYGGTAPERVREQVAAAKAALS

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=462, Percent_Identity=44.3722943722944, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI68303542, Length=462, Percent_Identity=44.3722943722944, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI68303549, Length=462, Percent_Identity=42.4242424242424, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI68303547, Length=462, Percent_Identity=41.7748917748918, Blast_Score=332, Evalue=6e-91,
Organism=Escherichia coli, GI1790398, Length=456, Percent_Identity=48.2456140350877, Blast_Score=406, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6321806, Length=469, Percent_Identity=42.2174840085288, Blast_Score=350, Evalue=2e-97,
Organism=Drosophila melanogaster, GI221473854, Length=455, Percent_Identity=39.3406593406593, Blast_Score=325, Evalue=5e-89,
Organism=Drosophila melanogaster, GI78706858, Length=455, Percent_Identity=39.3406593406593, Blast_Score=325, Evalue=5e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_DEIGD (Q1IWM5)

Other databases:

- EMBL:   CP000359
- RefSeq:   YP_605528.1
- ProteinModelPortal:   Q1IWM5
- SMR:   Q1IWM5
- STRING:   Q1IWM5
- GeneID:   4058162
- GenomeReviews:   CP000359_GR
- KEGG:   dge:Dgeo_2065
- NMPDR:   fig|68909.1.peg.2250
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   EDIHTVI
- PhylomeDB:   Q1IWM5
- ProtClustDB:   PRK00855
- BioCyc:   DGEO319795:DGEO_2065-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 50730; Mature: 50599

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNTTQDKKLWGGRFAEATDGLVELFNASVAFDQRLAEQDIRGSLAHVAMLGQTGILTPD
CCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
EVAQIEEGLQGILADIRAGRFDWRLDREDVHMNVEAALRDRIGPVAGKLHTARSRNDQVA
HHHHHHHHHHHHHHHHHCCCCCEEECHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCEE
VDFRLFTKEAALDLAAKVRALRAVLVAEAEKHLQDEVILPGYTHLQVAQPILLSHWLMAY
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
AAMLERDEGRFRDAAERMDESPLGSSALAGTPWPIDRFATAAALGFARPTANSLDGVGSR
HHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCH
DFALEFLSACAILAAHLSRLSEELILYSTFEFGFLTLPDSHTTGSSIMPQKKNPDVAELA
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEECCCCCCCCCCCCCCCCCCCHHHHH
RGKAGRVFGNLMGLLTVVKGTPLAYNKDLQEDKEGVFDSYDTLSIVLRLYADMLPKTVWH
CCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
ADVTKLAAARGFSTATDLADFLARSGVPFREAHEVVGRLVGLASRTGRQLWDLTDEELRA
HHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHH
AHPLLSAEVARALTVEESVKSRRSYGGTAPERVREQVAAAKAALS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TNTTQDKKLWGGRFAEATDGLVELFNASVAFDQRLAEQDIRGSLAHVAMLGQTGILTPD
CCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
EVAQIEEGLQGILADIRAGRFDWRLDREDVHMNVEAALRDRIGPVAGKLHTARSRNDQVA
HHHHHHHHHHHHHHHHHCCCCCEEECHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCEE
VDFRLFTKEAALDLAAKVRALRAVLVAEAEKHLQDEVILPGYTHLQVAQPILLSHWLMAY
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
AAMLERDEGRFRDAAERMDESPLGSSALAGTPWPIDRFATAAALGFARPTANSLDGVGSR
HHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCH
DFALEFLSACAILAAHLSRLSEELILYSTFEFGFLTLPDSHTTGSSIMPQKKNPDVAELA
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEECCCCCCCCCCCCCCCCCCCHHHHH
RGKAGRVFGNLMGLLTVVKGTPLAYNKDLQEDKEGVFDSYDTLSIVLRLYADMLPKTVWH
CCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
ADVTKLAAARGFSTATDLADFLARSGVPFREAHEVVGRLVGLASRTGRQLWDLTDEELRA
HHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHH
AHPLLSAEVARALTVEESVKSRRSYGGTAPERVREQVAAAKAALS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA