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The map label for this gene is copA2 [H]

Identifier: 94314590

GI number: 94314590

Start: 2429320

End: 2431137

Strand: Reverse

Name: copA2 [H]

Synonym: Rmet_5671

Alternate gene names: 94314590

Gene position: 2431137-2429320 (Counterclockwise)

Preceding gene: 94314593

Following gene: 94314589

Centisome position: 94.23

GC content: 64.41

Gene sequence:

>1818_bases
ATGCGAGCCAACGTTCCGGCCGATCTGATTTTGCCTGTGCGAGCGGGGTTGTCCCGGCGTCGCTTCGTCCAGGGTCTTGC
CGCCGGGGGTGTGCTCGGCGCGCTCGGGGGATTGTCGTCCGGAAGCTGGGCCAGTTCCGGGGGCGGACAGGCTGCAACGG
GCAATGGCACTGCACCGGTCTTGCGTGGCACGGAGTTCGATCTCGTGATTGGCGAGTCGGCGGTCAACTTCACGGGCAAG
CCCGGCATGGCCACCACCATCAACGGCATGCTTCCCGGTCCCACGCTGCGCTGGCGCAAGGGCGACACGGTGACGATCCG
CGTCACCAATCGCCTGAACGAGCCTACCTCGATTCACTGGCACGGCATCATCCTGCCGTATCAGATGGACGGCGTGCCCG
GTATCAGCTTCCCGGGCATTCCGCCCGGCGAGACGTTCACCTACCGCTTCAAGGTGGATCAGACCGGTAGCTACTGGTAC
CACTCGCACTCGGGCTTTCAGGAGATGACTGGTGTCTACGGCAGCCTGATCATCGACGGCGACGAAGACCCAGTGCGTGC
CGACCGCGACTACGCGGTGCTGCTGTCCGACTGGACGGACGAGGATCCGATGCGGGTCATGTCCAAGCTCAAGATCCAGA
GCGACTACTACAACTACAACCAACCCACCGTGGTGGACTTCTTCCGCGACGTTTCCAACGATGGGCTTGGCGCCGCGCTG
GAGAAGCGAAAGATGTGGAACCAGATGCGGATGAGCCCGACCGATCTGGCGGACCTGTCGGGCGCCACGCTGACGTACCT
GATGAATGGCGTCACCCCTGCCGGCAACTGGACCGGGCTGTTCCGTCCCGGCGAGCGCGTGCGCCTGCGCTTCGTCAACG
GCGCAGGCAACACGTTCTACGACGTGCGCATTCCGGGCCTGAAGCTCAAGGTGATACAGGTCGACGGCCAGAACATCGAG
CCCGTGACGGTCGACGAGTTCCGCATCGGCCCGGGGGAAACCTGCGACGTGCTGGTGGAGCCGACCGACGACGCGCACAC
GATCTTCGCCCAGTCGATGGACCGCACTGGCTTCGCGCGCGGCACGCTGGCCGTGCGCGAGGGCCTGCAGCCACCGGTAC
CGGCCCTCGACAAGGCGGAGTGGCTGACCATGGGTGACATGATGGGCAGCATGAACCATGGCGCCATGAATCACGGTGCG
ATGCCCATGGATCACAGCCAGCACGATATGTCCGGTATGTCCGGCATGGCTGGGATGAGTGCCATGTCGCATGGCGACTC
GCTCAAGGTACCCAGCACGCGGGCCCGTCATGCGCGTACTGAGTACGGTCCGAGCACCGACATGCGCGTGGACATGGCGC
GCACCAACCTCGACGACCCCGGCATCGGGCTGCGCAACAACGGGCGCCGGGTGCTGACACTGGCGGACATGCATACGGTC
GGTGGACCGATGGACCACCGTGGCCCGGGCCGTGAGGTGGAATTGCATCTGACCGGCAATATGGAGCGCTACACGTGGTC
GTTCGACGGCGTGGAGTACGGCAAGTCGACCCCGGTGTTCTTCAAGCATGGCGAGCGCCTGCGGGTGATTCTCCACAACG
ACACGATGATGACCCACCCGATGCACATGCATGGCATGTGGAGCGAACTGGAGGCGCCCGACGGCACGTTCCAGGCCCGT
CGTCATACGATTCCGGTGCAGCCCGCGCAACGCATCAGCTTCCTCGTGACCGCCGATGCGCTCGGGCGCTGGGCATGGCA
CTGCCACTTGATGATGCATATGGACATGGGCATGTTCCGTGAAGTGGTGGTGGCATGA

Upstream 100 bases:

>100_bases
TGTAATTTTTGGGTCATTAGGTGGTTACCGCGCCCTGACTACTCTGTGCTCGCTGCGCCATTTTGCTGGCGCGATTTCAC
GATGAGAAGGAATTGACAGC

Downstream 100 bases:

>100_bases
TGAACGCACGCAACCCACTCACACTGACGCTGCTCGCGGCGGTGCTTCTTTCCGTCAGCATGGGCACCGCATGGGCGCAG
CATTCGCACGCAGACCATGC

Product: copper resistance protein A, multi-copper oxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 605; Mature: 605

Protein sequence:

>605_residues
MRANVPADLILPVRAGLSRRRFVQGLAAGGVLGALGGLSSGSWASSGGGQAATGNGTAPVLRGTEFDLVIGESAVNFTGK
PGMATTINGMLPGPTLRWRKGDTVTIRVTNRLNEPTSIHWHGIILPYQMDGVPGISFPGIPPGETFTYRFKVDQTGSYWY
HSHSGFQEMTGVYGSLIIDGDEDPVRADRDYAVLLSDWTDEDPMRVMSKLKIQSDYYNYNQPTVVDFFRDVSNDGLGAAL
EKRKMWNQMRMSPTDLADLSGATLTYLMNGVTPAGNWTGLFRPGERVRLRFVNGAGNTFYDVRIPGLKLKVIQVDGQNIE
PVTVDEFRIGPGETCDVLVEPTDDAHTIFAQSMDRTGFARGTLAVREGLQPPVPALDKAEWLTMGDMMGSMNHGAMNHGA
MPMDHSQHDMSGMSGMAGMSAMSHGDSLKVPSTRARHARTEYGPSTDMRVDMARTNLDDPGIGLRNNGRRVLTLADMHTV
GGPMDHRGPGREVELHLTGNMERYTWSFDGVEYGKSTPVFFKHGERLRVILHNDTMMTHPMHMHGMWSELEAPDGTFQAR
RHTIPVQPAQRISFLVTADALGRWAWHCHLMMHMDMGMFREVVVA

Sequences:

>Translated_605_residues
MRANVPADLILPVRAGLSRRRFVQGLAAGGVLGALGGLSSGSWASSGGGQAATGNGTAPVLRGTEFDLVIGESAVNFTGK
PGMATTINGMLPGPTLRWRKGDTVTIRVTNRLNEPTSIHWHGIILPYQMDGVPGISFPGIPPGETFTYRFKVDQTGSYWY
HSHSGFQEMTGVYGSLIIDGDEDPVRADRDYAVLLSDWTDEDPMRVMSKLKIQSDYYNYNQPTVVDFFRDVSNDGLGAAL
EKRKMWNQMRMSPTDLADLSGATLTYLMNGVTPAGNWTGLFRPGERVRLRFVNGAGNTFYDVRIPGLKLKVIQVDGQNIE
PVTVDEFRIGPGETCDVLVEPTDDAHTIFAQSMDRTGFARGTLAVREGLQPPVPALDKAEWLTMGDMMGSMNHGAMNHGA
MPMDHSQHDMSGMSGMAGMSAMSHGDSLKVPSTRARHARTEYGPSTDMRVDMARTNLDDPGIGLRNNGRRVLTLADMHTV
GGPMDHRGPGREVELHLTGNMERYTWSFDGVEYGKSTPVFFKHGERLRVILHNDTMMTHPMHMHGMWSELEAPDGTFQAR
RHTIPVQPAQRISFLVTADALGRWAWHCHLMMHMDMGMFREVVVA
>Mature_605_residues
MRANVPADLILPVRAGLSRRRFVQGLAAGGVLGALGGLSSGSWASSGGGQAATGNGTAPVLRGTEFDLVIGESAVNFTGK
PGMATTINGMLPGPTLRWRKGDTVTIRVTNRLNEPTSIHWHGIILPYQMDGVPGISFPGIPPGETFTYRFKVDQTGSYWY
HSHSGFQEMTGVYGSLIIDGDEDPVRADRDYAVLLSDWTDEDPMRVMSKLKIQSDYYNYNQPTVVDFFRDVSNDGLGAAL
EKRKMWNQMRMSPTDLADLSGATLTYLMNGVTPAGNWTGLFRPGERVRLRFVNGAGNTFYDVRIPGLKLKVIQVDGQNIE
PVTVDEFRIGPGETCDVLVEPTDDAHTIFAQSMDRTGFARGTLAVREGLQPPVPALDKAEWLTMGDMMGSMNHGAMNHGA
MPMDHSQHDMSGMSGMAGMSAMSHGDSLKVPSTRARHARTEYGPSTDMRVDMARTNLDDPGIGLRNNGRRVLTLADMHTV
GGPMDHRGPGREVELHLTGNMERYTWSFDGVEYGKSTPVFFKHGERLRVILHNDTMMTHPMHMHGMWSELEAPDGTFQAR
RHTIPVQPAQRISFLVTADALGRWAWHCHLMMHMDMGMFREVVVA

Specific function: Could be involved in copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=478, Percent_Identity=27.8242677824268, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6321067, Length=539, Percent_Identity=22.6345083487941, Blast_Score=97, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6320714, Length=293, Percent_Identity=26.2798634812287, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323703, Length=277, Percent_Identity=28.158844765343, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24650186, Length=575, Percent_Identity=24.8695652173913, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI18859919, Length=264, Percent_Identity=27.2727272727273, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI28574104, Length=98, Percent_Identity=46.9387755102041, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24585842, Length=272, Percent_Identity=26.8382352941176, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281360167, Length=272, Percent_Identity=26.8382352941176, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221330000, Length=271, Percent_Identity=26.9372693726937, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221329998, Length=275, Percent_Identity=26.9090909090909, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 66595; Mature: 66595

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
6.4 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
6.4 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRANVPADLILPVRAGLSRRRFVQGLAAGGVLGALGGLSSGSWASSGGGQAATGNGTAPV
CCCCCCCCEEEECCCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCE
LRGTEFDLVIGESAVNFTGKPGMATTINGMLPGPTLRWRKGDTVTIRVTNRLNEPTSIHW
EECCEEEEEECCCEECCCCCCCCEEEECCCCCCCEEEEECCCEEEEEEECCCCCCCEEEE
HGIILPYQMDGVPGISFPGIPPGETFTYRFKVDQTGSYWYHSHSGFQEMTGVYGSLIIDG
EEEEEEEEECCCCCCCCCCCCCCCEEEEEEEECCCCCEEEECCCCHHHHHCCEEEEEECC
DEDPVRADRDYAVLLSDWTDEDPMRVMSKLKIQSDYYNYNQPTVVDFFRDVSNDGLGAAL
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCHHHH
EKRKMWNQMRMSPTDLADLSGATLTYLMNGVTPAGNWTGLFRPGERVRLRFVNGAGNTFY
HHHHHHHHHCCCCCCHHHCCCCEEEHHHCCCCCCCCCEEECCCCCEEEEEEEECCCCEEE
DVRIPGLKLKVIQVDGQNIEPVTVDEFRIGPGETCDVLVEPTDDAHTIFAQSMDRTGFAR
EEEECCEEEEEEEECCCCCCCEEECEEECCCCCCEEEEEECCCCHHHHHHHHCCCCCCCC
GTLAVREGLQPPVPALDKAEWLTMGDMMGSMNHGAMNHGAMPMDHSQHDMSGMSGMAGMS
CHHHHHCCCCCCCCCCCCCHHEEHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCCHHHHH
AMSHGDSLKVPSTRARHARTEYGPSTDMRVDMARTNLDDPGIGLRNNGRRVLTLADMHTV
HHCCCCCCCCCCCHHHHCCCCCCCCCCEEEEEHHCCCCCCCCCCCCCCCEEEEEECHHHC
GGPMDHRGPGREVELHLTGNMERYTWSFDGVEYGKSTPVFFKHGERLRVILHNDTMMTHP
CCCCCCCCCCCEEEEEEECCCEEEEEEECCEECCCCCCEEEECCCEEEEEEECCEEEECC
MHMHGMWSELEAPDGTFQARRHTIPVQPAQRISFLVTADALGRWAWHCHLMMHMDMGMFR
HHHCCCHHHHCCCCCCHHHHCCCCCCCHHHHEEEEEEHHHHCCEEEEEEEEEHHCHHHHH
EVVVA
HHHCC
>Mature Secondary Structure
MRANVPADLILPVRAGLSRRRFVQGLAAGGVLGALGGLSSGSWASSGGGQAATGNGTAPV
CCCCCCCCEEEECCCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCE
LRGTEFDLVIGESAVNFTGKPGMATTINGMLPGPTLRWRKGDTVTIRVTNRLNEPTSIHW
EECCEEEEEECCCEECCCCCCCCEEEECCCCCCCEEEEECCCEEEEEEECCCCCCCEEEE
HGIILPYQMDGVPGISFPGIPPGETFTYRFKVDQTGSYWYHSHSGFQEMTGVYGSLIIDG
EEEEEEEEECCCCCCCCCCCCCCCEEEEEEEECCCCCEEEECCCCHHHHHCCEEEEEECC
DEDPVRADRDYAVLLSDWTDEDPMRVMSKLKIQSDYYNYNQPTVVDFFRDVSNDGLGAAL
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCHHHH
EKRKMWNQMRMSPTDLADLSGATLTYLMNGVTPAGNWTGLFRPGERVRLRFVNGAGNTFY
HHHHHHHHHCCCCCCHHHCCCCEEEHHHCCCCCCCCCEEECCCCCEEEEEEEECCCCEEE
DVRIPGLKLKVIQVDGQNIEPVTVDEFRIGPGETCDVLVEPTDDAHTIFAQSMDRTGFAR
EEEECCEEEEEEEECCCCCCCEEECEEECCCCCCEEEEEECCCCHHHHHHHHCCCCCCCC
GTLAVREGLQPPVPALDKAEWLTMGDMMGSMNHGAMNHGAMPMDHSQHDMSGMSGMAGMS
CHHHHHCCCCCCCCCCCCCHHEEHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCCHHHHH
AMSHGDSLKVPSTRARHARTEYGPSTDMRVDMARTNLDDPGIGLRNNGRRVLTLADMHTV
HHCCCCCCCCCCCHHHHCCCCCCCCCCEEEEEHHCCCCCCCCCCCCCCCEEEEEECHHHC
GGPMDHRGPGREVELHLTGNMERYTWSFDGVEYGKSTPVFFKHGERLRVILHNDTMMTHP
CCCCCCCCCCCEEEEEEECCCEEEEEEECCEECCCCCCEEEECCCEEEEEEECCEEEECC
MHMHGMWSELEAPDGTFQARRHTIPVQPAQRISFLVTADALGRWAWHCHLMMHMDMGMFR
HHHCCCHHHHCCCCCCHHHHCCCCCCCHHHHEEEEEEHHHHCCEEEEEEEEEHHCHHHHH
EVVVA
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]