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The map label for this gene is mug [H]

Identifier: 94972036

GI number: 94972036

Start: 485135

End: 485668

Strand: Direct

Name: mug [H]

Synonym: Dgeo_2568

Alternate gene names: 94972036

Gene position: 485135-485668 (Clockwise)

Preceding gene: 94972037

Following gene: 94972034

Centisome position: 84.5

GC content: 70.79

Gene sequence:

>534_bases
ATGACACGGGACACAGCGGGTGCCCCCGTGCTCCAGGACCTGGTGGCCGAAGGCGTGCAGGTGCTGTTCGTAGGCTTCAA
CCCCAGCCCACGCTCGGTGCAGCAGGGGCACCACTACGCCGGGCGCGGCAACCAGTTCTGGCGGCTGCTGGCGGCTTCGG
GCCTCACGCCCCGGCTGCTGCGGCCCGAGGAAGACCACCTGCTGCCCCGCTGGGGCCTGGGATCCACCAACCTGGTGGCG
CGCCCGACCGTCAGCGCCGCCGAACTGAGCCGTTCGGAACTCCGCGCGGGTGTCCCGCACCTGCGCCGTCTCGTGGCGAG
GTACCAGGTTCCCCTCGTCGCCTACACCGGGAAGGGGGTGTACCTCGCCGCGACGGGAAAACAGCAAGCCCACTGGGGCG
CCCAGGAGGACAGCTTGATTGGGGGAGTGACGGACTTCGTGCTGCCGTCGCCGAGCGGTCTGGCGCGGCTGCCGTTCGCG
GAGAAGCTCGGGTACTACCGTGCGCTGGCGGAACTGGCCCAGCAGCCAGGGTGA

Upstream 100 bases:

>100_bases
GGGGTGGGTCCGGACCAGGCGCGCCGCCGAGCGGCCCGGCCAGGCCCGAGGCGCAGTGGGAAACGCCGGAGCCTTCTCCC
CCGGCTGTCCGGGACCGGGG

Downstream 100 bases:

>100_bases
CGACTGGGCCTTGGGACGACTGGGCCTTGGGGCGCGGGCGAGCCGGCCACCTGTGAACCACAGTTCACGCTGGATACACG
GGACCCGGAACGACATGCTG

Product: uracil-DNA glycosylase superfamily protein

Products: NA

Alternate protein names: Double-strand-specific uracil glycosylase; Mismatch-specific uracil DNA-glycosylase; MUG [H]

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MTRDTAGAPVLQDLVAEGVQVLFVGFNPSPRSVQQGHHYAGRGNQFWRLLAASGLTPRLLRPEEDHLLPRWGLGSTNLVA
RPTVSAAELSRSELRAGVPHLRRLVARYQVPLVAYTGKGVYLAATGKQQAHWGAQEDSLIGGVTDFVLPSPSGLARLPFA
EKLGYYRALAELAQQPG

Sequences:

>Translated_177_residues
MTRDTAGAPVLQDLVAEGVQVLFVGFNPSPRSVQQGHHYAGRGNQFWRLLAASGLTPRLLRPEEDHLLPRWGLGSTNLVA
RPTVSAAELSRSELRAGVPHLRRLVARYQVPLVAYTGKGVYLAATGKQQAHWGAQEDSLIGGVTDFVLPSPSGLARLPFA
EKLGYYRALAELAQQPG
>Mature_176_residues
TRDTAGAPVLQDLVAEGVQVLFVGFNPSPRSVQQGHHYAGRGNQFWRLLAASGLTPRLLRPEEDHLLPRWGLGSTNLVAR
PTVSAAELSRSELRAGVPHLRRLVARYQVPLVAYTGKGVYLAATGKQQAHWGAQEDSLIGGVTDFVLPSPSGLARLPFAE
KLGYYRALAELAQQPG

Specific function: Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone o

COG id: COG3663

COG function: function code L; G:T/U mismatch-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TDG/mug DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI59853162, Length=176, Percent_Identity=32.3863636363636, Blast_Score=92, Evalue=3e-19,
Organism=Escherichia coli, GI1789449, Length=162, Percent_Identity=37.037037037037, Blast_Score=105, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21356805, Length=175, Percent_Identity=34.8571428571429, Blast_Score=106, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015637
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.28 [H]

Molecular weight: Translated: 19144; Mature: 19013

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRDTAGAPVLQDLVAEGVQVLFVGFNPSPRSVQQGHHYAGRGNQFWRLLAASGLTPRLL
CCCCCCCCHHHHHHHHCCEEEEEECCCCCCHHHHCCCCCCCCCHHHHHHHHHCCCCCCCC
RPEEDHLLPRWGLGSTNLVARPTVSAAELSRSELRAGVPHLRRLVARYQVPLVAYTGKGV
CCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCE
YLAATGKQQAHWGAQEDSLIGGVTDFVLPSPSGLARLPFAEKLGYYRALAELAQQPG
EEEECCCCHHCCCCCCCCHHCCHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TRDTAGAPVLQDLVAEGVQVLFVGFNPSPRSVQQGHHYAGRGNQFWRLLAASGLTPRLL
CCCCCCCHHHHHHHHCCEEEEEECCCCCCHHHHCCCCCCCCCHHHHHHHHHCCCCCCCC
RPEEDHLLPRWGLGSTNLVARPTVSAAELSRSELRAGVPHLRRLVARYQVPLVAYTGKGV
CCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCE
YLAATGKQQAHWGAQEDSLIGGVTDFVLPSPSGLARLPFAEKLGYYRALAELAQQPG
EEEECCCCHHCCCCCCCCHHCCHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA