Click here to switch to the map view.

The map label for this gene is ethA [H]

Identifier: 94314147

GI number: 94314147

Start: 1923406

End: 1924935

Strand: Reverse

Name: ethA [H]

Synonym: Rmet_5228

Alternate gene names: 94314147

Gene position: 1924935-1923406 (Counterclockwise)

Preceding gene: 94314149

Following gene: 94314146

Centisome position: 74.61

GC content: 62.35

Gene sequence:

>1530_bases
GTGAACGCCAATTACGACGTATTGATTATCGGCGCCGGACTATCCGGCATCGGCATGGCATGCCACCTGGCTGAGGCATG
TCCGGGCAAGCGCGTCGGCATCCTGGAGCGGCGCAGTGCCATCGGCGGGACATGGGACCTGTTCCGGTATCCCGGCATCC
GCTCAGATTCGGACATGTTCAGCTTCGGCTACAAGTTCCGCCCGTGGCACGAGTTGAAAGTCCTTGCCGACGGCCCTTCG
ATCCGTCGCTACATTGGCGATACCGCGCGCGAATACGGTGTCGACAAGTGGATCCAGTTCGGGCTGAAAGTCCTGCGGGC
ATCGTGGTCGAGCGAGGACCAGTACTGGACCGTCACCACACAGCAGGAAGGCAGCCACGATACCCGTACCCTCACTTGCA
AGTTCCTGATCCCCTGCACGGGCTACTACAACTACGACCACGGGCACCGGCCCGACTTTGCCGGCCTTGAGCGGTTCCAG
GGCATCTGCGTCCATCCGCAACACTGGCCTGAAGATCTGGACTATCGGGGCAAGCGTGTCGTCGTGATCGGCAGTGGCGC
GACGGCGGTGACGCTGGTCCCGGCCATGGCCGGTCAGGCGTCACACGTCACGATGCTGCAGCGCTCGCCCAGCTACGTCT
TCTCGGTGCCGGCATATGACAAGATCTCTGCCGTCCTGCAAAAGATGCTGCCGGCACGCTGGGTGTATGGCCTGGCACGG
TGGCGCAATATCCGCCTGCAGCGCTTCATCTACAGGACCGCAAAGCGGTGGCCGCGGCGCGTCCGCTCCTGGCTGCTGTC
GCATGTTGAACAACAGCTCGGACATGGCGCCGACATGCGGCACTTTTCGCCCAGTTACAACCCGTGGGACCAGCGGTTGT
GCGCAGTGCCTGACGGCGATCTCTTCAAGGTTATCTCCGAAGGCAAGGCCTCTGTGGTGACGGACCACATCGAGACCTTT
ACCGAAACCGGCGTCCGCCTGAAGTCGGGCAAGAGCCTCGACGCTGACATCATCATCACGGCCACCGGGCTTCAGCTCCA
GTCCCTTGGTGGCATGGAGGTACAGGTGGATGGGCGGCCGCGGCACCCCAGCAGTCTCATGACCTACAAGAGCGTGCTGA
TGCAGGACGTGCCCAACCTGGCCAACCTGTTTGGCTATACCAACGCATCCTGGACATTGAAGGTCGACCTGGCCGCCAAC
TACATCTGCCGCCTGCTCAACCACATGGACCGCCACGGCTACAACGTCGTAACGCCAATCGCCCCAGCCGGGGAAATGCT
GGAAGAAACGGTCATGGATTCCCTGCAGTCTGGTTACGTGCAACGCGGTCGGAGTACCTTGCCTCGTCAGGGCCGTACGC
CTCCCTGGCGCGTTCTCCACAACTTCGTGGCCGATCGCGAGATGTTGACGAGGCATCCGATTCACGATCCAGCGCTGAGG
TTCGTCCGTGCCGCAACGACCACGACGGTGGCGCGCGGCCGGCCAGCCTGCGACCTTGTGGCAACCAGCATGGACGAAAC
AGCCGTGTGA

Upstream 100 bases:

>100_bases
TGGCTCGTAACGTAAATTAATTGTCTCGTGACGTCAAGAGTGGCTTGGCGCCACGCGCTACAGTTTCCGGACGACAAGGC
CAGACATAAGGAGACGCTGC

Downstream 100 bases:

>100_bases
GGTTCAGCCGCATTCCGCATCGGAGCCTTGCATGGTCAGCATTGATTCTTCCTTCCAAAGCCACGGTGAGCGTTGCGCGG
CCACGCTGATGCTGCCGAGC

Product: putative monooxygenase

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MNANYDVLIIGAGLSGIGMACHLAEACPGKRVGILERRSAIGGTWDLFRYPGIRSDSDMFSFGYKFRPWHELKVLADGPS
IRRYIGDTAREYGVDKWIQFGLKVLRASWSSEDQYWTVTTQQEGSHDTRTLTCKFLIPCTGYYNYDHGHRPDFAGLERFQ
GICVHPQHWPEDLDYRGKRVVVIGSGATAVTLVPAMAGQASHVTMLQRSPSYVFSVPAYDKISAVLQKMLPARWVYGLAR
WRNIRLQRFIYRTAKRWPRRVRSWLLSHVEQQLGHGADMRHFSPSYNPWDQRLCAVPDGDLFKVISEGKASVVTDHIETF
TETGVRLKSGKSLDADIIITATGLQLQSLGGMEVQVDGRPRHPSSLMTYKSVLMQDVPNLANLFGYTNASWTLKVDLAAN
YICRLLNHMDRHGYNVVTPIAPAGEMLEETVMDSLQSGYVQRGRSTLPRQGRTPPWRVLHNFVADREMLTRHPIHDPALR
FVRAATTTTVARGRPACDLVATSMDETAV

Sequences:

>Translated_509_residues
MNANYDVLIIGAGLSGIGMACHLAEACPGKRVGILERRSAIGGTWDLFRYPGIRSDSDMFSFGYKFRPWHELKVLADGPS
IRRYIGDTAREYGVDKWIQFGLKVLRASWSSEDQYWTVTTQQEGSHDTRTLTCKFLIPCTGYYNYDHGHRPDFAGLERFQ
GICVHPQHWPEDLDYRGKRVVVIGSGATAVTLVPAMAGQASHVTMLQRSPSYVFSVPAYDKISAVLQKMLPARWVYGLAR
WRNIRLQRFIYRTAKRWPRRVRSWLLSHVEQQLGHGADMRHFSPSYNPWDQRLCAVPDGDLFKVISEGKASVVTDHIETF
TETGVRLKSGKSLDADIIITATGLQLQSLGGMEVQVDGRPRHPSSLMTYKSVLMQDVPNLANLFGYTNASWTLKVDLAAN
YICRLLNHMDRHGYNVVTPIAPAGEMLEETVMDSLQSGYVQRGRSTLPRQGRTPPWRVLHNFVADREMLTRHPIHDPALR
FVRAATTTTVARGRPACDLVATSMDETAV
>Mature_509_residues
MNANYDVLIIGAGLSGIGMACHLAEACPGKRVGILERRSAIGGTWDLFRYPGIRSDSDMFSFGYKFRPWHELKVLADGPS
IRRYIGDTAREYGVDKWIQFGLKVLRASWSSEDQYWTVTTQQEGSHDTRTLTCKFLIPCTGYYNYDHGHRPDFAGLERFQ
GICVHPQHWPEDLDYRGKRVVVIGSGATAVTLVPAMAGQASHVTMLQRSPSYVFSVPAYDKISAVLQKMLPARWVYGLAR
WRNIRLQRFIYRTAKRWPRRVRSWLLSHVEQQLGHGADMRHFSPSYNPWDQRLCAVPDGDLFKVISEGKASVVTDHIETF
TETGVRLKSGKSLDADIIITATGLQLQSLGGMEVQVDGRPRHPSSLMTYKSVLMQDVPNLANLFGYTNASWTLKVDLAAN
YICRLLNHMDRHGYNVVTPIAPAGEMLEETVMDSLQSGYVQRGRSTLPRQGRTPPWRVLHNFVADREMLTRHPIHDPALR
FVRAATTTTVARGRPACDLVATSMDETAV

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI50541965, Length=356, Percent_Identity=25.2808988764045, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI50541961, Length=356, Percent_Identity=25.2808988764045, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI4503757, Length=356, Percent_Identity=23.876404494382, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI4503759, Length=357, Percent_Identity=24.6498599439776, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25145785, Length=353, Percent_Identity=24.929178470255, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17555726, Length=364, Percent_Identity=23.0769230769231, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 57342; Mature: 57342

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNANYDVLIIGAGLSGIGMACHLAEACPGKRVGILERRSAIGGTWDLFRYPGIRSDSDMF
CCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHCCCCCCCCCCHH
SFGYKFRPWHELKVLADGPSIRRYIGDTAREYGVDKWIQFGLKVLRASWSSEDQYWTVTT
HCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCEEEEEE
QQEGSHDTRTLTCKFLIPCTGYYNYDHGHRPDFAGLERFQGICVHPQHWPEDLDYRGKRV
CCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHCCEEECCCCCCCCCCCCCCEE
VVIGSGATAVTLVPAMAGQASHVTMLQRSPSYVFSVPAYDKISAVLQKMLPARWVYGLAR
EEEECCCCEEEEHHHHCCCCHHEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
WRNIRLQRFIYRTAKRWPRRVRSWLLSHVEQQLGHGADMRHFSPSYNPWDQRLCAVPDGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCEEEECCCCH
LFKVISEGKASVVTDHIETFTETGVRLKSGKSLDADIIITATGLQLQSLGGMEVQVDGRP
HHHHHHCCCHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCCEEECCCCEEEEECCCC
RHPSSLMTYKSVLMQDVPNLANLFGYTNASWTLKVDLAANYICRLLNHMDRHGYNVVTPI
CCCHHHHHHHHHHHHHCCHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCEEECCC
APAGEMLEETVMDSLQSGYVQRGRSTLPRQGRTPPWRVLHNFVADREMLTRHPIHDPALR
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHH
FVRAATTTTVARGRPACDLVATSMDETAV
HHHHHHHHHHHCCCCCHHHHHCCCHHCCC
>Mature Secondary Structure
MNANYDVLIIGAGLSGIGMACHLAEACPGKRVGILERRSAIGGTWDLFRYPGIRSDSDMF
CCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHCCCCCCCCCCHH
SFGYKFRPWHELKVLADGPSIRRYIGDTAREYGVDKWIQFGLKVLRASWSSEDQYWTVTT
HCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCEEEEEE
QQEGSHDTRTLTCKFLIPCTGYYNYDHGHRPDFAGLERFQGICVHPQHWPEDLDYRGKRV
CCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHCCEEECCCCCCCCCCCCCCEE
VVIGSGATAVTLVPAMAGQASHVTMLQRSPSYVFSVPAYDKISAVLQKMLPARWVYGLAR
EEEECCCCEEEEHHHHCCCCHHEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
WRNIRLQRFIYRTAKRWPRRVRSWLLSHVEQQLGHGADMRHFSPSYNPWDQRLCAVPDGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCEEEECCCCH
LFKVISEGKASVVTDHIETFTETGVRLKSGKSLDADIIITATGLQLQSLGGMEVQVDGRP
HHHHHHCCCHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCCEEECCCCEEEEECCCC
RHPSSLMTYKSVLMQDVPNLANLFGYTNASWTLKVDLAANYICRLLNHMDRHGYNVVTPI
CCCHHHHHHHHHHHHHCCHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCEEECCC
APAGEMLEETVMDSLQSGYVQRGRSTLPRQGRTPPWRVLHNFVADREMLTRHPIHDPALR
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHH
FVRAATTTTVARGRPACDLVATSMDETAV
HHHHHHHHHHHCCCCCHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]