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The map label for this gene is exoA [H]

Identifier: 94984569

GI number: 94984569

Start: 477037

End: 477840

Strand: Reverse

Name: exoA [H]

Synonym: Dgeo_0461

Alternate gene names: 94984569

Gene position: 477840-477037 (Counterclockwise)

Preceding gene: 94984571

Following gene: 94984568

Centisome position: 19.37

GC content: 66.92

Gene sequence:

>804_bases
ATGCTCCCGCCGATGCCGCGCACCGTCCCCTCTACCCTCAAGGTCACCACCCTGAACGTGAACGGCCTGCGCAGCGCCCT
GCGCAAGGGACTCACAACCTGGCTGGCCCGCGAGCGGCCCGACGTGTTGCTGCTTCAGGAGGTCCGCGCCCACCCAATGC
CGGAAGCCTTCTCTGACCTGGGCTACGCGGGGGCGTGGTTTGGGGCGCAAAAGGCCGGCTACAGCGGCGTGGCACTCCTC
AGTCTGCATCCACTCTCGGACGTGCGGGCGGGCATGGCCCATCCGGAAATGGATGCCGAAGGTCGCGTGCTGAGCGCGGT
AGTGTGGGGCGTGCGTTTTGTCAGCGTATACCTCCCAAGCGGCAGCAGCAGCCCTGAGCGCCAGAGCTTCAAAGACCGGG
TGCTGGAGGATTATCACGCCTGGACCCAGGCCGCGCTGGCAGAAGGCCTTCCGCTGGTGATCGGCGGGGACTACAACATC
GCGCACAGTGAGCTAGACCTGAAGAACTGGCGCAGCAACAGGAAAAACAGCGGCTTCCTGCCCCACGAGCGCGCGTGGAT
GAGCGCACACCTCGCCTGCGGCCTGACCGACACCCACCGGGCGCACCTGGGCGAGCGCAGCGAATATACCTGGTGGAGTC
AACGCGGCAAGGCCTATGCGAACGACGTGGGCTGGCGCATCGACTACCTGCTGGCGGCGGGCGTGCCGGTGCGCGACCTG
TGGGTGGACCGGGCGGCGCGGTTGAGTGACCACGCGCCACTCACCGGCACTGTGGACCTGGGGGGCAAAGGCAACTTCAT
GTAG

Upstream 100 bases:

>100_bases
GAAACTTGATCTCAGGCATGATACGACCAGCGTAGCCGACCCTGGGTGTACCCGACACACGAAGAGGCTGAGCGTTCCTT
GATCACGTGCCCGGCACGTT

Downstream 100 bases:

>100_bases
AAACGTGACCTGGGAACACGTGATAGACTACCGATGCTGCCGGGCAACAGGACAGCGTTTCCGCGCCGTCACCCGTCACA
AGGCGGAACGGGTGGGGCGC

Product: exodeoxyribonuclease III (xth)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MLPPMPRTVPSTLKVTTLNVNGLRSALRKGLTTWLARERPDVLLLQEVRAHPMPEAFSDLGYAGAWFGAQKAGYSGVALL
SLHPLSDVRAGMAHPEMDAEGRVLSAVVWGVRFVSVYLPSGSSSPERQSFKDRVLEDYHAWTQAALAEGLPLVIGGDYNI
AHSELDLKNWRSNRKNSGFLPHERAWMSAHLACGLTDTHRAHLGERSEYTWWSQRGKAYANDVGWRIDYLLAAGVPVRDL
WVDRAARLSDHAPLTGTVDLGGKGNFM

Sequences:

>Translated_267_residues
MLPPMPRTVPSTLKVTTLNVNGLRSALRKGLTTWLARERPDVLLLQEVRAHPMPEAFSDLGYAGAWFGAQKAGYSGVALL
SLHPLSDVRAGMAHPEMDAEGRVLSAVVWGVRFVSVYLPSGSSSPERQSFKDRVLEDYHAWTQAALAEGLPLVIGGDYNI
AHSELDLKNWRSNRKNSGFLPHERAWMSAHLACGLTDTHRAHLGERSEYTWWSQRGKAYANDVGWRIDYLLAAGVPVRDL
WVDRAARLSDHAPLTGTVDLGGKGNFM
>Mature_267_residues
MLPPMPRTVPSTLKVTTLNVNGLRSALRKGLTTWLARERPDVLLLQEVRAHPMPEAFSDLGYAGAWFGAQKAGYSGVALL
SLHPLSDVRAGMAHPEMDAEGRVLSAVVWGVRFVSVYLPSGSSSPERQSFKDRVLEDYHAWTQAALAEGLPLVIGGDYNI
AHSELDLKNWRSNRKNSGFLPHERAWMSAHLACGLTDTHRAHLGERSEYTWWSQRGKAYANDVGWRIDYLLAAGVPVRDL
WVDRAARLSDHAPLTGTVDLGGKGNFM

Specific function: Major Apurinic-Apyrimidinic Endonuclease Of E.Coli. It Removes The Damaged DNA At Cytosines And Guanines By Cleaving On The 3' Side Of The Ap Site By A Beta-Elimination Reaction. It Exhibits 3'-5'-Exonuclease, 3'-Phosphomonoesterase, 3'-Repair Diesterase

COG id: COG0708

COG function: function code L; Exonuclease III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA repair enzymes AP/ExoA family [H]

Homologues:

Organism=Homo sapiens, GI18375505, Length=268, Percent_Identity=36.5671641791045, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI18375503, Length=268, Percent_Identity=36.5671641791045, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI18375501, Length=268, Percent_Identity=36.5671641791045, Blast_Score=140, Evalue=1e-33,
Organism=Escherichia coli, GI1788046, Length=270, Percent_Identity=30.3703703703704, Blast_Score=108, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71989536, Length=258, Percent_Identity=31.7829457364341, Blast_Score=133, Evalue=9e-32,
Organism=Drosophila melanogaster, GI221330655, Length=253, Percent_Identity=33.9920948616601, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI17136678, Length=253, Percent_Identity=33.9920948616601, Blast_Score=116, Evalue=2e-26,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000097
- InterPro:   IPR020847
- InterPro:   IPR020848
- InterPro:   IPR005135
- InterPro:   IPR004808 [H]

Pfam domain/function: PF03372 Exo_endo_phos [H]

EC number: =3.1.11.2 [H]

Molecular weight: Translated: 29495; Mature: 29495

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPPMPRTVPSTLKVTTLNVNGLRSALRKGLTTWLARERPDVLLLQEVRAHPMPEAFSDL
CCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHCCCCHHHHHHC
GYAGAWFGAQKAGYSGVALLSLHPLSDVRAGMAHPEMDAEGRVLSAVVWGVRFVSVYLPS
CCCHHHCCCCCCCCCCEEEEEECCHHHHHHCCCCCCCCCCCHHHHHHHHHHHEEEEEECC
GSSSPERQSFKDRVLEDYHAWTQAALAEGLPLVIGGDYNIAHSELDLKNWRSNRKNSGFL
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCHHHHHCCCCCCCCC
PHERAWMSAHLACGLTDTHRAHLGERSEYTWWSQRGKAYANDVGWRIDYLLAAGVPVRDL
CHHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHCCCCHHHCCCCCEEEHHHCCCCHHHH
WVDRAARLSDHAPLTGTVDLGGKGNFM
HHHHHHHHCCCCCCEEEEECCCCCCCC
>Mature Secondary Structure
MLPPMPRTVPSTLKVTTLNVNGLRSALRKGLTTWLARERPDVLLLQEVRAHPMPEAFSDL
CCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHCCCCHHHHHHC
GYAGAWFGAQKAGYSGVALLSLHPLSDVRAGMAHPEMDAEGRVLSAVVWGVRFVSVYLPS
CCCHHHCCCCCCCCCCEEEEEECCHHHHHHCCCCCCCCCCCHHHHHHHHHHHEEEEEECC
GSSSPERQSFKDRVLEDYHAWTQAALAEGLPLVIGGDYNIAHSELDLKNWRSNRKNSGFL
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCHHHHHCCCCCCCCC
PHERAWMSAHLACGLTDTHRAHLGERSEYTWWSQRGKAYANDVGWRIDYLLAAGVPVRDL
CHHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHCCCCHHHCCCCCEEEHHHCCCCHHHH
WVDRAARLSDHAPLTGTVDLGGKGNFM
HHHHHHHHCCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]