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The map label for this gene is lysA [H]

Identifier: 94984897

GI number: 94984897

Start: 846628

End: 847785

Strand: Reverse

Name: lysA [H]

Synonym: Dgeo_0790

Alternate gene names: 94984897

Gene position: 847785-846628 (Counterclockwise)

Preceding gene: 94984900

Following gene: 94984895

Centisome position: 34.36

GC content: 71.5

Gene sequence:

>1158_bases
GTGAGTCTTCCCCGCGCTGAACTCCTAACCGCCGCCGCTCGCTTTGGAACACCCCTTTACGTCTACGACGCCGCCGAACT
CGATGCGGCGCTCGCGCGGGTGCGGGCAGCCTTCGGGGAGGCGCGGGTGTTCTATGCGATGAAGGCCAATCCCAACCTCA
CCCTGCTGAGGCGTCTGCGGGCGGCAGGCGTGGGCTTTGAGTGCGTCAGCGCGGGCGAGATCGCACGGGCGGAACATGTG
GGTGCGAGCGGAGACGCGCTGCTGATCAACGGCCCGGCCAAATCAGCCCAGGAATACGCGGCTGGTGCGCAGCTGGGCGC
GACTTTGATCGTGGACCGAGCAGAGGAGGTGGGACTCTTGCCGCCCCGCTCCAAGGCCTTGGTGCGCGTGAATCCGGCCC
TGGCCGTCAGCACGCACGACCACCTCGCCACCGGGGCAGCGGGCAGCAAGTTCGGCGTGACCCTGGAACAGGCGCCCGAC
GTGCTGCGTGCCCTGCGCGCGGCTGGACACGACGCGCGGGGTCTGCACGTGCACATCGGCAGCGCGATTCGAGAGGCCGC
CGACTTCAGCGCGGCGTTCGCACGGGTGGCGGAGCTGCGCCCGCAGACGGGCAACCTGGAGGTGCTGGACGTGGGCGGCG
GCTGGAGCGTGGGGGCCGATTTGCCCGGAATCGCGCGGGAAGCGCGGGCCGCGGCCGCGGTCTTTGGAGCGCAGCTCTGG
GTGGAGCCGGGGCGGTATCTGGTGGCGCAGGCGGGCACGCTGCTCACCCGCGTGGTGGGCACCAAGCGCACCGGGCGCAA
CTTCCTGCTCACCGACGCGGGCATGACCGAACTGCTGCGGCCGATGCTGTACGGCGCGCAGCACCCGGTCACAGCACTCT
GGGACGACCCACAGCCCGAGACGGCGGGGGAACGGTGGGACGTGGCCGGGCCTGCCTGCGAGAGCGGCGACCTGCTCGCG
CGGGACGTGTGCCTGCCCTCTCCCCACCCCGGTGACCTGCTCGCCATCGCGGAAGCCGGAGCCTACGGCGCGAGCATGAG
CAGCAGCTACCTCACCCGCTCCCGGCCCGCCGAGGCGCTGTGGGACGGCTCGGACTGGATCCTGATCCGCCGCCGCGAGA
CGCCGCAGGAGCTGTGGGCCGCGGAAGAGATCGGCTAG

Upstream 100 bases:

>100_bases
GGGGCGCAGCAGAAGACGCATAGACCAAGTGTGGCGGGCAGCAGCAGAAAAGACATGCGCCGGATGGCCTGACCGGGAGT
GTCTGCCCTACACTTCCCCC

Downstream 100 bases:

>100_bases
GCAGACTCAGGCGGGGGTGCGGGCTCAATCCGTCTCGTTCTCCCGCGCGGTCCTGTGGCCATCCGGCGCATACGAGAAGC
GCACGACCAGGGTGCGGGTC

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MSLPRAELLTAAARFGTPLYVYDAAELDAALARVRAAFGEARVFYAMKANPNLTLLRRLRAAGVGFECVSAGEIARAEHV
GASGDALLINGPAKSAQEYAAGAQLGATLIVDRAEEVGLLPPRSKALVRVNPALAVSTHDHLATGAAGSKFGVTLEQAPD
VLRALRAAGHDARGLHVHIGSAIREAADFSAAFARVAELRPQTGNLEVLDVGGGWSVGADLPGIAREARAAAAVFGAQLW
VEPGRYLVAQAGTLLTRVVGTKRTGRNFLLTDAGMTELLRPMLYGAQHPVTALWDDPQPETAGERWDVAGPACESGDLLA
RDVCLPSPHPGDLLAIAEAGAYGASMSSSYLTRSRPAEALWDGSDWILIRRRETPQELWAAEEIG

Sequences:

>Translated_385_residues
MSLPRAELLTAAARFGTPLYVYDAAELDAALARVRAAFGEARVFYAMKANPNLTLLRRLRAAGVGFECVSAGEIARAEHV
GASGDALLINGPAKSAQEYAAGAQLGATLIVDRAEEVGLLPPRSKALVRVNPALAVSTHDHLATGAAGSKFGVTLEQAPD
VLRALRAAGHDARGLHVHIGSAIREAADFSAAFARVAELRPQTGNLEVLDVGGGWSVGADLPGIAREARAAAAVFGAQLW
VEPGRYLVAQAGTLLTRVVGTKRTGRNFLLTDAGMTELLRPMLYGAQHPVTALWDDPQPETAGERWDVAGPACESGDLLA
RDVCLPSPHPGDLLAIAEAGAYGASMSSSYLTRSRPAEALWDGSDWILIRRRETPQELWAAEEIG
>Mature_384_residues
SLPRAELLTAAARFGTPLYVYDAAELDAALARVRAAFGEARVFYAMKANPNLTLLRRLRAAGVGFECVSAGEIARAEHVG
ASGDALLINGPAKSAQEYAAGAQLGATLIVDRAEEVGLLPPRSKALVRVNPALAVSTHDHLATGAAGSKFGVTLEQAPDV
LRALRAAGHDARGLHVHIGSAIREAADFSAAFARVAELRPQTGNLEVLDVGGGWSVGADLPGIAREARAAAAVFGAQLWV
EPGRYLVAQAGTLLTRVVGTKRTGRNFLLTDAGMTELLRPMLYGAQHPVTALWDDPQPETAGERWDVAGPACESGDLLAR
DVCLPSPHPGDLLAIAEAGAYGASMSSSYLTRSRPAEALWDGSDWILIRRRETPQELWAAEEIG

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=390, Percent_Identity=24.3589743589744, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI16506287, Length=346, Percent_Identity=25.4335260115607, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI22538418, Length=387, Percent_Identity=21.7054263565891, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI21361583, Length=387, Percent_Identity=21.7054263565891, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1789203, Length=403, Percent_Identity=33.4987593052109, Blast_Score=175, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17562780, Length=359, Percent_Identity=26.7409470752089, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322664, Length=362, Percent_Identity=26.2430939226519, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24586472, Length=363, Percent_Identity=24.7933884297521, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24586474, Length=337, Percent_Identity=26.1127596439169, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 40532; Mature: 40401

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPRAELLTAAARFGTPLYVYDAAELDAALARVRAAFGEARVFYAMKANPNLTLLRRLR
CCCCHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHH
AAGVGFECVSAGEIARAEHVGASGDALLINGPAKSAQEYAAGAQLGATLIVDRAEEVGLL
HCCCCEEEECCCCHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCEEEEEECHHHCCCC
PPRSKALVRVNPALAVSTHDHLATGAAGSKFGVTLEQAPDVLRALRAAGHDARGLHVHIG
CCCCCEEEEECCEEEEECCCHHHCCCCCCCCCEEHHHHHHHHHHHHHCCCCCCEEEEEEC
SAIREAADFSAAFARVAELRPQTGNLEVLDVGGGWSVGADLPGIAREARAAAAVFGAQLW
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHEE
VEPGRYLVAQAGTLLTRVVGTKRTGRNFLLTDAGMTELLRPMLYGAQHPVTALWDDPQPE
ECCCCEEEHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEECCCCCCC
TAGERWDVAGPACESGDLLARDVCLPSPHPGDLLAIAEAGAYGASMSSSYLTRSRPAEAL
CCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCHHHHHCCCCHHHH
WDGSDWILIRRRETPQELWAAEEIG
CCCCCEEEEEECCCHHHHHHHHCCC
>Mature Secondary Structure 
SLPRAELLTAAARFGTPLYVYDAAELDAALARVRAAFGEARVFYAMKANPNLTLLRRLR
CCCHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHH
AAGVGFECVSAGEIARAEHVGASGDALLINGPAKSAQEYAAGAQLGATLIVDRAEEVGLL
HCCCCEEEECCCCHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCEEEEEECHHHCCCC
PPRSKALVRVNPALAVSTHDHLATGAAGSKFGVTLEQAPDVLRALRAAGHDARGLHVHIG
CCCCCEEEEECCEEEEECCCHHHCCCCCCCCCEEHHHHHHHHHHHHHCCCCCCEEEEEEC
SAIREAADFSAAFARVAELRPQTGNLEVLDVGGGWSVGADLPGIAREARAAAAVFGAQLW
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHEE
VEPGRYLVAQAGTLLTRVVGTKRTGRNFLLTDAGMTELLRPMLYGAQHPVTALWDDPQPE
ECCCCEEEHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEECCCCCCC
TAGERWDVAGPACESGDLLARDVCLPSPHPGDLLAIAEAGAYGASMSSSYLTRSRPAEAL
CCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCHHHHHCCCCHHHH
WDGSDWILIRRRETPQELWAAEEIG
CCCCCEEEEEECCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]