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The map label for this gene is iscS [H]

Identifier: 94986051

GI number: 94986051

Start: 2057028

End: 2058182

Strand: Reverse

Name: iscS [H]

Synonym: Dgeo_1952

Alternate gene names: 94986051

Gene position: 2058182-2057028 (Counterclockwise)

Preceding gene: 94986052

Following gene: 94986047

Centisome position: 83.42

GC content: 69.7

Gene sequence:

>1155_bases
ATGATCTACCTCGACTACGCTGCCACCCATCCCATGACGTCCGAGGCACTGGCCGCCTACCTGGAGGCCGCCGCGCTGCC
CGGCAACCCAGCCAGTGTGCACACGGCGGGACAGGCTGCCCGTGAGCGGCTGGAGGAAGGCCGCGCCCGTGTTGCCGCCG
CGCTGAGGGTGGACGCCCGGACCCTGATTGCCAACGGCGGCGGTACCGAGGGAAACAACCATGTGCTGCTGGGGATGGCG
CAGGCCTGGACAGAGGCCCATGGGCGGCCCGGCCACCTCGTCACCACCCTGACCGAACATTCGGCGGTGCTTGCCCCCGC
GCGCTGGCTTGCCGGGCAGGGCTGGAACGTAAGCTGGCTGACGCCTGACGCTCAGGGGCGCTACCATCCGGCGCAACTTG
CGGAGGTGCTGCGGGACGACACCGCCCTTGTCTCCATTCACCACGCGAACAATGAACTCGGCACCGTACAGGACACGCCC
GCGCTGGCTGCCGTTGCCGCTGCACGCGGGATTCCGTACCACACCGATGCCGTGCAGGCTCCCGGCGTGCTGCCCCTCGA
CCTAGGAGCGTGGGGCGTCACCTTTGCCACCTTCAGCGCCCACAAGTGGGGTGGGCCGCGCGGGGTGGGCTTCCTGTATG
TGAAACGTGGAACGGTCTTGCCCCCTGTCACGTTGGGTGGCGGGCAGGAAGGTGGCCTGCGTCCCGGTACCCAGAACACG
GCGGGCGTGTATGCGGCGGGCGTGGCGTTGACGCATGCTGAGGCGGTGCGGACCCAGACTTTTGCCCACCTCACCCGCCT
GCGCGAACGCTTCCTGCAGGAGATCGCGGACATCCCCGGCCTGCGCGTCAACCATCCGCCGGACGCCAGCCCCAAGGTGG
CCTCCGTCACCGTACCAAGGGCAGACGGTGAGGCGCTGCTGATGAATCTGGACCTGCTGGGTGTCTCGGCCAGCGCAGGG
AGCGCCTGCGCCGCTGGGACGATGCAGCCCAGCCATGTCTTGACAGCCATCGGCCTGAGCGAGGCCGACGCCCGTGCGAC
CCTGCGTTTCAGTTTTGGGCGGGCGACGACAGCAGCCGAGGTGGATGCGGCGGCGCAGGCGCTCCGGCAAGCCGCGGCGT
GGAGCCGAGGCTGGCGGCTGGACGGGCTGGCCTGA

Upstream 100 bases:

>100_bases
GGTGGTGCGGGGCGATGCCACTTTCATCATCCGGCGGAACGGGGAGGAGTACGCGACCGTTAAGCCTTAGGGGTGCCTGG
GGCCTCCTCCCTTCCTGATC

Downstream 100 bases:

>100_bases
CCCGCCGTACCAGCAGGCCACGGCGGGTCAGGTGATCCGAAATTCCCGCTAGTTGCGCGGGCGCGCCCTCAGAACTGCGC
CAGCACCGCCTCCAGCCGTT

Product: aminotransferase, class V

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MIYLDYAATHPMTSEALAAYLEAAALPGNPASVHTAGQAARERLEEGRARVAAALRVDARTLIANGGGTEGNNHVLLGMA
QAWTEAHGRPGHLVTTLTEHSAVLAPARWLAGQGWNVSWLTPDAQGRYHPAQLAEVLRDDTALVSIHHANNELGTVQDTP
ALAAVAAARGIPYHTDAVQAPGVLPLDLGAWGVTFATFSAHKWGGPRGVGFLYVKRGTVLPPVTLGGGQEGGLRPGTQNT
AGVYAAGVALTHAEAVRTQTFAHLTRLRERFLQEIADIPGLRVNHPPDASPKVASVTVPRADGEALLMNLDLLGVSASAG
SACAAGTMQPSHVLTAIGLSEADARATLRFSFGRATTAAEVDAAAQALRQAAAWSRGWRLDGLA

Sequences:

>Translated_384_residues
MIYLDYAATHPMTSEALAAYLEAAALPGNPASVHTAGQAARERLEEGRARVAAALRVDARTLIANGGGTEGNNHVLLGMA
QAWTEAHGRPGHLVTTLTEHSAVLAPARWLAGQGWNVSWLTPDAQGRYHPAQLAEVLRDDTALVSIHHANNELGTVQDTP
ALAAVAAARGIPYHTDAVQAPGVLPLDLGAWGVTFATFSAHKWGGPRGVGFLYVKRGTVLPPVTLGGGQEGGLRPGTQNT
AGVYAAGVALTHAEAVRTQTFAHLTRLRERFLQEIADIPGLRVNHPPDASPKVASVTVPRADGEALLMNLDLLGVSASAG
SACAAGTMQPSHVLTAIGLSEADARATLRFSFGRATTAAEVDAAAQALRQAAAWSRGWRLDGLA
>Mature_384_residues
MIYLDYAATHPMTSEALAAYLEAAALPGNPASVHTAGQAARERLEEGRARVAAALRVDARTLIANGGGTEGNNHVLLGMA
QAWTEAHGRPGHLVTTLTEHSAVLAPARWLAGQGWNVSWLTPDAQGRYHPAQLAEVLRDDTALVSIHHANNELGTVQDTP
ALAAVAAARGIPYHTDAVQAPGVLPLDLGAWGVTFATFSAHKWGGPRGVGFLYVKRGTVLPPVTLGGGQEGGLRPGTQNT
AGVYAAGVALTHAEAVRTQTFAHLTRLRERFLQEIADIPGLRVNHPPDASPKVASVTVPRADGEALLMNLDLLGVSASAG
SACAAGTMQPSHVLTAIGLSEADARATLRFSFGRATTAAEVDAAAQALRQAAAWSRGWRLDGLA

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=375, Percent_Identity=34.6666666666667, Blast_Score=211, Evalue=8e-55,
Organism=Homo sapiens, GI156713448, Length=415, Percent_Identity=32.7710843373494, Blast_Score=151, Evalue=9e-37,
Organism=Escherichia coli, GI48994898, Length=380, Percent_Identity=37.1052631578947, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1787970, Length=399, Percent_Identity=27.8195488721804, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1789175, Length=396, Percent_Identity=27.7777777777778, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25143064, Length=369, Percent_Identity=36.3143631436314, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17533177, Length=338, Percent_Identity=29.8816568047337, Blast_Score=127, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6319831, Length=380, Percent_Identity=34.4736842105263, Blast_Score=217, Evalue=2e-57,
Organism=Drosophila melanogaster, GI20129463, Length=372, Percent_Identity=36.0215053763441, Blast_Score=198, Evalue=5e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 39968; Mature: 39968

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYLDYAATHPMTSEALAAYLEAAALPGNPASVHTAGQAARERLEEGRARVAAALRVDAR
CEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHEECCE
TLIANGGGTEGNNHVLLGMAQAWTEAHGRPGHLVTTLTEHSAVLAPARWLAGQGWNVSWL
EEEECCCCCCCCCEEEEEEHHHHHHHCCCCCCEEEEEECCCHHCCHHHHHCCCCCEEEEE
TPDAQGRYHPAQLAEVLRDDTALVSIHHANNELGTVQDTPALAAVAAARGIPYHTDAVQA
CCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
PGVLPLDLGAWGVTFATFSAHKWGGPRGVGFLYVKRGTVLPPVTLGGGQEGGLRPGTQNT
CCCEEEECCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCEEECCCCCCCCCCCCCCC
AGVYAAGVALTHAEAVRTQTFAHLTRLRERFLQEIADIPGLRVNHPPDASPKVASVTVPR
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECC
ADGEALLMNLDLLGVSASAGSACAAGTMQPSHVLTAIGLSEADARATLRFSFGRATTAAE
CCCCEEEEEEEEEEEECCCCCCCCCCCCCHHHHEEEECCCCCCCEEEEEEECCCCCCHHH
VDAAAQALRQAAAWSRGWRLDGLA
HHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MIYLDYAATHPMTSEALAAYLEAAALPGNPASVHTAGQAARERLEEGRARVAAALRVDAR
CEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHEECCE
TLIANGGGTEGNNHVLLGMAQAWTEAHGRPGHLVTTLTEHSAVLAPARWLAGQGWNVSWL
EEEECCCCCCCCCEEEEEEHHHHHHHCCCCCCEEEEEECCCHHCCHHHHHCCCCCEEEEE
TPDAQGRYHPAQLAEVLRDDTALVSIHHANNELGTVQDTPALAAVAAARGIPYHTDAVQA
CCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
PGVLPLDLGAWGVTFATFSAHKWGGPRGVGFLYVKRGTVLPPVTLGGGQEGGLRPGTQNT
CCCEEEECCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCEEECCCCCCCCCCCCCCC
AGVYAAGVALTHAEAVRTQTFAHLTRLRERFLQEIADIPGLRVNHPPDASPKVASVTVPR
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECC
ADGEALLMNLDLLGVSASAGSACAAGTMQPSHVLTAIGLSEADARATLRFSFGRATTAAE
CCCCEEEEEEEEEEEECCCCCCCCCCCCCHHHHEEEECCCCCCCEEEEEEECCCCCCHHH
VDAAAQALRQAAAWSRGWRLDGLA
HHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA