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The map label for this gene is purE [H]

Identifier: 94984190

GI number: 94984190

Start: 77080

End: 77613

Strand: Reverse

Name: purE [H]

Synonym: Dgeo_0082

Alternate gene names: 94984190

Gene position: 77613-77080 (Counterclockwise)

Preceding gene: 94984193

Following gene: 94984189

Centisome position: 3.15

GC content: 70.97

Gene sequence:

>534_bases
ATGCGGGCCGTGACGGAAGGACAGGGGACGCCCCGTGTGGGTGTGGTGATGGGCAGCCGCAGCGATTTCGAGACGATGGG
GAGCGCACTCGACGTGTTGCGCGATCTGGGCATCCCCTACGAGGTACGGGTGCTCTCGGCGCACCGCACGCCGCATCTGC
TGGCCCGCTACGCGGCACGGGCCGAGCGGCTGAATCTGAGCTGCCTCATCGCGGGCGCGGGCGGCGCGGCGCACCTGCCG
GGCATGCTCGCGGCCTTCACGCGCCTGCCGGTGCTGGGGGTGCCCGTCCAGTCCCGCGCCCTCTCAGGCCAAGACAGCCT
CCTGAGCATCGTGCAGATGCCCGCTGGAGTCCCGGTGGCCACCTTCGCCATCGGTTCGGCAGGTGCGAAAAACGCGGCAC
TCTTCGCCGCCGCCCTGCTCGCCACCACTGACCCGACCGTGCGTGACCGGCTGAACGCCTTCCGCGCAGCGCAGACCCAG
GCCGTGCTGGACGACCCCTTCTTCGAGGGCCACCCGGCAGCGGAGGCAGAATGA

Upstream 100 bases:

>100_bases
GTCGTAATCGGGGGCGGCGCTCATGGGCTGAGGGTAGCGCAGGCAAACCAGATCGGGGTGCTCGCCGCGTTCCAGCAACC
GCTGCGCGATTTGCCTTAGG

Downstream 100 bases:

>100_bases
CGTCCGGCGCCCCCCCCACCCTCGGCATCCTGGGCGGCGGCCAGCTCGCGCAGATGCTCGCCCTCGCGGCTCTGCCGCTG
GGCGTGAGGGCCGTGGTGCT

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 177; Mature: 177

Protein sequence:

>177_residues
MRAVTEGQGTPRVGVVMGSRSDFETMGSALDVLRDLGIPYEVRVLSAHRTPHLLARYAARAERLNLSCLIAGAGGAAHLP
GMLAAFTRLPVLGVPVQSRALSGQDSLLSIVQMPAGVPVATFAIGSAGAKNAALFAAALLATTDPTVRDRLNAFRAAQTQ
AVLDDPFFEGHPAAEAE

Sequences:

>Translated_177_residues
MRAVTEGQGTPRVGVVMGSRSDFETMGSALDVLRDLGIPYEVRVLSAHRTPHLLARYAARAERLNLSCLIAGAGGAAHLP
GMLAAFTRLPVLGVPVQSRALSGQDSLLSIVQMPAGVPVATFAIGSAGAKNAALFAAALLATTDPTVRDRLNAFRAAQTQ
AVLDDPFFEGHPAAEAE
>Mature_177_residues
MRAVTEGQGTPRVGVVMGSRSDFETMGSALDVLRDLGIPYEVRVLSAHRTPHLLARYAARAERLNLSCLIAGAGGAAHLP
GMLAAFTRLPVLGVPVQSRALSGQDSLLSIVQMPAGVPVATFAIGSAGAKNAALFAAALLATTDPTVRDRLNAFRAAQTQ
AVLDDPFFEGHPAAEAE

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=155, Percent_Identity=60, Blast_Score=151, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324702, Length=158, Percent_Identity=51.8987341772152, Blast_Score=157, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 18386; Mature: 18386

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVTEGQGTPRVGVVMGSRSDFETMGSALDVLRDLGIPYEVRVLSAHRTPHLLARYAAR
CCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHH
AERLNLSCLIAGAGGAAHLPGMLAAFTRLPVLGVPVQSRALSGQDSLLSIVQMPAGVPVA
HHHCCEEEEEECCCCCHHHHHHHHHHHHCCEECCCHHHHHCCCHHHHHHHHHCCCCCCEE
TFAIGSAGAKNAALFAAALLATTDPTVRDRLNAFRAAQTQAVLDDPFFEGHPAAEAE
EEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MRAVTEGQGTPRVGVVMGSRSDFETMGSALDVLRDLGIPYEVRVLSAHRTPHLLARYAAR
CCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHH
AERLNLSCLIAGAGGAAHLPGMLAAFTRLPVLGVPVQSRALSGQDSLLSIVQMPAGVPVA
HHHCCEEEEEECCCCCHHHHHHHHHHHHCCEECCCHHHHHCCCHHHHHHHHHCCCCCCEE
TFAIGSAGAKNAALFAAALLATTDPTVRDRLNAFRAAQTQAVLDDPFFEGHPAAEAE
EEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8816818; 10984043 [H]