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The map label for this gene is ctaB [H]

Identifier: 94984516

GI number: 94984516

Start: 416869

End: 417807

Strand: Reverse

Name: ctaB [H]

Synonym: Dgeo_0408

Alternate gene names: 94984516

Gene position: 417807-416869 (Counterclockwise)

Preceding gene: 94984517

Following gene: 94984515

Centisome position: 16.93

GC content: 65.6

Gene sequence:

>939_bases
ATGACGGTTGACCGCATGACGCCCCCTTCGGGTGTGGGCCACACCACCCGTCCCCTGCGGGCCACCTGGCGCGACTACCT
GGCCCTGACCAAGCCCAAGGTCATCAGCCTGCTGCTGTGGACCACCCTCACGGCGATGTTCATGGCCGCGCGCGGTTGGC
CAGGCCTCGGCCTGCTCGTCGTGGTCTCGCTCGCCGGGTACATGTCGGCGGGATCAGCGGGCGTGTTCAACATGATCATC
GACCGCGACATCGACCTCAGGATGAAGCGCACCGCAACCCGGCCCACCTCCAGCGGCCTGATCTCGACCCGCGACGCGGC
GATCTTCGGGGGCGCGCTGCAAGTCCTGTCCTTCGGGATGCTGTGGGTGTGGGCCACCCCGCTGGCGGCCTGGATGAGCC
TGGCGGGCTTTCTCACGTACGTGGTCGTGTACACGCTCTGGCTCAAGCGCAACACCTGGCACAACATTGTGCTGGGCGGT
GCCGCCGGTTGCTTCCCGCCGCTGGTGGGCTGGGCCGCCGTGACGGGCGACCTCAACCTCTTTGCCTGGTTCCTCTTTGC
CATCATCTTCTTTTGGACACCCGTTCACTTCTGGGCGCTCGCGCTGATGATCAAAGACGAATACCGTGAGGTCGGCATTC
CCATGCTGCCGGTCGTTCACGGCGACCGGTTGACCGTCGCGCAGATCGGCCTGTACGCGATCTACACCGTCGTGCTGTCG
GTGATGCCGGTCTTTCTGGGGGAAGTCGGCTGGCTCTACTTTTTGTCGGCCCTGGTCTTGGGCTGGCTGCTGCTGCAGCG
GTCCTGGGTGCTCTACCGGCACGTGATGGCCGGCAACAAGGTCGAGCGCAAGGTGGCAGTGCCGCTCTACCTGTACTCGA
TGCTGTACCTGGCGCTGCTGTTCGTCGCCGGCGCGGTCGACCGGGTGTTGCTGGGGTAG

Upstream 100 bases:

>100_bases
TGCTGGCGTGCATCATGTGGCTGGTGATGGTTTTGCTCAGCTACGAGGCGCTCACAGCGCTGCGCCGTGTTCCCCAACCA
GCACGCCAACCGGTGGCAGT

Downstream 100 bases:

>100_bases
CGGGTCAAGCACAAGCTCCTGCGGGCGGTCCGACGTGGCCGCCTTTCTTTGCTTACTTGTGCTGGCGGCTGGCCGCTCTC
CCGTTGCCCCAGTTGACCAA

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MTVDRMTPPSGVGHTTRPLRATWRDYLALTKPKVISLLLWTTLTAMFMAARGWPGLGLLVVVSLAGYMSAGSAGVFNMII
DRDIDLRMKRTATRPTSSGLISTRDAAIFGGALQVLSFGMLWVWATPLAAWMSLAGFLTYVVVYTLWLKRNTWHNIVLGG
AAGCFPPLVGWAAVTGDLNLFAWFLFAIIFFWTPVHFWALALMIKDEYREVGIPMLPVVHGDRLTVAQIGLYAIYTVVLS
VMPVFLGEVGWLYFLSALVLGWLLLQRSWVLYRHVMAGNKVERKVAVPLYLYSMLYLALLFVAGAVDRVLLG

Sequences:

>Translated_312_residues
MTVDRMTPPSGVGHTTRPLRATWRDYLALTKPKVISLLLWTTLTAMFMAARGWPGLGLLVVVSLAGYMSAGSAGVFNMII
DRDIDLRMKRTATRPTSSGLISTRDAAIFGGALQVLSFGMLWVWATPLAAWMSLAGFLTYVVVYTLWLKRNTWHNIVLGG
AAGCFPPLVGWAAVTGDLNLFAWFLFAIIFFWTPVHFWALALMIKDEYREVGIPMLPVVHGDRLTVAQIGLYAIYTVVLS
VMPVFLGEVGWLYFLSALVLGWLLLQRSWVLYRHVMAGNKVERKVAVPLYLYSMLYLALLFVAGAVDRVLLG
>Mature_311_residues
TVDRMTPPSGVGHTTRPLRATWRDYLALTKPKVISLLLWTTLTAMFMAARGWPGLGLLVVVSLAGYMSAGSAGVFNMIID
RDIDLRMKRTATRPTSSGLISTRDAAIFGGALQVLSFGMLWVWATPLAAWMSLAGFLTYVVVYTLWLKRNTWHNIVLGGA
AGCFPPLVGWAAVTGDLNLFAWFLFAIIFFWTPVHFWALALMIKDEYREVGIPMLPVVHGDRLTVAQIGLYAIYTVVLSV
MPVFLGEVGWLYFLSALVLGWLLLQRSWVLYRHVMAGNKVERKVAVPLYLYSMLYLALLFVAGAVDRVLLG

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=195, Percent_Identity=31.2820512820513, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1786631, Length=235, Percent_Identity=34.468085106383, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1790473, Length=269, Percent_Identity=28.6245353159851, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71998235, Length=270, Percent_Identity=28.8888888888889, Blast_Score=84, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6325085, Length=241, Percent_Identity=27.8008298755187, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19921064, Length=282, Percent_Identity=25.531914893617, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 34681; Mature: 34550

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVDRMTPPSGVGHTTRPLRATWRDYLALTKPKVISLLLWTTLTAMFMAARGWPGLGLLV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
VVSLAGYMSAGSAGVFNMIIDRDIDLRMKRTATRPTSSGLISTRDAAIFGGALQVLSFGM
HHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LWVWATPLAAWMSLAGFLTYVVVYTLWLKRNTWHNIVLGGAAGCFPPLVGWAAVTGDLNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHCCHHH
FAWFLFAIIFFWTPVHFWALALMIKDEYREVGIPMLPVVHGDRLTVAQIGLYAIYTVVLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
VMPVFLGEVGWLYFLSALVLGWLLLQRSWVLYRHVMAGNKVERKVAVPLYLYSMLYLALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
FVAGAVDRVLLG
HHHHHHHHHHCC
>Mature Secondary Structure 
TVDRMTPPSGVGHTTRPLRATWRDYLALTKPKVISLLLWTTLTAMFMAARGWPGLGLLV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHH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HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA