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The map label for this gene is mntH [H]

Identifier: 94984816

GI number: 94984816

Start: 766415

End: 767743

Strand: Reverse

Name: mntH [H]

Synonym: Dgeo_0709

Alternate gene names: 94984816

Gene position: 767743-766415 (Counterclockwise)

Preceding gene: 94984818

Following gene: 94984813

Centisome position: 31.12

GC content: 66.37

Gene sequence:

>1329_bases
ATGTCGTCGGCGCCCTCCTCTCCTTCTTCGGGCGGGCAACCCCCGCTGTCCCACGCTTCTGCTCTCGATGGGCGCATGAC
TGCACGCGCCGCCGAGGTGCTTTCCCGGCCCCAGCAGCGCCGGGGGCTGGGGCGAATCGTGCCCTTTCTCGGTCCCGCCA
TCATCGCCTCCATCGCCTATATGGACCCCGGCAATTTCGCCACCAACATCGAGGGGGGAGCGCAGTTCGGCTACACGCTG
CTGTGGGTCATTCTGGCGGCGAACCTGATGGCGATGCTGATTCAGAATCTCAGCGCCAAGCTGGGGATCGCCACCGGGAA
AAACCTGCCGGAAGTGATCCGCGAACGCTGGCCGCGCCCGCTGGTGTGGCTGTACTGGATTCAGGCCGAACTCGTGGCGA
TGGCGACTGACCTCGCGGAGTTCCTGGGCGCGGCGCTGGCAATCCACCTGCTCACGGGCCTGCCGCTGGTCTGGGGTGCT
GTCATCACCGCTATCCTGACCTTCGCACTGCTGACCCTCCAAAAGCGCGGATTTCGCCCGCTTGAACTCGCCATCTTGGG
CTTCGTGCTGGTGATTGGCGTCGCGTACCTGGTGCAGATGCTGGTCGCGCGGCCCGGTGCCGAGGCGCTGCGGGGCTTCA
TTCCCAGTTTCCAGGGATCGCAAAGCGTGTACCTCGCGGTCGGCATCATCGGTGCGACCGTCATGCCGCACGTGATCTAC
CTGCACTCGGCCCTCACCCAGGGCCGCATCCCTACCCGCAGCGACGAAGAAAAGGTGCGTCTCTCGCGTCTAAATCGCCT
GGACGTGCTCTTGGCGATGGGCTTCGCAGGCCTGATCAACATGAGCATGCTGGCGGTCAGCGCAGCCACCTTTCACGGCA
AGGGCATCGAGGACGCCGGGAACCTCGAAACGGCCTACCACACCCTCACCCCCCTGCTTGGCCCGGCGGCGGGGATCGCC
TTTGCGGTCGCGCTCCTGGCGAGCGGCCTGAGCAGCAGCGCGGTCGGCACAATGGCCGGGCAGGTGATCATGCAGGGCTT
CGTGAGCTTCAGCATTCCGCTGTGGCTGCGGCGCACCCTGACCATGCTGCCCGCTTTCGCCGTGATCCTGGCCGGCGCGG
ACCCCACCGCTACGCTCGTGCTGTCGCAGGTCGTGCTGAGTTTCGGCGTGCCCTTCGCGCTGGTCCCCCTCCTGCTCTTC
ACCGCCCGCCGCGACGTGATGGGCGTGCTGGTCAGCCGACCGCTTCTCAGCGGGCTGGGTTGGCTCTTTGCGGCAGTCAT
CATCGGGTTGAACGTGTACCTGCTCTGGGGGGCGTTCGGCGGGCGTTAG

Upstream 100 bases:

>100_bases
GCGCACCCAGATCGGCAGGAGTTGGCTAGGGGGAAACCCCAACCCCGCACAGCTTTTGGTCAAGCTGGACTTTATTTTTA
GGCTGTCCTAAAATCAGGCC

Downstream 100 bases:

>100_bases
TGGGCAGGGCTCGGTGGAGAAAAAAGCTTGGGCCACGGCATCCGCCGACTCTTCCACCGACCACCTCCCGCTCGCCACTC
ACAGCGCAGCGTCTCGCTCC

Product: manganese transport protein MntH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MSSAPSSPSSGGQPPLSHASALDGRMTARAAEVLSRPQQRRGLGRIVPFLGPAIIASIAYMDPGNFATNIEGGAQFGYTL
LWVILAANLMAMLIQNLSAKLGIATGKNLPEVIRERWPRPLVWLYWIQAELVAMATDLAEFLGAALAIHLLTGLPLVWGA
VITAILTFALLTLQKRGFRPLELAILGFVLVIGVAYLVQMLVARPGAEALRGFIPSFQGSQSVYLAVGIIGATVMPHVIY
LHSALTQGRIPTRSDEEKVRLSRLNRLDVLLAMGFAGLINMSMLAVSAATFHGKGIEDAGNLETAYHTLTPLLGPAAGIA
FAVALLASGLSSSAVGTMAGQVIMQGFVSFSIPLWLRRTLTMLPAFAVILAGADPTATLVLSQVVLSFGVPFALVPLLLF
TARRDVMGVLVSRPLLSGLGWLFAAVIIGLNVYLLWGAFGGR

Sequences:

>Translated_442_residues
MSSAPSSPSSGGQPPLSHASALDGRMTARAAEVLSRPQQRRGLGRIVPFLGPAIIASIAYMDPGNFATNIEGGAQFGYTL
LWVILAANLMAMLIQNLSAKLGIATGKNLPEVIRERWPRPLVWLYWIQAELVAMATDLAEFLGAALAIHLLTGLPLVWGA
VITAILTFALLTLQKRGFRPLELAILGFVLVIGVAYLVQMLVARPGAEALRGFIPSFQGSQSVYLAVGIIGATVMPHVIY
LHSALTQGRIPTRSDEEKVRLSRLNRLDVLLAMGFAGLINMSMLAVSAATFHGKGIEDAGNLETAYHTLTPLLGPAAGIA
FAVALLASGLSSSAVGTMAGQVIMQGFVSFSIPLWLRRTLTMLPAFAVILAGADPTATLVLSQVVLSFGVPFALVPLLLF
TARRDVMGVLVSRPLLSGLGWLFAAVIIGLNVYLLWGAFGGR
>Mature_441_residues
SSAPSSPSSGGQPPLSHASALDGRMTARAAEVLSRPQQRRGLGRIVPFLGPAIIASIAYMDPGNFATNIEGGAQFGYTLL
WVILAANLMAMLIQNLSAKLGIATGKNLPEVIRERWPRPLVWLYWIQAELVAMATDLAEFLGAALAIHLLTGLPLVWGAV
ITAILTFALLTLQKRGFRPLELAILGFVLVIGVAYLVQMLVARPGAEALRGFIPSFQGSQSVYLAVGIIGATVMPHVIYL
HSALTQGRIPTRSDEEKVRLSRLNRLDVLLAMGFAGLINMSMLAVSAATFHGKGIEDAGNLETAYHTLTPLLGPAAGIAF
AVALLASGLSSSAVGTMAGQVIMQGFVSFSIPLWLRRTLTMLPAFAVILAGADPTATLVLSQVVLSFGVPFALVPLLLFT
ARRDVMGVLVSRPLLSGLGWLFAAVIIGLNVYLLWGAFGGR

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=418, Percent_Identity=34.4497607655502, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI295293167, Length=451, Percent_Identity=32.5942350332594, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI295293178, Length=480, Percent_Identity=31.875, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI295293175, Length=480, Percent_Identity=31.875, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI295293173, Length=480, Percent_Identity=31.875, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI10835169, Length=480, Percent_Identity=31.875, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI295293171, Length=451, Percent_Identity=32.5942350332594, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI295293169, Length=451, Percent_Identity=32.5942350332594, Blast_Score=184, Evalue=2e-46,
Organism=Escherichia coli, GI1788736, Length=390, Percent_Identity=54.8717948717949, Blast_Score=407, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17569473, Length=376, Percent_Identity=31.9148936170213, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI193210616, Length=452, Percent_Identity=29.4247787610619, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71999499, Length=485, Percent_Identity=28.8659793814433, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71993856, Length=232, Percent_Identity=34.9137931034483, Blast_Score=145, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6323062, Length=400, Percent_Identity=35.5, Blast_Score=226, Evalue=8e-60,
Organism=Saccharomyces cerevisiae, GI6324450, Length=456, Percent_Identity=30.7017543859649, Blast_Score=207, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6321841, Length=413, Percent_Identity=32.4455205811138, Blast_Score=187, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24648607, Length=432, Percent_Identity=31.712962962963, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI281362176, Length=432, Percent_Identity=31.712962962963, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24648609, Length=432, Percent_Identity=31.712962962963, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI45553443, Length=409, Percent_Identity=31.7848410757946, Blast_Score=199, Evalue=5e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 46782; Mature: 46651

Theoretical pI: Translated: 10.56; Mature: 10.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SSAPSSPSSGGQPPLSHASALDGRMTARAAEVLSRPQQRRGLGRIVPFLGPAIIASIAY
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHH
MDPGNFATNIEGGAQFGYTLLWVILAANLMAMLIQNLSAKLGIATGKNLPEVIRERWPRP
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCC
LVWLYWIQAELVAMATDLAEFLGAALAIHLLTGLPLVWGAVITAILTFALLTLQKRGFRP
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
LELAILGFVLVIGVAYLVQMLVARPGAEALRGFIPSFQGSQSVYLAVGIIGATVMPHVIY
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHH
LHSALTQGRIPTRSDEEKVRLSRLNRLDVLLAMGFAGLINMSMLAVSAATFHGKGIEDAG
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
NLETAYHTLTPLLGPAAGIAFAVALLASGLSSSAVGTMAGQVIMQGFVSFSIPLWLRRTL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TMLPAFAVILAGADPTATLVLSQVVLSFGVPFALVPLLLFTARRDVMGVLVSRPLLSGLG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLFAAVIIGLNVYLLWGAFGGR
HHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]