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The map label for this gene is aldH [H]

Identifier: 94314015

GI number: 94314015

Start: 1786872

End: 1788359

Strand: Reverse

Name: aldH [H]

Synonym: Rmet_5096

Alternate gene names: 94314015

Gene position: 1788359-1786872 (Counterclockwise)

Preceding gene: 94314016

Following gene: 94314014

Centisome position: 69.31

GC content: 65.66

Gene sequence:

>1488_bases
ATGCAGAGCTTTCGTGCTCCGCTCGCTTCTCCGCTTTTCCGTCAGACTCCCTCGTTTCCATTCATGCACGCTTCCGAACA
GAACCAAGTCTTCGCGATCATCGACCAGCACGCCACGCGCGCCCACGAGGCCAGCGCGGCATGGGCGCATTCGAGTCCCA
CGGTCCGCAGTGGCGTGCTGCGTGCGCTGGCCGACGCCCTCGACGCGCGCGCGAATGAACTCGCGGTGATGGCCGACGAG
GAAACCGGCCTCGGCATCCCACGGCTGACGGGGGAGATCGCCCGCACATCGTTCCAGTTGCGGGGCTTCGCGGATGAAGT
CGTGGCGGGCGTCCCCTACGTCCAGGTGGATGACGAAGCCATTCCCGGCCCGCCTCCGTCGGGCCGTCCGCGTCTGACCC
GTGTCATGGTCCCGATTGGTCCGGTTGCCGTATTTGCAGCCAGCAACTTCCCGTTCGCGTTCTCGGTCCTGGGCGGAGAC
ACCGCATCGGCGTTGGCTGCGGGTTGTCCGGTCATCGTGAAGCCGCATGGCGGACATCCGCGCCTGTCAATCGAGGTGGC
GAAGATTGCCGCAGAGGTCCTGCGCGCGCAAGGTGTGGAAGAGGGCGTGTTCTCGATGCTCGACTGCGACATGTCGCGCG
ACGCCAATATCCATCTGGTCAAGCATCCGCTGATCGCGGGCGTGGCGTTCACGGGCTCCTATCAGGGTGGCGTGGCCTTG
TGGCGCGCCGCGAATGAGCGCGAGATCCCGATTCCCTTCTTCGGCGAACTCGGTTCGATCAATCCGGTGGTGGTGCTCCC
TGCGGCACTGCATGACGACCCGGTTGCGCCGGCCAAGGTGCTGGCGGCGTCGATGCTGCAAGGCTGCGGCCAGTTCTGTA
CCAGCCCCGGCGTTATCGTGGTGGTCGATGACCAGCGCGGCCGCGAGTTTGTCTCGGCGCTGGGCGACTCGCTGGCGGGG
CAGGCCACCCATCGGATGCTGAGCGAAGGCATCCGCAATGGTTTTGAAGATGCCGTCGCGCGTATCAAGGCGAATGCCAA
TATCGAGGTCGTACTGGAAGGGAATGAGGCTGGGGCCGGCCCGGCTCCCCGCCTGTTCCAGACCACCGGCGCTGCCTTTA
TCGCGGATGCCAGCCTCCACGAGGAAATGTTCGGTCCAGCGGCCGTAGTGGTCATGGTGCCATCCGTCGATGCGATTCCC
GATGTACTCTCCGCCGTCAAGGGATCGCTCACGGTCACGATCTGGGGGGGCGACCAGGACAACCACGAGAATCGCGAGAT
CGTGCGCGTGGCCCAGAACATTGGGGGCCGCGTGCTGTTCTCTGGTGTACCGACCGGCGTCGCCGTGACGCGCGCGCAGC
AACATGGCGGCCCCTGGCCGGCGTCCACCGATCCGAAGACCACGTCGGTCGGGTATGCTGCCTTGCAGCGTTTTCTTCGG
CCCGTGGCACTTCAGGATGCGCCGGAGTGGCTGCTCCAGCGCGCGTGA

Upstream 100 bases:

>100_bases
CGTGGACGCCTGATCCTGTCTGACCCTGCATGACCATCCCAAGGCGGCGAAGTCGGCTGCCTTGGGCGCATGTTCTACCC
ATCTGTACTCCTTCTCCGCG

Downstream 100 bases:

>100_bases
TATCTCACAGGCAACGATAAGGAGGCATGGCAGATCAATGTCGGAAACCATCCAGCTCTCGCTCGCGGAGGTACGCGAGC
TTTCGCTCAACGTTCTGCAA

Product: 2-ketoglutarate semialdehyde dehydrogenase / NADP-dependent aldehyde dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MQSFRAPLASPLFRQTPSFPFMHASEQNQVFAIIDQHATRAHEASAAWAHSSPTVRSGVLRALADALDARANELAVMADE
ETGLGIPRLTGEIARTSFQLRGFADEVVAGVPYVQVDDEAIPGPPPSGRPRLTRVMVPIGPVAVFAASNFPFAFSVLGGD
TASALAAGCPVIVKPHGGHPRLSIEVAKIAAEVLRAQGVEEGVFSMLDCDMSRDANIHLVKHPLIAGVAFTGSYQGGVAL
WRAANEREIPIPFFGELGSINPVVVLPAALHDDPVAPAKVLAASMLQGCGQFCTSPGVIVVVDDQRGREFVSALGDSLAG
QATHRMLSEGIRNGFEDAVARIKANANIEVVLEGNEAGAGPAPRLFQTTGAAFIADASLHEEMFGPAAVVVMVPSVDAIP
DVLSAVKGSLTVTIWGGDQDNHENREIVRVAQNIGGRVLFSGVPTGVAVTRAQQHGGPWPASTDPKTTSVGYAALQRFLR
PVALQDAPEWLLQRA

Sequences:

>Translated_495_residues
MQSFRAPLASPLFRQTPSFPFMHASEQNQVFAIIDQHATRAHEASAAWAHSSPTVRSGVLRALADALDARANELAVMADE
ETGLGIPRLTGEIARTSFQLRGFADEVVAGVPYVQVDDEAIPGPPPSGRPRLTRVMVPIGPVAVFAASNFPFAFSVLGGD
TASALAAGCPVIVKPHGGHPRLSIEVAKIAAEVLRAQGVEEGVFSMLDCDMSRDANIHLVKHPLIAGVAFTGSYQGGVAL
WRAANEREIPIPFFGELGSINPVVVLPAALHDDPVAPAKVLAASMLQGCGQFCTSPGVIVVVDDQRGREFVSALGDSLAG
QATHRMLSEGIRNGFEDAVARIKANANIEVVLEGNEAGAGPAPRLFQTTGAAFIADASLHEEMFGPAAVVVMVPSVDAIP
DVLSAVKGSLTVTIWGGDQDNHENREIVRVAQNIGGRVLFSGVPTGVAVTRAQQHGGPWPASTDPKTTSVGYAALQRFLR
PVALQDAPEWLLQRA
>Mature_495_residues
MQSFRAPLASPLFRQTPSFPFMHASEQNQVFAIIDQHATRAHEASAAWAHSSPTVRSGVLRALADALDARANELAVMADE
ETGLGIPRLTGEIARTSFQLRGFADEVVAGVPYVQVDDEAIPGPPPSGRPRLTRVMVPIGPVAVFAASNFPFAFSVLGGD
TASALAAGCPVIVKPHGGHPRLSIEVAKIAAEVLRAQGVEEGVFSMLDCDMSRDANIHLVKHPLIAGVAFTGSYQGGVAL
WRAANEREIPIPFFGELGSINPVVVLPAALHDDPVAPAKVLAASMLQGCGQFCTSPGVIVVVDDQRGREFVSALGDSLAG
QATHRMLSEGIRNGFEDAVARIKANANIEVVLEGNEAGAGPAPRLFQTTGAAFIADASLHEEMFGPAAVVVMVPSVDAIP
DVLSAVKGSLTVTIWGGDQDNHENREIVRVAQNIGGRVLFSGVPTGVAVTRAQQHGGPWPASTDPKTTSVGYAALQRFLR
PVALQDAPEWLLQRA

Specific function: Catalyzes the oxidation of long-chain aliphatic aldehydes to acids. May be implicated in controlling luminescence as it catalyzes the oxidation of the fatty aldehyde substrate for the light-emitting reaction [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldehyde dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507229, Length=360, Percent_Identity=28.0555555555556, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI25777721, Length=369, Percent_Identity=27.10027100271, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1787558, Length=400, Percent_Identity=25.75, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI87081896, Length=261, Percent_Identity=29.5019157088123, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789015, Length=335, Percent_Identity=27.4626865671642, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1786504, Length=241, Percent_Identity=27.3858921161826, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71995613, Length=294, Percent_Identity=29.2517006802721, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71995606, Length=294, Percent_Identity=29.2517006802721, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25143874, Length=299, Percent_Identity=29.4314381270903, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25143876, Length=299, Percent_Identity=29.4314381270903, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17534119, Length=411, Percent_Identity=26.5206812652068, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI115534176, Length=272, Percent_Identity=29.7794117647059, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6319478, Length=395, Percent_Identity=24.5569620253165, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI281362580, Length=298, Percent_Identity=28.5234899328859, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI62472918, Length=298, Percent_Identity=28.5234899328859, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI62472926, Length=298, Percent_Identity=28.5234899328859, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI62472936, Length=298, Percent_Identity=28.5234899328859, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21356737, Length=298, Percent_Identity=28.5234899328859, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.4 [H]

Molecular weight: Translated: 52065; Mature: 52065

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSFRAPLASPLFRQTPSFPFMHASEQNQVFAIIDQHATRAHEASAAWAHSSPTVRSGVL
CCCCCCCCCCHHHHCCCCCCEEECCCCCCEEEEEEHHHHHHHHHHHHCCCCCCHHHHHHH
RALADALDARANELAVMADEETGLGIPRLTGEIARTSFQLRGFADEVVAGVPYVQVDDEA
HHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCEEEECCCC
IPGPPPSGRPRLTRVMVPIGPVAVFAASNFPFAFSVLGGDTASALAAGCPVIVKPHGGHP
CCCCCCCCCCCEEEEEECCCCEEEEEECCCCEEEEEECCCHHHHHHCCCCEEEECCCCCC
RLSIEVAKIAAEVLRAQGVEEGVFSMLDCDMSRDANIHLVKHPLIAGVAFTGSYQGGVAL
EEEEHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEECCCEEEEEEECCCCCCEEE
WRAANEREIPIPFFGELGSINPVVVLPAALHDDPVAPAKVLAASMLQGCGQFCTSPGVIV
EECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEE
VVDDQRGREFVSALGDSLAGQATHRMLSEGIRNGFEDAVARIKANANIEVVLEGNEAGAG
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEECCCCCCC
PAPRLFQTTGAAFIADASLHEEMFGPAAVVVMVPSVDAIPDVLSAVKGSLTVTIWGGDQD
CCCCHHHHCCCCEEECCHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCEEEEEECCCCC
NHENREIVRVAQNIGGRVLFSGVPTGVAVTRAQQHGGPWPASTDPKTTSVGYAALQRFLR
CCCHHHHHHHHHHCCCEEEEECCCCCCEEEEHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
PVALQDAPEWLLQRA
HHHHCCCHHHHHCCC
>Mature Secondary Structure
MQSFRAPLASPLFRQTPSFPFMHASEQNQVFAIIDQHATRAHEASAAWAHSSPTVRSGVL
CCCCCCCCCCHHHHCCCCCCEEECCCCCCEEEEEEHHHHHHHHHHHHCCCCCCHHHHHHH
RALADALDARANELAVMADEETGLGIPRLTGEIARTSFQLRGFADEVVAGVPYVQVDDEA
HHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCEEEECCCC
IPGPPPSGRPRLTRVMVPIGPVAVFAASNFPFAFSVLGGDTASALAAGCPVIVKPHGGHP
CCCCCCCCCCCEEEEEECCCCEEEEEECCCCEEEEEECCCHHHHHHCCCCEEEECCCCCC
RLSIEVAKIAAEVLRAQGVEEGVFSMLDCDMSRDANIHLVKHPLIAGVAFTGSYQGGVAL
EEEEHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEECCCEEEEEEECCCCCCEEE
WRAANEREIPIPFFGELGSINPVVVLPAALHDDPVAPAKVLAASMLQGCGQFCTSPGVIV
EECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEE
VVDDQRGREFVSALGDSLAGQATHRMLSEGIRNGFEDAVARIKANANIEVVLEGNEAGAG
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEECCCCCCC
PAPRLFQTTGAAFIADASLHEEMFGPAAVVVMVPSVDAIPDVLSAVKGSLTVTIWGGDQD
CCCCHHHHCCCCEEECCHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCEEEEEECCCCC
NHENREIVRVAQNIGGRVLFSGVPTGVAVTRAQQHGGPWPASTDPKTTSVGYAALQRFLR
CCCHHHHHHHHHHCCCEEEEECCCCCCEEEEHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
PVALQDAPEWLLQRA
HHHHCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8527447; 10903148 [H]