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The map label for this gene is map [H]

Identifier: 94985385

GI number: 94985385

Start: 1363505

End: 1364284

Strand: Reverse

Name: map [H]

Synonym: Dgeo_1284

Alternate gene names: 94985385

Gene position: 1364284-1363505 (Counterclockwise)

Preceding gene: 94985388

Following gene: 94985384

Centisome position: 55.3

GC content: 65.38

Gene sequence:

>780_bases
ATGCTAGCCTCTCACGTTATGAGCCGTGTCGCCCTGAAATCCGCCCGCGAGATCGAAGCTATGCGCCGTGCGGGGGCGCT
CGTCGCCGAGACGTTCCGAGTGCTGGAACCCTATGTGAAACCCGGTGTCACCCTGGCCGAACTCGACCGAATCGCGGAGG
AACACATTCGCAAGCACGGCGCGACGCCTGCCTACCTCGGATATGGCCCCAAGAACAACCCCTTTCCCGCCACCATCTGC
GCCAGCGTAAACGAGGTGATTTGCCACGGCATTCCCGGCTCCCGCGAACTGAAGGAGGGGGATATTGTCGGCGTGGACAT
CGGTGTGCTGCTGAACGGCGTGTATGGCGACGCCTGCTATACCTATACGGTGGGCACCGTCCGCCCCGAGGTGCAGGGGC
TGGTGGATACCACCCGCCAGAGCCTGGCGGCGGGCCTGGAGATGGTGAAGCCCGGCAACCGTACCGGCGATATCGGCCAT
GCCATCCAGTCGCTCGCGGAGGCGCGCGGCTATGGCGTGGTGCGCGAGTACACCGGCCACGGCATCGGCCGGCGCCTCCA
CGAGGAACCGACCATCTACCACTGGGGCGCGCGTTACACGGGTCTCAAGCTCCAGCCCGGCATGGTCTTTACGGTCGAGC
CGATGATCAACCTGGGAACGCCGGACACCCGCCTGCTGGCGGACGGCTGGACGGTGGTCACGGCCGACAAGCAGCCCAGC
GCCCAGTTCGAACACACGGTCGTCGTCACGCCGAAGGGCCACGAGATTCTCACGTTGTGA

Upstream 100 bases:

>100_bases
CAGCGAATTCTGGTGCCTTGCTGGCCAGCGGCTCGCTGCGGTTTTCCGCGCATGGAGGCAAGGCTTCCCCACCCTGCTTC
GCAATTGCCTGTCCGGCCCC

Downstream 100 bases:

>100_bases
GAGCGAGCAGGATGTTCCACCCAAAGCTGCCGGATCTGCCCGGTGCCCGGCCTCTCACTCCAGAGAAGGTTCCCAGGCAG
AGGCAGAGCAGCGGTTGATC

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MLASHVMSRVALKSAREIEAMRRAGALVAETFRVLEPYVKPGVTLAELDRIAEEHIRKHGATPAYLGYGPKNNPFPATIC
ASVNEVICHGIPGSRELKEGDIVGVDIGVLLNGVYGDACYTYTVGTVRPEVQGLVDTTRQSLAAGLEMVKPGNRTGDIGH
AIQSLAEARGYGVVREYTGHGIGRRLHEEPTIYHWGARYTGLKLQPGMVFTVEPMINLGTPDTRLLADGWTVVTADKQPS
AQFEHTVVVTPKGHEILTL

Sequences:

>Translated_259_residues
MLASHVMSRVALKSAREIEAMRRAGALVAETFRVLEPYVKPGVTLAELDRIAEEHIRKHGATPAYLGYGPKNNPFPATIC
ASVNEVICHGIPGSRELKEGDIVGVDIGVLLNGVYGDACYTYTVGTVRPEVQGLVDTTRQSLAAGLEMVKPGNRTGDIGH
AIQSLAEARGYGVVREYTGHGIGRRLHEEPTIYHWGARYTGLKLQPGMVFTVEPMINLGTPDTRLLADGWTVVTADKQPS
AQFEHTVVVTPKGHEILTL
>Mature_259_residues
MLASHVMSRVALKSAREIEAMRRAGALVAETFRVLEPYVKPGVTLAELDRIAEEHIRKHGATPAYLGYGPKNNPFPATIC
ASVNEVICHGIPGSRELKEGDIVGVDIGVLLNGVYGDACYTYTVGTVRPEVQGLVDTTRQSLAAGLEMVKPGNRTGDIGH
AIQSLAEARGYGVVREYTGHGIGRRLHEEPTIYHWGARYTGLKLQPGMVFTVEPMINLGTPDTRLLADGWTVVTADKQPS
AQFEHTVVVTPKGHEILTL

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=251, Percent_Identity=43.4262948207171, Blast_Score=194, Evalue=5e-50,
Organism=Homo sapiens, GI40385867, Length=249, Percent_Identity=37.7510040160643, Blast_Score=184, Evalue=7e-47,
Organism=Escherichia coli, GI1786364, Length=254, Percent_Identity=49.2125984251969, Blast_Score=248, Evalue=2e-67,
Organism=Escherichia coli, GI1788728, Length=252, Percent_Identity=26.1904761904762, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71996291, Length=250, Percent_Identity=40.4, Blast_Score=176, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6323273, Length=253, Percent_Identity=40.3162055335968, Blast_Score=191, Evalue=9e-50,
Organism=Drosophila melanogaster, GI21355531, Length=251, Percent_Identity=40.2390438247012, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24583427, Length=247, Percent_Identity=38.8663967611336, Blast_Score=184, Evalue=5e-47,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28048; Mature: 28048

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLASHVMSRVALKSAREIEAMRRAGALVAETFRVLEPYVKPGVTLAELDRIAEEHIRKHG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
ATPAYLGYGPKNNPFPATICASVNEVICHGIPGSRELKEGDIVGVDIGVLLNGVYGDACY
CCCCEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHEECCCCCCEE
TYTVGTVRPEVQGLVDTTRQSLAAGLEMVKPGNRTGDIGHAIQSLAEARGYGVVREYTGH
EEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEHHHCCC
GIGRRLHEEPTIYHWGARYTGLKLQPGMVFTVEPMINLGTPDTRLLADGWTVVTADKQPS
CHHHHHCCCCCEEECCCEECCEEECCCEEEEECCCEECCCCCCEEEECCEEEEEECCCCC
AQFEHTVVVTPKGHEILTL
CCCCEEEEECCCCCEEEEC
>Mature Secondary Structure
MLASHVMSRVALKSAREIEAMRRAGALVAETFRVLEPYVKPGVTLAELDRIAEEHIRKHG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
ATPAYLGYGPKNNPFPATICASVNEVICHGIPGSRELKEGDIVGVDIGVLLNGVYGDACY
CCCCEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHEECCCCCCEE
TYTVGTVRPEVQGLVDTTRQSLAAGLEMVKPGNRTGDIGHAIQSLAEARGYGVVREYTGH
EEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEHHHCCC
GIGRRLHEEPTIYHWGARYTGLKLQPGMVFTVEPMINLGTPDTRLLADGWTVVTADKQPS
CHHHHHCCCCCEEECCCEECCEEECCCEEEEECCCEECCCCCCEEEECCEEEEEECCCCC
AQFEHTVVVTPKGHEILTL
CCCCEEEEECCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192928; 11058132 [H]