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The map label for this gene is pcp [H]

Identifier: 94984549

GI number: 94984549

Start: 455263

End: 455898

Strand: Reverse

Name: pcp [H]

Synonym: Dgeo_0441

Alternate gene names: 94984549

Gene position: 455898-455263 (Counterclockwise)

Preceding gene: 94984556

Following gene: 94984539

Centisome position: 18.48

GC content: 69.03

Gene sequence:

>636_bases
ATGCCCACCCTGCTCCTGACTGGCTTCGAGCGCTTCCACACCCACCCCAGCAACCCCAGCGCCCAGGCAGCGGAGGCGCT
GAACGGGCAGGCGGTGGGGCAGGCGCACGTCGTATCCGCTCTGCTCCCAGTCGAACCACAGGCGGCAGCCGCAGCTCTGC
GCGCCCTGCTGGAGCGGCATCAACCCGATGCTGTGCTGCTCACCGGCCTCGCAGCGGGACGCCCGCAGGTGACGGTGGAG
CGGGTCGCTCTGAATGTGATGGACTTCCTGATCCCCGACAACGCCGGGCAGACCTACCGCGACCTCCCCGCCTGCACGGA
GCCGAACGCCCCCGCCGCCTACCTCAGCACGCTGCCCCTGCGCGCGGTCGTGAAGGGGTGGCACTCGGCGGGGATTCCCG
GCAGCATCAGCAACACTGCAGGCCTGTACGTCTGTAATTTCGTGCTGTATCACGCGCTGCATCAGCTTGCCCGGCTGGGC
CGCGCCCAGGTCCCCTGCGGCTTCCTGCATGTGCCCGCCAATGCGGAGCTTGCCCTTGCCGTGTCCGAAGACCAACCCCC
ACTCCCCTACCTGCCGCAGGAGGAGATCACGCGGGCGGTACGGGTGGCGGTGGAGATTGTCGGACGCAGGCTGTAG

Upstream 100 bases:

>100_bases
GCGCGTGGTTTCGACCTCGGGCAGTTCGGGCACAGAGCGAGCATACCCGCCCGGGCGGCGAAGAACTGCGCGGGGAGGCA
GCTTTCTCTATCCTCTCGCC

Downstream 100 bases:

>100_bases
CCGCCCACTCCGCTACGGAAAAGGCGCCTTGCCCGCCACCCAACCGCCCTCTGCTCCCCCCGCCCAGTACCACTCGCCCT
CCCGCGGTTTCTGTGCGAGG

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase; Pyroglutamyl-peptidase I; PGP-I; Pyrase [H]

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MPTLLLTGFERFHTHPSNPSAQAAEALNGQAVGQAHVVSALLPVEPQAAAAALRALLERHQPDAVLLTGLAAGRPQVTVE
RVALNVMDFLIPDNAGQTYRDLPACTEPNAPAAYLSTLPLRAVVKGWHSAGIPGSISNTAGLYVCNFVLYHALHQLARLG
RAQVPCGFLHVPANAELALAVSEDQPPLPYLPQEEITRAVRVAVEIVGRRL

Sequences:

>Translated_211_residues
MPTLLLTGFERFHTHPSNPSAQAAEALNGQAVGQAHVVSALLPVEPQAAAAALRALLERHQPDAVLLTGLAAGRPQVTVE
RVALNVMDFLIPDNAGQTYRDLPACTEPNAPAAYLSTLPLRAVVKGWHSAGIPGSISNTAGLYVCNFVLYHALHQLARLG
RAQVPCGFLHVPANAELALAVSEDQPPLPYLPQEEITRAVRVAVEIVGRRL
>Mature_210_residues
PTLLLTGFERFHTHPSNPSAQAAEALNGQAVGQAHVVSALLPVEPQAAAAALRALLERHQPDAVLLTGLAAGRPQVTVER
VALNVMDFLIPDNAGQTYRDLPACTEPNAPAAYLSTLPLRAVVKGWHSAGIPGSISNTAGLYVCNFVLYHALHQLARLGR
AQVPCGFLHVPANAELALAVSEDQPPLPYLPQEEITRAVRVAVEIVGRRL

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline [H]

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000816
- InterPro:   IPR016125 [H]

Pfam domain/function: PF01470 Peptidase_C15 [H]

EC number: =3.4.19.3 [H]

Molecular weight: Translated: 22443; Mature: 22312

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS01333 PYRASE_GLU ; PS01334 PYRASE_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTLLLTGFERFHTHPSNPSAQAAEALNGQAVGQAHVVSALLPVEPQAAAAALRALLERH
CCCEEEECHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHC
QPDAVLLTGLAAGRPQVTVERVALNVMDFLIPDNAGQTYRDLPACTEPNAPAAYLSTLPL
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCHHHHHHHHH
RAVVKGWHSAGIPGSISNTAGLYVCNFVLYHALHQLARLGRAQVPCGFLHVPANAELALA
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCEEEEE
VSEDQPPLPYLPQEEITRAVRVAVEIVGRRL
ECCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PTLLLTGFERFHTHPSNPSAQAAEALNGQAVGQAHVVSALLPVEPQAAAAALRALLERH
CCEEEECHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHC
QPDAVLLTGLAAGRPQVTVERVALNVMDFLIPDNAGQTYRDLPACTEPNAPAAYLSTLPL
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCHHHHHHHHH
RAVVKGWHSAGIPGSISNTAGLYVCNFVLYHALHQLARLGRAQVPCGFLHVPANAELALA
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCEEEEE
VSEDQPPLPYLPQEEITRAVRVAVEIVGRRL
ECCCCCCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]