Click here to switch to the map view.

The map label for this gene is aslA [H]

Identifier: 94314335

GI number: 94314335

Start: 2160936

End: 2162675

Strand: Direct

Name: aslA [H]

Synonym: Rmet_5416

Alternate gene names: 94314335

Gene position: 2160936-2162675 (Clockwise)

Preceding gene: 94314334

Following gene: 94314336

Centisome position: 83.75

GC content: 62.07

Gene sequence:

>1740_bases
ATGAGGCAAGCTGAAATGAGAAAGACAAGAATCGGGGGACTGGCGACGCTTGCCATTGCCGCTGCCGTACTGACATTGGC
GGGCTGCGGCAAGCAGGAAGAGCCCAAGGCACCGGCAGCACAAGCACCAGCCGCGCAATCTTCCGCCGAGGCGCCTGCAG
CGCCGCAGGCCGCCCGCGAGAATCCCCCTGTCGCCGCGAATGCACCGGAGTCGGCAGCTTCCGCGCCGGCACTGCCGCCG
GTGGCCAATTCAGGCAAGAAGCCGAACATCCTGGTGATCTTCGGTGACGACATTGGCCAGACCAACATCAGCGCCTACAG
CCATGGCGTGGTTGGCTACCGCACCCCGAACATCGATCGCATCGCCCGTGAGGGGATGATGATGACCGACTACTACGGCG
AGAACAGCTGTACCGCGGGCCGCTCTACCTTCATCACTGGTGAAGTCGGCTTGCGTACCGGCCTGCTGAAGGTCGGCATC
CCCGGCGCGACCGTGGGCCTGCAGGCGCAGAACGCGACCATTGCCGAAGCGCTGAAGCCGCTTGGCTATGCCACCGGCCA
GTTCGGCAAGAACCACCTTGGCGACCGCAACGAATACCTGCCGACCGCGCACGGCTTCGACGAGTTCTACGGCAACCTGT
ATCACCTGAACGCCGAAGAGGAGCCGGAGCGTCCGTATTATCCGAAGAACGATGCGGCCTTCGTGAAGGCAAATTCGCCG
CGTGGCGTGATCCACTCGTTCTCCGACGGCAAGGTGGAAGACACCGGCCCACTGACGCGCAAGCGCATGGAGACCATCGA
CGACGAGACCACGGCAGCAGCCATCGGCTTCATGGAGAAGCAGGTCAAGGCGGACAAGCCGTTCTTCGTGTGGATGAACA
CCACCCGCATGCACTTGTTCACCCATGTACGCGAGTCGATGCGCGGCCAGAGCGGTATGCCGGGCAACGAGTACGCGGAC
GGCATGCTCGAGCATGACGCCGACGTGGGCAAGCTGCTCAGGACGCTCGACGACCTGAAGATCGCCGACAACACCATCGT
GGTCTACACGACGGACAATGGCCCGAACCAGTTCAGCTGGCCGGATGCGGCAACCACGCCGTTCCGCAGCGAGAAGGACA
CCAACTGGGAAGGCGCATTCCGCGTGCCGGCGCTGGTGAAGTGGCCGGGCCGCATCAAACCGGGCACGGTCTCCACAACG
ATGATGTCCGGCCTTGACTGGTTCCCCACGCTGCTTGCGGCCGCGGGCGATACCGACATCAAGGAACGACTGCTCAAGGG
CACCAGCCTTGGTGGCAAATCGTTCAAGGTGCATCTGGACGGCTATAACTTCCTGCCGTACCTGACCGGGCAGACCAATA
CCGGCCCGCGCCAGGACTTCTACTACTTCAACGATGACGGGCAACTGGTCGCCTATCGCTACAACGACTGGAAAATCGTC
TTCTGTGAGCAGCGGCAGCCAGGCGGCTTCCAGGTGTGGTCCAACCCGTTCACCTGCTTGCGCGCACCCAAGGCGTTCAA
CCTGCGCATGGACCCATACGAGCGCGCCGATACGGTATCCGATCAATACTATGACTGGGCCACGAAGAACGCCTACCTGA
TGCAGTACGGCGTCTATCGCGTGATTCCGTTCCTTCAAACGTTCAAGGACTATCCGCCCAGCCAGCGTCCCGCGAGCTTC
AGTATCGACCAGGCGGTCGAGCAACTGATGAAGACGCTGGACAAGACGCCAGCCAAGTAA

Upstream 100 bases:

>100_bases
TCACTTCATACCTCCAATAAACTGAATTCCGTTGATCTCACTCAACAGCGATACTTCACGAGACTTATGCGCCATTGCGA
TTTGCACCGGAGGCACTTTC

Downstream 100 bases:

>100_bases
CACCGGATAGCGTCTGACACCACCGGCCGGCTTCCGCCTCGCGGAACGCCGGCCGGTGGCATTCTGGGCAGTCAGAAAAC
ACGCAGGAGGTCTCGTCGCG

Product: arylsulfatase-like enzyme

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 579; Mature: 579

Protein sequence:

>579_residues
MRQAEMRKTRIGGLATLAIAAAVLTLAGCGKQEEPKAPAAQAPAAQSSAEAPAAPQAARENPPVAANAPESAASAPALPP
VANSGKKPNILVIFGDDIGQTNISAYSHGVVGYRTPNIDRIAREGMMMTDYYGENSCTAGRSTFITGEVGLRTGLLKVGI
PGATVGLQAQNATIAEALKPLGYATGQFGKNHLGDRNEYLPTAHGFDEFYGNLYHLNAEEEPERPYYPKNDAAFVKANSP
RGVIHSFSDGKVEDTGPLTRKRMETIDDETTAAAIGFMEKQVKADKPFFVWMNTTRMHLFTHVRESMRGQSGMPGNEYAD
GMLEHDADVGKLLRTLDDLKIADNTIVVYTTDNGPNQFSWPDAATTPFRSEKDTNWEGAFRVPALVKWPGRIKPGTVSTT
MMSGLDWFPTLLAAAGDTDIKERLLKGTSLGGKSFKVHLDGYNFLPYLTGQTNTGPRQDFYYFNDDGQLVAYRYNDWKIV
FCEQRQPGGFQVWSNPFTCLRAPKAFNLRMDPYERADTVSDQYYDWATKNAYLMQYGVYRVIPFLQTFKDYPPSQRPASF
SIDQAVEQLMKTLDKTPAK

Sequences:

>Translated_579_residues
MRQAEMRKTRIGGLATLAIAAAVLTLAGCGKQEEPKAPAAQAPAAQSSAEAPAAPQAARENPPVAANAPESAASAPALPP
VANSGKKPNILVIFGDDIGQTNISAYSHGVVGYRTPNIDRIAREGMMMTDYYGENSCTAGRSTFITGEVGLRTGLLKVGI
PGATVGLQAQNATIAEALKPLGYATGQFGKNHLGDRNEYLPTAHGFDEFYGNLYHLNAEEEPERPYYPKNDAAFVKANSP
RGVIHSFSDGKVEDTGPLTRKRMETIDDETTAAAIGFMEKQVKADKPFFVWMNTTRMHLFTHVRESMRGQSGMPGNEYAD
GMLEHDADVGKLLRTLDDLKIADNTIVVYTTDNGPNQFSWPDAATTPFRSEKDTNWEGAFRVPALVKWPGRIKPGTVSTT
MMSGLDWFPTLLAAAGDTDIKERLLKGTSLGGKSFKVHLDGYNFLPYLTGQTNTGPRQDFYYFNDDGQLVAYRYNDWKIV
FCEQRQPGGFQVWSNPFTCLRAPKAFNLRMDPYERADTVSDQYYDWATKNAYLMQYGVYRVIPFLQTFKDYPPSQRPASF
SIDQAVEQLMKTLDKTPAK
>Mature_579_residues
MRQAEMRKTRIGGLATLAIAAAVLTLAGCGKQEEPKAPAAQAPAAQSSAEAPAAPQAARENPPVAANAPESAASAPALPP
VANSGKKPNILVIFGDDIGQTNISAYSHGVVGYRTPNIDRIAREGMMMTDYYGENSCTAGRSTFITGEVGLRTGLLKVGI
PGATVGLQAQNATIAEALKPLGYATGQFGKNHLGDRNEYLPTAHGFDEFYGNLYHLNAEEEPERPYYPKNDAAFVKANSP
RGVIHSFSDGKVEDTGPLTRKRMETIDDETTAAAIGFMEKQVKADKPFFVWMNTTRMHLFTHVRESMRGQSGMPGNEYAD
GMLEHDADVGKLLRTLDDLKIADNTIVVYTTDNGPNQFSWPDAATTPFRSEKDTNWEGAFRVPALVKWPGRIKPGTVSTT
MMSGLDWFPTLLAAAGDTDIKERLLKGTSLGGKSFKVHLDGYNFLPYLTGQTNTGPRQDFYYFNDDGQLVAYRYNDWKIV
FCEQRQPGGFQVWSNPFTCLRAPKAFNLRMDPYERADTVSDQYYDWATKNAYLMQYGVYRVIPFLQTFKDYPPSQRPASF
SIDQAVEQLMKTLDKTPAK

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI4503899, Length=458, Percent_Identity=30.7860262008734, Blast_Score=169, Evalue=8e-42,
Organism=Homo sapiens, GI146229331, Length=408, Percent_Identity=30.6372549019608, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI146229329, Length=408, Percent_Identity=30.6372549019608, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI6005990, Length=408, Percent_Identity=30.6372549019608, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI146229324, Length=408, Percent_Identity=30.6372549019608, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI45430057, Length=384, Percent_Identity=28.90625, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI109389362, Length=484, Percent_Identity=26.6528925619835, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI157266309, Length=487, Percent_Identity=26.4887063655031, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI53831991, Length=465, Percent_Identity=24.3010752688172, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI146229327, Length=343, Percent_Identity=29.1545189504373, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI38569405, Length=511, Percent_Identity=25.8317025440313, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI58743319, Length=445, Percent_Identity=26.7415730337079, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI38569407, Length=345, Percent_Identity=27.536231884058, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI71852584, Length=519, Percent_Identity=25.4335260115607, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI59797060, Length=470, Percent_Identity=25.1063829787234, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI71852586, Length=169, Percent_Identity=36.6863905325444, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI31742482, Length=138, Percent_Identity=37.6811594202899, Blast_Score=83, Evalue=8e-16,
Organism=Escherichia coli, GI1790233, Length=492, Percent_Identity=30.8943089430894, Blast_Score=184, Evalue=9e-48,
Organism=Escherichia coli, GI87081924, Length=451, Percent_Identity=22.8381374722838, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI115533416, Length=415, Percent_Identity=27.710843373494, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI115533418, Length=405, Percent_Identity=27.1604938271605, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17559078, Length=242, Percent_Identity=28.5123966942149, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24666175, Length=401, Percent_Identity=26.9326683291771, Blast_Score=122, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24666109, Length=419, Percent_Identity=25.2983293556086, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI281363223, Length=450, Percent_Identity=26, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI281366397, Length=424, Percent_Identity=25.9433962264151, Blast_Score=110, Evalue=4e-24,
Organism=Drosophila melanogaster, GI281366395, Length=424, Percent_Identity=25.9433962264151, Blast_Score=110, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24666163, Length=424, Percent_Identity=25.9433962264151, Blast_Score=110, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 63723; Mature: 63723

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00284 SERPIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQAEMRKTRIGGLATLAIAAAVLTLAGCGKQEEPKAPAAQAPAAQSSAEAPAAPQAARE
CCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCC
NPPVAANAPESAASAPALPPVANSGKKPNILVIFGDDIGQTNISAYSHGVVGYRTPNIDR
CCCCCCCCCCHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHCCEEEEECCCHHH
IAREGMMMTDYYGENSCTAGRSTFITGEVGLRTGLLKVGIPGATVGLQAQNATIAEALKP
HHHCCCEEEEECCCCCCCCCCCEEEEECCCHHHCEEEECCCCCEEEEEECCCHHHHHHHH
LGYATGQFGKNHLGDRNEYLPTAHGFDEFYGNLYHLNAEEEPERPYYPKNDAAFVKANSP
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCEEEECCCCCCCCCCCCCCCCEEEEECCC
RGVIHSFSDGKVEDTGPLTRKRMETIDDETTAAAIGFMEKQVKADKPFFVWMNTTRMHLF
CCEEECCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHH
THVRESMRGQSGMPGNEYADGMLEHDADVGKLLRTLDDLKIADNTIVVYTTDNGPNQFSW
HHHHHHHCCCCCCCCCHHHCCHHHCCCHHHHHHHHHHHCEECCCEEEEEECCCCCCCCCC
PDAATTPFRSEKDTNWEGAFRVPALVKWPGRIKPGTVSTTMMSGLDWFPTLLAAAGDTDI
CCCCCCCCCCCCCCCCCCEEECCEEEECCCCCCCCCCHHHHHHCCHHHHHHHHHCCCHHH
KERLLKGTSLGGKSFKVHLDGYNFLPYLTGQTNTGPRQDFYYFNDDGQLVAYRYNDWKIV
HHHHHHCCCCCCCEEEEEECCCCCCEEECCCCCCCCCCCEEEECCCCCEEEEEECCEEEE
FCEQRQPGGFQVWSNPFTCLRAPKAFNLRMDPYERADTVSDQYYDWATKNAYLMQYGVYR
EEECCCCCCEEEECCCCCEEECCCEEEEECCCHHHHHCCCHHHHHHCCCCEEEEHHHHHH
VIPFLQTFKDYPPSQRPASFSIDQAVEQLMKTLDKTPAK
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRQAEMRKTRIGGLATLAIAAAVLTLAGCGKQEEPKAPAAQAPAAQSSAEAPAAPQAARE
CCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCC
NPPVAANAPESAASAPALPPVANSGKKPNILVIFGDDIGQTNISAYSHGVVGYRTPNIDR
CCCCCCCCCCHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHCCEEEEECCCHHH
IAREGMMMTDYYGENSCTAGRSTFITGEVGLRTGLLKVGIPGATVGLQAQNATIAEALKP
HHHCCCEEEEECCCCCCCCCCCEEEEECCCHHHCEEEECCCCCEEEEEECCCHHHHHHHH
LGYATGQFGKNHLGDRNEYLPTAHGFDEFYGNLYHLNAEEEPERPYYPKNDAAFVKANSP
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCEEEECCCCCCCCCCCCCCCCEEEEECCC
RGVIHSFSDGKVEDTGPLTRKRMETIDDETTAAAIGFMEKQVKADKPFFVWMNTTRMHLF
CCEEECCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHH
THVRESMRGQSGMPGNEYADGMLEHDADVGKLLRTLDDLKIADNTIVVYTTDNGPNQFSW
HHHHHHHCCCCCCCCCHHHCCHHHCCCHHHHHHHHHHHCEECCCEEEEEECCCCCCCCCC
PDAATTPFRSEKDTNWEGAFRVPALVKWPGRIKPGTVSTTMMSGLDWFPTLLAAAGDTDI
CCCCCCCCCCCCCCCCCCEEECCEEEECCCCCCCCCCHHHHHHCCHHHHHHHHHCCCHHH
KERLLKGTSLGGKSFKVHLDGYNFLPYLTGQTNTGPRQDFYYFNDDGQLVAYRYNDWKIV
HHHHHHCCCCCCCEEEEEECCCCCCEEECCCCCCCCCCCEEEECCCCCEEEEEECCEEEE
FCEQRQPGGFQVWSNPFTCLRAPKAFNLRMDPYERADTVSDQYYDWATKNAYLMQYGVYR
EEECCCCCCEEEECCCCCEEECCCEEEEECCCHHHHHCCCHHHHHHCCCCEEEEHHHHHH
VIPFLQTFKDYPPSQRPASFSIDQAVEQLMKTLDKTPAK
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]