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The map label for this gene is panC

Identifier: 94984777

GI number: 94984777

Start: 728117

End: 729007

Strand: Reverse

Name: panC

Synonym: Dgeo_0670

Alternate gene names: 94984777

Gene position: 729007-728117 (Counterclockwise)

Preceding gene: 94984778

Following gene: 94984776

Centisome position: 29.55

GC content: 67.12

Gene sequence:

>891_bases
TTGAACCGGACGGCGACGCGGGTCCTCAGCAGCATCGAGGAGGTCCGTGAGGCGCTGGCAGGGCCAGGCCGCGTGGGGCT
GGTGCCCACGATGGGCTACCTGCATGAGGGGCACGCGGCGCTGATCCGGCGGGCGCGCGCGGAATGCGACACGGTGGTGC
TGAGTGTGTTCGTGAATCCACGGCAGTTTGGCGTCAACGAGGACCTCAGCCGCTACCCGCGCGACCTGAACCGTGATCTG
GCGGTGGCGGAGGCGGCGGGCGCTGACCTGCTGTTTCACCCGGATGTGGCCACGATGTATCCGGCAGGCTACGCAACGAC
CGTTGCGGTGGGCGGCGTGTCGGAACCACTTGAGGGAAGTTCACGGCCCGGACATTTCGACGGCGTGGCGACGGTGGTGC
TGAAGCTGCTGAACATCGTGCAGCCGGAGCGGGCGTATTTTGGGGAAAAGGACTGGCAGCAGCTCGCCGTGGTGCGGCGG
ATGGTGCGCGACCTCAACGTGCCGGTACAGATCGTGGGCGTGCCAACTGTCCGCGAACCGTCTGGGCTGGCCCTCAGCAG
CCGCAACAGTTACCTCACACCTGAACAGCAGGCGCGGGCGGCCATTCTCTCCCGCGCCCTGCAGGCGGTGCAGGCCGCAG
CCGCAGCGGGCGAACGCGACACAGCCCGCTTGCGGCAGGCCGGTCTGGCTGTGCTGGCTGAGGAGCCGGAGATCGAACTC
GACTATTTGGCGGTGGTGGACGGTGACATGCGCGAAAAAGCACACGTGGAGAATGATCCCCTGACCCGCGTGCTGGTGGC
CGCCCGGCTGTTCGGCGTTCGGCTGATCGACAACGTCCCCCTGTCTCCAGCAGAACGGCGACTATCGGAACGGGAGAGCC
GCAACACGTGA

Upstream 100 bases:

>100_bases
CGGGCTTCGGGGCAGCCATTGTGGGCGCGCTGATCCTGGCCTTCATCAGCTGGGTGCTCGACGCCATCGTTGGGGCACTG
GGCCTGAATGGGGGGCGCCA

Downstream 100 bases:

>100_bases
CCCTCGACGAGCTGCTGCGCGAGATGGTGGGCCGCCGCGCCTCAGACGTGCATCTCCAGGTGGGCAGCCCGCCCATGGGC
CGCATCGACGGCAGCCTGCT

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MNRTATRVLSSIEEVREALAGPGRVGLVPTMGYLHEGHAALIRRARAECDTVVLSVFVNPRQFGVNEDLSRYPRDLNRDL
AVAEAAGADLLFHPDVATMYPAGYATTVAVGGVSEPLEGSSRPGHFDGVATVVLKLLNIVQPERAYFGEKDWQQLAVVRR
MVRDLNVPVQIVGVPTVREPSGLALSSRNSYLTPEQQARAAILSRALQAVQAAAAAGERDTARLRQAGLAVLAEEPEIEL
DYLAVVDGDMREKAHVENDPLTRVLVAARLFGVRLIDNVPLSPAERRLSERESRNT

Sequences:

>Translated_296_residues
MNRTATRVLSSIEEVREALAGPGRVGLVPTMGYLHEGHAALIRRARAECDTVVLSVFVNPRQFGVNEDLSRYPRDLNRDL
AVAEAAGADLLFHPDVATMYPAGYATTVAVGGVSEPLEGSSRPGHFDGVATVVLKLLNIVQPERAYFGEKDWQQLAVVRR
MVRDLNVPVQIVGVPTVREPSGLALSSRNSYLTPEQQARAAILSRALQAVQAAAAAGERDTARLRQAGLAVLAEEPEIEL
DYLAVVDGDMREKAHVENDPLTRVLVAARLFGVRLIDNVPLSPAERRLSERESRNT
>Mature_296_residues
MNRTATRVLSSIEEVREALAGPGRVGLVPTMGYLHEGHAALIRRARAECDTVVLSVFVNPRQFGVNEDLSRYPRDLNRDL
AVAEAAGADLLFHPDVATMYPAGYATTVAVGGVSEPLEGSSRPGHFDGVATVVLKLLNIVQPERAYFGEKDWQQLAVVRR
MVRDLNVPVQIVGVPTVREPSGLALSSRNSYLTPEQQARAAILSRALQAVQAAAAAGERDTARLRQAGLAVLAEEPEIEL
DYLAVVDGDMREKAHVENDPLTRVLVAARLFGVRLIDNVPLSPAERRLSERESRNT

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=257, Percent_Identity=47.8599221789883, Blast_Score=215, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6322046, Length=306, Percent_Identity=37.2549019607843, Blast_Score=181, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_DEIGD (Q1J0L2)

Other databases:

- EMBL:   CP000359
- RefSeq:   YP_604141.1
- ProteinModelPortal:   Q1J0L2
- SMR:   Q1J0L2
- STRING:   Q1J0L2
- GeneID:   4058252
- GenomeReviews:   CP000359_GR
- KEGG:   dge:Dgeo_0670
- NMPDR:   fig|68909.1.peg.973
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   YRAYFGQ
- PhylomeDB:   Q1J0L2
- ProtClustDB:   PRK00380
- BioCyc:   DGEO319795:DGEO_0670-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 32200; Mature: 32200

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: ACT_SITE 38-38 BINDING 62-62 BINDING 62-62 BINDING 154-154 BINDING 177-177

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRTATRVLSSIEEVREALAGPGRVGLVPTMGYLHEGHAALIRRARAECDTVVLSVFVNP
CCHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECH
RQFGVNEDLSRYPRDLNRDLAVAEAAGADLLFHPDVATMYPAGYATTVAVGGVSEPLEGS
HHCCCCCHHHHHHHHHCCCHHHHHHCCCCEEECCCHHHHCCCCCHHHEEECCCCCCCCCC
SRPGHFDGVATVVLKLLNIVQPERAYFGEKDWQQLAVVRRMVRDLNVPVQIVGVPTVREP
CCCCCCHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
SGLALSSRNSYLTPEQQARAAILSRALQAVQAAAAAGERDTARLRQAGLAVLAEEPEIEL
CCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHEEECCCCCCE
DYLAVVDGDMREKAHVENDPLTRVLVAARLFGVRLIDNVPLSPAERRLSERESRNT
EEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MNRTATRVLSSIEEVREALAGPGRVGLVPTMGYLHEGHAALIRRARAECDTVVLSVFVNP
CCHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECH
RQFGVNEDLSRYPRDLNRDLAVAEAAGADLLFHPDVATMYPAGYATTVAVGGVSEPLEGS
HHCCCCCHHHHHHHHHCCCHHHHHHCCCCEEECCCHHHHCCCCCHHHEEECCCCCCCCCC
SRPGHFDGVATVVLKLLNIVQPERAYFGEKDWQQLAVVRRMVRDLNVPVQIVGVPTVREP
CCCCCCHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
SGLALSSRNSYLTPEQQARAAILSRALQAVQAAAAAGERDTARLRQAGLAVLAEEPEIEL
CCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHEEECCCCCCE
DYLAVVDGDMREKAHVENDPLTRVLVAARLFGVRLIDNVPLSPAERRLSERESRNT
EEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA