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The map label for this gene is strD [H]

Identifier: 94972110

GI number: 94972110

Start: 398190

End: 399254

Strand: Direct

Name: strD [H]

Synonym: Dgeo_2643

Alternate gene names: 94972110

Gene position: 398190-399254 (Clockwise)

Preceding gene: 94972112

Following gene: 94972109

Centisome position: 69.36

GC content: 62.91

Gene sequence:

>1065_bases
ATGAAAGCGATCATCCCCGCCGCCGGATTCGGCACACGGCTGCGGCCCCTGACCTATGCCCGGCCCAAACCTGTATTGCC
CGTCGCCAACAAACCGATTATCTGTCACGCGGTTCAAAATTTGGCTGCCGCCGGCATCAGGGAGATCGCCATCATTGTCT
CCAGCGTCACCCGCAAGGCCATCGAGGGGGCAGTGAGCGATCTGGAAGGCGTTCAGATCGCGTACATCGAGCAGCCAGAG
ATGCTCGGCCTAGGCGACGCCGTCAGATGGGCCCGTGACTGGGTCGGCGAGAGTGACTTCTGCGTGTACCTGGGGGACAA
TCTTTTCGAGCATGGCGTAACCAGCTTCTTGGACGCCTTCCGCAGCCGGCCGGTAGACGCGGTCCTCGCGCTCGTTGAGG
TGCCGGATGCCCGCGCCTTTGGTGTGGCCGTTCTTGACGACCAGGACCGCATCACGCAACTGTTTGAAAAGCCCAAGTGC
CCTCCAAGCAATCTTGCTGTGGCCGGGGTGTACTGCTTCAAAGCTTCGCTGTTCGGCATCCTTGAGGCGTTGCCTCCCAG
TGCGCGCGGCGAGTATGAGATCACCGACGCCATTCAGCGGTTGATCGAGGACGGCGGACAGGTGATTGGCCAGCGTGTGG
TGGGCTGGTGGAAAGACACCGGGCGCCCCCTTGACCTGATCGAGACCAACCGCCTGCTGCTCGAACGGCTCGAACCCTGT
GTGCTGGGTGAGGTGACCGGCTCGCGCCTGGCAGGGCGGGTTGTGGTTGAGCCGGGGGCCGAGGTGCACGGCAGTGTGAT
CATGGGACCCGTGACCATCGCCAGCGGTGCCCGCATCGAGAACGCCTACCTGGGTCCTTTTACCAGCGTGGGGCGCGGCA
GCGTGATTCGCAACGCCGAGGTCGAGTACAGCGTGATTGACGAGGAGGCCGAAATCTGCGACGTGAATGTGCGGCTTCAG
GAATGCCTGATCGGGCTGCGCGCCCGCATTGTCGGGCACGGCGAGGTACCCAAGGTCCACCGCTTGATTCTGTCCGATAC
CAGTGTCCTGGAATTCGGCTGCTGA

Upstream 100 bases:

>100_bases
GTGCGGACGGCAGAGACCGAACATTCTTCTGAAGAGAAAGGCGGAAGTGAATGTCCCTGATCCTCTCGACGCCCTCCATC
ACCCTGCCAGGTGTCCCGGC

Downstream 100 bases:

>100_bases
CGGGCGGCCCCGCTGCCCCGCGCTCCTTGAGAAGACCAGCCAGGTAAGACCAGCAAGAAAGGTAGCCACCACATGACCTA
CAGCGCTTCCTCCCGCACCG

Product: glucose-1-phosphate thymidyltransferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MKAIIPAAGFGTRLRPLTYARPKPVLPVANKPIICHAVQNLAAAGIREIAIIVSSVTRKAIEGAVSDLEGVQIAYIEQPE
MLGLGDAVRWARDWVGESDFCVYLGDNLFEHGVTSFLDAFRSRPVDAVLALVEVPDARAFGVAVLDDQDRITQLFEKPKC
PPSNLAVAGVYCFKASLFGILEALPPSARGEYEITDAIQRLIEDGGQVIGQRVVGWWKDTGRPLDLIETNRLLLERLEPC
VLGEVTGSRLAGRVVVEPGAEVHGSVIMGPVTIASGARIENAYLGPFTSVGRGSVIRNAEVEYSVIDEEAEICDVNVRLQ
ECLIGLRARIVGHGEVPKVHRLILSDTSVLEFGC

Sequences:

>Translated_354_residues
MKAIIPAAGFGTRLRPLTYARPKPVLPVANKPIICHAVQNLAAAGIREIAIIVSSVTRKAIEGAVSDLEGVQIAYIEQPE
MLGLGDAVRWARDWVGESDFCVYLGDNLFEHGVTSFLDAFRSRPVDAVLALVEVPDARAFGVAVLDDQDRITQLFEKPKC
PPSNLAVAGVYCFKASLFGILEALPPSARGEYEITDAIQRLIEDGGQVIGQRVVGWWKDTGRPLDLIETNRLLLERLEPC
VLGEVTGSRLAGRVVVEPGAEVHGSVIMGPVTIASGARIENAYLGPFTSVGRGSVIRNAEVEYSVIDEEAEICDVNVRLQ
ECLIGLRARIVGHGEVPKVHRLILSDTSVLEFGC
>Mature_354_residues
MKAIIPAAGFGTRLRPLTYARPKPVLPVANKPIICHAVQNLAAAGIREIAIIVSSVTRKAIEGAVSDLEGVQIAYIEQPE
MLGLGDAVRWARDWVGESDFCVYLGDNLFEHGVTSFLDAFRSRPVDAVLALVEVPDARAFGVAVLDDQDRITQLFEKPKC
PPSNLAVAGVYCFKASLFGILEALPPSARGEYEITDAIQRLIEDGGQVIGQRVVGWWKDTGRPLDLIETNRLLLERLEPC
VLGEVTGSRLAGRVVVEPGAEVHGSVIMGPVTIASGARIENAYLGPFTSVGRGSVIRNAEVEYSVIDEEAEICDVNVRLQ
ECLIGLRARIVGHGEVPKVHRLILSDTSVLEFGC

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=343, Percent_Identity=28.8629737609329, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI11761619, Length=343, Percent_Identity=28.8629737609329, Blast_Score=122, Evalue=3e-28,
Organism=Escherichia coli, GI1790224, Length=237, Percent_Identity=36.2869198312236, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1788351, Length=236, Percent_Identity=34.3220338983051, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1787488, Length=268, Percent_Identity=30.2238805970149, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788355, Length=243, Percent_Identity=30.0411522633745, Blast_Score=86, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI133931050, Length=312, Percent_Identity=27.5641025641026, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17509979, Length=338, Percent_Identity=26.0355029585799, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17509981, Length=337, Percent_Identity=25.8160237388724, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320148, Length=321, Percent_Identity=27.4143302180685, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21355443, Length=306, Percent_Identity=27.7777777777778, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24644084, Length=306, Percent_Identity=27.7777777777778, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24653912, Length=387, Percent_Identity=25.0645994832041, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 38271; Mature: 38271

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIIPAAGFGTRLRPLTYARPKPVLPVANKPIICHAVQNLAAAGIREIAIIVSSVTRKA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEGAVSDLEGVQIAYIEQPEMLGLGDAVRWARDWVGESDFCVYLGDNLFEHGVTSFLDAF
HHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHH
RSRPVDAVLALVEVPDARAFGVAVLDDQDRITQLFEKPKCPPSNLAVAGVYCFKASLFGI
HCCCHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHH
LEALPPSARGEYEITDAIQRLIEDGGQVIGQRVVGWWKDTGRPLDLIETNRLLLERLEPC
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC
VLGEVTGSRLAGRVVVEPGAEVHGSVIMGPVTIASGARIENAYLGPFTSVGRGSVIRNAE
EEECCCCCHHCCEEEECCCCCCCCCEEEECEEECCCCEECCCCCCCCCCCCCCCEEECCC
VEYSVIDEEAEICDVNVRLQECLIGLRARIVGHGEVPKVHRLILSDTSVLEFGC
CEEEEECCCCCEEEECHHHHHHHHHHHHHEECCCCCCHHHHHHHCCCCCEECCC
>Mature Secondary Structure
MKAIIPAAGFGTRLRPLTYARPKPVLPVANKPIICHAVQNLAAAGIREIAIIVSSVTRKA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEGAVSDLEGVQIAYIEQPEMLGLGDAVRWARDWVGESDFCVYLGDNLFEHGVTSFLDAF
HHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHH
RSRPVDAVLALVEVPDARAFGVAVLDDQDRITQLFEKPKCPPSNLAVAGVYCFKASLFGI
HCCCHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHH
LEALPPSARGEYEITDAIQRLIEDGGQVIGQRVVGWWKDTGRPLDLIETNRLLLERLEPC
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC
VLGEVTGSRLAGRVVVEPGAEVHGSVIMGPVTIASGARIENAYLGPFTSVGRGSVIRNAE
EEECCCCCHHCCEEEECCCCCCCCCEEEECEEECCCCEECCCCCCCCCCCCCCCEEECCC
VEYSVIDEEAEICDVNVRLQECLIGLRARIVGHGEVPKVHRLILSDTSVLEFGC
CEEEEECCCCCEEEECHHHHHHHHHHHHHEECCCCCCHHHHHHHCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]