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The map label for this gene is pdhR [H]

Identifier: 94314450

GI number: 94314450

Start: 2278125

End: 2279036

Strand: Direct

Name: pdhR [H]

Synonym: Rmet_5531

Alternate gene names: 94314450

Gene position: 2278125-2279036 (Clockwise)

Preceding gene: 94314444

Following gene: 94314451

Centisome position: 88.3

GC content: 57.24

Gene sequence:

>912_bases
ATGTGGGAGGCCATGCTCGGTGCAAGGAATGCAGTGGAGGAAACCCTCAAGTGCCGTATGAGGCATACACTCTCTGATAA
CATATGTGCAGAGGTTGATCCAATGCAAGACACGCCCAAAATGCCTACGAAAACAAAGCCTGCCGTACCTGACCAACAAG
ACCCGAGTCCTGCAGGCCCTATATTTAGGCGGGTTCGAACACGGCGAGCATTCGAGGCTGTAAGCGACCAGATCCGCCAG
CAGTTGGCGTCGGGAGAGTTGCGTCCAGGCGACCGACTCCCCGGTGAGCGCGAACTCGCCGAGCAATTTACCGTCAGCCG
AAGTGCTGTACGCGAGGCGTTACGAAGCCTTGAGGCCGCCAGCGTTGTGGAAGCCCGAACTGGTATCAACGGCGGCTTCT
TTATCCGGAGTACGAGTAGCACGACCGGGCTCACACAAACAGTCCAAGACCTAGTGTCCCTCGGCCAAGTGTCCATTGCG
AACGTTACCGAGGCTCGCGTGGAACTGATGGCCGTCGCAATCCGTCTGGCCTGCGCTCGGGCCACGGAAGAGGAGCTGGA
TGCCATTGAGGCCGACATCAGCTACCACACGGAACTGTTCCGACAAGGTGACGGCTCACGTAACTCCAAATCGGTGATTG
AGTTCTATCGCCTGATTGCGCAAGCTACGCACAACGCTGTAATCGTTCTGATGGTGGACGCGCTTTCGGAGATCATTCGC
AAGCTGTTGGCGCAAATCGCGCCCGAACCTCGCAAGGACATCATGCAGGTGCGACGCAAGGTCCTCACCCTGCTCCGACA
ACGCGACGCCCAGGGAGCTTGTGACGCGATGGCGACTCATCTCCGTCACGTCAGCGACTACCTAGAAAGCGAAAGTAAGA
AATCTGCGCGTAAGAAGAAGATTGCCGCATGA

Upstream 100 bases:

>100_bases
CGTAGATCCATCCTTCTTCTCCTCCTACGTCGACTCGCGCCGTGCGAGTACGTGCGTTATTTTGGTTCAACCATTATACT
TAACGCAAGAGGATTGTGAG

Downstream 100 bases:

>100_bases
CCCAGGCTGAGAAGGACACAATGACCACCACTGTGAAAACTGCGGACACGCCTTTGGAAACGAATACGCCGCGCTTCGAG
GCGGTACGCTCGGCACGTGC

Product: putative GntR-family transcriptional regulator (HTH)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MWEAMLGARNAVEETLKCRMRHTLSDNICAEVDPMQDTPKMPTKTKPAVPDQQDPSPAGPIFRRVRTRRAFEAVSDQIRQ
QLASGELRPGDRLPGERELAEQFTVSRSAVREALRSLEAASVVEARTGINGGFFIRSTSSTTGLTQTVQDLVSLGQVSIA
NVTEARVELMAVAIRLACARATEEELDAIEADISYHTELFRQGDGSRNSKSVIEFYRLIAQATHNAVIVLMVDALSEIIR
KLLAQIAPEPRKDIMQVRRKVLTLLRQRDAQGACDAMATHLRHVSDYLESESKKSARKKKIAA

Sequences:

>Translated_303_residues
MWEAMLGARNAVEETLKCRMRHTLSDNICAEVDPMQDTPKMPTKTKPAVPDQQDPSPAGPIFRRVRTRRAFEAVSDQIRQ
QLASGELRPGDRLPGERELAEQFTVSRSAVREALRSLEAASVVEARTGINGGFFIRSTSSTTGLTQTVQDLVSLGQVSIA
NVTEARVELMAVAIRLACARATEEELDAIEADISYHTELFRQGDGSRNSKSVIEFYRLIAQATHNAVIVLMVDALSEIIR
KLLAQIAPEPRKDIMQVRRKVLTLLRQRDAQGACDAMATHLRHVSDYLESESKKSARKKKIAA
>Mature_303_residues
MWEAMLGARNAVEETLKCRMRHTLSDNICAEVDPMQDTPKMPTKTKPAVPDQQDPSPAGPIFRRVRTRRAFEAVSDQIRQ
QLASGELRPGDRLPGERELAEQFTVSRSAVREALRSLEAASVVEARTGINGGFFIRSTSSTTGLTQTVQDLVSLGQVSIA
NVTEARVELMAVAIRLACARATEEELDAIEADISYHTELFRQGDGSRNSKSVIEFYRLIAQATHNAVIVLMVDALSEIIR
KLLAQIAPEPRKDIMQVRRKVLTLLRQRDAQGACDAMATHLRHVSDYLESESKKSARKKKIAA

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=197, Percent_Identity=32.48730964467, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1790032, Length=250, Percent_Identity=28, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790780, Length=232, Percent_Identity=28.0172413793103, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789621, Length=257, Percent_Identity=25.6809338521401, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 33607; Mature: 33607

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: PS50949 HTH_GNTR ; PS01332 UPF0074

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWEAMLGARNAVEETLKCRMRHTLSDNICAEVDPMQDTPKMPTKTKPAVPDQQDPSPAGP
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
IFRRVRTRRAFEAVSDQIRQQLASGELRPGDRLPGERELAEQFTVSRSAVREALRSLEAA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SVVEARTGINGGFFIRSTSSTTGLTQTVQDLVSLGQVSIANVTEARVELMAVAIRLACAR
HHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
ATEEELDAIEADISYHTELFRQGDGSRNSKSVIEFYRLIAQATHNAVIVLMVDALSEIIR
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHHH
KLLAQIAPEPRKDIMQVRRKVLTLLRQRDAQGACDAMATHLRHVSDYLESESKKSARKKK
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAA
CCC
>Mature Secondary Structure
MWEAMLGARNAVEETLKCRMRHTLSDNICAEVDPMQDTPKMPTKTKPAVPDQQDPSPAGP
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
IFRRVRTRRAFEAVSDQIRQQLASGELRPGDRLPGERELAEQFTVSRSAVREALRSLEAA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SVVEARTGINGGFFIRSTSSTTGLTQTVQDLVSLGQVSIANVTEARVELMAVAIRLACAR
HHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
ATEEELDAIEADISYHTELFRQGDGSRNSKSVIEFYRLIAQATHNAVIVLMVDALSEIIR
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHHH
KLLAQIAPEPRKDIMQVRRKVLTLLRQRDAQGACDAMATHLRHVSDYLESESKKSARKKK
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]