Click here to switch to the map view.

The map label for this gene is zwf [H]

Identifier: 94314720

GI number: 94314720

Start: 2558741

End: 2560231

Strand: Reverse

Name: zwf [H]

Synonym: Rmet_5801

Alternate gene names: 94314720

Gene position: 2560231-2558741 (Counterclockwise)

Preceding gene: 94314722

Following gene: 94314719

Centisome position: 99.23

GC content: 65.53

Gene sequence:

>1491_bases
TTGCCGGGGCGCCCCATCCCCCGCAAGGAGCCCAGGGTGAGCTTGCCCGATTTCGACATGGTGCTGTTCGGCGGCACCGG
AGACCTGGCGCGGCGCAAGCTGCTGCCAGCCCTTTTCGACGCGCACCGCACGGGGTGTCTCCACCCGTCCTCGCGCATTC
TCGCTACCGGAAGTCATCCGCACACCACCGAGCAATACAAGGCGATGCTCGAGGAAAGCGTGCGTCCTGGCCTCGAACAT
GCGCCACCCGAAGCGTGGACCTCGTTCATGGATCGTATCGGCTACGTGCAGGCCGACGCGCGCCAGCCGGCGCACTTCGA
CGCGCTGGCCGAGCAGGTGCTGGCCCGCAAGCCCGAAGTGGTCGTGTGCTATCTGGCCACGGCGCCGCATATCTTCGTGC
CGATCTGCGAGCAACTGGGGCGAACCGGCCTCAATGCACCCAACGTGCGCGTGGTGCTTGAGAAGCCGCTCGGCCATGAT
CTCGACTCGTCGGAGGCGATCAACAACGCCGTGTCGCGGTATTTCGGCGAGGAACAGATCTACCGGATCGACCATTACCT
GGGCAAGGAATCGGTCCAGAACCTGATGGCGATCCGCTTCGCCAACGCGCTGTTCGAGCCGCTGTGGCGGCGCGAGTGGG
TGCAGGACGTGCAGATCACCATCGCCGAGGAACTGGGCGTGGAGACACGCGGTGATTTCTACGATCGCACCGGCGCGCTG
CGAGACATGGTGCAGAACCACCTGGTGCAACTGCTGTGCATGGTGGCGATGGAACCGCCGGCCAGCCTGTCCGAAGACGC
GATTCGCGACGAGAAGATCAAGATCCTCAAGGCGCTCAAGCCAATCCTGCCGCAGGACGTTGCCGAGAAGACCGTGCGCG
GCCAGTATCGCGCCGGCGCCGTCGGCGGCAAGCCCGTGGTCAGCTACGTCGACGAGCAGGGCATCGCCGCCGACAGCACG
ACCGAGACCTTTGTTGCCATCAAGGCCGAAATCGCCAACTGGCGCTGGGAAGGGGTGCCGTTCTACCTGCGCACGGGCAA
GCGGATGCAATCGCGCGTGGCCGAGATCGTGGTCCATTTCCGCGACGTGCCCCATGCGATCTTTCCCCGGCCGCTGACCC
TGTCGCCGCAGAACCGGCTCGTGATACGGCTGCAGCCCGAAGAGAGCATCCGCCTGTATTTCCTGGTCAAGCAACCGGGC
GATACCGTGGAGCTGACGCCGACCTCGCTCGATCTCGACTTCGCCAACTCGTTCAAGATGCGCCGTGCGGGCGCATACGA
GCGGCTGTTGCTCGACGTGATCCGCGGCAAGCTTGGCCTGTTCGTGCGACGCGACGAGCAGGTGCAGGCGTGGCGCTGGG
TCGAGCCGATTCTCGATACGTGGGACCAGAGCACCGTGCCGCCCAAACCGTACACGGCCGGCACCTGGGGACCGGCGGCA
TCGTCGGCCCTGATGTCGCGCGACGGCGCGTTATGGCATGAGGAGGCCTGA

Upstream 100 bases:

>100_bases
GTGCGGCGCGGGTCATGCTCGTGGCCACTTCCCCCTGCCCAAGCGGCGGCGAGTGACGTACCATGGCCGGAACCAATGCG
CCGCGCGGCGGACTCAATAG

Downstream 100 bases:

>100_bases
CGCGCCACCGAAGGATCGGAGACATCGGAAACATCGGATTCACCACGACACGAGAACCATAAGGAGTAGAAGGAGCAGCC
CATGCGCCAATTCGAACATG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MPGRPIPRKEPRVSLPDFDMVLFGGTGDLARRKLLPALFDAHRTGCLHPSSRILATGSHPHTTEQYKAMLEESVRPGLEH
APPEAWTSFMDRIGYVQADARQPAHFDALAEQVLARKPEVVVCYLATAPHIFVPICEQLGRTGLNAPNVRVVLEKPLGHD
LDSSEAINNAVSRYFGEEQIYRIDHYLGKESVQNLMAIRFANALFEPLWRREWVQDVQITIAEELGVETRGDFYDRTGAL
RDMVQNHLVQLLCMVAMEPPASLSEDAIRDEKIKILKALKPILPQDVAEKTVRGQYRAGAVGGKPVVSYVDEQGIAADST
TETFVAIKAEIANWRWEGVPFYLRTGKRMQSRVAEIVVHFRDVPHAIFPRPLTLSPQNRLVIRLQPEESIRLYFLVKQPG
DTVELTPTSLDLDFANSFKMRRAGAYERLLLDVIRGKLGLFVRRDEQVQAWRWVEPILDTWDQSTVPPKPYTAGTWGPAA
SSALMSRDGALWHEEA

Sequences:

>Translated_496_residues
MPGRPIPRKEPRVSLPDFDMVLFGGTGDLARRKLLPALFDAHRTGCLHPSSRILATGSHPHTTEQYKAMLEESVRPGLEH
APPEAWTSFMDRIGYVQADARQPAHFDALAEQVLARKPEVVVCYLATAPHIFVPICEQLGRTGLNAPNVRVVLEKPLGHD
LDSSEAINNAVSRYFGEEQIYRIDHYLGKESVQNLMAIRFANALFEPLWRREWVQDVQITIAEELGVETRGDFYDRTGAL
RDMVQNHLVQLLCMVAMEPPASLSEDAIRDEKIKILKALKPILPQDVAEKTVRGQYRAGAVGGKPVVSYVDEQGIAADST
TETFVAIKAEIANWRWEGVPFYLRTGKRMQSRVAEIVVHFRDVPHAIFPRPLTLSPQNRLVIRLQPEESIRLYFLVKQPG
DTVELTPTSLDLDFANSFKMRRAGAYERLLLDVIRGKLGLFVRRDEQVQAWRWVEPILDTWDQSTVPPKPYTAGTWGPAA
SSALMSRDGALWHEEA
>Mature_495_residues
PGRPIPRKEPRVSLPDFDMVLFGGTGDLARRKLLPALFDAHRTGCLHPSSRILATGSHPHTTEQYKAMLEESVRPGLEHA
PPEAWTSFMDRIGYVQADARQPAHFDALAEQVLARKPEVVVCYLATAPHIFVPICEQLGRTGLNAPNVRVVLEKPLGHDL
DSSEAINNAVSRYFGEEQIYRIDHYLGKESVQNLMAIRFANALFEPLWRREWVQDVQITIAEELGVETRGDFYDRTGALR
DMVQNHLVQLLCMVAMEPPASLSEDAIRDEKIKILKALKPILPQDVAEKTVRGQYRAGAVGGKPVVSYVDEQGIAADSTT
ETFVAIKAEIANWRWEGVPFYLRTGKRMQSRVAEIVVHFRDVPHAIFPRPLTLSPQNRLVIRLQPEESIRLYFLVKQPGD
TVELTPTSLDLDFANSFKMRRAGAYERLLLDVIRGKLGLFVRRDEQVQAWRWVEPILDTWDQSTVPPKPYTAGTWGPAAS
SALMSRDGALWHEEA

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=482, Percent_Identity=37.551867219917, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI109389365, Length=482, Percent_Identity=37.551867219917, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI52145310, Length=492, Percent_Identity=27.8455284552846, Blast_Score=159, Evalue=6e-39,
Organism=Escherichia coli, GI1788158, Length=480, Percent_Identity=47.2916666666667, Blast_Score=459, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI17538218, Length=484, Percent_Identity=36.5702479338843, Blast_Score=313, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6324088, Length=480, Percent_Identity=36.25, Blast_Score=289, Evalue=6e-79,
Organism=Drosophila melanogaster, GI24643350, Length=468, Percent_Identity=36.5384615384615, Blast_Score=286, Evalue=3e-77,
Organism=Drosophila melanogaster, GI24643352, Length=468, Percent_Identity=36.5384615384615, Blast_Score=285, Evalue=4e-77,
Organism=Drosophila melanogaster, GI221513548, Length=499, Percent_Identity=29.4589178356713, Blast_Score=214, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 55907; Mature: 55776

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGRPIPRKEPRVSLPDFDMVLFGGTGDLARRKLLPALFDAHRTGCLHPSSRILATGSHP
CCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCC
HTTEQYKAMLEESVRPGLEHAPPEAWTSFMDRIGYVQADARQPAHFDALAEQVLARKPEV
CCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHCCCCE
VVCYLATAPHIFVPICEQLGRTGLNAPNVRVVLEKPLGHDLDSSEAINNAVSRYFGEEQI
EEEEECCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCHHHH
YRIDHYLGKESVQNLMAIRFANALFEPLWRREWVQDVQITIAEELGVETRGDFYDRTGAL
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
RDMVQNHLVQLLCMVAMEPPASLSEDAIRDEKIKILKALKPILPQDVAEKTVRGQYRAGA
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCC
VGGKPVVSYVDEQGIAADSTTETFVAIKAEIANWRWEGVPFYLRTGKRMQSRVAEIVVHF
CCCCHHHHHHHCCCCCCCCCCCEEEEEEEECCCCEECCCCEEECCCHHHHHHHHHHHHHH
RDVPHAIFPRPLTLSPQNRLVIRLQPEESIRLYFLVKQPGDTVELTPTSLDLDFANSFKM
HCCCHHHCCCCCEECCCCCEEEEECCCCCEEEEEEEECCCCEEEECCCEECCCHHHHHHH
RRAGAYERLLLDVIRGKLGLFVRRDEQVQAWRWVEPILDTWDQSTVPPKPYTAGTWGPAA
HHHHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHH
SSALMSRDGALWHEEA
HHHHHHCCCCCCCCCC
>Mature Secondary Structure 
PGRPIPRKEPRVSLPDFDMVLFGGTGDLARRKLLPALFDAHRTGCLHPSSRILATGSHP
CCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCC
HTTEQYKAMLEESVRPGLEHAPPEAWTSFMDRIGYVQADARQPAHFDALAEQVLARKPEV
CCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHCCCCE
VVCYLATAPHIFVPICEQLGRTGLNAPNVRVVLEKPLGHDLDSSEAINNAVSRYFGEEQI
EEEEECCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCHHHH
YRIDHYLGKESVQNLMAIRFANALFEPLWRREWVQDVQITIAEELGVETRGDFYDRTGAL
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
RDMVQNHLVQLLCMVAMEPPASLSEDAIRDEKIKILKALKPILPQDVAEKTVRGQYRAGA
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCC
VGGKPVVSYVDEQGIAADSTTETFVAIKAEIANWRWEGVPFYLRTGKRMQSRVAEIVVHF
CCCCHHHHHHHCCCCCCCCCCCEEEEEEEECCCCEECCCCEEECCCHHHHHHHHHHHHHH
RDVPHAIFPRPLTLSPQNRLVIRLQPEESIRLYFLVKQPGDTVELTPTSLDLDFANSFKM
HCCCHHHCCCCCEECCCCCEEEEECCCCCEEEEEEEECCCCEEEECCCEECCCHHHHHHH
RRAGAYERLLLDVIRGKLGLFVRRDEQVQAWRWVEPILDTWDQSTVPPKPYTAGTWGPAA
HHHHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHH
SSALMSRDGALWHEEA
HHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]