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The map label for this gene is ycdW [C]

Identifier: 94984900

GI number: 94984900

Start: 849965

End: 850855

Strand: Reverse

Name: ycdW [C]

Synonym: Dgeo_0793

Alternate gene names: 94984900

Gene position: 850855-849965 (Counterclockwise)

Preceding gene: 94984901

Following gene: 94984897

Centisome position: 34.49

GC content: 70.48

Gene sequence:

>891_bases
GTGCGCGTGCTGGTGCCTGAATGGCCTGAATTCCGGGCGTTGCGGGTGGAGGGTGTGGAGTTGGCCTTTTACGGCCCCGA
GGGGTTACCGGCAGGTGAGGCGGACGGGCTGGTGCTGTGGTTGACTCCACCCGATCTGCGGGACCAGTTGCTGGACTGGC
CCGGCTTGAGGTGGGTGCTGACGCTGACCGCGGGTATTGACCACGTGGCCGGAAGGCTGCCGGAGGGCGTCACGCTCTAC
AACGCCCACCGCCTGCATGACCGCGCCGTGGCCGTTCACACGCTCGCCGGAATGCTCGCCGCCGAGCGGGGCCTGCACCG
GTTCCGCGACCGCCAAAGGGAAGGCCGCTGGCAACCCACCCTCGACCTTGGGGGGCTGGATGGGGCACGCGTGGCGATCT
GGGGGTACGGACACATCGGGAAGATTCTGGAAGACCTCCTGCGGCCCTTCGGCGCGCAGGTGACGGGCATCCGCTCCCGC
ACCCCGGCAGCCGAGCGGGACGCTGCACTCGCTGAGGCCGACTGGGTCGTTCTCCTGCTGCCCAGCACGCCGGAGACGCG
AGGTATCGTGGACGCGGACGTGCTCGCCCGCCTCAAGCCCGGCGCGTGGCTCAGCAACCAGGGCCGGGGCGACCTGATCG
AGACTGGCGCCCTCCTCGCGGCGCTGGACTCCGGTCACCTCGGCGGCGCGGTCCTCGACGTCACCGACCCCGAGCCGTTG
CCGGAGGGACACCCGCTGTGGGAGCAGCCCAACGTCATCATTACCCCGCACATCGCCAGCGCCACCCGTGACCTGATTCA
GCGCGGCGCCGACTACACCCGCGCCTTCCTGACCGAGATGCAGGCGGGGCGGGAACCGGAAGGGCGGGTGAAGGCCGGGC
AGCGGTACTGA

Upstream 100 bases:

>100_bases
CAGCGGGCCTTTCTGGCGTGCGGCTTCCGCGAGGTGGGTCGCTCGGAGGGGCCGGGCCACACCGACGTTCACATGGAGAT
CACGAAAGGAGAGTGGGAAA

Downstream 100 bases:

>100_bases
GAAACGGAGCCAAGCGGCGAGACTCGACTGCGCGGGTTCTCGCCGCTTGGCTGTTGCTGGCTCTTTGTTCGCCGCTAACC
TGAAACAGGAACGGGCTGCG

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NADPH; glyoxylate; glycerate [C]

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MRVLVPEWPEFRALRVEGVELAFYGPEGLPAGEADGLVLWLTPPDLRDQLLDWPGLRWVLTLTAGIDHVAGRLPEGVTLY
NAHRLHDRAVAVHTLAGMLAAERGLHRFRDRQREGRWQPTLDLGGLDGARVAIWGYGHIGKILEDLLRPFGAQVTGIRSR
TPAAERDAALAEADWVVLLLPSTPETRGIVDADVLARLKPGAWLSNQGRGDLIETGALLAALDSGHLGGAVLDVTDPEPL
PEGHPLWEQPNVIITPHIASATRDLIQRGADYTRAFLTEMQAGREPEGRVKAGQRY

Sequences:

>Translated_296_residues
MRVLVPEWPEFRALRVEGVELAFYGPEGLPAGEADGLVLWLTPPDLRDQLLDWPGLRWVLTLTAGIDHVAGRLPEGVTLY
NAHRLHDRAVAVHTLAGMLAAERGLHRFRDRQREGRWQPTLDLGGLDGARVAIWGYGHIGKILEDLLRPFGAQVTGIRSR
TPAAERDAALAEADWVVLLLPSTPETRGIVDADVLARLKPGAWLSNQGRGDLIETGALLAALDSGHLGGAVLDVTDPEPL
PEGHPLWEQPNVIITPHIASATRDLIQRGADYTRAFLTEMQAGREPEGRVKAGQRY
>Mature_296_residues
MRVLVPEWPEFRALRVEGVELAFYGPEGLPAGEADGLVLWLTPPDLRDQLLDWPGLRWVLTLTAGIDHVAGRLPEGVTLY
NAHRLHDRAVAVHTLAGMLAAERGLHRFRDRQREGRWQPTLDLGGLDGARVAIWGYGHIGKILEDLLRPFGAQVTGIRSR
TPAAERDAALAEADWVVLLLPSTPETRGIVDADVLARLKPGAWLSNQGRGDLIETGALLAALDSGHLGGAVLDVTDPEPL
PEGHPLWEQPNVIITPHIASATRDLIQRGADYTRAFLTEMQAGREPEGRVKAGQRY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=247, Percent_Identity=34.412955465587, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI23308577, Length=241, Percent_Identity=27.3858921161826, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI61743967, Length=253, Percent_Identity=26.8774703557312, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI4557497, Length=253, Percent_Identity=26.8774703557312, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI87081824, Length=285, Percent_Identity=31.2280701754386, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1789279, Length=224, Percent_Identity=31.6964285714286, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082289, Length=233, Percent_Identity=31.7596566523605, Blast_Score=89, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17532191, Length=199, Percent_Identity=26.6331658291457, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320925, Length=231, Percent_Identity=27.2727272727273, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322116, Length=211, Percent_Identity=27.4881516587678, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28574286, Length=260, Percent_Identity=31.9230769230769, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28571528, Length=225, Percent_Identity=32, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI45551003, Length=301, Percent_Identity=29.9003322259136, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI28574284, Length=301, Percent_Identity=29.9003322259136, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI45552429, Length=301, Percent_Identity=29.9003322259136, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24585514, Length=249, Percent_Identity=30.9236947791165, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI28574282, Length=249, Percent_Identity=30.9236947791165, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24585516, Length=245, Percent_Identity=28.9795918367347, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI19921140, Length=165, Percent_Identity=32.7272727272727, Blast_Score=81, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: NA

Molecular weight: Translated: 32383; Mature: 32383

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLVPEWPEFRALRVEGVELAFYGPEGLPAGEADGLVLWLTPPDLRDQLLDWPGLRWVL
CEECCCCCCCCEEEEEECEEEEEECCCCCCCCCCCCEEEEECCCHHHHHHHCCCCCEEEE
TLTAGIDHVAGRLPEGVTLYNAHRLHDRAVAVHTLAGMLAAERGLHRFRDRQREGRWQPT
EEHHCHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LDLGGLDGARVAIWGYGHIGKILEDLLRPFGAQVTGIRSRTPAAERDAALAEADWVVLLL
EECCCCCCCEEEEEECCHHHHHHHHHHHHHCCEEECCCCCCCCCHHHHHHCCCCEEEEEE
PSTPETRGIVDADVLARLKPGAWLSNQGRGDLIETGALLAALDSGHLGGAVLDVTDPEPL
CCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHCHHEEEECCCCCCCEEEECCCCCCC
PEGHPLWEQPNVIITPHIASATRDLIQRGADYTRAFLTEMQAGREPEGRVKAGQRY
CCCCCCCCCCCEEEECCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRVLVPEWPEFRALRVEGVELAFYGPEGLPAGEADGLVLWLTPPDLRDQLLDWPGLRWVL
CEECCCCCCCCEEEEEECEEEEEECCCCCCCCCCCCEEEEECCCHHHHHHHCCCCCEEEE
TLTAGIDHVAGRLPEGVTLYNAHRLHDRAVAVHTLAGMLAAERGLHRFRDRQREGRWQPT
EEHHCHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LDLGGLDGARVAIWGYGHIGKILEDLLRPFGAQVTGIRSRTPAAERDAALAEADWVVLLL
EECCCCCCCEEEEEECCHHHHHHHHHHHHHCCEEECCCCCCCCCHHHHHHCCCCEEEEEE
PSTPETRGIVDADVLARLKPGAWLSNQGRGDLIETGALLAALDSGHLGGAVLDVTDPEPL
CCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHCHHEEEECCCCCCCEEEECCCCCCC
PEGHPLWEQPNVIITPHIASATRDLIQRGADYTRAFLTEMQAGREPEGRVKAGQRY
CCCCCCCCCCCEEEECCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glycolate; NADP; hydroxypyruvate; NADPH [C]

Specific reaction: glycolate + NADP = NADPH + glyoxylate hydroxypyruvate + NADPH = glycerate + NADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]