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The map label for this gene is purK [H]

Identifier: 94984189

GI number: 94984189

Start: 75968

End: 77083

Strand: Reverse

Name: purK [H]

Synonym: Dgeo_0081

Alternate gene names: 94984189

Gene position: 77083-75968 (Counterclockwise)

Preceding gene: 94984190

Following gene: 94984188

Centisome position: 3.12

GC content: 72.13

Gene sequence:

>1116_bases
ATGACGTCCGGCGCCCCCCCCACCCTCGGCATCCTGGGCGGCGGCCAGCTCGCGCAGATGCTCGCCCTCGCGGCTCTGCC
GCTGGGCGTGAGGGCCGTGGTGCTGGAACCCGACCCGCAGGCCCCTGCGCGGCTGTGTGCCGAACACCTCCAGGCCCCCT
ACACCGACCCCGCCGGGCTGGCCCGCCTCGCCGCATGCACCGCCGTGACTCTGGAATTCGAGAACGTGCCGGTGGAGGCC
CTGGACGCGCTCGAGAGCCGAGTGCCGGTGCGGCCAGGCGGGGCGCTCCTCGCCCGCAGCAAACACCGGGCCCGCGAGAA
GGAAGCCCTGCGGGCAGCGGGCGCACAAACCGCCCCCTTCCTTCCCATCGAGCGCGAGGCGGACCTGACGGGTGCGCTGA
CCGCGGTGGGCGGGCAAGGCCTCCTCAAGACCAGCGAACTGGGCTATGACGGCAAAGGCCAGCGGCGCGTGAACAGCGAG
GCGGAGCTGCGCGACGCTTGGATCGCCCTAGGCCGCGTGTCCTGTGTGCTGGAAGGGTTGGTTCCCTTCGAGCGCGAGGT
GAGCCTGGCGGTGGCGCGCAGTGCCGAGGGTGAGGTGGCCTTTGGGCCGCTGGTCGAGAACACGCATCGGCAGGGCATCC
TCCGCACCAGTGTGTTTCCCGCCGCCGCCCCCGAGGGAACGGAGGCCCGCGCCCGTGAGGTGGCCCGCGCCGTTGCAGAA
GCCTGGGAGCTAGCAGGGCTGCTGACGCTGGAGTTTTTTCAGTTGCCCGGCGGCGCGCTGCTGGTGAACGAGGTCGCGCC
ACGAGTCCACAACAGCGGCCACCTCACGCAAGATGGCGGGGGCCTCAGCCAGTTCGAGGCGCAGGTGCGCGCGGTCCTGG
GCCTGCCGCTGCGCGACTGGGCGCCGCTGCACCCCACCGCGATGGTGAACATCGTCGGCACGGCAGACGGCCAGCAGCCC
GACTGGGCCGGAATCGACGCACTGCCCGGCTCCCGGCTGCACCTCTACCACAAAGCGCCACGCCCTGGGCGCAAGCTGGG
GCACGTCAACCTCGTCGCGCCGGACCTGGAAACGCTGCGGGCGCGGCTGGACCAACTGGAGGTGCTGGTGCCCTGA

Upstream 100 bases:

>100_bases
ACCCGACCGTGCGTGACCGGCTGAACGCCTTCCGCGCAGCGCAGACCCAGGCCGTGCTGGACGACCCCTTCTTCGAGGGC
CACCCGGCAGCGGAGGCAGA

Downstream 100 bases:

>100_bases
GGGTGCGCCCCGCATGACAGTCCCGCATTACAGTGCTGCCATGCCCACCCTCCCCGACGTTCCCACCGAGGTCCGCACGC
CTCGCCTCCTCCTGCGAGCG

Product: phosphoribosylaminoimidazole carboxylase, ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MTSGAPPTLGILGGGQLAQMLALAALPLGVRAVVLEPDPQAPARLCAEHLQAPYTDPAGLARLAACTAVTLEFENVPVEA
LDALESRVPVRPGGALLARSKHRAREKEALRAAGAQTAPFLPIEREADLTGALTAVGGQGLLKTSELGYDGKGQRRVNSE
AELRDAWIALGRVSCVLEGLVPFEREVSLAVARSAEGEVAFGPLVENTHRQGILRTSVFPAAAPEGTEARAREVARAVAE
AWELAGLLTLEFFQLPGGALLVNEVAPRVHNSGHLTQDGGGLSQFEAQVRAVLGLPLRDWAPLHPTAMVNIVGTADGQQP
DWAGIDALPGSRLHLYHKAPRPGRKLGHVNLVAPDLETLRARLDQLEVLVP

Sequences:

>Translated_371_residues
MTSGAPPTLGILGGGQLAQMLALAALPLGVRAVVLEPDPQAPARLCAEHLQAPYTDPAGLARLAACTAVTLEFENVPVEA
LDALESRVPVRPGGALLARSKHRAREKEALRAAGAQTAPFLPIEREADLTGALTAVGGQGLLKTSELGYDGKGQRRVNSE
AELRDAWIALGRVSCVLEGLVPFEREVSLAVARSAEGEVAFGPLVENTHRQGILRTSVFPAAAPEGTEARAREVARAVAE
AWELAGLLTLEFFQLPGGALLVNEVAPRVHNSGHLTQDGGGLSQFEAQVRAVLGLPLRDWAPLHPTAMVNIVGTADGQQP
DWAGIDALPGSRLHLYHKAPRPGRKLGHVNLVAPDLETLRARLDQLEVLVP
>Mature_370_residues
TSGAPPTLGILGGGQLAQMLALAALPLGVRAVVLEPDPQAPARLCAEHLQAPYTDPAGLARLAACTAVTLEFENVPVEAL
DALESRVPVRPGGALLARSKHRAREKEALRAAGAQTAPFLPIEREADLTGALTAVGGQGLLKTSELGYDGKGQRRVNSEA
ELRDAWIALGRVSCVLEGLVPFEREVSLAVARSAEGEVAFGPLVENTHRQGILRTSVFPAAAPEGTEARAREVARAVAEA
WELAGLLTLEFFQLPGGALLVNEVAPRVHNSGHLTQDGGGLSQFEAQVRAVLGLPLRDWAPLHPTAMVNIVGTADGQQPD
WAGIDALPGSRLHLYHKAPRPGRKLGHVNLVAPDLETLRARLDQLEVLVP

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=361, Percent_Identity=34.3490304709141, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1788155, Length=358, Percent_Identity=27.3743016759777, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324702, Length=376, Percent_Identity=31.3829787234043, Blast_Score=192, Evalue=5e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 39135; Mature: 39004

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSGAPPTLGILGGGQLAQMLALAALPLGVRAVVLEPDPQAPARLCAEHLQAPYTDPAGL
CCCCCCCCEEEECCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCHHHH
ARLAACTAVTLEFENVPVEALDALESRVPVRPGGALLARSKHRAREKEALRAAGAQTAPF
HHHHHHHEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
LPIEREADLTGALTAVGGQGLLKTSELGYDGKGQRRVNSEAELRDAWIALGRVSCVLEGL
CCCCCCCCCCHHHHHCCCCCCEEHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
VPFEREVSLAVARSAEGEVAFGPLVENTHRQGILRTSVFPAAAPEGTEARAREVARAVAE
CCCCHHHHHHEEECCCCCEEECCHHHCHHHCCEEHHCCCCCCCCCCCHHHHHHHHHHHHH
AWELAGLLTLEFFQLPGGALLVNEVAPRVHNSGHLTQDGGGLSQFEAQVRAVLGLPLRDW
HHHHHHHHHHHHHHCCCCEEEHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHCCCCCCC
APLHPTAMVNIVGTADGQQPDWAGIDALPGSRLHLYHKAPRPGRKLGHVNLVAPDLETLR
CCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEECCCHHHHH
ARLDQLEVLVP
HHHHHHHCCCC
>Mature Secondary Structure 
TSGAPPTLGILGGGQLAQMLALAALPLGVRAVVLEPDPQAPARLCAEHLQAPYTDPAGL
CCCCCCCEEEECCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCHHHH
ARLAACTAVTLEFENVPVEALDALESRVPVRPGGALLARSKHRAREKEALRAAGAQTAPF
HHHHHHHEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
LPIEREADLTGALTAVGGQGLLKTSELGYDGKGQRRVNSEAELRDAWIALGRVSCVLEGL
CCCCCCCCCCHHHHHCCCCCCEEHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
VPFEREVSLAVARSAEGEVAFGPLVENTHRQGILRTSVFPAAAPEGTEARAREVARAVAE
CCCCHHHHHHEEECCCCCEEECCHHHCHHHCCEEHHCCCCCCCCCCCHHHHHHHHHHHHH
AWELAGLLTLEFFQLPGGALLVNEVAPRVHNSGHLTQDGGGLSQFEAQVRAVLGLPLRDW
HHHHHHHHHHHHHHCCCCEEEHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHCCCCCCC
APLHPTAMVNIVGTADGQQPDWAGIDALPGSRLHLYHKAPRPGRKLGHVNLVAPDLETLR
CCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEECCCHHHHH
ARLDQLEVLVP
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8816818; 10984043 [H]