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The map label for this gene is adk

Identifier: 94985946

GI number: 94985946

Start: 1954347

End: 1954940

Strand: Reverse

Name: adk

Synonym: Dgeo_1846

Alternate gene names: 94985946

Gene position: 1954940-1954347 (Counterclockwise)

Preceding gene: 94985947

Following gene: 94985945

Centisome position: 79.24

GC content: 62.29

Gene sequence:

>594_bases
ATGACACAATCCAAAAACAAGGTCGTGATTTTCCTCGGCCCGCCCGGTGCGGGCAAGGGCACCCAGGCCGAGCGCCTGGC
CCGTGAGCAGAATCTGGCCAAAATCAGTACCGGGGATATCCTGCGTGACCATGTAGCACGGGGCACCGCACTTGGCCAGC
GGGTCAAACCTATCCTCGATGCCGGACAGCTCGTTCCCGATGACATCTTGATTGCTTTGATCCGTGACCGCCTGGCAGGA
ATGGAACCGGTACGCGTGATTTTTGACGGCTTCCCGCGCACCTGCGCGCAGGCGGAGGCGCTCGATATGCTGCTGGAAGA
ATTGGGCGCGCCGGTGAGTGCGGTGCCACTGCTCGAGGTGCCTGATGAGACGCTCATCGAGCGCATCGTGGAGCGCGGGC
GACAAGCTGCTCTTCGGGGCGAGCCGGTTCGCAGCGATGACACCGAAGAGGTAGCGCGGCGGCGCCAGCAGGTCTATCGC
GAGCAGACCCAGCCATTGATCGACTACTATGCGGCACGCGGCCATCTTCAGCACGTCAATGGTGTGGGAACGCCGGATGA
GGTCTACAACCGCATCCTGCAAGTCGTGCGCTAG

Upstream 100 bases:

>100_bases
ATCTGCTGCCGGTTCCGTCACCATAGAGGGAACAGGGCTGGGCAGCAGCGCGTTGGTGTTGCTGCTGGGCCTCTATGCTG
TAGAGCCTAGAGGAGGAACG

Downstream 100 bases:

>100_bases
TTGGCTGCGGGCGGAGCAGCGCACCTTCCGGAGGAAACACCGGCAATTTCCACCCCCTGTTCGCCGTCCCTCTTGCTGAT
TGGGATGAGGTCATGCTAGC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MTQSKNKVVIFLGPPGAGKGTQAERLAREQNLAKISTGDILRDHVARGTALGQRVKPILDAGQLVPDDILIALIRDRLAG
MEPVRVIFDGFPRTCAQAEALDMLLEELGAPVSAVPLLEVPDETLIERIVERGRQAALRGEPVRSDDTEEVARRRQQVYR
EQTQPLIDYYAARGHLQHVNGVGTPDEVYNRILQVVR

Sequences:

>Translated_197_residues
MTQSKNKVVIFLGPPGAGKGTQAERLAREQNLAKISTGDILRDHVARGTALGQRVKPILDAGQLVPDDILIALIRDRLAG
MEPVRVIFDGFPRTCAQAEALDMLLEELGAPVSAVPLLEVPDETLIERIVERGRQAALRGEPVRSDDTEEVARRRQQVYR
EQTQPLIDYYAARGHLQHVNGVGTPDEVYNRILQVVR
>Mature_196_residues
TQSKNKVVIFLGPPGAGKGTQAERLAREQNLAKISTGDILRDHVARGTALGQRVKPILDAGQLVPDDILIALIRDRLAGM
EPVRVIFDGFPRTCAQAEALDMLLEELGAPVSAVPLLEVPDETLIERIVERGRQAALRGEPVRSDDTEEVARRRQQVYRE
QTQPLIDYYAARGHLQHVNGVGTPDEVYNRILQVVR

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=206, Percent_Identity=40.7766990291262, Blast_Score=137, Evalue=5e-33,
Organism=Homo sapiens, GI7524346, Length=206, Percent_Identity=40.7766990291262, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI4502011, Length=190, Percent_Identity=31.5789473684211, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI19923437, Length=196, Percent_Identity=34.1836734693878, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI7706497, Length=195, Percent_Identity=30.7692307692308, Blast_Score=107, Evalue=5e-24,
Organism=Homo sapiens, GI310110345, Length=196, Percent_Identity=33.6734693877551, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI53832003, Length=196, Percent_Identity=33.6734693877551, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI8051579, Length=196, Percent_Identity=33.6734693877551, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI53832001, Length=196, Percent_Identity=33.6734693877551, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI28144899, Length=194, Percent_Identity=29.3814432989691, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI28144897, Length=194, Percent_Identity=29.3814432989691, Blast_Score=100, Evalue=8e-22,
Organism=Homo sapiens, GI22749187, Length=126, Percent_Identity=32.5396825396825, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1786680, Length=186, Percent_Identity=40.8602150537634, Blast_Score=123, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17552384, Length=209, Percent_Identity=38.755980861244, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17567503, Length=185, Percent_Identity=29.1891891891892, Blast_Score=109, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17537943, Length=213, Percent_Identity=34.2723004694836, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17533833, Length=193, Percent_Identity=29.5336787564767, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17550688, Length=193, Percent_Identity=29.0155440414508, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25147457, Length=194, Percent_Identity=24.2268041237113, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320432, Length=217, Percent_Identity=37.7880184331797, Blast_Score=139, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6321018, Length=195, Percent_Identity=38.4615384615385, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322828, Length=194, Percent_Identity=29.8969072164948, Blast_Score=108, Evalue=7e-25,
Organism=Drosophila melanogaster, GI22026816, Length=210, Percent_Identity=36.6666666666667, Blast_Score=130, Evalue=7e-31,
Organism=Drosophila melanogaster, GI17737899, Length=198, Percent_Identity=32.3232323232323, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24645822, Length=198, Percent_Identity=32.3232323232323, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI221459597, Length=197, Percent_Identity=24.3654822335025, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21356893, Length=197, Percent_Identity=24.3654822335025, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17647141, Length=191, Percent_Identity=26.1780104712042, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24663208, Length=191, Percent_Identity=26.1780104712042, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_DEIGD (Q1IX93)

Other databases:

- EMBL:   CP000359
- RefSeq:   YP_605310.1
- ProteinModelPortal:   Q1IX93
- SMR:   Q1IX93
- STRING:   Q1IX93
- GeneID:   4057576
- GenomeReviews:   CP000359_GR
- KEGG:   dge:Dgeo_1846
- NMPDR:   fig|68909.1.peg.211
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   MVLIGPP
- ProtClustDB:   PRK14527
- BioCyc:   DGEO319795:DGEO_1846-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 21801; Mature: 21670

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSKNKVVIFLGPPGAGKGTQAERLAREQNLAKISTGDILRDHVARGTALGQRVKPILD
CCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
AGQLVPDDILIALIRDRLAGMEPVRVIFDGFPRTCAQAEALDMLLEELGAPVSAVPLLEV
CCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PDETLIERIVERGRQAALRGEPVRSDDTEEVARRRQQVYREQTQPLIDYYAARGHLQHVN
CCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCC
GVGTPDEVYNRILQVVR
CCCCHHHHHHHHHHHHC
>Mature Secondary Structure 
TQSKNKVVIFLGPPGAGKGTQAERLAREQNLAKISTGDILRDHVARGTALGQRVKPILD
CCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
AGQLVPDDILIALIRDRLAGMEPVRVIFDGFPRTCAQAEALDMLLEELGAPVSAVPLLEV
CCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PDETLIERIVERGRQAALRGEPVRSDDTEEVARRRQQVYREQTQPLIDYYAARGHLQHVN
CCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCC
GVGTPDEVYNRILQVVR
CCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA