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The map label for this gene is hofD [H]

Identifier: 94984482

GI number: 94984482

Start: 378749

End: 379891

Strand: Reverse

Name: hofD [H]

Synonym: Dgeo_0374

Alternate gene names: 94984482

Gene position: 379891-378749 (Counterclockwise)

Preceding gene: 94984483

Following gene: 94984476

Centisome position: 15.4

GC content: 67.63

Gene sequence:

>1143_bases
GTGAGCCTTGACGTTCTGCTCGTGGTCTTCGCCGGCGTGTTTGGGTTGCTGGTGGGGTCGTTTTCGAACGTGCTGATCCA
TCGCCTGCCCCGGGGGGAAAACATTGCTTTTCCGCCCAGCCACTGCCCGCAGTGTAACCATCGCCTCGCGCCGCGCGATC
TGGTGCCGGTGGGCTCGTGGCTGAGCCTGGGGGGCAGATGCCGGTACTGCCGGGCGCCGATCCGAGTGCGCTATCCGGTG
GTCGAAGGGCTGACTGGCTTGGGCTACGCGCTCATCGCTGCGCTGTTTCCCCTCACCACATTCGGGGCAGGCACCCTGGG
CCTGATGCTGCTGTTCACACTGCTGCTGGTGGCGAGTGTGATCGATCTGGACACCTTCACCATTCCCGACGAATTGACGC
TGCCGGGGGTGGCCCTGGGGTTGGCCTTCGCAGGGTGGAACACCCGCGCGGGGGCCGTGGCGGCGGGGCTCCCCACCCTG
GCCGGCGCTCTGCAGGGCGCATTGCTGGGCGCGGGGCTGCTGGTGACCATCGATCTGCTGGGCTCCTGGGTGCTGCGGCG
CTTTCGGGAGCGGCAGTATCCAGAACGACCCATCGGCTACCAGCAGATCAGTCTCGGCCTGCTGGTGGGGGCGTGGCTGG
GGCCGTGGTGGGGGCTGGGGGCGGCCTTGCTGTCGGCTGCTGTGAATGTGGCTGCCCGCCGGGTGGTTCGTATTCCCGAG
TTGCTCACCCTGGGTGGCTTTCTCGTCAGCGTGGCGCTCGGCAGCGCGGGCTTCGGCCCCGGCCTGATTCTGATGGTGCA
GGGGGCGCTGGCCGCAGCAGGCGCAGCGGCGCTGAGCGCAGGGGTCTACTGGTGGCTGCGCCGCGAACCCCTGGCGGAAG
AAGACGCGCCCTTCGACCCTTCTGCGATGGGTTTTGGGGATGTGAAGCTGGCCGCCGTGATCGGGGCCTTCCTGGGCTGG
GAACGGCTGCTGGTCGCCGTTGTGGTGGCGGTGTTTGCGGGCGCGCTGCTCGGCCTCTTACAGGTTGCCCTCAGACGCGA
GAACCGGGTGAAGTTTGGACCATACTTGGCGCTGGGCGCGGTTGTGGCATTGTTCTGGGGCGGGGAGATCGTGGCAACCT
ACCGGGGCATATTGGGCCTCTAA

Upstream 100 bases:

>100_bases
AACGTGCCCTTGCTGGGTCACTTCGGAAAACACTGAGGGGCAACACGGTTCCAGGGGGCGCGCAAGCTCCCTGTCAGAAC
GAACGGCCTAGACTCTGCGG

Downstream 100 bases:

>100_bases
CGCGGTCAGGTCTCCCTGTCTTCCGGCTTCGCCACCACCAGCACCCGTTGCTCCTGTCGCAGTCCATTCAGGCACACCTG
CGCCGTCGCCGTGACCTCCA

Product: peptidase A24A-like protein

Products: NA

Alternate protein names: Leader peptidase; Prepilin peptidase; N-methyltransferase [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MSLDVLLVVFAGVFGLLVGSFSNVLIHRLPRGENIAFPPSHCPQCNHRLAPRDLVPVGSWLSLGGRCRYCRAPIRVRYPV
VEGLTGLGYALIAALFPLTTFGAGTLGLMLLFTLLLVASVIDLDTFTIPDELTLPGVALGLAFAGWNTRAGAVAAGLPTL
AGALQGALLGAGLLVTIDLLGSWVLRRFRERQYPERPIGYQQISLGLLVGAWLGPWWGLGAALLSAAVNVAARRVVRIPE
LLTLGGFLVSVALGSAGFGPGLILMVQGALAAAGAAALSAGVYWWLRREPLAEEDAPFDPSAMGFGDVKLAAVIGAFLGW
ERLLVAVVVAVFAGALLGLLQVALRRENRVKFGPYLALGAVVALFWGGEIVATYRGILGL

Sequences:

>Translated_380_residues
MSLDVLLVVFAGVFGLLVGSFSNVLIHRLPRGENIAFPPSHCPQCNHRLAPRDLVPVGSWLSLGGRCRYCRAPIRVRYPV
VEGLTGLGYALIAALFPLTTFGAGTLGLMLLFTLLLVASVIDLDTFTIPDELTLPGVALGLAFAGWNTRAGAVAAGLPTL
AGALQGALLGAGLLVTIDLLGSWVLRRFRERQYPERPIGYQQISLGLLVGAWLGPWWGLGAALLSAAVNVAARRVVRIPE
LLTLGGFLVSVALGSAGFGPGLILMVQGALAAAGAAALSAGVYWWLRREPLAEEDAPFDPSAMGFGDVKLAAVIGAFLGW
ERLLVAVVVAVFAGALLGLLQVALRRENRVKFGPYLALGAVVALFWGGEIVATYRGILGL
>Mature_379_residues
SLDVLLVVFAGVFGLLVGSFSNVLIHRLPRGENIAFPPSHCPQCNHRLAPRDLVPVGSWLSLGGRCRYCRAPIRVRYPVV
EGLTGLGYALIAALFPLTTFGAGTLGLMLLFTLLLVASVIDLDTFTIPDELTLPGVALGLAFAGWNTRAGAVAAGLPTLA
GALQGALLGAGLLVTIDLLGSWVLRRFRERQYPERPIGYQQISLGLLVGAWLGPWWGLGAALLSAAVNVAARRVVRIPEL
LTLGGFLVSVALGSAGFGPGLILMVQGALAAAGAAALSAGVYWWLRREPLAEEDAPFDPSAMGFGDVKLAAVIGAFLGWE
RLLVAVVVAVFAGALLGLLQVALRRENRVKFGPYLALGAVVALFWGGEIVATYRGILGL

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue [H]

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family [H]

Homologues:

Organism=Escherichia coli, GI87082194, Length=197, Percent_Identity=37.5634517766497, Blast_Score=97, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010627
- InterPro:   IPR014032
- InterPro:   IPR000045 [H]

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24 [H]

EC number: =3.4.23.43 [H]

Molecular weight: Translated: 39906; Mature: 39775

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDVLLVVFAGVFGLLVGSFSNVLIHRLPRGENIAFPPSHCPQCNHRLAPRDLVPVGSW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
LSLGGRCRYCRAPIRVRYPVVEGLTGLGYALIAALFPLTTFGAGTLGLMLLFTLLLVASV
HHCCCCCEEECCCCEEECHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
IDLDTFTIPDELTLPGVALGLAFAGWNTRAGAVAAGLPTLAGALQGALLGAGLLVTIDLL
HHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSWVLRRFRERQYPERPIGYQQISLGLLVGAWLGPWWGLGAALLSAAVNVAARRVVRIPE
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLTLGGFLVSVALGSAGFGPGLILMVQGALAAAGAAALSAGVYWWLRREPLAEEDAPFDP
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
SAMGFGDVKLAAVIGAFLGWERLLVAVVVAVFAGALLGLLQVALRRENRVKFGPYLALGA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
VVALFWGGEIVATYRGILGL
HHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure 
SLDVLLVVFAGVFGLLVGSFSNVLIHRLPRGENIAFPPSHCPQCNHRLAPRDLVPVGSW
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
LSLGGRCRYCRAPIRVRYPVVEGLTGLGYALIAALFPLTTFGAGTLGLMLLFTLLLVASV
HHCCCCCEEECCCCEEECHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
IDLDTFTIPDELTLPGVALGLAFAGWNTRAGAVAAGLPTLAGALQGALLGAGLLVTIDLL
HHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSWVLRRFRERQYPERPIGYQQISLGLLVGAWLGPWWGLGAALLSAAVNVAARRVVRIPE
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLTLGGFLVSVALGSAGFGPGLILMVQGALAAAGAAALSAGVYWWLRREPLAEEDAPFDP
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
SAMGFGDVKLAAVIGAFLGWERLLVAVVVAVFAGALLGLLQVALRRENRVKFGPYLALGA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
VVALFWGGEIVATYRGILGL
HHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]