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The map label for this gene is purD [H]

Identifier: 94985447

GI number: 94985447

Start: 1435158

End: 1436411

Strand: Reverse

Name: purD [H]

Synonym: Dgeo_1347

Alternate gene names: 94985447

Gene position: 1436411-1435158 (Counterclockwise)

Preceding gene: 94985448

Following gene: 94985446

Centisome position: 58.22

GC content: 69.22

Gene sequence:

>1254_bases
ATGAGGGTGTTGGTCGTGGGCGGCGGGGGCCGCGAACATGCCCTTGTGGATGCCTGTGGGCGCGCGGGCCATGAGGTGCT
GTGCACGCCCGGCAATCCTGGGATCGCGCAGCAGGCGCGGGTTGTGGCCAGTGCCCAGGACGCCGCTTCGCTGGCTGACC
TCGCAGTGCGCGAAGGGGTGGATGTGGTGATTGTTGGCCCCGAGGCCTATCTCGCTGCTGGGTTGGTGGATGCCTGCCGC
GAGCGGGGGGTGCCCGCCTTCGGCCCCACCCGCGCCGCCGCCCGACTGGAGGGTGACAAGGCGTGGAGCAAGGCCTTTAT
GGGGCGGCACGGCATCCCCACTGCGGCCCACCGCAGCTTCGCTGACCTGGAGGAGGCGCTGACCTACGCCAGGGTGCAGC
CGTTGCCGCTGGTTGTGAAGGATGCGGGGCTGCGTGCCGGGAAGGGTGTGACCATCGCCCGGACCCACGCCGAGGCAGAA
GCTGCCCTGCGGGACATCTTCGCTCAAGAGGGGGCACAAGCCGTCCTGGAAGAGTTCATGACCGGCCAGGAGGTCACGGT
CCTGGCGCTGACGGATGGCGAACGCTATGCCCTGACCCCGCCCAGCCAGGACCACAAGACCATCTTTGAGGGCGATACCG
GCCCGATGACGGGGGGGATGGGCGTGATCTGTCCCTTTCCCTTGACAGCGACGGACCTGGAACGCATCCGCGCCGAGATC
ATCGAACCGGCCCTGGCGGGGATGCGGGCCGAGGGTCATCCCTTTACGGGTGTGCTGTACGCGGGCCTGATGCTCACGCC
GGCTGGCCCCCGAGTGGTGGAGTTCAACGCCCGCTTTGGTGATCCCGAGGCGGAGGCGGTGCTGCCGCTGCTGAGTTCTG
ACCTCGCTCAGCACGCGCTGGACGCGGCCCTGGGTCACCTCGACCCGGCAACCGTTCACTTCCGCGACGGCGCCAGCGCG
GTGGTGGTCTTGGCTGCACCCGGCTATCCCGGTGAAGCGCAAAAGGGGATTCCCCTGCGCCTCCCTCCGCTGGGAAGTGG
CGAGGTGATCTATCACGCCGGAACCGCTGAACAAGAGGGCCAGTTGGTCGCGAGTGGAGGCCGCGTGCTGGCTGTGACCG
CCACCGCACCCACCCTGAATGCCGCCCTGGGCCGCGCTTATGCGCTGGCGGACCGTGTGGACTTCCCCGGCGCGCAGCTG
CGCCGTGACCTGGGGGCGCGGATTGGTGCGCGGCCAGACCCCCGCCAGGTTTGA

Upstream 100 bases:

>100_bases
GCTACGAGTTTGCCTGCCCGCCCTGGATGAGCGTGCAGGGCTTGGTGCGCTATTGGCAACGAGCAGCGGCCCGAAGCGGC
GCGCAGCCGGAGCGGCGCGG

Downstream 100 bases:

>100_bases
GACAGGCGCGTTTGACCCCAGACCCCCAGACGCGCTAGGATCCGCGTGCCCGGGTTCGGGGACACCGGCCGGTGTGGCGG
AATTGGTAGACGCACTCGAC

Product: phosphoribosylamine--glycine ligase

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MRVLVVGGGGREHALVDACGRAGHEVLCTPGNPGIAQQARVVASAQDAASLADLAVREGVDVVIVGPEAYLAAGLVDACR
ERGVPAFGPTRAAARLEGDKAWSKAFMGRHGIPTAAHRSFADLEEALTYARVQPLPLVVKDAGLRAGKGVTIARTHAEAE
AALRDIFAQEGAQAVLEEFMTGQEVTVLALTDGERYALTPPSQDHKTIFEGDTGPMTGGMGVICPFPLTATDLERIRAEI
IEPALAGMRAEGHPFTGVLYAGLMLTPAGPRVVEFNARFGDPEAEAVLPLLSSDLAQHALDAALGHLDPATVHFRDGASA
VVVLAAPGYPGEAQKGIPLRLPPLGSGEVIYHAGTAEQEGQLVASGGRVLAVTATAPTLNAALGRAYALADRVDFPGAQL
RRDLGARIGARPDPRQV

Sequences:

>Translated_417_residues
MRVLVVGGGGREHALVDACGRAGHEVLCTPGNPGIAQQARVVASAQDAASLADLAVREGVDVVIVGPEAYLAAGLVDACR
ERGVPAFGPTRAAARLEGDKAWSKAFMGRHGIPTAAHRSFADLEEALTYARVQPLPLVVKDAGLRAGKGVTIARTHAEAE
AALRDIFAQEGAQAVLEEFMTGQEVTVLALTDGERYALTPPSQDHKTIFEGDTGPMTGGMGVICPFPLTATDLERIRAEI
IEPALAGMRAEGHPFTGVLYAGLMLTPAGPRVVEFNARFGDPEAEAVLPLLSSDLAQHALDAALGHLDPATVHFRDGASA
VVVLAAPGYPGEAQKGIPLRLPPLGSGEVIYHAGTAEQEGQLVASGGRVLAVTATAPTLNAALGRAYALADRVDFPGAQL
RRDLGARIGARPDPRQV
>Mature_417_residues
MRVLVVGGGGREHALVDACGRAGHEVLCTPGNPGIAQQARVVASAQDAASLADLAVREGVDVVIVGPEAYLAAGLVDACR
ERGVPAFGPTRAAARLEGDKAWSKAFMGRHGIPTAAHRSFADLEEALTYARVQPLPLVVKDAGLRAGKGVTIARTHAEAE
AALRDIFAQEGAQAVLEEFMTGQEVTVLALTDGERYALTPPSQDHKTIFEGDTGPMTGGMGVICPFPLTATDLERIRAEI
IEPALAGMRAEGHPFTGVLYAGLMLTPAGPRVVEFNARFGDPEAEAVLPLLSSDLAQHALDAALGHLDPATVHFRDGASA
VVVLAAPGYPGEAQKGIPLRLPPLGSGEVIYHAGTAEQEGQLVASGGRVLAVTATAPTLNAALGRAYALADRVDFPGAQL
RRDLGARIGARPDPRQV

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=434, Percent_Identity=44.0092165898618, Blast_Score=328, Evalue=6e-90,
Organism=Homo sapiens, GI209869995, Length=434, Percent_Identity=44.0092165898618, Blast_Score=328, Evalue=6e-90,
Organism=Homo sapiens, GI209869993, Length=434, Percent_Identity=44.0092165898618, Blast_Score=328, Evalue=6e-90,
Organism=Homo sapiens, GI28416899, Length=432, Percent_Identity=44.212962962963, Blast_Score=327, Evalue=9e-90,
Organism=Escherichia coli, GI1790438, Length=423, Percent_Identity=43.9716312056738, Blast_Score=313, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI17567511, Length=421, Percent_Identity=37.0546318289786, Blast_Score=254, Evalue=5e-68,
Organism=Saccharomyces cerevisiae, GI6321203, Length=440, Percent_Identity=38.6363636363636, Blast_Score=268, Evalue=1e-72,
Organism=Drosophila melanogaster, GI62471619, Length=427, Percent_Identity=42.3887587822014, Blast_Score=282, Evalue=4e-76,
Organism=Drosophila melanogaster, GI24582400, Length=427, Percent_Identity=42.3887587822014, Blast_Score=281, Evalue=6e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020559
- InterPro:   IPR020562
- InterPro:   IPR011054 [H]

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N [H]

EC number: =6.3.4.13 [H]

Molecular weight: Translated: 43278; Mature: 43278

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS50975 ATP_GRASP ; PS00184 GARS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLVVGGGGREHALVDACGRAGHEVLCTPGNPGIAQQARVVASAQDAASLADLAVREGV
CEEEEECCCCCCHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
DVVIVGPEAYLAAGLVDACRERGVPAFGPTRAAARLEGDKAWSKAFMGRHGIPTAAHRSF
CEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHCCCCCCHHHHHHH
ADLEEALTYARVQPLPLVVKDAGLRAGKGVTIARTHAEAEAALRDIFAQEGAQAVLEEFM
HHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
TGQEVTVLALTDGERYALTPPSQDHKTIFEGDTGPMTGGMGVICPFPLTATDLERIRAEI
CCCCEEEEEEECCCEEEECCCCCCCCEEEECCCCCCCCCCCEEECCCCCHHHHHHHHHHH
IEPALAGMRAEGHPFTGVLYAGLMLTPAGPRVVEFNARFGDPEAEAVLPLLSSDLAQHAL
HHHHHHCCCCCCCCCHHHHHHCEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
DAALGHLDPATVHFRDGASAVVVLAAPGYPGEAQKGIPLRLPPLGSGEVIYHAGTAEQEG
HHHHHCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCEECCCCCCCCEEEECCCCCCCC
QLVASGGRVLAVTATAPTLNAALGRAYALADRVDFPGAQLRRDLGARIGARPDPRQV
EEEECCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRVLVVGGGGREHALVDACGRAGHEVLCTPGNPGIAQQARVVASAQDAASLADLAVREGV
CEEEEECCCCCCHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
DVVIVGPEAYLAAGLVDACRERGVPAFGPTRAAARLEGDKAWSKAFMGRHGIPTAAHRSF
CEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHCCCCCCHHHHHHH
ADLEEALTYARVQPLPLVVKDAGLRAGKGVTIARTHAEAEAALRDIFAQEGAQAVLEEFM
HHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
TGQEVTVLALTDGERYALTPPSQDHKTIFEGDTGPMTGGMGVICPFPLTATDLERIRAEI
CCCCEEEEEEECCCEEEECCCCCCCCEEEECCCCCCCCCCCEEECCCCCHHHHHHHHHHH
IEPALAGMRAEGHPFTGVLYAGLMLTPAGPRVVEFNARFGDPEAEAVLPLLSSDLAQHAL
HHHHHHCCCCCCCCCHHHHHHCEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
DAALGHLDPATVHFRDGASAVVVLAAPGYPGEAQKGIPLRLPPLGSGEVIYHAGTAEQEG
HHHHHCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCEECCCCCCCCEEEECCCCCCCC
QLVASGGRVLAVTATAPTLNAALGRAYALADRVDFPGAQLRRDLGARIGARPDPRQV
EEEECCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]